Researchers at MSU solved the long-standing enigma of the magnesium dimer's high-lying vibrational states using advanced computational methods. The team's findings, published in Science Advances, provide new insights into the molecule's behavior and pave the way for future experimental studies.
Patients with germline or somatic mutations in DNA repair genes showed better clinical outcomes after platinum-based chemotherapy. These mutations were found in genes such as BRCA1, BRCA2, and PALB2, which are involved in a form of DNA repair known as homologous recombination.
The Harvard Data Science Review special issue delves into the COVID-19 pandemic's complex issues, incorporating data-driven insights to better understand its effects. The rolling publication series offers a unique perspective on the crisis, combining multiple disciplines for a comprehensive understanding.
A study published in Scientific Reports found that AI can accurately predict personality traits from 'selfie' photographs, with women's faces being more reliable than men's. The technology has potential applications in customer service, dating, and online tutoring.
Astronomers using ALMA have spotted quasi-periodic flickers in millimeter-waves from the center of the Milky Way, suggesting a rotating radio spot circling a supermassive black hole. The findings provide insight into space-time with extreme gravity and may shed light on the behavior of gas around the black hole.
A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...
A key cell signaling pathway drives cancer-associated muscle loss, and targeting this pathway with a drug like GKT137831 could prevent cachexia. The study found that restoring SIRT1 levels can prevent muscle degeneration and extend the life of mice with pancreatic cancer
Researchers have successfully synthesized a 2D honeycomb kagome polymer, revealing predicted topological properties and opening up new possibilities for electronic devices. The material's unique structure combines the properties of graphene and superconductors.
A study by Johns Hopkins Medicine found that women and older adults are still vastly underrepresented in lipid lowering therapy trials, despite their high disease burden. The researchers analyzed 60 studies from 1990 to 2018 and reported a modest increase in representation of women, but many trials excluded pregnant or breastfeeding wo...
The Penium margaritaceum genome provides insights into the origins of land plants by revealing footprints of adaptations for UV radiation protection and cell wall structure. The genome contains genes involved in regulatory systems, hormone signaling, and mucilage production, which are essential for structural support.
Researchers from Germany and Vietnam discover two new species and one subspecies of crocodile newts in northern Vietnam, bringing the total of crocodile newt taxa known from the country to seven. The discovery highlights the urgent need for conservation efforts due to habitat loss and overcollection.
A new study has found that high blood glucose levels before pregnancy can increase the risk of severe maternal morbidity and death, even in women without diabetes. The study analyzed data from over 31,000 women and found that elevated hemoglobin A1c levels were associated with a higher risk of adverse outcomes
Kali Thomas, a researcher at Brown University, has been honored with the inaugural Terrie Fox Wetle Rising Star Award in Health Services and Aging Research. She is being recognized for her work on organizing and delivering long-term services and supports to improve health outcomes for older adults.
NASA's Aqua satellite gathers temperature information about Tropical Storm Mangga's cloud tops, revealing powerful thunderstorms with potential to generate heavy rainfall. The strongest storms have coldest cloud top temperatures, indicating strong and potentially destructive weather.
A new COVID-19 vaccine has demonstrated safety and a rapid immune response in a phase 1 clinical trial involving 108 healthy adults. The Ad5-nCoV vaccine produced virus-specific antibodies and T cells in 14 days, with the majority of recipients showing either a positive T cell response or had detectable neutralising antibodies against ...
A study led by University of Maryland Baltimore County Ph.D. candidate Samuel Hulse demonstrates a strong correlation between the visual patterns on male darter fish and their environments, supporting sensory drive theory. The findings show that male fish with colors easily perceivable in their environment are more likely to reproduce.
Researchers identified two novel biomarkers, PDL1/CD274 copy number alteration and PD-L1 combined positive score, that correlate with improved outcomes in patients with metastatic breast cancer treated with immunotherapy. These biomarkers may help identify patients most likely to benefit from this treatment.
Investigating potential adverse effects and antibody-dependent enhancement is crucial for vaccine development. Comprehensive safety tests are necessary before widespread implementation.
Researchers discovered a new resistance mechanism that inhibits protein dynamics in Neisseria gonorrhoeae, making existing treatments ineffective. The findings suggest that designing new antimicrobials targeting this mechanism could lead to effective treatments.
A study on chicken adaptation reveals that genetic changes play a more prominent role when organisms return to their ancestral homelands. Researchers found that plastic phenotypic changes are sufficient to help animals adapt when reintroduced to familiar environments, but mutation-induced changes are necessary for initial adaptation.
Researchers from CNRS and IGBMC demonstrate that meiosis in mice begins and proceeds normally even without retinoic acid. Meiosis is a crucial process for the transmission of unique sets of genes to offspring, resulting in novel assortments of chromosomes.
A new study analyzed four years' worth of data from two million patients and found that those having dental procedures on Fridays or before holidays were more likely to fill opioid prescriptions. Non-opioid painkillers are equally effective at controlling pain with lower risks.
Researchers from Monash, Swinburne and RMIT universities recorded Australia's fastest internet data speed and the world's from a single optical chip, capable of supporting 1.8 million households' high-speed connections. The technology has the potential to scale up existing infrastructure and enable ultra-high speed communications.
Researchers have created a high-performance cancer vaccine utilizing self-healing polylactic acid microcapsules, which efficiently activate the immune system and inhibit tumor growth. The vaccine achieves effective T cell response, potent tumor inhibition, and anti-metastatic effects in various tumor models.
A large observational study found that chloroquine and hydroxychloroquine offer no therapeutic benefits for COVID-19 patients, increasing the risk of serious heart rhythm complications. The study analyzed data from nearly 15,000 patients with COVID-19 and 81,000 controls.
A new onboard separation technology developed at PNNL can separate ethanol from gasoline, enabling an octane-on-demand system that improves fuel economy. The technology has shown promising results in separating 95% of ethanol from commercial gasoline.
A quantum physicist at the University of Sydney has invented a new type of error-correcting code for quantum computers that will free up more hardware to do useful calculations. This approach allows companies like Google and IBM to design better quantum microchips, enabling the development of large-scale quantum technology.
A study of fruit fly sensory neurons has identified a 'thermometer' circuit that relays cold temperature information to the brain, inhibiting morning wakefulness. This finding sheds light on why humans struggle to wake up in winter and may have implications for understanding human sleep regulation.
Lyme disease is the most reported vector-borne disease in the country, with a dramatic increase in cases over the past 20 years. The research aims to understand how the bacterium Borrelia burgdorferi causes sustained inflammation and Lyme arthritis symptoms.
A study found that breast cancer survivors underutilize recommended strategies for reducing fatigue, despite high prevalence and persistence. The analysis also revealed differences in utilization of physical activity and supportive care depending on the type of fatigue experienced.
A recent study presents an automatic method to detect and segment the intrauterine cavity using artificial intelligence and deep learning techniques on MRI data from 71 pregnancies. The proposed method achieves high segmentation performance, highlighting its potential for use in daily clinical practice as a surgical planning method.
Stroke survivors who receive early visual training can recover more of their lost vision than those trained later. Researchers discovered that the brain's visual structures degenerate over time after an occipital stroke, but early intervention can halt this loss.
A parasitic wasp species has been discovered that can control a major pest affecting oilseed rape crops. The wasp, Microctonus brassicae, lays eggs within the beetle's body, rendering it sterile and causing its death.
A new study maps genetic diversity in terrestrial mammals, revealing regions with high evolutionary history and stable climates as strongholds of genetic diversity. The research suggests that conservation efforts should prioritize the protection of these 'arks of biodiversity' due to climate change.
Researchers found that COVID-19 patients' survival rates after resuscitation vary greatly, with probabilities ranging from less than 3% to over 22%. Younger patients with shockable rhythms had higher survival rates without severe neurological disability.
Research finds that ferropericlase transforms into superoxide when exposed to water at deep lower mantle conditions. The discovery suggests the lower mantle is locally oxidized where water is present, contrary to previous theories.
A report from Johns Hopkins Medicine recommends adding home visit codes to MIPS quality measures and fostering research on home-based primary care. Currently, only 12% of homebound patients receive their medical care at home, highlighting the need for improved quality measures.
Researchers found that contacts form between particles, stabilizing microstructure and stiffening materials. This discovery explains age-related changes in paste materials and has implications for industries using similar materials.
A study revealed that insufficient insulin action in adipocytes leads to the development of diabetes and NASH by hyperactivating the protein FoxO1. This finding could serve as a potential target for new drug development for these conditions.
High-entropy alloys (HEAs) exhibit remarkable mechanical properties at high temperatures and exceptional strength, ductility, and fracture toughness at cryogenic temperatures. Researchers reviewed the recent achievements in 3D printing of HEAs, validating laser-based techniques for producing high-quality products.
A study of over 96,000 hospitalized COVID-19 patients found no reduction in death rate among those treated with hydroxychloroquine or chloroquine. Patients on these regimens were more likely to experience severe heart rhythms and higher mortality rates.
A new study by Duke University researchers finds that reusing oilfield water in California's Kern County does not pose major health risks. The water can be safely used for irrigation if mixed with surface water, but farmers must plant boron-tolerant crops and monitor soil quality to avoid potential issues.
Researchers found that the orientation and configuration of hexagonal boron nitride on bilayer graphene significantly affect Berry curvature, a stable dissipationless current. Encapsulating bilayer graphene with hBN in phase increases asymmetry and large Berry curvature.
Researchers at Skoltech and Southampton University develop a fully optical approach to control couplings between polariton condensates, enabling simulation of condensed matter phases. This technology uses laser excitation patterns to generate complex polariton graphs in a scalable manner.
Researchers from McMaster University discuss cloth masks and ventilation techniques in reducing COVID-19 transmission. They conclude that noninvasive ventilation may reduce mortality but increase risk for healthcare workers.
A Rice University study reveals that blood flow to the brain recovers faster than brain function after a microstroke. The research used advanced neural monitoring technology to measure both blood flow and neuronal recovery simultaneously, showing a significant disconnect between the two processes.
A new urine-testing system inspired by nature can identify metabolites that cause kidney stones to form, enabling patients to receive results within 30 minutes. The test is more cost-effective and simpler than current methods, making it a promising solution for managing urinary stone disease.
A preclinical study led by Children's Hospital Los Angeles surgeon Tracy Grikscheit successfully grew a fully functional gut nervous system in a pre-clinical model, offering hope for babies with Hirschsprung's disease. The study uses tissue engineering to grow the complete nervous system from scratch.
A new study reveals that bumblebees bite leaves of flowerless plants to accelerate flowering, causing blooms to occur two weeks to a month earlier. This behavior suggests that bumblebees can manipulate plant flowering through deliberate damage, providing pollination systems with more plasticity and resilience to climate change.
Researchers at the University of Southampton have discovered a way to convert an antagonist CD40 antibody into an agonist, which can stimulate the immune system and cure cancer more effectively. The study shows that this
A Monash University study found that inhibiting cell death pathways in oocytes allows them to rapidly repair DNA damage, maintaining fertility. Double-strand breaks are the most harmful type of DNA damage, promoting genetic instability if not repaired correctly.
A new study reveals that the brain can update poorly formed memories with incorrect information, leading to inaccurate recall. The research suggests targeting updating mechanisms therapeutically to treat memory and anxiety disorders.
Researchers found that COVID-19 patients with ischemic strokes tend to be younger and have more severe strokes compared to non-COVID stroke patients. Additionally, the rate of imaging-confirmed acute ischemic stroke in hospitalized patients with COVID-19 is lower globally than for non-COVID patients.
A new University of Stirling study investigates the effects of full-time home-based work on productivity and wellbeing, particularly among lower socio-economic groups. The £275,000 project aims to identify key challenges and develop coping strategies for workers and their households during this unprecedented shift.
Researchers at MIT and WHOI have developed a lightweight instrument that can measure both physical and biological features of the ocean's vertical layers. The EcoCTD uses a combination of sensors to capture data on temperature, salinity, and chlorophyll content, providing insights into nutrient cycles and carbon sequestration.
Researchers at NIST have developed a technology that boosts the stability of microwave signals 100-fold, enabling more accurate time dissemination, navigation, and imaging. The new method uses advanced atomic clocks and frequency combs to transfer optical clock stability to the microwave domain.
Current ICU protocols lack detail, leaving doctors exposed to legal liability in case of medical shortages. The study argues that denying treatment based on disability or age could violate patient rights and cause unlawful death.
Researchers have made significant progress in understanding plasma behavior at the edge of fusion facilities, which could help achieve fusion power. The Gkeyll code simulates turbulent fluctuations and reduces particle flux near the plasma edge, potentially increasing efficiency.
A survey of adolescent cancer patients and their families found that parents have a poor understanding of their teens' preferred time to discuss end-of-life issues. Family-centered pediatric advance care planning interventions can help address this gap, enabling open conversations about treatment preferences and improving quality of life.
Researchers found that tropical forests can handle heat up to a certain threshold of 32 degrees Celsius, but limiting global temperatures is crucial to avoid accelerating climate change. The study analyzed over half a million trees across 813 forests in the tropics.