A new study by researchers at Mount Sinai found that a specific gene, HHIP, helps regulate the development of the coronal suture, a fibrous joint that connects the front and middle bone plates. The study showed that embryos with a missing HHIP gene had misshapen skulls and fewer mesenchymal cells separating the bones.
Hospitalized COVID-19 patients with chronic exposure to higher particulate matter had increased risks for ICU admission and death. Chronic air pollution exposure was associated with an 11% higher risk of mortality and a 13% higher risk of ICU admission.
A large-scale genome-wide association study has identified a region on chromosome 7 containing DNA variations that increase the risk of attempting suicide. The study found overlap between the genetic basis of suicide attempts and related psychiatric disorders, as well as non-psychiatric risk factors such as smoking and sleep disturbances.
A new study led by scientists at Mount Sinai highlights the role of rare genomic differences in obsessive-compulsive disorder (OCD) risk. The research found that about 10% of the risk for OCD is attributed to rare genomic variations, which were not seen in previous studies.
Researchers developed a novel model to identify specific genes and genetic alterations in multiple myeloma, stratifying the cancer's severity via DNA and RNA sequencing. This model revealed diverse subtypes and high-risk patients beyond current classifications.
A Mount Sinai study reveals that young adult cancer patients exhibit distinct genetic hallmarks and immune system responses compared to their older counterparts. These findings suggest personalized treatment approaches for young adults with various types of cancers.
A new risk score developed by Mount Sinai researchers can help predict possible contrast-associated acute kidney injury among patients undergoing PCI. The 'Mehran-2 CA-AKI Risk Score' enhances management of high-risk patients before, during, and after the procedure.
Research conducted by Mount Sinai Hospital reveals that cannabis exposure in utero can lead to higher levels of anxiety, aggression, and hyperactivity in children. Placental gene expression also shows lower immune-activating genes, predicting these outcomes.
A new trial shows that the novel surgical device venous external support (VEST) may improve outcomes of coronary bypass grafting using leg veins by preventing intimal hyperplasia, a key factor in vein graft failure.
Researchers at Mount Sinai have developed a diverse library of well-characterized human induced pluripotent stem cell lines from clinically healthy individuals, offering valuable resources for studying normal human biology, evaluating drug responses, and disease modeling.
Mount Sinai joins a nationwide network of medical centers specializing in rare disorders to foster knowledge-sharing, connect patients with specialists, and improve treatment and research. The designation aims to establish a standard of care for rare diseases.
A new study found that QFR-guided PCI resulted in lower one-year rates of heart attack and a lesser chance of needing additional PCI, with a 35% reduction in mortality. The technology helped eliminate unnecessary stents and identified more obstructive lesions.
Research reveals brief DBS exposure triggers significant brain state changes and sustained antidepressant response. A decrease in beta power is identified as a novel biomarker for DBS treatment optimization.
Researchers at Mount Sinai found that people used forward thinking when trying to influence others, regardless of controllability. This neural activity was linked to the ventromedial prefrontal cortex, a decision-making center involved in strategic thinking.
A new study found that Long COVID can cause symptoms such as fatigue, brain fog, and cognitive impairment lasting over a year. The study also showed that more than 60% of patients experienced some level of cognitive impairment, with significant impacts on employment and quality of life.
The Icahn School of Medicine at Mount Sinai has received a five-year, $16 million grant from the National Institutes of Health (NIH) to foster inclusive excellence in the biomedical sciences. The grant aims to recruit and hire faculty members from underrepresented groups across four research areas.
A new AI-based computer algorithm created by Mount Sinai researchers can identify subtle changes in electrocardiograms to predict heart failure. The algorithm was 94% accurate at predicting healthy ejection fractions and 87% accurate at detecting weakened hearts, offering a promising alternative to traditional diagnosis methods.
Patients with multiple myeloma often mount a poor antibody response to COVID-19 vaccines and have a weak T cell response, underscoring the need for booster vaccination and safety precautions. Researchers found that these patients are at high risk of severe COVID-19 infection.
Researchers have discovered a new drug target for myelodysplastic syndrome (MDS) and other hematologic malignancies, which are sensitive to MEK inhibitors. The study found that mutations affecting RNA splicing alter cells to develop MDS and solid tumors, providing a potential new approach to treating this rare blood cancer.
Researchers developed a novel machine learning algorithm to identify previously unknown air pollutant mixtures linked to poor asthma outcomes in children. The study found that early exposure to individual and mixed pollutants can lead to longer-term problems with asthma, affecting about seven percent of US children.
The Charles Lazarus Children’s Abilities Center at Mount Sinai offers cutting-edge treatments for children with disabilities, including physical, occupational, and speech therapy. The center features state-of-the-art equipment and a multidisciplinary team of experts providing comprehensive care to children from birth to age 21.
Researchers at Mount Sinai have developed a novel therapy called MS67 that effectively fights acute myeloid leukemia with mixed lineage leukemia rearrangement. The therapy degrades the WDR5 protein, which drives the proliferation of this type of leukemia and other cancers such as pancreatic cancer.
Researchers found that shrinking waveforms on electrocardiograms can help identify high-risk patients with COVID-19 or influenza, allowing for more aggressive monitoring and treatment. The study also showed that this technique may be particularly useful in overwhelmed systems where timely intervention is crucial.
Researchers at Mount Sinai Hospital are testing a novel light therapy to slow Alzheimer's debilitating effects, aiming to improve both cognition and sleep. The treatment involves flashing pulses of light designed to enhance electrical brain waves and reset the sleep-wake cycle.
A study published in the Journal of Medical Internet Research found that healthcare workers with high emotional support or resilience were protected against stress related to COVID-19. The study used wearable devices to measure heart rate variability and found a unique nervous system profile in these individuals.
A Mount Sinai study found that polygenic risk scores were no better at predicting worsening symptoms than written reports in schizophrenia patients. The results raise questions about the use of polygenic risk scores in real-world situations, suggesting a doctor's report may be an untapped source of predictive information.
A new algorithm, Phe2vec, accurately identified patients with certain diseases, outperforming traditional methods in classifying diagnoses. The study suggests that this automation will facilitate further research in clinical informatics.
A recent study by Mount Sinai researchers discovered that certain neurons in the brain's decision-making centers monitor body-state dynamics and hijack the decision-making process during intense states of arousal. This suggests that changes in heart rate and other bodily responses can impact the brain's ability to make rational decisions.
A large-scale international study found that edoxaban is non-inferior to warfarin for efficacy in preventing adverse events, but led to higher bleeding complications. The trial suggests that treatment with edoxaban can be valuable in managing AF patients after TAVR, especially when a lower dose of edoxaban is used.
Researchers discovered that a brain area traditionally thought to specialize in old habits also plays a role in learning new actions. The study found that the dorsolateral striatum is involved in consolidating action learning immediately after the new action has been learned.
Researchers identified physical binding sites for cholesterol in GIRK channels, which play a role in neurodegenerative diseases. The study provides structural insights into how cholesterol alters channel function, paving the way for drug development.
A Mount Sinai study found significant inequalities among low-risk births, with Black and Hispanic infants experiencing higher rates of unexpected complications. Hospital quality was identified as a key contributor to these disparities, with lower-quality hospitals serving more Black and Hispanic women.
Researchers identified a large list of candidate genes associated with alcohol consumption and AUD, including SPI1 and MAPT. These genes are linked to other psychiatric and neurodegenerative disorders, such as depression and Alzheimer's disease.
A rare rheumatoid-like autoinflammatory condition is found to be treatable with FDA-approved TNF inhibitors due to the absence of a protein that activates antiviral defenses. Researchers confirm its underlying biology and mechanisms of autoinflammation, leading to quick and substantial clinical improvement.
Researchers identified genes and cell types involved in rare inflammatory disease MIS-C in children following COVID-19 infection. The study found that specific immune cells are downregulated and associated with a sustained inflammatory response.
Researchers found that a mobile interventional stroke team treated patients faster and with better outcomes than standard care. Patients treated by the MIST team were more likely to be functionally independent at 90 days post-stroke.
Researchers linked World Trade Center dust exposure to increased risk of liver disease in responders. Analysis of lung scans found evidence of hepatic steatosis, a condition associated with chemical exposures.
Researchers recreated damage seen in a widely studied form of frontotemporal dementia by growing special types of cerebral organoids. The study found that the mutated tau protein triggers the death of specific class of neurons, which can be prevented with an experimental drug.
A novel therapeutic agent, MS21, has been developed to disrupt a biological pathway that helps cancer survive. The therapy shows high effectiveness in vitro by causing the degradation of AKT, an enzyme overly active in many cancers.
Researchers discovered that CaMKII is a key regulator of the survival of retinal ganglion cells, which process visual information. Gene therapy reactivating CaMKII provided robust protection against vision loss in multiple disease and injury models.
A Mount Sinai study reveals the complex mechanisms of Ebola virus evasion, highlighting the critical role of VP24 protein in disrupting the nuclear envelope. This disruption compromises cell function, DNA leakage, and antiviral immunity, ultimately contributing to disease severity.
A study published in Cancer Cell found that multiple myeloma patients exhibited a widely variable response to COVID-19 vaccines, with some showing undetectable antibodies after mRNA vaccines. This variation underscores the importance of routine blood tests and continued precautions for these patients.
A Mount Sinai study reveals rotator cuff injuries are the most common type, accounting for nearly half of all shoulder injuries. The research also identifies other risk factors, including pitching and throwing, and highlights the need for improved injury prevention strategies.
A new class of drugs inhibiting the SOX 11 oncogene has been discovered by researchers at Mount Sinai, showing promising results in treating mantle cell lymphoma. The discovery could lead to new therapies for a disease resistant to existing treatments.
Researchers created a neighborhood-level COVID-19 inequity index to analyze disparities in New York City neighborhoods. The index showed that areas with higher inequity indices had higher subway ridership, implying lower social distancing capacity.
Researchers at Mount Sinai Hospital discovered that early-stage lung cancer tumors hijack immune cells called tissue-resident macrophages to facilitate their invasion of lung tissue. This process allows the tumor to evade the immune system and grow into more deadly stages of cancer.
A large-scale study found that high caffeine intake may increase the risk of glaucoma by three-fold in individuals with a strong family history. Caffeine consumption above 480mg daily was associated with higher intraocular pressure and increased glaucoma prevalence.
A phase 3 clinical trial shows that immunotherapy nivolumab after surgery can nearly double the time before relapse for patients with high-risk urothelial cancer. The treatment significantly reduces metastatic recurrence risk, offering hope for thousands of patients worldwide.
A new study suggests that an emotional regulation technique called cognitive reappraisal can help disrupt compulsive cocaine addiction. The technique, which involves reinterpreting the meaning of drug-related cues, was found to reduce attention-bias in individuals with cocaine use disorder.
Researchers developed a machine learning model to predict patients requiring dialysis or critical illness leading to death in COVID-19 hospitalizations. The XGBoost without imputation method outperformed other models with higher precision and recall, using data from electronic health records.