A study published in Anesthesiology found that IV acetaminophen does not meaningfully decrease opioid use after surgery compared to oral acetaminophen. Researchers suggest that eliminating IV acetaminophen may result in significant cost savings for hospitals.
A Journal of Neuroscience study found that a transcription factor called FosB plays a key role in regulating aggressive behavior in mice. Increased FosB levels were linked to increased aggression intensity and dominance.
A new diagnostic test that uses a simple nasal brush to identify mild to moderate asthma has been developed by Mount Sinai researchers. The test, which uses machine learning algorithms and RNA sequencing, can differentiate asthma from other respiratory conditions and is less expensive than traditional pulmonary function testing.
Researchers developed an experimental model of HIV infection in mice that shows HIV causes learning and memory dysfunction, a common problem in half of HIV-infected people. The virus establishes latent and active reservoirs in T cells and macrophages, leading to cognitive impairment.
Research reveals that impaired neural mechanisms in six large-scale brain networks contribute to human drug addiction behaviors, affecting cognition, emotional processing, and decision-making. The study identifies consistent impairments in brain function across these networks, which can inform the development of targeted treatment inte...
Researchers identified epigenetic mutations as significant contributors to neurodevelopmental disorders and congenital anomalies. The discovery could lead to advanced diagnostic tools, say researchers from the Icahn School of Medicine at Mount Sinai.
The i3 Asset Accelerator is a new fund that fast-tracks select research discoveries to reach patients sooner. The accelerator has selected its first two projects, focused on cancer treatment and influenza B viral infections, with the goal of advancing commercially relevant solutions globally.
A study published in JAMA Internal Medicine found that palliative care is associated with shorter hospital stays and lower costs, particularly for patients with complex conditions. The study showed a cost savings of $4,251 per patient with cancer and $2,105 for those with non-cancer diagnoses.
A common genetics study method called Mendelian randomization has been found to be distorted by a phenomenon called horizontal pleiotropy in nearly 50% of its studies. This distortion can lead to false positive causal relationships and affects the accuracy of drug discovery and disease management.
A recent Mount Sinai study reveals individuals with IBD have a 28% higher risk of developing Parkinson's disease; treated patients show significant reduction in risk after anti-TNFα therapy. The study suggests exploring anti-TNFα to prevent Parkinson's disease in high-risk individuals.
The Mount Sinai team will develop software tools for efficient and interactive analysis of large amounts of single-cell data, accelerating progress toward curing all diseases by the end of the century. The CZI grant aims to provide a platform for scientists to analyze massive data sets interactively and quickly.
The study, funded by the National Eye Institute, tested oral omega-3 supplementation on patients with dry eye disease. Despite finding some improvement in symptoms and signs, researchers concluded that omega-3 supplements did not show a beneficial effect relative to placebo.
Researchers found that simultaneous chemotherapy and immunotherapy is safe and patients with certain genetic mutations may respond particularly well. The combination approach was shown to boost immune cells in the blood, allaying previous concerns about chemotherapy's impact on immunotherapy.
A US task force identified five global best practices for improving community health, including local anchor institutions, shared goals, and simple protocols. These findings hold great potential to improve the health of struggling communities in America.
Research reveals non-coding RNA in tumors may predict immunotherapy response and influence patients' outcomes. Specific repetitive elements were found to alter immune responses in colon and pancreatic cancers.
The Collaborative for Healing and Renewal in Medicine has presented a framework for individuals, organizations, and health systems to address physician burnout. The Charter on Physician Well-Being provides guidelines for developing regulations and policies that support physician well-being and maximize meaningful engagement.
A study by Mount Sinai researchers found associations between age, body mass index, substance use, and brain structure in patients with psychosis. Higher IQs were positively linked to improved brain health, while higher age, BMI, and substance use were negatively associated.
A newly identified protein, RGSz1, can be manipulated to make opioid painkillers effective at lower doses while reducing the risk of addiction. This discovery provides novel avenues for pharmacological interventions that can optimize the actions of opioid medications and lead to safer treatments.
Grape-derived polyphenols, such as DHCA and Mal-gluc, may attenuate depression by targeting inflammation and synaptic plasticity. The study found that these compounds can promote resilience in mouse models of depression by modulating immune responses and brain function.
Researchers found that adding cetirizine to standard therapy significantly reduced annualized relapse rates in patients with neuromyelitis optica, a rare disease causing inflammation and demyelination. The study suggests that cetirizine may be beneficial in preventing relapses by modulating eosinophil activity.
A Mount Sinai study found that white adults with mental illness were 50% more likely than blacks to experience delays in care, and 20% more likely to lack sufficient funds for treatments. The researchers suggest that the Great Recession may have contributed to these disparities.
Researchers trained machine learning models on radiologist reports to identify clinical concepts in CT scans, achieving an accuracy of 91%. This technology will help develop artificial intelligence to diagnose diseases and improve patient care.
A new study found that direct aspiration first pass (ADAPT) approach is clinically equivalent to stent retriever first-line (SRFL) approach for treating large vessel occlusion strokes. Patients treated with ADAPT achieved functional independence at 90 days similar to those treated with SRFL.
A computer-based language classifier predicted psychosis in at-risk youths with up to 83% accuracy, identifying disturbances in speech flow and tangential thinking as indicative of psychosis. The technology has the potential to improve prediction and prevention of psychosis by targeting cognitive deficits.
Researchers identified G-CSF as a key player in the development of cocaine addiction, altering mice's desire for the drug but not other rewards. Manipulating G-CSF in the brain's reward center could reduce addiction-like behaviors, paving the way for new treatments.
Researchers found a higher frequency of LRRK2 gene mutations in Ashkenazi Jewish patients with Crohn's disease, which also increases the risk of developing Parkinson's disease. The study's findings could lead to better understanding and treatment of both conditions.
A recent study discovered a significant association between acetaminophen use during pregnancy and an increased risk of language delay in girls. The research found that girls born to mothers who took more than six doses of acetaminophen were nearly six times more likely to experience language delays.
A large-scale study published in Nature Genetics identified 13 genes associated with body mass index (BMI) and obesity. The study found that genetic variations in these genes can affect the function of the genes and their proteins, leading to weight gain or loss. The researchers hope that this discovery will lead to personalized treatm...
A study conducted at Mount Sinai Hospital found that transitional care nurses can significantly reduce the risk of inpatient admissions for geriatric patients. The program, which includes assessments for cognitive function and caregiver strain, led to a 10% lower chance of hospitalization for those treated by a transitional care nurse.
A study of NYC hospitals found that black and Hispanic preterm infants are more likely to be born at hospitals with higher morbidity-mortality rates, contributing to racial disparities in neonatal deaths and severe complications. These differences explained 39.9% of the black-white disparity and 29.5% of the Hispanic-white disparity in...
Researchers found that macrophages, which reside in healthy breast tissue, help early breast cancer cells leave the breast for other parts of the body. The study identified how macrophages and early cancer cells form a 'microenvironment of early dissemination' that can be targeted to prevent metastasis.
Researchers discovered significant racial disparities in hospital admission, emergency department visits, and hospice disenrollment among African American and white patients at the end of life. Black patients were more likely to experience higher-intensity care, which may negatively impact their quality of life and caregiver burden.
A new method developed by Mount Sinai and Sema4 researchers accurately identifies individual microbial species and strains in communities, providing a more comprehensive approach to microbiome analysis. The technique uses DNA methylation patterns as natural barcodes to discriminate between closely related species.
Researchers used adaptive optics technology to examine microscopic structures of the eye in living patients, obtaining high-resolution images of damaged photoreceptors. This study may lead to a deeper understanding of solar retinopathy and potentially develop new treatments.
A team of surgeons at Mount Sinai Hospital performed the first robot-assisted radical neck dissection in the US using the bilateral axillo-breast approach. The surgery successfully removed 59 lymph nodes from a patient diagnosed with thyroid cancer, showcasing the technique's potential for minimally invasive procedures.
A study found a positive relationship between working memory and healthy traits like physical endurance and cognitive function. Traits associated with suboptimal cardiovascular health, smoking, and binge drinking were linked to less cohesive brain networks.
Researchers identified AMIGO2 and PTK7 as key players in melanoma cell growth and survival. Targeting these proteins may lead to new treatments for metastatic melanoma.
A protein called tyrosine kinase 6 (PTK6) has been identified as a potential therapeutic target for estrogen receptor positive (ER+) breast cancer. PTK6 promotes cancer cell survival and growth in ER+ breast cancer cells, making it a promising avenue for developing new treatments.
A new study finds that a simple tool, Fuster-BEWAT score, can predict cardiovascular risk in healthy individuals using five health indicators: blood pressure, physical activity, body-mass index, fruit and vegetable intake, and smoking status. The Fuster-BEWAT score is as effective as the American Heart Association-recommended ICHS index.
Scientists at Mount Sinai developed a mathematical model that accurately predicts how tumors will respond to immunotherapies. The model also identifies key neoantigens that can stimulate an immune response, offering new insights for developing personalized cancer treatments.
A new study by The Arnhold Institute for Global Health found that microfinance institutions can effectively distribute essential health products to rural communities, leading to improved child health outcomes. Microfinance networks were used to deliver micronutrient supplements, resulting in a significant impact on the health of childr...
Researchers found that 46% of patients experienced mucosal healing after 48 weeks in a tight control protocol compared to 30% in clinical management. The study demonstrated superior outcomes using biomarker monitoring and symptom assessment.
Scientists at Mount Sinai & Sema4 validated a biomarker indicative of glioblastoma patient prognosis and likely response to therapies. BUB1B-sensitive tumors had significantly worse prognosis but were more likely to respond to many drugs already in clinical use.
Researchers at Mount Sinai Hospital discovered a genomic recipe in rare benign tumors that can regenerate insulin-producing human beta cells, potentially treating diabetes. The study's findings have the potential to develop new drugs that increase healthy beta cell mass.
Researchers used gene therapy to improve heart function in a large animal model, finding a 25% improvement in left ventricular function and a 20% improvement in left atrial function. The treatment also reduced heart size by 10%.
Researchers identified unique structural, biological and chemical insights in opioid drug activation, shedding light on beneficial and adverse effects. The findings may provide a blueprint for designing improved painkillers with reduced side effects.
Researchers developed a predictive model of inflammatory bowel disease by integrating DNA variation, gene expression, and clinical information. The model identifies key regulators of the immune component and may lead to new treatments for patients.
Chronic cocaine users exhibit impaired learning and memory in the ventromedial prefrontal cortex, making it hard for them to form new associations and quit using the drug. This finding highlights potential limitations of extinction-based therapy in treating addiction.
A scoping review of palliative care development in Africa found that only a small subset of countries have made progress, with the majority concentrated in East Africa. The review highlights the need for increased access to opioids and postgraduate educational opportunities to address structural inequities in care delivery.
Research at Mount Sinai Hospital identified two distinct brain areas involved in decision-making: the orbital frontal cortex (OFC) and ventrolateral prefrontal cortex (VLPFC). Monkeys with OFC lesions lost ability to track reward probability, while those with VLPFC lesions showed preference for M&Ms.