Research in animal models shows that social isolation during adolescence can lead to disruptions in social behavior and activity patterns of inhibitory neurons involved in social approach. Increasing activity of these neurons in adult animals restores normal social behavior. The study highlights the importance of social experience duri...
Researchers at Mount Sinai discovered a novel combination of two classes of drugs that cause the highest rate of human beta cell proliferation without harming most other cells in the body. This finding is an important step toward a diabetes treatment that restores insulin production. The study, published in Science Translational Medici...
A new study found that a behavioral therapy-assisted smartphone app delivered via telemedicine was an effective treatment for symptoms of binge eating disorders. Patients who received the app-based treatment reported significant reductions in binge days and achieved higher remission rates compared to those receiving standard care.
A recent study highlights breakthroughs in understanding the association of specific genes with disorders, driving medical innovation and personalized health. Researchers emphasize the need for joint efforts between industry and academia to establish comprehensive inventories of genotype-phenotype relationships.
Researchers identified 102 genes associated with autism spectrum disorder (ASD), including 49 linked to developmental delays. The large international cohort of nearly 12,000 ASD participants enabled the team to increase the number of associated genes from 65 in 2015.
Research reveals that liver cancer tumors contain diverse sets of cells, affecting tumor growth and immune response. A single biopsy may mischaracterize a tumor's genetic makeup and immune cell infiltration.
A young boy with a fatal genetic disease has made a remarkable recovery thanks to a collaborative effort between physicians and immunologists from around the world. The team combined exceptional clinical care, genetic diagnosis, and a novel immunotherapeutic drug to bring the child into full remission.
Researchers found an elevated overall cancer incidence among World Trade Center responders, especially in thyroid and prostate cancers. Leukemia is also reported for the first time, likely due to low-level benzene fuel exposure.
The Mount Sinai Diversity Innovation Hub has been named among the Top 50 Leaders in Digital Health for 2020, recognizing its efforts to improve healthcare through technology. The hub aims to diversify the pipeline for career paths in healthcare innovation and technology.
Researchers have developed a minimally invasive procedure to treat chronic Achilles tendon disorder, reducing pain and recovery time. The percutaneous Zadek osteotomy (ZO) technique has shown significant improvement in functional outcomes and faster recovery times compared to traditional open surgery.
Researchers at Mount Sinai are exploring new treatments for brain tumors, including magnetic hyperthermia therapy and studies on glioma dormancy and tumor microenvironment. The grant funding will support five-year projects focused on improving patient outcomes through innovative therapies.
A study published in Clinical Cancer Research identified neoantigens in 184 patients with multiple myeloma, showing an increase in these genetic markers in patients who had relapsed. The researchers found common neoantigens between patients, which could lead to new vaccine therapies.
A study found that different mutations in a single gene can cause various problems in brain cells. Researchers discovered that even healthy proteins may interfere with mutant proteins' actions, leading to irregular neuronal firing. The findings emphasize the importance of understanding each mutation for personalized medicine.
A study published in the Journal of Allergy and Clinical Immunology identified over 300 genes and 200 CpG sites associated with reaction severity. The research suggests that neutrophil-mediated immunity plays a prominent role in peanut allergy reactions, offering potential new targets for treatment.
A new study has identified a genetic variation that significantly increases the risk of heart failure in African and Latino Americans. The transthyretin or TTR V122I genetic variant was associated with an increased risk of heart failure, with patients being two-fold more likely to have the condition.
Researchers at The Mount Sinai Hospital have discovered a potential therapy, MS1943, that selectively degrades EZH2 protein in cancer cells. Effective against triple-negative breast cancer, it reduces EZH2 levels and kills cancer cells.
Dr. Mone Zaidi has been recognized as an AAAS Fellow for his groundbreaking research on pituitary-metabolic circuits and their impact on body fat, bone mass, and energy metabolism. His work holds strong clinical potential for treating osteoporosis.
The Milton and Carroll Petrie Department of Urology at Mount Sinai has received a $1 million grant from The Arthur M. Blank Family Foundation to fund the Prostate Cancer Program. The program aims to advance immunotherapy and personalized genomic vaccine trials aimed at treating prostate cancer.
A new study published in Nature Microbiology has discovered that epigenetic chemical modifications play a crucial role in the survival and spread of C. difficile bacteria. The research found that inhibiting these modifications can reduce bacterial populations by up to 100 times, paving the way for potential treatments for this deadly i...
Mount Sinai researchers used MGNA to identify key regulators of the Parkinson's molecular network, including STMN2. The study found that reduction of STMN2 led to upregulation of genes associated with the disease and disrupted motor function control in mice.
A study by Mount Sinai researchers found that more than half of patients taking ruxolitinib gained over 5% in body weight, associated with increased systolic blood pressure and liver enzymes. The study highlights the need for physicians to counsel patients about potential metabolic effects.
A study in a multi-ethnic community found that teaching young adults healthy behaviors and showing them ultrasound images of plaque in their arteries improved their cardiovascular health. The FAMILIA Project showed significant benefits for caregivers who strictly adhered to simple education plans, reducing risk factors for heart disease.
The study found that high blood pressure, high cholesterol, and diabetes were the most common triplet of chronic conditions, while lung disease and heart attacks were a surprisingly common pair. Patients living in lower-income areas developed a second chronic condition 15 years earlier than their counterparts in higher-income areas.
Research found that maternal exposure to particulate air pollution during pregnancy is associated with decreased heart rate variability in six-month-old infants. This decrease in heart rate variability is a known risk factor for mental and physical health problems later in life.
Researchers have found a rare toxic reaction caused by high doses of over-the-counter niacin, which can lead to severe vision loss. Discontinuing the supplement reversed the condition and restored retinal function.
A recent study found that acetate, a byproduct of alcohol metabolism, affects the brain's memory system and contributes to cravings. The research team discovered that alcohol metabolism impacts histone acetylation in the hippocampus, leading to increased gene expression and memory formation.
Mount Sinai researchers have identified a targeted therapy called tazemetostat that can help children with neuroblastoma, a deadly pediatric nerve cancer. Tazemetostat disables an enzyme called EZH2, killing neuroblastoma cells.
Researchers at Mount Sinai develop a novel vaccine using chimeric hemagglutinin, inducing broad antibody responses against human and avian influenza viruses. The study shows promise for a universal flu vaccine, but interim results indicate further work is needed.
A new artificial pancreas system improved blood glucose control throughout the day and overnight, reducing time in range for high and low glucose levels. The system also showed improvements in hemoglobin A1c and other measurements related to diabetes control compared to current technology.
Researchers discovered a brain circuit linking cigarette smoking to type 2 diabetes, showing that nicotine consumption leads to reduced insulin release and higher blood sugar levels. The study found that variations in the Tcf7l2 gene may influence both tobacco addiction and diabetes development.
Researchers have identified RGS4 as a multifunctional protein that contributes to the transition from acute and sub-acute pain to pathological pain states. Inhibiting RGS4 action disrupts the maintenance of chronic pain, promoting recovery in preclinical models.
A new study uses tape strips to analyze skin lesions and non-lesional skin in infants and young children with early-onset eczema, identifying biomarkers for immune and barrier abnormalities. The technique provides a non-invasive alternative to skin biopsies, which are often difficult to perform in children.
A recent study found that deep brain stimulation (DBS) of the subcallosal cingulate area provides a robust and sustained antidepressant effect in patients with treatment-resistant depression. Most participants experienced an antidepressant response and maintained it over eight years, with significant improvements in quality of life.
Researchers at Mount Sinai Hospital have discovered the near-atomic-resolution structure of DNA polymerase delta, a crucial enzyme in genome replication. The team also mapped mutations associated with cancers and other diseases.
Researchers found that patients with schizophrenia who experienced auditory hallucinations had abnormal tonotopic organization of the auditory cortex, established in infancy. This suggests that the vulnerability to develop 'voices' is probably established many years before symptoms begin.
A study published in Translational Psychiatry identified elemental signatures in baby teeth unique to ADHD, autism, and co-occurring conditions. The researchers found that each condition has a distinct metabolic signature involving essential and toxic elements.
Researchers at The Mount Sinai Hospital have identified a unique cell signature associated with drug resistance in Crohn's disease patients. This discovery may enable the development of personalized treatment plans and improved patient outcomes.
Researchers tested AuroLase Therapy, a treatment using gold-silica nanoshells, in 16 men with low- to intermediate-grade prostate cancer. The treatment was successful in 87.5 percent of lesions treated at one year of follow-up, preserving quality of life.
A study published in Cell found that intermittent fasting reduces the release of pro-inflammatory cells called monocytes, which can cause serious tissue damage. Fasting also leads to these cells going into a less inflammatory state.
A clinical trial discovered that selinexor, a novel therapy, effectively knocked down bone marrow cancer in over a quarter of patients, including two who achieved complete remission. The treatment showed promise for patients resistant to multiple therapies and offered new hope for those with limited treatment options.
Researchers found links between early-life manganese exposure and altered functional connectivity of brain areas supporting cognitive and motor control. This association was observed even before birth and during early childhood.
A recent study published by Mount Sinai researchers found that fluoride exposure may contribute to complex changes in kidney and liver function among youth in the US. The findings suggest that adolescents with poorer kidney or liver function may absorb more fluoride, highlighting potential health concerns.
Researchers combine checkpoint blockade therapy with stem cell transplantation to boost efficacy in non-Hodgkin's lymphomas and melanoma. The approach increases cancer-killing immune response tenfold, allowing it to be effective for previously treatment-resistant cancers.
Mount Sinai researchers have developed a novel vaccine consisting of DNA and recombinant proteins, which was tested in monkeys and induced antibodies similar to those associated with protection from HIV. The vaccine targets the V1V2 loop of the gp120 envelope protein and showed strong protective effects against HIV infection.
Researchers analyzed 2-million-year-old teeth to understand breastfeeding patterns in extinct early human species Australopithecus africanus. They found the species breastfed for up to one year and experienced cycles of food scarcity, influencing their nursing behaviors.
Researchers from Mount Sinai highlight the importance of multidimensional data for stratifying a complex disease like asthma. Carefully designed, integrated multi-'omic' studies could accelerate precision medicine for asthma patients by defining asthma subtypes through transcriptomics and other omic approaches.
A comprehensive review by Mount Sinai experts aims to help clinicians understand medical issues relevant to transgender people, addressing the biggest barrier to care - lack of knowledgeable providers. Recommendations include determining transgender identity, prescribing hormone therapy, and updating electronic medical records.
A study by Mount Sinai researchers found that World Trade Center responders with prostate cancer exhibited chronic inflammation in their prostates, which may have contributed to their cancer. The researchers suggest that this link could lead to the development of anti-inflammatory therapies for similar cases.
A study by Mount Sinai researchers found that 35% of cancer survivors have chronic pain, with specific types of cancer having a higher incidence. Chronic pain is more prevalent among unemployed and uninsured survivors.
A recent study has analyzed the genomes of nearly 50,000 non-European individuals to maximize genetic discovery and lessen clinical disparities. The study revealed nearly 1,500 associations between genes and disease in minority populations, providing valuable insights into the genetic underpinnings of disease affecting non-whites.