Researchers have developed a new microscopy technique, light beads microscopy, that captures detailed images of activity from one million neurons across the mouse brain at high speed and single-cell resolution. This innovation allows scientists to investigate biological questions in a way that was not possible before.
Researchers found that high levels of MYO10 induce chronic inflammation, reducing T cell function, but also increasing immune response. This led to improved outcomes with immune checkpoint blockade therapy for certain tumors.
Researchers developed a new, accurate method to detect North Atlantic Right Whale up-calls using Multimodal Deep Learning algorithms. The technology outperformed conventional methods in detecting up-calls, non-up-calls, and false alarms.
Researchers found that BAK/MCL1 complexes can predict the sensitivity of paclitaxel and MCL1 inhibitors in ovarian cancer. The study suggests that this complex can be used to improve treatment outcomes for patients with ovarian cancer.
A study by the University of Waterloo suggests that reducing brand imagery and increasing health warnings on cannabis packaging can decrease its appeal to children. The researchers found that products with white backgrounds and limited branding were rated as less harmful and more memorable for warning messages.
Researchers identified a crucial epigenetic regulator, PRC1, that contributes to uveal melanoma progression. By inhibiting PRC1, they transformed indolent cells into the more metastatic subtype, highlighting new treatment strategies and challenging current clinical testing methods.
A study found that adding melatonin to vancomycin treatment significantly reduces acute kidney injury in hospitalized patients, alleviating oxidative stress and restoring kidney function. The findings could lead to larger therapeutic breakthroughs and pave the way for further clinical studies.
Researchers found that modest weight loss was achieved through financial incentives and environmental changes, but participants felt more guidance would have helped. The study suggests that ongoing support and personalized coaching could lead to better weight loss outcomes.
Researchers investigated aerosol production from singing and playing wind instruments to develop recommendations for minimizing COVID transmission. They found that placing a surgical mask reduced plume velocities and lengths, decreasing aerosol concentrations.
A new study by researchers at the University of Waterloo found that stricter non-pharmaceutical interventions, such as policy restrictions on business operations and indoor mask mandates, are associated with reduced COVID-19 cases in Ontario. The study also suggests that increases in workplace attendance correlate with higher case counts.
A new intranasal subunit vaccine has been developed to provide durable local immunity against inhaled pathogens, addressing a significant limitation of existing vaccines. The vaccine elicits comprehensive immunity against SARS-CoV-2 within seven days and is stable for over 11 months, making it suitable for global distribution.
Researchers at EMPA created a flame retardant cotton textile that retains the natural properties of cotton fibers while providing fireproof and antimicrobial functionalities. The fabric does not contain carcinogenic formaldehyde and can absorb water, maintaining a favorable microclimate on the skin.
Researchers developed a high-precision THz time-domain ellipsometry system to characterize wide-gap semiconductors. The system can measure carrier densities up to 10^20 cm^-3 with superior accuracy and precision, resolving a long-standing challenge in the field.
Archaeologists have developed a new statistical approach to overcome the challenges of radiocarbon dating, allowing for more accurate population estimates. The new method uses Bayesian reasoning and flexible probability models to combine radiocarbon dates with additional archaeological information.
A new study using big data to examine LBD in Singapore's transport gig economy aims to reveal what enables LBD and how it can be promoted. The researchers propose a novel framework to measure individual drivers' productivity and skills, including their ability to anticipate demands and competition.
Scientists discovered two distinct sardine populations in South Africa, one adapted to cool-temperate waters and the other to warmer subtropical conditions. The study suggests the Sardine Run may be a relic of spawning behavior dating back to the glacial period.
A comprehensive study found that marching band students are at risk of heat-related illnesses due to their physical demands and lack of protective measures. The study analyzed news reports of heat illnesses among band members from 1990 to 2020, revealing nearly 400 cases, including hospitalizations and heat stroke.
A new study reveals that the Early Bronze Age Yamnaya pastoralists adopted milk drinking, leading to vast steppe expansions across Europe and Asia. Analysis of ancient tartar samples identified a strong correlation between dairy consumption and expansion, with 94% of individuals showing evidence of milk drinking
Researchers developed a 25-gene signature predicting breast cancer sensitivity to chemotherapy, showing high accuracy and generalizability across subtypes. The gene signature can help choose optimal treatment strategies and avoid overtreatment.
University of Rochester psychologists train adolescents and young adults to reinterpret their stress response as adaptive, leading to reduced anxiety, improved test scores, and healthier coping mechanisms. The study finds that 'good stress' mindset resets help students perform better under pressure and stay enrolled in classes.
A new AI-powered training program aims to improve the skills of safety-critical professionals by generating scenarios based on past occurrences. The program uses reinforcement learning to increase learning and generate explanations for its decisions.
Researchers found a link between HPV genotype 16/18 infection in the first and third trimesters and an increased risk of preterm birth. The study highlights the importance of prenatal screening for HPV to inform pregnancy management.
A new saliva test for congenital cytomegalovirus (cCMV) has been shown to be feasible and well-received by parents, with high uptake and accuracy rates. The test could lead to early diagnosis and treatment of cCMV-related hearing loss and neurodevelopmental disorders.
Using surrogate endpoints to measure new drug efficacy can reduce trial costs and complexity but also makes decisions more challenging for patients and clinicians. Experts call for more selective use of surrogate endpoints in chronic diseases with patient-relevant outcomes.
The university will support research on normal and abnormal brain development, including rare diseases that cause intellectual disabilities. Researchers aim to improve care and treatment for children with IDDs.
A new study found that job seekers' self-perceived risk of catching COVID-19 affects their mental health and job search behaviors. Those who feel less invulnerable to the virus face greater challenges in securing employment, highlighting the need for accommodations and transparency from employers.
Astronomers have mapped out the chemicals inside planetary nurseries with unprecedented detail, revealing dozens of molecules within five protoplanetary disks. The locations of these molecules vary dramatically across each disk, resulting in diverse chemical environments that may impact planetary formation and potential for life.
A new five-year study found that some shark species, like sandbar and tiger sharks, have low mortality rates after being caught and released, while others, like blacktip and spinner sharks, face higher mortality rates. The study's findings are crucial for sustainably managing shark populations.
The study examines changes in pregnancy intentions among women following the COVID-19 outbreak. Women's reproductive healthcare and family planning were significantly impacted by the pandemic, with many experiencing increased stress, anxiety, and decreased access to reproductive health services.
Researchers developed a method to forecast blue whale locations up to three weeks in advance, enabling proactive conservation and management. The tool helps minimize the burden on ocean users while protecting whales.
A large multicenter study of US children with COVID-19 found that older age and chronic conditions like obesity and diabetes are associated with more severe disease. The study aims to inform mitigation strategies for high-risk children and support vaccination efforts.
Research reveals how genetic mutations in aminoacyl-tRNA synthetases cause CMT by halting protein production and inducing integrated stress response. The study's findings provide new avenues for therapies against the disease.
Scientists at KU Leuven developed a method to multiply coconut trees faster and store them more efficiently, preserving genetic diversity and meeting the demand for coconuts. The technique allows thousands of new specimens with the same genetic profile to be obtained, offering potential for coconut plantations worldwide.
Researchers at Mainz University have conducted a literature review on cathodic corrosion in electrosynthesis, highlighting the need for new materials and methods to prevent electrode dissolution. The team aims to develop a method to generate plastic precursors from agricultural waste using electrosynthesis.
A study found that parents prioritize atmosphere and teacher approach over academic standards when selecting a special school for their child. High-quality inclusive education provision means a sense of belonging, social acceptance, and individualized curriculum. Only a minority reported experiencing 'hard choice' due to limited options.
Scientists from Hungary, Russia, and Finland created SpheroidPicker, an AI device that selects cancer cells of specific shape and size. The system enables a more standardized approach to working with tumour samples, producing a more realistic response to treatments.
HKU astrophysicists identify historical supernova of AD 1181 with recent discovery of 'Parker's star' and its surrounding nebula Pa30. The team found the event matches ancient Chinese reports within 3.5 degrees, providing a firm historical basis for the rare Type Iax designation.
A new algorithmic approach predicts strong leaders by analyzing shared traits and attributes associated with effective leadership. The study identifies liberators and explorers as the most effective leaders, while media celebrities are seen as lacking in leadership qualities.
A study published in SLEEP reveals an association between early lower respiratory tract infections and the development of obstructive sleep apnea in children. Children who had a history of severe RSV bronchiolitis during early infancy were found to have a higher risk of developing OSA.
Despite consent complications, vulnerable individuals and their guardians often participate in research projects. A new study explores attitudes towards research participation among legally supervised individuals with and without prior experience.
A study has identified key risk factors for SARS-CoV-2 infection among farmworkers in California. These include proximity to infected individuals, lack of personal protective equipment (PPE), and seasonal flu-like symptoms.
Dr. Neil Hayes, MD, and Katherine A. Hoadley, PhD, will extend the Cancer Genome Atlas (TCGA) research for five years using a $1.8 million National Cancer Institute grant. The project analyzes cancer genetics and therapeutics to better understand patient responses to treatments.
Researchers have solved the 900-year-old mystery of the Chinese supernova of 1181AD by identifying a matching nebula and star in the Milky Way. The Pa30 nebula, surrounding Parker's Star, matches the profile, location, and age of the historic supernova.
Researchers found significant reservoirs of large organic molecules in protoplanetary disks, providing a potential pathway for life to form elsewhere. The presence of these molecules suggests basic chemical conditions that led to life on Earth could exist more widely across the Galaxy.
Researchers from Osaka University have developed a laser-driven neutron source that can generate fast neutrons in short bursts, enabling rapid imaging. The technique was used to detect hazardous substances in batteries and images materials like boron carbide.
A team led by Indiana University Professor Travis O'Brien is embarking on a monumental project to better predict water availability in the Western US. The SAIL campaign will collect vast amounts of data to improve modeling and prediction of rainfall, snowfall, and runoff.
Researchers at the University of Alabama at Birmingham found that SARS-CoV-2 viruses grown in successive generations exhibit increased infectivity, binding to heparan sulfate, and reduced virulence. The study suggests that evolved strains may be used as a basis for development of stable live attenuated vaccines.
Married couples in supportive relationships showed a significant decrease in stress levels when watching horror movie clips with their partner compared to alone. The study found that spousal emotional support and relationship quality have a buffering effect on pupillary response to horror movies.
A campaign is being launched to encourage COVID-19 vaccination among people with intellectual and developmental disabilities (IDD) in New York State. The Einstein-Montefiore team has received grants from the state and federal governments to create tailored messages and content to counter vaccine misinformation and promote vaccination.
Some women report changes in their periods after COVID-19 vaccination, with over 30,000 reports made to the UK's MHRA surveillance scheme. While most changes are short-lived, research into this possible adverse reaction is critical for the success of the vaccination programme.
A study found that Filipino, Vietnamese, and Thai students are less likely to major in STEM fields and have lower math scores than other Asian American students. The research highlights the need for policymakers to understand the specific needs of underrepresented Asian American ethnic subgroups.
The new EQUIPS workflow provides a more accurate and reliable way to process 3D images for computer simulations. It uses machine learning to automate the drawing process and produces a range of simulation outcomes, allowing decision-makers to consider best- and worst-case scenarios.
Researchers found that subjects' heart rates synchronized even when listening to a story alone, as long as they were paying attention. This synchronization was predictive of conscious processing of the narrative, and had implications for understanding mindfulness and the brain-body connection.
Kazan Federal University researchers designed a unique dielectric cell to study gas hydrate formation and decomposition under pressure. The device's effectiveness was demonstrated, allowing for further investigation of hydrate inhibitors.
A new study suggests that prebiotics can help realign sleep-wake cycles and core body temperature after chronic disruption of rhythms, hosting health-promoting microbes and a different metabolome. Researchers hope to develop customized prebiotic mixtures for individuals with frequent circadian disruptions.
Researchers found that state-driven emissions controls are only slightly more expensive than federally mandated ones, with nationwide costs being one-tenth higher. This approach relies on technologies like low-carbon electricity and advanced biofuels, which can be traded between states to even out costs.
Researchers Lucas Parra and Jens Madsen found that listening to recorded narratives synchronizes heart rates among individuals, suggesting a link between cognitive processing and physiological responses. The study's findings have implications for understanding disorders of consciousness and determining prognosis.
Patients treated with immune checkpoint inhibitors show better quality of life and reduced symptoms compared to those without immunotherapy. The study analyzed self-reported outcomes of 26 published studies and found that patients' global quality of life was stable or improved, but breathing difficulties increased
The grant will support the work of the Irving Institute for Clinical and Translational Research in accelerating the application of scientific discoveries. The funding has enabled the establishment of over 70 services and programs to help Columbia researchers translate medical discoveries into treatments.
Researchers at Baylor College of Medicine discovered changes in brain activity triggered by LSD, explaining altered behaviors such as reduced running speed and increased resting time. The study suggests that LSD disrupts the normal communication between brain regions, leading to a 'fuzzy' map of the environment.