Researchers have discovered a potential treatment for sepsis and other responses to infection by using tiny doses of a cancer drug. The new treatment may benefit millions worldwide who are affected by infections and pandemics.
A new study identifies a small molecule that simultaneously inhibits signaling pathways activated by mutated RAS oncogenes, representing a new paradigm for targeting this elusive cancer gene. The discovery has significant implications for the treatment of RAS-driven cancers.
A powerful genetic regulator, miR-9, has been identified as a risk factor for schizophrenia, controlling the activity of hundreds of genes involved in fetal brain development. The study, led by Kristen Brennand and Gang Fang, found that miR-9 was under-expressed in brains of schizophrenic patients, leading to miswiring of neurons.
Researchers found that removing Dnmt1 during OPC differentiation led to inefficient myelin formation and neurological deterioration in mice. This discovery could lead to a better understanding of myelin disorders and potentially develop treatments.
The Mount Sinai Hospital and Sage Bionetworks conducted a genome study of over 589,000 adults to identify individuals resistant to severe Mendelian childhood diseases. Thirteen healthy people with associated genetic variants were found, but limitations in the original studies' informed consent policies hinder further analysis.
A multi-site clinical trial is assessing the safety and effectiveness of bariatric arterial embolization in treating patients with morbid obesity. The procedure targets ghrelin, reducing hunger sensation and promoting weight loss.
Researchers from the Icahn School of Medicine at Mount Sinai present new findings on CABG alone or with mitral valve repair for moderate ischemic MR, as well as rate versus rhythm control in patients with postoperative atrial fibrillation after cardiac surgery.
A study led by Dr. Roger J. Hajjar and Dr. Woo Jin Park found that CCN5 protein can reverse established cardiac fibrosis in heart failure models. The researchers used trichrome staining to show the reversal of cardiac fibrosis, demonstrating potential for new anti-cardiac fibrosis therapies.
Mount Sinai researchers found that testing service and time of collection significantly influenced results, with some test providers flagging more abnormal readings than others. The study highlights the importance of accurate lab test results in medical decision-making.
A new study from Mount Sinai found that light exposure therapy can decrease depressive symptoms among cancer survivors. Participants who received bright white light therapy showed improvement, while those with dim red light therapy experienced no change.
Researchers at Mount Sinai identified precursor cells in mice embryos that can be matured into hematopoietic stem/progenitor cells (HSPCs) using reprogramming technology. This breakthrough could lead to the development of patient-specific HSPCs for cell-replacement therapy and alleviate the need for transplantable stem cells.
Researchers have identified a new therapeutic target for multiple myeloma, targeting CDK4 and ARK5 proteins. The compound ON123300 showed potent cytotoxicity against myeloma cells while sparing normal peripheral blood cells.
Higher intake of food-based vitamin D during pregnancy was associated with reduced risk of development of allergies in children. Vitamin D modulates the immune system and its potential role in asthma and allergy has been of interest.
Researchers demonstrate that C-section infants can be enriched with vaginal bacteria, improving their immune system development. The study's findings have significant implications for the health risks associated with C-section deliveries.
A team of researchers used a fruit fly model to identify a potential targeted therapy for non-small cell lung cancer, which may lead to improved overall survival. The study found that combining two FDA-approved drugs suppressed tumor formation and inhibited key genetic mutations associated with NSCLC.
A three-year study aims to determine the effectiveness of a comprehensive lifestyle intervention in reducing cardiovascular disease risk factors. Participants will receive personalized counseling and monitoring, while others will receive standard occupational health care.
Researchers found that head-down yoga poses, such as downward-facing dog, can cause a rise in eye pressure in glaucoma patients. Glaucoma patients should inform their yoga instructors about their condition to modify poses and avoid potential damage to the optic nerve.
A long-term surveillance study shows chromoendoscopy is more effective than random biopsy or white-light colonoscopy in detecting dysplasia in patients with inflammatory bowel diseases. Chromoendoscopy identified precancerous lesions in 27 out of 208 examinations, while white-light examination detected them in only 11.
Researchers found that commensal bacteria in the lungs instruct immune cells to produce IgA, a protein protecting against infections and allergies. The study suggests a link between antibiotic use, dysbiosis, and reduced IgA production, potentially contributing to rising allergy rates.
Naturally occurring brain wiring changes can help patients at high genetic risk of developing bipolar disorder avoid the illness. Researchers found that resilient siblings showed additional changes in brain wiring within networks involved in emotional processing, which may help them avoid the disease.
A new study published in Health Affairs found that palliative care consultation within two days of hospitalization resulted in significant savings in hospital costs for cancer patients with multiple chronic conditions. Patients with higher numbers of comorbidities showed greater reductions in direct hospital costs.
Patients with COPD who received music therapy in conjunction with standard rehabilitation showed improved symptoms, psychological well-being, and quality of life. Music therapy incorporated breath control techniques, patient-preferred music, and visualizations to increase engagement and cope with chronic disease challenges.
The WATCHMAN device is more cost-effective than warfarin and NOACs for reducing strokes in patients with non-valvular atrial fibrillation, according to a study led by Dr. Reddy. The device achieved cost effectiveness relative to warfarin at seven years and NOACs at 16 years, generating annual cost savings thereafter.
A study found that syringe service programs are scarce in rural and suburban areas, where rates of opioid addiction are on the rise. The programs, which exchange used needles for new ones, reduce the risk of HIV transmission and overdose. Despite their benefits, many SSPs struggle with recruitment, funding, and staffing issues.
Mount Sinai researchers developed a synthetic vector to rapidly eliminate total cellular miRNA populations, revealing the limited role of microRNAs in modulating cell biology over long periods. This tool enables manipulation of miRNA responses for potential treatment of diseases like cancer.
A team of researchers discovered non-coding RNA molecules in cancer cells that stimulate an immune response by mimicking pathogens. The findings suggest these molecules may play a significant role in mediating immune responses against cancer.
Researchers presented landmark studies on newly diagnosed multiple myeloma, revealing key biological processes and disease mechanisms. Two combination therapy strategies showed high response rates in patients with difficult-to-treat myeloma.
New tools, MEGENA and SuperExactTest, help genomics researchers study hierarchical organization patterns in complex networks and compare large sets of data. These tools were published in PLoS Computational Biology and Scientific Reports.
Immune cells called Langerhans cells can uniquely repair DNA damage caused by radiotherapy, making them resistant to treatment. Researchers found that mimicking immunotherapy drugs can block this ability, preventing immune response and improving radiation therapy effectiveness.
A city-wide coalition launched by NYC DOHMH and Mount Sinai resulted in a 40% increase in colorectal cancer screening rates over four years. Screening rates rose from 42% in 2003 to 62% in 2007, with significant reductions in disparities based on ethnicity.
A study found that group therapy significantly improves cardiovascular health by promoting healthy behaviors, including smoking cessation and increased physical activity. The intervention improved cardiovascular risk factors in 67% of participants compared to 56% in the control group.
Researchers at Mount Sinai Hospital found seven barriers to implementing an integrated family-based health promotion program for children and caregivers in Harlem, including knowledge gaps on social determinants of chronic diseases and cultural sensitivity. The study suggests actions to address these barriers could be effective in impr...
Scientists developed JEDI T-cells to visualize immune responses and model disease states, enabling targeted cell depletion and advancing immunotherapy in cancer care. This breakthrough has implications for autoimmune diseases and brain malignancies like glioblastoma.
Researchers have developed an online database called Hair-GEL that provides a bird's eye view of hair follicle formation. By analyzing the genetic activity of skin cells during fetal development, scientists can gain insights into how stem cells and niche cells interact to form functional hair follicles.
A study led by Mount Sinai researchers identifies zinc finger protein 217 (ZFP217) as a factor that regulates stem cell self-renewal and differentiation, potentially balancing medically useful qualities for therapeutic applications. The discovery builds on understanding epigenetic mechanisms controlling gene expression.
Researchers used data analysis to identify three distinct subtypes of patients with type 2 diabetes, each associated with different clinical characteristics and genetic variants. The study suggests a novel approach that can be applied to virtually any disease, potentially leading to more effective diagnosis and treatment.
A study published in Annals of Internal Medicine found that the average total cost for deceased patients with dementia was $287,038 in the last five years of life, significantly higher than those who died from other causes. Out-of-pocket spending for dementia patients was 81% higher.
A study at Mount Sinai found that inhibiting a family of epigenetic brain proteins, known as BETs, can induce an autism-like syndrome in mice. This links environmental factors to gene transcription and may provide insights into the disease's pathology.
Scientists engineered stem cells with PTPN11 mutations to recreate JMML, clarifying early events in its development and providing new targets for drug design. This 'leukemia in a dish' model can help improve treatment options for patients with this rare blood cancer.
A multicenter clinical trial led by Mount Sinai researchers found that brodalumab achieved a 100 percent reduction in psoriasis symptoms, exceeding the results of ustekinumab. The study demonstrated that targeting the IL-17 receptor is highly effective in treating moderate to severe plaque psoriasis.
Researchers have discovered a molecule produced by skeletal muscle that increases bone mass and strength. This finding has significant implications for treating sarcopenia and osteoporosis, two conditions that often occur together.
Researchers have developed ImmuNet, an online tool that uses public experiments and machine learning algorithms to predict new immune pathway interactions and disease-associated genes. The tool accelerates the understanding of immunological mechanisms and diseases, ultimately leading to improved treatment options.
A study found that repeated exposure to anesthesia during infancy can alter emotional behavior, which persists for at least five months. The research used a rhesus monkey model and found that exposed subjects exhibited anxious behaviors compared to healthy controls.
A study at Mount Sinai Hospital found that antidepressants regulate chronic pain and depression through actions in the nucleus accumbens, a key brain reward center. The research discovered a gene (RGS9) controlling molecular adaptations for recovery from pain and depression.
Research suggests retinal changes can serve as measures of brain pathology in schizophrenia, predicting disease risk and progression. The findings may help guide future treatment adjustments.
Researchers found that teeth can provide a chronological record of exposure to chemicals, including iron, from fetal development. This technology can help track the impact of pollution on health globally and potentially link early life exposures to neurodegenerative diseases like Parkinson's and Alzheimer's.
A recent study published in Molecular Aspects of Medicine has identified genetic markers that link an increased risk for developing both type 2 diabetes and Alzheimer's disease. The research, led by Dr. Giulio Maria Pasinetti, found specific genetic variations associated with higher susceptibility to both conditions.
Researchers found a correlation between hippocampal activity and movement through abstract social space, suggesting a common mechanism for coding physical space, time, and social relationships. The study's findings may yield new insights into psychiatric disorders like schizophrenia and depression.
Researchers discovered a new epigenetic mechanism in brain cells that enables genetic adaptation to the environment through histone turnover. Histone replacement, or turnover, allows genes to be switched on and off in response to external stimuli.
Researchers found that afamelanotide significantly improves pain-free sun exposure and quality of life in patients with erythropoietic protoporphyria. The treatment reduced the number of phototoxic reactions and improved overall quality of life, offering patients increased daily functionality.