Researchers identified reproductive and metabolic subtypes of PCOS associated with novel gene regions, promising to transform understanding of the disorder. The study used clustering of clinical, metabolic, and hormonal data from women with PCOS, revealing two distinct subtypes with different genetic architectures.
A study published in Cell reveals that viruses can produce previously undetected proteins by stitching together host and viral sequences, altering the course of viral infection. These new proteins could be exploited for vaccine purposes and may hold key to understanding viral virulence.
A study found that 36% of hospitalized COVID-19 patients had heart damage, leading to a three times higher risk of death. Patients with mild myocardial injury still faced a 75% higher risk of death compared to those with normal levels.
A study published in Cell Reports reveals that human acute myeloid leukemia (AML) stem cells are dependent on the transcription factor RUNX1, which could lead to lasting remissions or even cures. The researchers used induced pluripotent stem cells from a patient with AML to recreate leukemia stem cell biology in the lab.
A Mount Sinai research team has identified the scaffolding protein histone deacetylase 3 (HDAC3) as essential for proper skin development and barrier formation. Mice lacking HDAC3 in the epidermis fail to develop a functional skin barrier, leading to dehydration and death shortly after birth.
Mount Sinai researchers found lower ACE2 expression in younger children, increasing with age. This could help explain why children are less likely to get COVID-19 and account for only 2% of identified cases.
Scientists discovered biological markers in teeth of children who later developed ALS, shedding light on the disease's early stages and potential preventive strategies. The study found abnormal metal uptake patterns, suggesting a link between environmental factors and disease onset.
Researchers developed an AI model using CT scans and clinical data to diagnose COVID-19, achieving higher sensitivity than radiologists. The algorithm can rapidly detect the virus, isolate patients, and prevent its spread during pandemics.
Researchers used chest X-rays to identify patients at higher risk of severe illness from COVID-19. A unique scoring system evaluated lung patterns, predicting outcomes and guiding treatment for high-risk patients.
A clinical trial led by Mount Sinai researchers showed that combining chemotherapy and immunotherapy can significantly delay the progression of metastatic bladder cancer. The trial also found that immunotherapy alone may be an option for patients with high PD-L1 protein expression in their tumors.
A new study by Mount Sinai researchers found that insulin resistance is a key factor mediating racial disparities in breast cancer prognosis. Black women with invasive breast cancer had higher rates of insulin resistance and more aggressive tumors than white women.
Researchers found that anticoagulants improved survival rates among COVID-19 patients in and out of the intensive care unit setting. Treatment with anticoagulants was associated with reduced mortality and longer hospital stays for ventilated patients.
A study analyzing NYC birth data found stark differences in severe maternal morbidity risk across neighborhoods with extreme racial and economic polarization. Black and Latina women faced the largest magnitude of associations with severe maternal morbidity.
Researchers at Mount Sinai have identified a novel class of genes, specifically LINC00473, that regulate mood and drive sex-specific susceptibility versus resilience to depression. These findings provide evidence for an important new family of molecular targets that could help scientists develop more effective pharmacotherapies.
A clinical trial found that immunotherapy significantly slowed the worsening of urothelial cancer when given after platinum-based chemotherapy, with a 60% longer time to cancer progression compared to the control group. The switch maintenance immunotherapy approach is expected to become a standard of care for metastatic bladder cancer.
Dopamine plays a critical role in regulating gene expression, particularly in the context of cocaine abuse. Histone dopaminylation affects brain regions involved in motivation and reward behavior.
A new study found that nicotinamide inhibits aggressive cell transformations and reverses the development of fibrous membranes in the retina, potentially treating fibrotic eye diseases. The compound also promotes the transition from mesenchymal to epithelial cells, helping to preserve their original identity.
Researchers at Mount Sinai have found a way to regulate special immune system cells in lung cancer tumors, suppressing them and allowing tumors to grow. By blocking this pathway, the immune system can be boosted to prevent tumor formation or growth, offering a potential new treatment for immunotherapy.
Researchers identified predictive models for Crohn's disease, including a serum biomarker model with 76% accuracy, and explored the link between metal exposure in early life and IBD risk. Achieving deep remission early on was also associated with a significant decrease in long-term complications.
A new study identifies Plexin-B2 as a key protein in wound healing and neural repair following spinal cord injury. The finding could aid the development of therapies targeting axon guidance pathways for more effective treatment of SCI patients.
Researchers at Mount Sinai have discovered a method to increase the potency of hematopoietic stem cells, which could improve bone marrow transplants. By manipulating lysosomal activity, they enhanced the potency of these stem cells by over 90-fold.
Researchers at Mount Sinai have developed an AI model that can accurately determine the type of lower back pain by analyzing clinical notes in electronic medical records. This breakthrough could lead to improved treatment options, reduced opioid prescriptions, and more accurate billing and therapy recommendations.
Mount Sinai physicians analyzed chest CT scans of Chinese COVID-19 patients, identifying specific patterns in lung disease as it develops over a week and a half. The study could lead to quicker diagnosis and prompt isolation in early stages.
A new brain scan-blood test panel has been developed to help diagnose brain trauma following battlefield blasts. The panel combines functional assessment with blood tests and brain scans to estimate brain degeneration in human veterans exposed to IED blasts.
Research in animal models shows that social isolation during adolescence can lead to disruptions in social behavior and activity patterns of inhibitory neurons involved in social approach. Increasing activity of these neurons in adult animals restores normal social behavior. The study highlights the importance of social experience duri...
Researchers at Mount Sinai discovered a novel combination of two classes of drugs that cause the highest rate of human beta cell proliferation without harming most other cells in the body. This finding is an important step toward a diabetes treatment that restores insulin production. The study, published in Science Translational Medici...
A new study found that a behavioral therapy-assisted smartphone app delivered via telemedicine was an effective treatment for symptoms of binge eating disorders. Patients who received the app-based treatment reported significant reductions in binge days and achieved higher remission rates compared to those receiving standard care.
A recent study highlights breakthroughs in understanding the association of specific genes with disorders, driving medical innovation and personalized health. Researchers emphasize the need for joint efforts between industry and academia to establish comprehensive inventories of genotype-phenotype relationships.
Researchers identified 102 genes associated with autism spectrum disorder (ASD), including 49 linked to developmental delays. The large international cohort of nearly 12,000 ASD participants enabled the team to increase the number of associated genes from 65 in 2015.
Research reveals that liver cancer tumors contain diverse sets of cells, affecting tumor growth and immune response. A single biopsy may mischaracterize a tumor's genetic makeup and immune cell infiltration.
A young boy with a fatal genetic disease has made a remarkable recovery thanks to a collaborative effort between physicians and immunologists from around the world. The team combined exceptional clinical care, genetic diagnosis, and a novel immunotherapeutic drug to bring the child into full remission.
Researchers found an elevated overall cancer incidence among World Trade Center responders, especially in thyroid and prostate cancers. Leukemia is also reported for the first time, likely due to low-level benzene fuel exposure.
The Mount Sinai Diversity Innovation Hub has been named among the Top 50 Leaders in Digital Health for 2020, recognizing its efforts to improve healthcare through technology. The hub aims to diversify the pipeline for career paths in healthcare innovation and technology.
Researchers have developed a minimally invasive procedure to treat chronic Achilles tendon disorder, reducing pain and recovery time. The percutaneous Zadek osteotomy (ZO) technique has shown significant improvement in functional outcomes and faster recovery times compared to traditional open surgery.
Researchers at Mount Sinai are exploring new treatments for brain tumors, including magnetic hyperthermia therapy and studies on glioma dormancy and tumor microenvironment. The grant funding will support five-year projects focused on improving patient outcomes through innovative therapies.
A study published in Clinical Cancer Research identified neoantigens in 184 patients with multiple myeloma, showing an increase in these genetic markers in patients who had relapsed. The researchers found common neoantigens between patients, which could lead to new vaccine therapies.
A study found that different mutations in a single gene can cause various problems in brain cells. Researchers discovered that even healthy proteins may interfere with mutant proteins' actions, leading to irregular neuronal firing. The findings emphasize the importance of understanding each mutation for personalized medicine.
A study published in the Journal of Allergy and Clinical Immunology identified over 300 genes and 200 CpG sites associated with reaction severity. The research suggests that neutrophil-mediated immunity plays a prominent role in peanut allergy reactions, offering potential new targets for treatment.
A new study has identified a genetic variation that significantly increases the risk of heart failure in African and Latino Americans. The transthyretin or TTR V122I genetic variant was associated with an increased risk of heart failure, with patients being two-fold more likely to have the condition.
Researchers at The Mount Sinai Hospital have discovered a potential therapy, MS1943, that selectively degrades EZH2 protein in cancer cells. Effective against triple-negative breast cancer, it reduces EZH2 levels and kills cancer cells.
Dr. Mone Zaidi has been recognized as an AAAS Fellow for his groundbreaking research on pituitary-metabolic circuits and their impact on body fat, bone mass, and energy metabolism. His work holds strong clinical potential for treating osteoporosis.
The Milton and Carroll Petrie Department of Urology at Mount Sinai has received a $1 million grant from The Arthur M. Blank Family Foundation to fund the Prostate Cancer Program. The program aims to advance immunotherapy and personalized genomic vaccine trials aimed at treating prostate cancer.
A new study published in Nature Microbiology has discovered that epigenetic chemical modifications play a crucial role in the survival and spread of C. difficile bacteria. The research found that inhibiting these modifications can reduce bacterial populations by up to 100 times, paving the way for potential treatments for this deadly i...
Mount Sinai researchers used MGNA to identify key regulators of the Parkinson's molecular network, including STMN2. The study found that reduction of STMN2 led to upregulation of genes associated with the disease and disrupted motor function control in mice.
A study by Mount Sinai researchers found that more than half of patients taking ruxolitinib gained over 5% in body weight, associated with increased systolic blood pressure and liver enzymes. The study highlights the need for physicians to counsel patients about potential metabolic effects.
A study in a multi-ethnic community found that teaching young adults healthy behaviors and showing them ultrasound images of plaque in their arteries improved their cardiovascular health. The FAMILIA Project showed significant benefits for caregivers who strictly adhered to simple education plans, reducing risk factors for heart disease.
The study found that high blood pressure, high cholesterol, and diabetes were the most common triplet of chronic conditions, while lung disease and heart attacks were a surprisingly common pair. Patients living in lower-income areas developed a second chronic condition 15 years earlier than their counterparts in higher-income areas.
Research found that maternal exposure to particulate air pollution during pregnancy is associated with decreased heart rate variability in six-month-old infants. This decrease in heart rate variability is a known risk factor for mental and physical health problems later in life.
Researchers have found a rare toxic reaction caused by high doses of over-the-counter niacin, which can lead to severe vision loss. Discontinuing the supplement reversed the condition and restored retinal function.
A recent study found that acetate, a byproduct of alcohol metabolism, affects the brain's memory system and contributes to cravings. The research team discovered that alcohol metabolism impacts histone acetylation in the hippocampus, leading to increased gene expression and memory formation.