Researchers identified G-CSF as a key player in the development of cocaine addiction, altering mice's desire for the drug but not other rewards. Manipulating G-CSF in the brain's reward center could reduce addiction-like behaviors, paving the way for new treatments.
Researchers found a higher frequency of LRRK2 gene mutations in Ashkenazi Jewish patients with Crohn's disease, which also increases the risk of developing Parkinson's disease. The study's findings could lead to better understanding and treatment of both conditions.
A recent study discovered a significant association between acetaminophen use during pregnancy and an increased risk of language delay in girls. The research found that girls born to mothers who took more than six doses of acetaminophen were nearly six times more likely to experience language delays.
A large-scale study published in Nature Genetics identified 13 genes associated with body mass index (BMI) and obesity. The study found that genetic variations in these genes can affect the function of the genes and their proteins, leading to weight gain or loss. The researchers hope that this discovery will lead to personalized treatm...
A study conducted at Mount Sinai Hospital found that transitional care nurses can significantly reduce the risk of inpatient admissions for geriatric patients. The program, which includes assessments for cognitive function and caregiver strain, led to a 10% lower chance of hospitalization for those treated by a transitional care nurse.
A study of NYC hospitals found that black and Hispanic preterm infants are more likely to be born at hospitals with higher morbidity-mortality rates, contributing to racial disparities in neonatal deaths and severe complications. These differences explained 39.9% of the black-white disparity and 29.5% of the Hispanic-white disparity in...
Researchers found that macrophages, which reside in healthy breast tissue, help early breast cancer cells leave the breast for other parts of the body. The study identified how macrophages and early cancer cells form a 'microenvironment of early dissemination' that can be targeted to prevent metastasis.
Researchers discovered significant racial disparities in hospital admission, emergency department visits, and hospice disenrollment among African American and white patients at the end of life. Black patients were more likely to experience higher-intensity care, which may negatively impact their quality of life and caregiver burden.
A new method developed by Mount Sinai and Sema4 researchers accurately identifies individual microbial species and strains in communities, providing a more comprehensive approach to microbiome analysis. The technique uses DNA methylation patterns as natural barcodes to discriminate between closely related species.
Researchers used adaptive optics technology to examine microscopic structures of the eye in living patients, obtaining high-resolution images of damaged photoreceptors. This study may lead to a deeper understanding of solar retinopathy and potentially develop new treatments.
A team of surgeons at Mount Sinai Hospital performed the first robot-assisted radical neck dissection in the US using the bilateral axillo-breast approach. The surgery successfully removed 59 lymph nodes from a patient diagnosed with thyroid cancer, showcasing the technique's potential for minimally invasive procedures.
A study found a positive relationship between working memory and healthy traits like physical endurance and cognitive function. Traits associated with suboptimal cardiovascular health, smoking, and binge drinking were linked to less cohesive brain networks.
Researchers identified AMIGO2 and PTK7 as key players in melanoma cell growth and survival. Targeting these proteins may lead to new treatments for metastatic melanoma.
A protein called tyrosine kinase 6 (PTK6) has been identified as a potential therapeutic target for estrogen receptor positive (ER+) breast cancer. PTK6 promotes cancer cell survival and growth in ER+ breast cancer cells, making it a promising avenue for developing new treatments.
A new study finds that a simple tool, Fuster-BEWAT score, can predict cardiovascular risk in healthy individuals using five health indicators: blood pressure, physical activity, body-mass index, fruit and vegetable intake, and smoking status. The Fuster-BEWAT score is as effective as the American Heart Association-recommended ICHS index.
Scientists at Mount Sinai developed a mathematical model that accurately predicts how tumors will respond to immunotherapies. The model also identifies key neoantigens that can stimulate an immune response, offering new insights for developing personalized cancer treatments.
A new study by The Arnhold Institute for Global Health found that microfinance institutions can effectively distribute essential health products to rural communities, leading to improved child health outcomes. Microfinance networks were used to deliver micronutrient supplements, resulting in a significant impact on the health of childr...
Researchers found that 46% of patients experienced mucosal healing after 48 weeks in a tight control protocol compared to 30% in clinical management. The study demonstrated superior outcomes using biomarker monitoring and symptom assessment.
Scientists at Mount Sinai & Sema4 validated a biomarker indicative of glioblastoma patient prognosis and likely response to therapies. BUB1B-sensitive tumors had significantly worse prognosis but were more likely to respond to many drugs already in clinical use.
Researchers at Mount Sinai Hospital discovered a genomic recipe in rare benign tumors that can regenerate insulin-producing human beta cells, potentially treating diabetes. The study's findings have the potential to develop new drugs that increase healthy beta cell mass.
Researchers used gene therapy to improve heart function in a large animal model, finding a 25% improvement in left ventricular function and a 20% improvement in left atrial function. The treatment also reduced heart size by 10%.
Researchers identified unique structural, biological and chemical insights in opioid drug activation, shedding light on beneficial and adverse effects. The findings may provide a blueprint for designing improved painkillers with reduced side effects.
Researchers developed a predictive model of inflammatory bowel disease by integrating DNA variation, gene expression, and clinical information. The model identifies key regulators of the immune component and may lead to new treatments for patients.
Chronic cocaine users exhibit impaired learning and memory in the ventromedial prefrontal cortex, making it hard for them to form new associations and quit using the drug. This finding highlights potential limitations of extinction-based therapy in treating addiction.
A scoping review of palliative care development in Africa found that only a small subset of countries have made progress, with the majority concentrated in East Africa. The review highlights the need for increased access to opioids and postgraduate educational opportunities to address structural inequities in care delivery.
Research at Mount Sinai Hospital identified two distinct brain areas involved in decision-making: the orbital frontal cortex (OFC) and ventrolateral prefrontal cortex (VLPFC). Monkeys with OFC lesions lost ability to track reward probability, while those with VLPFC lesions showed preference for M&Ms.
Researchers at Mount Sinai developed a clinical index to evaluate muscle-related symptoms associated with statin use. The team proposes re-challenging or switching statins, adopting healthy lifestyle changes, and exploring non-statin pharmacotherapies to optimize cholesterol treatment for patients experiencing adverse muscle symptoms.
A study by researchers at Mount Sinai identified a brain mechanism that makes siblings of bipolar patients resilient to the disease. The brain can adapt to its biological risk, opening new avenues for research on enhancing resilience.
A study examined the risk of intellectual disability (ID) in children born to mothers treated with antidepressants and found a slightly elevated risk, but it was not statistically significant. The researchers suggest that other factors such as parental age and psychiatric history may contribute to the risk.
A study applying machine learning techniques to the Look AHEAD Trial data found that 85% of participants experienced a clinically meaningful reduction in cardiovascular mortality and morbidity through intensive weight loss intervention. However, 15% of subjects had an increased risk of cardiovascular events due to weight loss.
A new study found that dying adults in the US receive almost twice as much caregiving support per week compared to those not at the end of life. Unpaid family caregivers, particularly spouses, report high levels of physical difficulty and time constraints.
The study found that men have a higher plaque burden than women, and that it increases with age. The 3D vascular ultrasound technique has the potential to become a key screening tool for identifying at-risk individuals.
Researchers at Mount Sinai Hospital have developed a novel technique to continuously monitor laryngeal and vagus nerve function during otolaryngology and neurosurgery procedures. This non-invasive method uses a special breathing tube to stimulate and record nerve responses, allowing surgeons to adjust their approach in real-time.
Researchers discovered an ancient antiviral defense system in human cells that could be used to deliver targeted therapies using engineered viruses or simple self-replicating RNAs. This system, which dates back billions of years, was originally designed to defend against viral infection and may hold the key to new treatments for diseases.
Researchers found that wire-free electrodes and the round window surgical approach improved long-term hearing preservation in cochlear implant patients. The study's lead investigator notes that these findings have major implications for doctors and patients seeking to restore their hearing.
Researchers identified a network of genes expressed in myeloid cells that contribute to Alzheimer's disease pathogenesis. A protein called PU.1 regulates this gene network, which may hold promise for therapeutic targets.
Researchers identify early stress as a molecular basis for lifelong depression susceptibility, revealing a critical role for the developmental transcription factor Otx2. Mice stressed in early life exhibit suppressed Otx2 levels and increased depression-like behavior in adulthood, highlighting a sensitive period for brain development.
A treatment for depression using the Emotional Faces Memory Task resulted in a significantly greater reduction of major depressive disorder symptoms compared to a control group. The digital therapeutic targets an imbalance in brain regions involved in emotion processing and cognitive control.
A new study published in Nature Communications found that differences in toxin and nutrient uptake during critical developmental windows increase autism risk. Researchers analyzed baby teeth to identify associations between metal exposure and ASD severity, suggesting a potential pathway for interplay between genes and environment.
A study found that repeated exposure to anesthesia during infancy results in impaired visual recognition memory, which emerges after the first year of life. The research used a rhesus monkey model and confirmed that multiple anesthesia exposures alone lead to memory impairment, with deficits not apparent until later developmental stages.
Researchers analyzed orangutan teeth to reconstruct diet histories and determine nursing patterns, shedding light on the evolution of human breast-feeding. Orangutans' cycles of milk consumption may inform models of population growth and resilience in humans.
A study published in JAMA found that systemic therapy with oral corticosteroids and immunosuppression can preserve or improve vision in the long term, better than regional implant therapy, for patients with severe uveitis. The treatment approach showed fewer ocular side effects and no significant increase in systemic side effects.
A research team identified a mechanism by which influenza A viruses hijack cellular machinery to replicate, including the RNA exosome. This process is linked to congenital defects and neurodegeneration in people with rare mutations. The study offers future insight into common brain disorders such as Alzheimer's and Parkinson's diseases.
A new study maps immune system components in early lung cancer, identifying potential targets for immunotherapy and suggesting a possible cure. The research reveals that early lesions are heavily infiltrated with immune cells, making immunotherapy a promising treatment option.
Patients operated on by high-volume mitral valve surgeons experience lower one-year mortality and reoperation rates compared to those performed by lower-volume surgeons. High-volume surgeons are more likely to perform durable repairs, with repair rates ranging from 77% for 51+ cases to 48% for fewer than 10 cases.
Researchers identified cyclic GMP-AMP synthase (cGAS) as the protein responsible for detecting viral infection, but dengue virus counteracts this by degrading cGAS. This study sheds light on a novel mechanism by which viruses evade immune detection and may inform techniques to dampen pro-inflammatory responses.
A new study from the Icahn School of Medicine at Mount Sinai suggests that the sympathetic nervous system, not macrophages, is the main driver of thermogenesis. The research team found that catecholamines released by the sympathetic nervous system can convert white fat tissue into a tissue resembling brown fat.
Researchers found that the prefrontal cortex teaches the hippocampus to differentiate goal-related memories, enabling rapid integration of memories with goals. This cognitive flexibility is disrupted in neuropsychiatric conditions like schizophrenia and depression.
Researchers found that pre-existing immunity to dengue and West Nile viruses can cause increased risk of severe Zika virus infection. High concentrations of antibodies from these infections offered protection, while lower concentrations led to enhanced morbidity and mortality.
A study led by Mount Sinai researchers found that knee replacement surgery provides only small improvements in quality of life, especially in patients with less severe physical function. The procedure's economic attractiveness increases when offered to those with more severe symptoms.