Mount Sinai researchers have identified a targeted therapy called tazemetostat that can help children with neuroblastoma, a deadly pediatric nerve cancer. Tazemetostat disables an enzyme called EZH2, killing neuroblastoma cells.
Researchers at Mount Sinai develop a novel vaccine using chimeric hemagglutinin, inducing broad antibody responses against human and avian influenza viruses. The study shows promise for a universal flu vaccine, but interim results indicate further work is needed.
A new artificial pancreas system improved blood glucose control throughout the day and overnight, reducing time in range for high and low glucose levels. The system also showed improvements in hemoglobin A1c and other measurements related to diabetes control compared to current technology.
Researchers discovered a brain circuit linking cigarette smoking to type 2 diabetes, showing that nicotine consumption leads to reduced insulin release and higher blood sugar levels. The study found that variations in the Tcf7l2 gene may influence both tobacco addiction and diabetes development.
Researchers have identified RGS4 as a multifunctional protein that contributes to the transition from acute and sub-acute pain to pathological pain states. Inhibiting RGS4 action disrupts the maintenance of chronic pain, promoting recovery in preclinical models.
A new study uses tape strips to analyze skin lesions and non-lesional skin in infants and young children with early-onset eczema, identifying biomarkers for immune and barrier abnormalities. The technique provides a non-invasive alternative to skin biopsies, which are often difficult to perform in children.
A recent study found that deep brain stimulation (DBS) of the subcallosal cingulate area provides a robust and sustained antidepressant effect in patients with treatment-resistant depression. Most participants experienced an antidepressant response and maintained it over eight years, with significant improvements in quality of life.
Researchers at Mount Sinai Hospital have discovered the near-atomic-resolution structure of DNA polymerase delta, a crucial enzyme in genome replication. The team also mapped mutations associated with cancers and other diseases.
Researchers found that patients with schizophrenia who experienced auditory hallucinations had abnormal tonotopic organization of the auditory cortex, established in infancy. This suggests that the vulnerability to develop 'voices' is probably established many years before symptoms begin.
A study published in Translational Psychiatry identified elemental signatures in baby teeth unique to ADHD, autism, and co-occurring conditions. The researchers found that each condition has a distinct metabolic signature involving essential and toxic elements.
Researchers at The Mount Sinai Hospital have identified a unique cell signature associated with drug resistance in Crohn's disease patients. This discovery may enable the development of personalized treatment plans and improved patient outcomes.
Researchers tested AuroLase Therapy, a treatment using gold-silica nanoshells, in 16 men with low- to intermediate-grade prostate cancer. The treatment was successful in 87.5 percent of lesions treated at one year of follow-up, preserving quality of life.
A study published in Cell found that intermittent fasting reduces the release of pro-inflammatory cells called monocytes, which can cause serious tissue damage. Fasting also leads to these cells going into a less inflammatory state.
A clinical trial discovered that selinexor, a novel therapy, effectively knocked down bone marrow cancer in over a quarter of patients, including two who achieved complete remission. The treatment showed promise for patients resistant to multiple therapies and offered new hope for those with limited treatment options.
Researchers found links between early-life manganese exposure and altered functional connectivity of brain areas supporting cognitive and motor control. This association was observed even before birth and during early childhood.
A recent study published by Mount Sinai researchers found that fluoride exposure may contribute to complex changes in kidney and liver function among youth in the US. The findings suggest that adolescents with poorer kidney or liver function may absorb more fluoride, highlighting potential health concerns.
Researchers combine checkpoint blockade therapy with stem cell transplantation to boost efficacy in non-Hodgkin's lymphomas and melanoma. The approach increases cancer-killing immune response tenfold, allowing it to be effective for previously treatment-resistant cancers.
Mount Sinai researchers have developed a novel vaccine consisting of DNA and recombinant proteins, which was tested in monkeys and induced antibodies similar to those associated with protection from HIV. The vaccine targets the V1V2 loop of the gp120 envelope protein and showed strong protective effects against HIV infection.
Researchers analyzed 2-million-year-old teeth to understand breastfeeding patterns in extinct early human species Australopithecus africanus. They found the species breastfed for up to one year and experienced cycles of food scarcity, influencing their nursing behaviors.
Researchers from Mount Sinai highlight the importance of multidimensional data for stratifying a complex disease like asthma. Carefully designed, integrated multi-'omic' studies could accelerate precision medicine for asthma patients by defining asthma subtypes through transcriptomics and other omic approaches.
A comprehensive review by Mount Sinai experts aims to help clinicians understand medical issues relevant to transgender people, addressing the biggest barrier to care - lack of knowledgeable providers. Recommendations include determining transgender identity, prescribing hormone therapy, and updating electronic medical records.
A study by Mount Sinai researchers found that World Trade Center responders with prostate cancer exhibited chronic inflammation in their prostates, which may have contributed to their cancer. The researchers suggest that this link could lead to the development of anti-inflammatory therapies for similar cases.
A study by Mount Sinai researchers found that 35% of cancer survivors have chronic pain, with specific types of cancer having a higher incidence. Chronic pain is more prevalent among unemployed and uninsured survivors.
A recent study has analyzed the genomes of nearly 50,000 non-European individuals to maximize genetic discovery and lessen clinical disparities. The study revealed nearly 1,500 associations between genes and disease in minority populations, providing valuable insights into the genetic underpinnings of disease affecting non-whites.
A Mount Sinai study reveals that over 30% of heart disease risk is attributed to genetic factors, surpassing previous estimates. Researchers identified 28 independent gene networks active in coronary artery disease and found an additional 11% contribution to the inherited risk.
A Mount Sinai study found improved asthma control and quality of life in older patients, with a significant reduction in emergency department visits. The study tested a patient-tailored self-management support intervention, which targeted social determinants of health and achieved meaningful improvements.
A genome-wide association study found that individuals who attempt suicide carry an increased genetic liability for depression, regardless of their underlying psychiatric disorder. The study analyzed the genomes of over 6,500 suicide attempters and 17,000 non-attempters with major depressive disorder, bipolar disorder, or schizophrenia.
A Mount Sinai scientist has been awarded $8 million to investigate the dynamic interface between environment and human physiology over a lifetime. The research aims to prevent diseases decades before clinical signs appear, with a focus on autism, schizophrenia, and ALS.
A study published in the American Journal of Psychiatry found that CBD significantly reduced craving and anxiety induced by drug cues in individuals with heroin use disorder. The study also revealed that CBD tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels.
Researchers at Mount Sinai have discovered Cdx2 cells, a type of placental stem cell, that can regenerate healthy heart cells after heart attacks in animal models. These cells have the ability to target injury sites and avoid rejection by the host immune system, making them promising for regenerative therapy.
Researchers identified 20 new genetic associations with bipolar disorder in a massive study of over 50,000 subjects across 14 countries. The findings highlight the complexity of the disease and its overlap with other psychiatric disorders.
Researchers found that MDM2 interacts with a mitochondrial protein to promote cancer cell death. Nutlin-3A enhances this interaction, helping kill cancer cells.
A study using family-based genetic analysis has identified the DENND1A gene as playing a major role in PCOS, enabling personalized medicine approaches and better disease prediction. The findings suggest that rare genetic variants in this gene contribute to the disorder's distinctive hormonal profile.
Researchers discovered that reports of human cases of West Nile virus were delayed by two to 14 weeks between illness onset and confirmation. Accurate and reliable forecasts are possible using real-time reports of human and mosquito testing positive for the virus.
Research found that offspring born to couples married for less than three years have a 50% increase in risk for schizophrenia, while longer marriage duration is associated with a 14% reduction in risk. The study controlled for paternal age and psychiatric disorders.
A Mount Sinai study shows that preschool intervention can improve healthy lifestyle habits in young children, with 12% increase in knowledge and attitudes towards a healthy lifestyle. The intervention group also showed improved behaviors in physical activity, diet, and emotional management.
Empagliflozin improved heart function, reduced pulmonary congestion, and enhanced systolic function in pigs with induced heart failure. The drug addressed heart failure by improving cardiac metabolism, boosting energy production and reducing glucose consumption.
Researchers at Mount Sinai have developed an innovative approach to cancer immunotherapy by injecting immune stimulants directly into a tumor. This 'in situ vaccination' teaches the immune system to destroy not only the primary tumor but also other tumor cells throughout the body, effectively turning the tumor into a vaccine factory.
Researchers at Mount Sinai identified 413 genetic associations with schizophrenia across 13 brain regions, shedding light on the disease's mechanisms. Abnormal gene expression in specific brain areas contributes to increased risk of schizophrenia.
Researchers found that cancer cells with fewer mitochondria are more likely to respond to certain drug treatments, offering a new avenue for targeted therapies. The study's findings suggest that enhancing understanding of the relationship between mitochondrial variability and drug response may lead to more effective cancer treatments.
The lack of diversity in genomic data from biobanks worldwide, with 68% coming from European ancestry, limits the ability to identify associations between genetic variants and disease. To overcome this, Mount Sinai researchers advocate for increasing ethnic diversity in genomic sampling and research.
Researchers found that serotonin molecules can directly attach to histone proteins in neurons, loosening the DNA spool and enabling more robust gene expression. This discovery has significant implications for understanding brain disorders and developing new treatments.
A study led by Mount Sinai researchers found that aspiration is equally effective as traditional stent retriever approach for clot removal, with significant cost savings. The study showed comparable clinical results between the two approaches, including similar functional outcomes and revascularization rates.
Researchers developed an AI platform to detect neurodegenerative diseases, including Alzheimer's and chronic traumatic encephalopathy. The Precise Informatics Platform uses deep learning to accurately identify neurofibrillary tangles in digitized images.
The Mount Sinai Health System, in collaboration with UC San Diego Health, has released a national framework report that identifies regulatory, financial, and technological obstacles to improving local and state EMS systems. The report provides recommendations to create a more dynamic system responsive to society's needs.
Researchers from Mount Sinai will investigate the role of follicle-stimulating hormone (FSH) in regulating bone mass, body composition, and fat deposits during aging and menopause. The program aims to develop an FSH-blocking antibody for preventing and treating osteoporosis and obesity.
Researchers at Mount Sinai found that dengue virus infection can enhance the severity of Zika virus infection during pregnancy, leading to increased placental damage, fetal growth restriction, and fetal resorption. This mechanism may explain the high rate of microcephaly and birth defects observed in recent Zika outbreaks.
A new machine-learning framework distinguishes between low- and high-risk prostate cancer with higher precision than existing tools. The framework aims to provide radiologists and clinicians with a sound prediction tool for personalized patient care.
The National Institutes of Health has awarded a grant to develop and evaluate an artificial pancreas for pregnant women with type 1 diabetes. The project aims to improve patient and fetal outcomes by adapting automated insulin delivery technology.
Researchers found that herpes viruses use human satellite II RNA (HSATII RNA) to manipulate their environment and grow, similar to cancer cells. This discovery could lead to new diagnostic tools and drug targets for diseases like colitis and neurodegenerative disorders.