Membrane-less organelles (MLOs) are liquid droplets made from proteins and RNA that facilitate storage and biochemical activity within cells. The study found that MLOs are highly sensitive to the level of divalent cations, with fluctuations in these ions profoundly tuning their liquid properties.
Some NHS trusts are introducing local schemes to help plan for increased demand over the winter due to pension tax charges. These schemes allow doctors to opt out of the NHS scheme and receive employer contributions in cash, reducing their tax burden.
A Finnish study of over 2 million individuals reveals that mental disorders experienced in adolescence and early adulthood can have a lasting impact on employment. Individuals who were hospitalised for serious mental disorders before turning 25 had significantly poorer job prospects, with less than 10% employed after 25.
Researchers at Cleveland Clinic have identified FGF2 as a novel druggable target for glioblastoma, the most common primary malignant brain tumor. The study reveals that FGF2 is an intermediary in a multi-step pro-cancer signaling loop, suggesting that targeting it may halt the growth and spread of glioblastoma.
A study published in the European Journal of Health Economics found that young adults in Sweden reduce their primary care visits by 7% when they turn 20 and start paying SEK 100 for each visit. Women from low-income groups are most affected, with a 14% decrease in visits.
A large-scale survey in rural Thailand and Laos found that people's attitudes towards antibiotics were often consistent with public health recommendations, but linked to disproportionately high rates of prescribed antibiotics. Wealthier and more educated individuals were also associated with receiving antibiotics from informal sources.
A study published in The BMJ found that China's universal two-child policy resulted in an additional 5.4 million births, with a significant increase in births to older mothers and multiparous mothers. However, the policy's impact on premature births was not significantly increased.
A large survey of adults in sub-Saharan Africa found that bribery is a major obstacle to healthcare access, with those who paid bribes four times more likely to report difficulties. The study suggests that efforts to address corruption may be needed to achieve universal health coverage.
Researchers discovered that Toxoplasma gondii requires linoleic acid to complete its sexual phase of life, a nutrient found at high levels in feline intestines. The finding may lead to the development of treatments to reduce the spread of toxoplasmosis from cats to humans.
Researchers at Texas A&M University have found that the AH receptor can actually block invasion of glioblastoma cells, rather than promoting it. Adding certain ligands to the receptor has been shown to inhibit cell invasion and provide additional protection to the brain.
A new model forecasts dusty conditions with 63% accuracy over the southwestern US and 71% in the Great Plains. High levels of airborne dust can affect health, transportation, and agriculture.
Research funded by the British Heart Foundation has challenged a long-held medical myth that women experience unusual heart attack symptoms. According to the study, both men and women present with similar key symptoms, such as chest pain and nausea, highlighting the need for awareness of common warning signs.
A UH engineer offers two winning proposals to the US Department of Energy to enhance the nation's electric grid, focusing on accommodating variable renewable energy generation. His projects include reconfiguring transmission networks and upgrading energy management systems with microgrids.
A new study at the University of Kentucky reveals that mitochondrial changes, rather than glucose, drive chronic inflammation in type 2 diabetes. This finding challenges the long-held assumption that glucose is the primary cause of inflammation in the disease.
The project aims to develop a cutting-edge, DNA-based toolset to monitor aquatic life in coastal waters and support sustainable fisheries, protect vulnerable species, and manage climate change impacts. eDNA techniques will provide a comprehensive view of marine life and validate the approach as an important tool for ecosystem management.
Researchers at the University of Bristol discovered that fiddler crabs separate polarisation and brightness channels to detect approaching objects. This method provides a greater range of information for the crab, with polarisation offering a more reliable source of information than brightness in detecting predators.
Researchers found strong evidence that cannabis alleviates pain, with users experiencing a significant drop in pain suffering after consumption. The study highlights the potential of cannabis as a safe and effective alternative to opioids for treating chronic pain.
A study by University of Göttingen researchers found that Germany and UK are the most popular destination countries for EU internal migration. The analysis showed that richer countries attract more immigrants, and neighboring countries have a high rate of movement between them.
A new study has shed light on the mechanisms behind autophagy, a process that helps destroy bacteria and viruses. The research suggests that faulty autophagy can contribute to neurodegenerative diseases like dementia, and that targeting a specific protein interaction may lead to new treatments.
New research finds that unusual ocean temperatures in the tropical Pacific and Atlantic can increase April tornado occurrences over the Great Plains. Climate researchers discovered a link between ocean temperatures and atmospheric conditions that enhance thunderstorms and tornado-favorable environments.
A large study published in The BMJ found that even light physical activity reduces the risk of early death, with more intense activity having a greater impact. The study analyzed data from over 36,000 adults and found that spending 9.5 hours or more sedentary per day increases the risk of death.
Researchers at Rice University discovered electron pairing in ultrapure lanthanum strontium copper oxide (LSCO) samples at temperatures well above the critical threshold for superconductivity. The finding suggests two energy scales exist, one where pairs form and another where they exhibit collective behavior.
Researchers at Ohio State University have made significant breakthroughs in gene replacement therapy for Niemann-Pick type A disease, demonstrating its safety and therapeutic effects in nonhuman primates and mouse models. The treatment has shown a 'bystander effect', preventing motor and memory impairment and increasing survival rates.
Researchers at the University of Waterloo found that speeding is a strong predictor of car crashes, while hard braking and acceleration had no statistically significant links. The analysis used data from 28 million trips and suggests that insurance companies should look at speed when assessing driver risk.
A survey of over 1,800 participants found that more than 67% were willing to share all items with researchers from their home institution, while fewer shared with other institutions. The way preferences are elicited also affects sharing, with opt-out forms resulting in greater sharing per item.
A multi-national team of researchers found that higher levels of physical activity, regardless of intensity, are associated with a lower risk of early death. The study also shows that spending 9.5 hours or more sedentary daily increases the risk of death.
Physicists have discovered magnon crystallization in a new material, Ba2CoSi2O6Cl2, revealing insights into the ordering of magnons and their effects on magnetic properties. This study expands our understanding of quantum mechanics and its applications.
A new mathematical technique developed by Caoxiang Zhu at the Princeton Plasma Physics Laboratory can help simplify the design of stellarators, reducing construction time and costs. The method identifies irregular magnetic fields produced by stellarator coils, allowing for the creation of more stable plasmas.
Researchers found that music chart statistics have changed significantly since the 1990s, with albums now having shorter lifetimes. The diversity of charts has doubled or tripled, and albums either reach the top immediately or never make it.
B. infantis EVC001 demonstrates improved metabolism of protein-bound glycans from human milk, providing a basis for facilitating colonization in formula-fed infants. The study's findings suggest that N-glycans from milk glycoproteins contribute to B. infantis EVC001 colonization in the infant gut.
A new study published in the American Journal of Public Health found that 88% of past-12-month prescription opioid users used the drugs only as prescribed by a physician, while 4% misused them. Prescription-only misusers were more likely to be depressed and have higher rates of substance use disorder and benzodiazepine misuse.
The British Ecological Society is conducting a randomized controlled trial to compare single- and double-blind peer review processes. The study aims to assess whether author characteristics affect peer-review scores and acceptance of papers, with a focus on reducing bias in science publishing.
Researchers at Aarhus University have successfully developed a new method for analyzing urine samples, making it cheaper and more accurate. The approach uses Nuclear Magnetic Resonance (NMR) spectroscopy with a contrast agent to identify and quantify small molecule compounds in urine.
The study analyzed skeletal remains from 37 localities across present-day Denmark, revealing a shift in human mobility at the beginning of the Nordic Bronze Age. Migrants came from diverse regions, including southern Scandinavia, the Italian Alps, and Cornwall in south England.
The NIH has awarded $4.6 million to Color to establish a nationwide genetic counseling resource as part of the All of Us Research Program. Participants will receive personalized interpretation and guidance on genomic testing results, ancestry, and risk factors for specific diseases.
Researchers discovered two male skeletons from ancient Croatia with artificially deformed skulls, indicating possible cultural distinctions among diverse European groups. Genetic analysis revealed distinct ancestries, hinting at the use of cranial modification to signify social status during the Great Migration Period.
Researchers at Cardiff University have identified the CYFIP1 gene as a potential cause of abnormalities in brain structure seen in psychiatric conditions. The study found that the deletion of this gene leads to thinning of the insulation around nerve cells, disrupting communication between brain regions.
Researchers at UC San Diego have developed a new therapeutic approach to convert tumor-associated macrophages (TAMs) into cancer killers. The antibody, LM609, induces ADCC and kills drug-resistant tumors, prolonging response to standard treatments.
Researchers at Johns Hopkins Kimmel Cancer Center found that taking a single course of antibiotics may boost the risk of developing colon cancer a decade later. The study, published in the journal Gut, highlights the need for judicious use of antibiotics and careful stewardship.
Researchers detected a large concentration of electron pairs outside key temperature and energy ranges in a copper-oxide material, sparking hope for improving the superconducting properties of cuprates. By leveraging this knowledge, scientists may be able to enhance superconductivity by tweaking parameters or searching for other materi...
A Yale study has trained adolescents with Tourette Syndrome to control their tics through real-time fMRI, achieving significant symptom reductions. The technique, called rt-fMRI-NF, involves monitoring brain activity in real time and adjusting it towards healthier patterns.
A study by UMass Amherst researcher Elizabeth Evans found that individuals who perceived buprenorphine as unacceptable were least likely to use the medication during follow-up. The study also identified common reasons people disliking buprenorphine, such as negative physical reactions and side effects.
Duke researchers identify biochemical receptor that can reverse bone degradation caused by osteoporosis, offering new potential treatment option. The study found that activating the adenosine receptor A2B can halt and even reverse bone deterioration in mouse models of osteoporosis.
Researchers have solved a 127-year-old physics problem regarding the Kelvin angle in boat wakes, finding that the traditional assumption is not always true. The study reveals that boat wakes can have a different angle and even be off-center when affected by shear flow or other environmental factors.
The US Department of Energy will provide approximately $31.5 million in funding for small businesses to establish the technical feasibility of new innovations advancing the Office of Science's mission. Small businesses can apply for Phase I grants with durations ranging from 6-12 months.
A new study suggests that Pseudomonas aeruginosa thrives in cystic fibrosis lungs due to an abundance of succinate, a byproduct of cellular metabolism. This excess succinate fuels the growth of the bacteria and promotes chronic infections.
A new study published in Neurology found that facial pain is a common symptom of headaches, affecting up to 10% of people with primary headaches. The study suggests that facial pain may be a distinct syndrome rather than just a headache variant.
Initial urinary tract infections can cause long-lasting changes to the bladder's immune response, making it more prone to future infections. The study found that targeting TNF-alpha or other inflammatory responses may help prevent or alleviate recurrent UTIs.
A new study measures life expectancy based on historical mortality conditions, revealing Australian men live to 74.1 years, surpassing other countries like Japan and the Nordic nations. This achievement is attributed to Australia's long history of stability and high standard of living, which have contributed to better health outcomes.
A new care program featuring home visits and mobile phone links to caregivers improves treatment and follow-up for teens and young women with pelvic inflammatory disease. The study found a significant decline in new STIs among those receiving the innovative care program.
Researchers create magnonic crystals using ferromagnetic/superconducting systems, offering potential for compact microdevices and wave electronics. The study demonstrates the feasibility of spin-wave devices in post-silicon era electronics.
A study by Saint Louis University found that clinically meaningful PTSD improvement is associated with a 49% lower risk of incident type 2 diabetes. The researchers also discovered that in patients with both PTSD and depression, improvement in both conditions may be necessary to reduce the risk for type 2 diabetes.
A study published in Science Advances found that individuals carrying the FMR1 gene premutation are at risk for a wide range of health conditions, including depression, anxiety, and sleep apnea. The research analyzed electronic health records of nearly 20,000 individuals and identified an astonishing range of symptoms affecting FMR1 ca...
The Residential Experience for Aspiring Leaders (REAL) program will provide clinical experiences and prepare aspiring school leaders to manage daily workloads and long-range initiatives. Participants will be paired with Lehigh educators, mentors, and a clinical supervisor to develop their skills.
Researchers discovered that EspG protein prevents E. coli from forming pedestals in intestinal cells, allowing the bacteria to anchor and grow. This finding offers new possibilities for treating diarrheal diseases caused by pathogenic strains of E. coli.
Researchers have discovered a vast reserve of methane in the Earth's oceanic crust, formed through chemical reactions involving seawater and olivine. This finding opens up new possibilities for understanding the origins of life beyond our planet.
The MIT team has created a submerged system that harnesses the vibration of 'piezoelectric' materials to generate power, transmit data, and receive signals without batteries. This technology enables long-term underwater sensing for climate change research, marine life tracking, and potential applications on other planets.
Researchers at Washington State University found that individuals who post more selfies are viewed as less likeable, more insecure, and less open to new experiences. On the other hand, those who share more posed photos are seen as higher in self-esteem, more adventurous, and having better social skills.
A meta-analysis of 70 studies and 55,000 offenders found that specialized psychological programmes significantly reduce reoffending rates. Consistent input from a qualified psychologist is key to programme effectiveness.
A study published in Biological Psychiatry found that relatives of patients with schizophrenia and bipolar disorder have unique brain abnormalities, despite symptom overlap. The findings suggest that familial risk for these disorders influences brain development already early in life.