A research team has solved the three-dimensional structure of PrimPol, a key protein that helps damaged cellular DNA repair itself. The knowledge gained from this study will likely aid in designing anti-cancer agents.
Researchers use optimal coherence tomography (OCT) angiography to identify characteristic patterns of different forms of glaucoma based on their vascular patterns. This breakthrough technology could lead to earlier diagnosis and potentially slow down the progression of vision loss.
Mount Sinai researchers used EEG to study cue-induced craving in cocaine addicts and found that vulnerability to relapse peaks between one and six months of abstinence. This period coincides with patients' release from treatment programs, highlighting the need for alternative interventions to prevent relapse.
Researchers created a human heart tissue model using induced pluripotent stem cells to study hypertrophic cardiomyopathy, an excessive thickening of the heart associated with rare genetic disorders. The model revealed a previously unknown role for fibroblasts in triggering cardiomyocyte hypertrophy, offering new therapeutic possibilities.
Researchers found that a resort vacation immediately impacts molecular networks associated with stress and immune pathways. Meditation retreats were associated with antiviral activity, while long-term meditators had distinct molecular signatures.
Researchers found that obese individuals with insulin resistance showed improvement by avoiding AGEs, a byproduct of dry heat-cooked foods. A diet low in AGEs reduced insulin resistance, body weight, and AGE levels.
Researchers from Mount Sinai and international partners have identified specific genes that contribute to cardiometabolic diseases, such as heart attack and stroke. The study analyzed gene-expression data from patients with coronary artery disease and found genes that regulate blood lipid levels in abdominal fat.
Researchers identify Polycomb Repressive Complex 2 (PRC2) as a key player in maintaining medium spiny neurons' identity and function throughout adulthood. The study reveals that PRC2's dysfunction contributes to Huntington's disease-like symptoms in mice, highlighting its potential role in neurodegenerative disorders.
Researchers developed a 'dual molecular tuner' to rapidly manipulate two proteins in mammalian cells, offering an easy way to perform in-depth analyses. The tool uses plant hormones to target specific proteins for degradation, allowing for reversible and controllable manipulation of protein levels.
Researchers have identified a panel of genes that can help predict whether a transplanted kidney will develop fibrosis, leading to organ failure. The study's findings have the potential to change how doctors monitor and manage renal transplant patients.
A new study found that buprenorphine implants are non-inferior to sublingual buprenorphine in maintaining abstinence from opioids. The implants reduced adherence issues and improved efficacy in stable patients, offering a potential solution for addressing opioid dependence.
A new method called MICSSS helps characterize human cells involved in immune responses at the tissue site, before and after treatment with immunotherapy. This technique enables views of co-expression of markers on the same cells while sparing material from tissues.
A study found that parvalbumin-interneurons in the amygdala regulate emotional reactivity by suppressing surrounding neurons. This inhibitory plasticity is a normal consequence of memory encoding, but dysregulation may lead to hyperexcitability and pathological fear expression.
Researchers linked traumatic brain injury with later development of Parkinson's disease, but not Alzheimer's disease or incident dementia. The study, involving over 7,000 participants, found an association between TBI and Parkinson's disease, contradicting common assumptions about the relationship between TBI and Alzheimer's.
A study at Mount Sinai Hospital found that brain reward circuits, specifically the basal forebrain and lateral habenula, mediate motivation to engage in or avoid bullying. The research used a mouse model to demonstrate that activating this circuit makes bullying behavior pleasurable for some individuals.
Researchers found the 2009 swine H1N1 flu virus originated from pigs in a small region in central Mexico, with genetic analysis revealing its precise location and molecular transformations. This discovery sheds light on how animal influenza viruses infect humans and spread globally.
Mount Sinai scientists identified CBX8 as a protein that promotes tumor growth in the most lethal forms of breast cancer. This study highlights the need to focus on epigenetic factors and suggests new strategies against these aggressive cancers.
Researchers found that patients who were asked about their preferred site of death and those in hospices with frequent symptom monitoring had lower hospitalization rates. For-profit hospices, however, showed persistently high hospitalization rates regardless of practice implementation.
Researchers at Mount Sinai have shown how infected immune cells directly transmit newly minted viral particles to uninfected sister cells, spreading the virus efficiently. This study highlights cell-to-cell transmission as a key route for HIV spread and may help develop new treatments.
A new study suggests that an avian influenza virus vaccine can trigger broad and durable protection against multiple flu strains, offering a promising path toward a universal flu vaccine. The research identifies unique epitopes on the virus and highlights the potential of non-neutralizing antibodies in providing protection.
A new study from Mount Sinai researchers reports a high success rate for a personalized medicine program that uses an integrated genomic approach to guide cancer treatment. The program led to therapeutic recommendations for 91% of patients, outperforming targeted cancer panels in clinical use.
Researchers at Mount Sinai Hospital have developed a strategy to create the first broad-spectrum antiviral drug, which could provide protection against seven deadly viruses, including Nipah and Ebola. By targeting a single gene, the approach boosts immunity against viral infections.
Using clinical data from over 7 million US armed forces members, researchers identified patients with Crohn's disease and found that specific antimicrobial antibodies in their serum samples were associated with increased risk of complications. These biomarkers could potentially predict IBD development and inform preventive strategies.
Scientists used gene therapy to halt pulmonary hypertension progression in a large animal model. The approach delivered SERCA2a gene via aerosol inhalation, slowing vascular changes and improving heart function. Further studies are needed to assess long-term efficacy and safety before human clinical trials.
Researchers have discovered a potential treatment for sepsis and other responses to infection by using tiny doses of a cancer drug. The new treatment may benefit millions worldwide who are affected by infections and pandemics.
A new study identifies a small molecule that simultaneously inhibits signaling pathways activated by mutated RAS oncogenes, representing a new paradigm for targeting this elusive cancer gene. The discovery has significant implications for the treatment of RAS-driven cancers.
A powerful genetic regulator, miR-9, has been identified as a risk factor for schizophrenia, controlling the activity of hundreds of genes involved in fetal brain development. The study, led by Kristen Brennand and Gang Fang, found that miR-9 was under-expressed in brains of schizophrenic patients, leading to miswiring of neurons.
Researchers found that removing Dnmt1 during OPC differentiation led to inefficient myelin formation and neurological deterioration in mice. This discovery could lead to a better understanding of myelin disorders and potentially develop treatments.
The Mount Sinai Hospital and Sage Bionetworks conducted a genome study of over 589,000 adults to identify individuals resistant to severe Mendelian childhood diseases. Thirteen healthy people with associated genetic variants were found, but limitations in the original studies' informed consent policies hinder further analysis.
A multi-site clinical trial is assessing the safety and effectiveness of bariatric arterial embolization in treating patients with morbid obesity. The procedure targets ghrelin, reducing hunger sensation and promoting weight loss.
Researchers from the Icahn School of Medicine at Mount Sinai present new findings on CABG alone or with mitral valve repair for moderate ischemic MR, as well as rate versus rhythm control in patients with postoperative atrial fibrillation after cardiac surgery.
A study led by Dr. Roger J. Hajjar and Dr. Woo Jin Park found that CCN5 protein can reverse established cardiac fibrosis in heart failure models. The researchers used trichrome staining to show the reversal of cardiac fibrosis, demonstrating potential for new anti-cardiac fibrosis therapies.
Mount Sinai researchers found that testing service and time of collection significantly influenced results, with some test providers flagging more abnormal readings than others. The study highlights the importance of accurate lab test results in medical decision-making.
A new study from Mount Sinai found that light exposure therapy can decrease depressive symptoms among cancer survivors. Participants who received bright white light therapy showed improvement, while those with dim red light therapy experienced no change.
Researchers at Mount Sinai identified precursor cells in mice embryos that can be matured into hematopoietic stem/progenitor cells (HSPCs) using reprogramming technology. This breakthrough could lead to the development of patient-specific HSPCs for cell-replacement therapy and alleviate the need for transplantable stem cells.
Researchers have identified a new therapeutic target for multiple myeloma, targeting CDK4 and ARK5 proteins. The compound ON123300 showed potent cytotoxicity against myeloma cells while sparing normal peripheral blood cells.
Higher intake of food-based vitamin D during pregnancy was associated with reduced risk of development of allergies in children. Vitamin D modulates the immune system and its potential role in asthma and allergy has been of interest.
Researchers demonstrate that C-section infants can be enriched with vaginal bacteria, improving their immune system development. The study's findings have significant implications for the health risks associated with C-section deliveries.
A team of researchers used a fruit fly model to identify a potential targeted therapy for non-small cell lung cancer, which may lead to improved overall survival. The study found that combining two FDA-approved drugs suppressed tumor formation and inhibited key genetic mutations associated with NSCLC.
A three-year study aims to determine the effectiveness of a comprehensive lifestyle intervention in reducing cardiovascular disease risk factors. Participants will receive personalized counseling and monitoring, while others will receive standard occupational health care.
Researchers found that head-down yoga poses, such as downward-facing dog, can cause a rise in eye pressure in glaucoma patients. Glaucoma patients should inform their yoga instructors about their condition to modify poses and avoid potential damage to the optic nerve.
A long-term surveillance study shows chromoendoscopy is more effective than random biopsy or white-light colonoscopy in detecting dysplasia in patients with inflammatory bowel diseases. Chromoendoscopy identified precancerous lesions in 27 out of 208 examinations, while white-light examination detected them in only 11.
Researchers found that commensal bacteria in the lungs instruct immune cells to produce IgA, a protein protecting against infections and allergies. The study suggests a link between antibiotic use, dysbiosis, and reduced IgA production, potentially contributing to rising allergy rates.
Naturally occurring brain wiring changes can help patients at high genetic risk of developing bipolar disorder avoid the illness. Researchers found that resilient siblings showed additional changes in brain wiring within networks involved in emotional processing, which may help them avoid the disease.
A new study published in Health Affairs found that palliative care consultation within two days of hospitalization resulted in significant savings in hospital costs for cancer patients with multiple chronic conditions. Patients with higher numbers of comorbidities showed greater reductions in direct hospital costs.
Patients with COPD who received music therapy in conjunction with standard rehabilitation showed improved symptoms, psychological well-being, and quality of life. Music therapy incorporated breath control techniques, patient-preferred music, and visualizations to increase engagement and cope with chronic disease challenges.
The WATCHMAN device is more cost-effective than warfarin and NOACs for reducing strokes in patients with non-valvular atrial fibrillation, according to a study led by Dr. Reddy. The device achieved cost effectiveness relative to warfarin at seven years and NOACs at 16 years, generating annual cost savings thereafter.
A study found that syringe service programs are scarce in rural and suburban areas, where rates of opioid addiction are on the rise. The programs, which exchange used needles for new ones, reduce the risk of HIV transmission and overdose. Despite their benefits, many SSPs struggle with recruitment, funding, and staffing issues.
Mount Sinai researchers developed a synthetic vector to rapidly eliminate total cellular miRNA populations, revealing the limited role of microRNAs in modulating cell biology over long periods. This tool enables manipulation of miRNA responses for potential treatment of diseases like cancer.
A team of researchers discovered non-coding RNA molecules in cancer cells that stimulate an immune response by mimicking pathogens. The findings suggest these molecules may play a significant role in mediating immune responses against cancer.