A new algorithm, Phe2vec, accurately identified patients with certain diseases, outperforming traditional methods in classifying diagnoses. The study suggests that this automation will facilitate further research in clinical informatics.
A recent study by Mount Sinai researchers discovered that certain neurons in the brain's decision-making centers monitor body-state dynamics and hijack the decision-making process during intense states of arousal. This suggests that changes in heart rate and other bodily responses can impact the brain's ability to make rational decisions.
A large-scale international study found that edoxaban is non-inferior to warfarin for efficacy in preventing adverse events, but led to higher bleeding complications. The trial suggests that treatment with edoxaban can be valuable in managing AF patients after TAVR, especially when a lower dose of edoxaban is used.
Researchers discovered that a brain area traditionally thought to specialize in old habits also plays a role in learning new actions. The study found that the dorsolateral striatum is involved in consolidating action learning immediately after the new action has been learned.
Researchers identified physical binding sites for cholesterol in GIRK channels, which play a role in neurodegenerative diseases. The study provides structural insights into how cholesterol alters channel function, paving the way for drug development.
A Mount Sinai study found significant inequalities among low-risk births, with Black and Hispanic infants experiencing higher rates of unexpected complications. Hospital quality was identified as a key contributor to these disparities, with lower-quality hospitals serving more Black and Hispanic women.
Researchers identified a large list of candidate genes associated with alcohol consumption and AUD, including SPI1 and MAPT. These genes are linked to other psychiatric and neurodegenerative disorders, such as depression and Alzheimer's disease.
A rare rheumatoid-like autoinflammatory condition is found to be treatable with FDA-approved TNF inhibitors due to the absence of a protein that activates antiviral defenses. Researchers confirm its underlying biology and mechanisms of autoinflammation, leading to quick and substantial clinical improvement.
Researchers identified genes and cell types involved in rare inflammatory disease MIS-C in children following COVID-19 infection. The study found that specific immune cells are downregulated and associated with a sustained inflammatory response.
Researchers found that a mobile interventional stroke team treated patients faster and with better outcomes than standard care. Patients treated by the MIST team were more likely to be functionally independent at 90 days post-stroke.
Researchers linked World Trade Center dust exposure to increased risk of liver disease in responders. Analysis of lung scans found evidence of hepatic steatosis, a condition associated with chemical exposures.
Researchers recreated damage seen in a widely studied form of frontotemporal dementia by growing special types of cerebral organoids. The study found that the mutated tau protein triggers the death of specific class of neurons, which can be prevented with an experimental drug.
A novel therapeutic agent, MS21, has been developed to disrupt a biological pathway that helps cancer survive. The therapy shows high effectiveness in vitro by causing the degradation of AKT, an enzyme overly active in many cancers.
Researchers discovered that CaMKII is a key regulator of the survival of retinal ganglion cells, which process visual information. Gene therapy reactivating CaMKII provided robust protection against vision loss in multiple disease and injury models.
A Mount Sinai study reveals the complex mechanisms of Ebola virus evasion, highlighting the critical role of VP24 protein in disrupting the nuclear envelope. This disruption compromises cell function, DNA leakage, and antiviral immunity, ultimately contributing to disease severity.
A study published in Cancer Cell found that multiple myeloma patients exhibited a widely variable response to COVID-19 vaccines, with some showing undetectable antibodies after mRNA vaccines. This variation underscores the importance of routine blood tests and continued precautions for these patients.
A Mount Sinai study reveals rotator cuff injuries are the most common type, accounting for nearly half of all shoulder injuries. The research also identifies other risk factors, including pitching and throwing, and highlights the need for improved injury prevention strategies.
A new class of drugs inhibiting the SOX 11 oncogene has been discovered by researchers at Mount Sinai, showing promising results in treating mantle cell lymphoma. The discovery could lead to new therapies for a disease resistant to existing treatments.
Researchers created a neighborhood-level COVID-19 inequity index to analyze disparities in New York City neighborhoods. The index showed that areas with higher inequity indices had higher subway ridership, implying lower social distancing capacity.
Researchers at Mount Sinai Hospital discovered that early-stage lung cancer tumors hijack immune cells called tissue-resident macrophages to facilitate their invasion of lung tissue. This process allows the tumor to evade the immune system and grow into more deadly stages of cancer.
A large-scale study found that high caffeine intake may increase the risk of glaucoma by three-fold in individuals with a strong family history. Caffeine consumption above 480mg daily was associated with higher intraocular pressure and increased glaucoma prevalence.
A phase 3 clinical trial shows that immunotherapy nivolumab after surgery can nearly double the time before relapse for patients with high-risk urothelial cancer. The treatment significantly reduces metastatic recurrence risk, offering hope for thousands of patients worldwide.
A new study suggests that an emotional regulation technique called cognitive reappraisal can help disrupt compulsive cocaine addiction. The technique, which involves reinterpreting the meaning of drug-related cues, was found to reduce attention-bias in individuals with cocaine use disorder.
Researchers developed a machine learning model to predict patients requiring dialysis or critical illness leading to death in COVID-19 hospitalizations. The XGBoost without imputation method outperformed other models with higher precision and recall, using data from electronic health records.
Researchers found that excess pericardial fat increases the risk of heart failure, even after adjusting for established risk factors. High pericardial fat volume was associated with a double increase in risk for women and a 50% increase for men, according to the study published in the Journal of the American College of Cardiology.
Researchers at Mount Sinai found that SARS-CoV-2 can infect surface cells of the eye, revealing presence of infection-associated proteins and suppressed IFNβ. Ocular surface cells are susceptible to infection, while central cornea is less vulnerable.
A study published in Nature Genetics found 64 genome regions associated with an increased risk of bipolar disorder, providing new insights into the condition's underlying biology. The research also highlights potential therapeutic targets for future treatments.
Evinacumab reduces triglyceride levels by up to 82 percent in patients with severe hypertriglyceridemia and a history of hospitalizations for acute pancreatitis. The therapy also lowers the risk of recurrent acute pancreatitis, quality of life, and cardiovascular events.
A global commission led by Mount Sinai cardiologist Roxana Mehran recommends expanding education and health programs, research on women's heart disease, and prioritizing sex-specific interventions. The report aims to improve women's heart health outcomes worldwide by 2030.
A new study found that artificial food colorants like Red 40 and Yellow 6 can cause disease in mice with dysregulated immune systems, specifically colitis. Researchers are now investigating the potential impact on humans, given that similar cytokine IL-23 dysregulation is a factor in human inflammatory bowel disease.
Researchers used OCT angiography to image patients with sickle cell retinopathy and found that sequential imaging can help assess disease progression and treatment effectiveness. The study showed that untreated patients had more flickering blood vessels, indicating a higher risk of permanent blockage.
Scientists found that LCH is caused by senescent cells with a BRAF mutation, leading to inflammation and organ damage. A new study suggests using senolytics to treat the disease, offering hope for patients who have not responded to chemotherapy.
Researchers found that combining remdesivir with four HCV drugs boosts its antiviral activity by up to 10 times. This combination therapy could be a game changer for patients with COVID-19 who are not vaccinated or have waned immunity.
A new Mount Sinai study found that patients hospitalized with COVID-19 have a small but significant risk of developing heart failure, even without a previous history of heart disease or cardiovascular risk factors. The study's findings may prompt clinicians to monitor for signs of congestive heart failure more closely in these patients.
A Mount Sinai study of over 40,000 patients reveals that tranexamic acid use in high-risk patients does not increase complications such as deep vein blood clots or strokes. The study confirms prior findings and provides new insights into the safety of the drug when used in high-risk patients undergoing hip and knee replacement surgeries.
A longitudinal study of over 3,000 young Marines found that past COVID-19 infection does not completely protect against reinfection. Young people with previous infection can still catch the virus and transmit it to others.
Genetic ancestry data provides specific insights into disease risk and management, allowing for targeted interventions. The study found that 25% of BioMe participants had links to populations predisposed to certain genetic diseases.
A study of over 42,000 children found that mothers who took antidepressants during pregnancy were more likely to have children with affective disorders, but not due to the medication itself. The research suggests that parental mental illness may be the underlying cause.
A personalized cancer vaccine developed using a computational platform raised no safety concerns and showed potential benefit in patients with high-risk cancer recurrences. The vaccine was well-tolerated, with minor injection-site reactions, and demonstrated early potential benefits after administration.
A study published in Clinical Cancer Research found that specific gene signatures and immune cells can predict response to immunotherapy in bladder cancer patients. The researchers identified potential biomarkers for treatment resistance and new combination therapeutic approaches to overcome such resistance.
Researchers developed a new method to detect multiple types of DNA methylation in individual bacteria and the gut microbiome using nanopore sequencing. This breakthrough enables reliable methylation discovery and high-resolution microbiome analysis.
Researchers at Mount Sinai Hospital have identified genetic and cellular mechanisms underlying Crohn's disease, providing new insights for tailored treatments. By blocking the gp130 protein, they found that some patients may benefit from alternative therapies, complementing standard anti-TNF treatments.
Researchers found that autophagy selectively degrades PKA inhibitory subunit RIa, promoting mitochondrial metabolism and tumor cell growth. Suppression of AKAP11 levels in tumor cells prevents degradation and blocks PKA activation, inhibiting tumor cell growth.
Researchers discovered that the widely available Topotecan (TPT) inhibits inflammatory genes in the lungs of mice as late as four days after infection, improving infection outcomes. The drug, an FDA-approved Topoisomerase I inhibitor, could be a valuable global strategy for treating severe COVID-19 cases.
A Mount Sinai study found immunotherapy to be significantly less effective in liver cancer patients with non-alcoholic steatohepatitis (NASH), while also fueling tumor growth. The research highlights the need for refined therapeutic strategies to treat both tumors and underlying liver disease.
A study at The Mount Sinai Hospital found that a specific epigenetic modification, H3K79me2, mediates the lasting effects of early-life stress on adult stress vulnerability. A small-molecule inhibitor of this enzyme reversed increased susceptibility to lifelong stress in animal models.
Researchers at Mount Sinai found that a single shot of COVID-19 vaccine can provide immunity to individuals who have previously been infected by the virus. This could help stretch limited vaccine supplies and spare individuals from unnecessary side effects of a second dose.
Researchers at Mount Sinai Hospital have identified a new molecular driver of frontal circuit maturation that is essential for cognitive function. By selectively suppressing communication via nicotinic receptors in the frontal circuit, attention deficits caused by Fragile X syndrome can be prevented in animal models.
A study published in Environment International found that overweight children exposed to lead in utero and during their first weeks of life are at risk for poorer kidney function in adulthood. The research measured blood levels of lead during pregnancy and eGFR levels in children between 8-12 years old.
Researchers have identified ezogabine, a drug that opens potassium channels in the brain, as a promising new approach to treating depression. The study showed significant improvements in depressive symptoms and anhedonia in patients with depression.