A Mount Sinai study reveals that over 30% of heart disease risk is attributed to genetic factors, surpassing previous estimates. Researchers identified 28 independent gene networks active in coronary artery disease and found an additional 11% contribution to the inherited risk.
A Mount Sinai study found improved asthma control and quality of life in older patients, with a significant reduction in emergency department visits. The study tested a patient-tailored self-management support intervention, which targeted social determinants of health and achieved meaningful improvements.
A genome-wide association study found that individuals who attempt suicide carry an increased genetic liability for depression, regardless of their underlying psychiatric disorder. The study analyzed the genomes of over 6,500 suicide attempters and 17,000 non-attempters with major depressive disorder, bipolar disorder, or schizophrenia.
A Mount Sinai scientist has been awarded $8 million to investigate the dynamic interface between environment and human physiology over a lifetime. The research aims to prevent diseases decades before clinical signs appear, with a focus on autism, schizophrenia, and ALS.
A study published in the American Journal of Psychiatry found that CBD significantly reduced craving and anxiety induced by drug cues in individuals with heroin use disorder. The study also revealed that CBD tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels.
Researchers at Mount Sinai have discovered Cdx2 cells, a type of placental stem cell, that can regenerate healthy heart cells after heart attacks in animal models. These cells have the ability to target injury sites and avoid rejection by the host immune system, making them promising for regenerative therapy.
Researchers identified 20 new genetic associations with bipolar disorder in a massive study of over 50,000 subjects across 14 countries. The findings highlight the complexity of the disease and its overlap with other psychiatric disorders.
Researchers found that MDM2 interacts with a mitochondrial protein to promote cancer cell death. Nutlin-3A enhances this interaction, helping kill cancer cells.
A study using family-based genetic analysis has identified the DENND1A gene as playing a major role in PCOS, enabling personalized medicine approaches and better disease prediction. The findings suggest that rare genetic variants in this gene contribute to the disorder's distinctive hormonal profile.
Researchers discovered that reports of human cases of West Nile virus were delayed by two to 14 weeks between illness onset and confirmation. Accurate and reliable forecasts are possible using real-time reports of human and mosquito testing positive for the virus.
Research found that offspring born to couples married for less than three years have a 50% increase in risk for schizophrenia, while longer marriage duration is associated with a 14% reduction in risk. The study controlled for paternal age and psychiatric disorders.
A Mount Sinai study shows that preschool intervention can improve healthy lifestyle habits in young children, with 12% increase in knowledge and attitudes towards a healthy lifestyle. The intervention group also showed improved behaviors in physical activity, diet, and emotional management.
Empagliflozin improved heart function, reduced pulmonary congestion, and enhanced systolic function in pigs with induced heart failure. The drug addressed heart failure by improving cardiac metabolism, boosting energy production and reducing glucose consumption.
Researchers at Mount Sinai have developed an innovative approach to cancer immunotherapy by injecting immune stimulants directly into a tumor. This 'in situ vaccination' teaches the immune system to destroy not only the primary tumor but also other tumor cells throughout the body, effectively turning the tumor into a vaccine factory.
Researchers at Mount Sinai identified 413 genetic associations with schizophrenia across 13 brain regions, shedding light on the disease's mechanisms. Abnormal gene expression in specific brain areas contributes to increased risk of schizophrenia.
Researchers found that cancer cells with fewer mitochondria are more likely to respond to certain drug treatments, offering a new avenue for targeted therapies. The study's findings suggest that enhancing understanding of the relationship between mitochondrial variability and drug response may lead to more effective cancer treatments.
The lack of diversity in genomic data from biobanks worldwide, with 68% coming from European ancestry, limits the ability to identify associations between genetic variants and disease. To overcome this, Mount Sinai researchers advocate for increasing ethnic diversity in genomic sampling and research.
Researchers found that serotonin molecules can directly attach to histone proteins in neurons, loosening the DNA spool and enabling more robust gene expression. This discovery has significant implications for understanding brain disorders and developing new treatments.
A study led by Mount Sinai researchers found that aspiration is equally effective as traditional stent retriever approach for clot removal, with significant cost savings. The study showed comparable clinical results between the two approaches, including similar functional outcomes and revascularization rates.
Researchers developed an AI platform to detect neurodegenerative diseases, including Alzheimer's and chronic traumatic encephalopathy. The Precise Informatics Platform uses deep learning to accurately identify neurofibrillary tangles in digitized images.
The Mount Sinai Health System, in collaboration with UC San Diego Health, has released a national framework report that identifies regulatory, financial, and technological obstacles to improving local and state EMS systems. The report provides recommendations to create a more dynamic system responsive to society's needs.
Researchers from Mount Sinai will investigate the role of follicle-stimulating hormone (FSH) in regulating bone mass, body composition, and fat deposits during aging and menopause. The program aims to develop an FSH-blocking antibody for preventing and treating osteoporosis and obesity.
Researchers at Mount Sinai found that dengue virus infection can enhance the severity of Zika virus infection during pregnancy, leading to increased placental damage, fetal growth restriction, and fetal resorption. This mechanism may explain the high rate of microcephaly and birth defects observed in recent Zika outbreaks.
A new machine-learning framework distinguishes between low- and high-risk prostate cancer with higher precision than existing tools. The framework aims to provide radiologists and clinicians with a sound prediction tool for personalized patient care.
The National Institutes of Health has awarded a grant to develop and evaluate an artificial pancreas for pregnant women with type 1 diabetes. The project aims to improve patient and fetal outcomes by adapting automated insulin delivery technology.
Researchers found that herpes viruses use human satellite II RNA (HSATII RNA) to manipulate their environment and grow, similar to cancer cells. This discovery could lead to new diagnostic tools and drug targets for diseases like colitis and neurodegenerative disorders.
A comprehensive meta-analysis of adults with autism found significant impairments in four key domains: theory of mind, emotion perception and knowledge, processing speed, and verbal learning and memory. The study highlights the importance of a broader approach to treating autism in adults, including non-social cognitive domains.
A team of researchers discovered that APOL1 risk variants, previously known to affect African and African American populations, are also found at appreciable frequencies in Caribbean and Latin American populations. This finding could help physicians tailor treatment more closely to their needs through precision medicine.
Researchers have developed a novel way to streamline genetic analysis by utilizing the blacklist computing concept. This method has shown promise as a key to faster therapeutic innovation, enabling clinicians and researchers to focus on true disease-causing mutations., By removing non-pathogenic genetic variants from consideration, thi...
A large-scale study identified 14 gene variants associated with PCOS, including new variants linked to metabolic and reproductive features of the disorder. The findings also suggest links between PCOS and other conditions like obesity, depression, and male pattern baldness.
Researchers at Mount Sinai have discovered a novel combination of drugs that induces the highest rate of proliferation in adult human beta cells, increasing insulin production and potentially treating diabetes. The study found a 5-8% daily growth rate, which is significant progress toward a cure for the disease.
Researchers from Mount Sinai's Icahn School of Medicine published four scientific papers highlighting their work on brain genomics and psychiatric diseases. They analyzed over 2,000 brains to identify non-coding functional genomic elements associated with schizophrenia risk, autism spectrum disorder, and bipolar disorder.
Imagination has been shown to be an effective tool in treating anxiety and fear-related disorders. A recent study found that imagining a threat can help reduce neural and physiological responses associated with fear, making it a promising treatment option for conditions like post-traumatic stress disorder and phobias.
A study published in Pediatrics found that nearly half of children exposed to second-hand marijuana smoke had detectable levels of THC, a reliable indicator of exposure. Researchers also discovered that third-hand smoke exposure can occur when individuals smoke and the residue lingers on their skin, hair, or clothes.
BioJupies accelerates RNA sequencing data analysis, enabling researchers to share results in minutes. The cloud-based platform provides interactive reports and reduces costs to under one cent per sample.
Researchers develop nano-immunotherapy that prevents immune cells from activating and attacking transplanted organs, allowing for long-term acceptance. This approach could transform patient care and help overcome barriers to successful transplant outcomes.
Researchers found that AI models performed significantly worse on X-rays from outside their own network compared to those from within. The study highlights the importance of carefully testing AI performance in real-world clinical settings.
Researchers found that people with Alzheimer's disease who were treated with diabetes drugs showed fewer markers of the disease, including abnormal microvasculature and gene expressions. The study suggests targeting the brain's capillary system could have beneficial effects in Alzheimer's patients, opening opportunities for new therapies.
Researchers found that ezogabine, an FDA-approved anti-seizure medication, significantly reduced depressive symptoms in patients with Major Depressive Disorder. The study showed a 45% reduction in depression and improved resilience after treatment.
Research suggests that prenatal exposure to most common medications does not increase the risk of autism, contrary to previous studies. Instead, a mother's general health before pregnancy appears to play a more significant role in her child's development.
A study published in Science Advances reveals short-term lead exposure in ancient Neanderthals, with implications for understanding human evolution and the effects of environmental exposures. The research team analyzed teeth to reconstruct climate and developmental events during and after birth.
Researchers at Mount Sinai Hospital have successfully induced desensitization in the majority of children with wheat allergies through oral immunotherapy. After 52 weeks, 52% of children consumed a cumulative dose of 4,443mg of wheat protein without adverse reactions.
Researchers found that females without schizophrenia used more complex brain regions to identify others' mental states, while men used less complex regions. Both groups with schizophrenia showed reduced complexity in brain processing, suggesting a potential link between olfaction and emotional processing.
Researchers developed a novel technology to analyze hundreds of genes at single cell level, revealing critical immune system weakness in cancer. The Pro-Code technique identified disease-causing genes and potential drug targets for cancer immunotherapy.
Young adults exposed to cannabis during adolescence show altered brain structure and gene expression related to psychosis risk. The study suggests that adolescent cannabis use can induce long-term changes in brain cells and gene networks, potentially increasing psychiatric vulnerability.
Researchers at Mount Sinai have discovered a new way to determine whether breast cancer cells are dormant or soon to turn deadly. Patients with high levels of the NR2F1 protein in their bone marrow are less likely to develop metastatic cancer, allowing for more targeted treatment and improved survival rates.
A new approach integrates genomic and temporal information to infer causal relationships between genes, drugs, and their environment, allowing for a more accurate prediction of their interactions over time. The tool demonstrates the improvements in inferring genetic causes of disease enabled by higher-resolution molecular profiling.
A new study finds that mastectomies do not completely eliminate the need for postoperative imaging and biopsy. For 10% to 15.5% of patients, subsequent imaging is required, and 6-8% undergo biopsy, with low malignancy rates.
A comprehensive genome-wide map of RNA splicing variation in the aging brain has been created, offering new insights into genetic mechanisms underlying Alzheimer's disease progression. The study identified specific RNA splicing events linked to the disease and suggests a potential therapeutic strategy using antisense oligonucleotides.
Researchers discovered anti-a4b7 therapy significantly reduces lymphoid aggregates in the GI tract of HIV-1 infected patients. The study found that this therapy may have significant implications for HIV treatment.