Researchers are investigating the role of MYRF in HLHS, a severe congenital heart defect requiring multiple surgeries. The study aims to better understand how MYRF regulates heart development, with potential implications for improved care and long-term outcomes.
Abhishek Mishra receives a prestigious $160,000 postdoctoral fellowship from the American Heart Association to explore the molecular mechanisms of heart failure with preserved ejection fraction. The funding will support Dr. Mishra's research on PTP1B inhibition as a potential therapeutic strategy for cardiometabolic diseases.
Jason McCarthy, a renowned biomedical researcher, has been promoted to professor at the Masonic Medical Research Institute. He has made significant contributions to medical research since joining the organization in 2018.
The Masonic Medical Research Institute (MMRI) Summer Fellowship is a 10-week program offering undergraduate and graduate students immersive scientific research experience. Students will gain valuable skills, network with peers and experts, and receive guidance on medical school applications.
Zhiqiang Lin, Ph.D., receives a $300,000 AHA grant to investigate VGLL4's role in protecting the liver from fatty liver disease. The study aims to slow MASH progression to liver failure, potentially improving quality of life for millions suffering from the illness.
A researcher at MMRI is working on a project to monitor the health of vascularized composite allografts in wounded veterans. He aims to enable more widespread adoption of VCA transplantation by developing technologies to detect rejection early, allowing for modification of immunosuppressive therapies.
A groundbreaking study published in Science Signaling has identified protein tyrosine phosphatase PTP1B as a key driver of maladaptive cardiac metabolism and dysfunction under dietary stress. Mice lacking PTP1B in cardiomyocytes were resistant to harmful changes, highlighting the enzyme's role in heart disease progression.
The Masonic Medical Research Institute (MMRI) has selected 13 undergraduate students for its highly competitive Summer Fellowship program. The students will engage in hands-on research using state-of-the-art techniques and participate in professional development workshops.
A recent study published by Dr. Matthew Nystoriak of Masonic Medical Research Institute has uncovered groundbreaking insights into heart health. Elevated levels of β-hydroxybutyrate, a ketone body produced by the liver, have been shown to improve cardiac blood flow and reduce ischemic heart disease.
A $3.7 million NIH grant supports a study to improve PE diagnosis and treatment by using advanced imaging techniques, which may measure the effectiveness of clot-dissolving therapies. The goal is to help clinicians better diagnose and treat patients with PE, a devastating cardiovascular ailment.
Researchers at MMRI have developed a novel approach to minimize cardiac damage after a heart attack by targeting the spleen with histone deacetylase inhibitors. This targeting strategy results in a significant decrease in cardiac scar size and preservation of heart function, even after just one dose.
A recent NIH grant will support research into the genetic factors contributing to cardiac arrhythmia, a condition affecting millions of Americans. The study aims to identify specific genes linked to arrhythmia risk and develop novel therapeutic approaches.
A study led by the Masonic Medical Research Institute found that VGLL4 is required for embryo development but dispensable for myocardial growth, providing new insights into congenital heart defects and heart failure. This discovery has significant implications for treating heart malformations.
Researchers found that the SARS-CoV-2 spike protein activates a natural immune response in heart muscle cells, leading to damage. This unique interaction with Toll-Like Receptor 4 is specific to COVID-19 and explains its high virulence levels compared to other coronaviruses.
A team of scientists has developed a single-cell map of the human heart, identifying molecular alterations in failing hearts at unprecedented resolution. This breakthrough uses Cripsr technology to profile human tissue samples, revealing novel therapeutic targets for heart failure and other cardiovascular diseases.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
A recent study published at Masonic Medical Research Institute found that electrocution-induced physiological stress can lead to overlapping cardiac conditions in individuals. The research used human induced pluripotent stem cells to investigate the mechanisms behind these conditions, shedding light on potential new treatments.
Researchers at Masonic Medical Research Institute are using human induced pluripotent stem cells (hiPSCs) to create scientific models for studying cardiac arrhythmias and testing therapeutics. The integration of mathematical modeling tools enables the prediction of drug efficacy with minimal adverse effects.
The American Heart Association has awarded a diversity grant supplement to the Masonic Medical Research Institute to investigate the connection between autism and heart disease. The grant will support Dr. Luana Nunes Santos' research on PTPN11 gene mutations and their effects on heart health.
Researchers developed a fluorescent probe that binds to activated platelets, enabling clinicians to proactively treat patients before clotting or scarring occurs. The tool uses intravascular catheter-based imaging and has the potential to optimize patient outcomes.
The Masonic Medical Research Institute has received a $750,000 Department of Defense Lupus Impact Award to investigate the role of protein tyrosine phosphatase SHP2 in systemic lupus erythematosus. The research aims to improve treatment options and quality of life for patients with this devastating autoimmune disease.
The Masonic Medical Research Institute has developed a novel technique for isolating brown fat cells, which can help study the relationship between brown fat cells and other cell types. This breakthrough could lead to better understanding of diseases and generate innovative cures and treatments.
Brown fat, a biological fuel that increases metabolic rate and decreases fat storage, continues to grow and divide after birth, according to Masonic Medical Research Institute researchers. This finding has major implications, as scientists can try to increase brown fat cells to prevent or reduce obesity.
A collaborative study by Masonic Medical Research Institute and leading institutions reveals a comprehensive map of the human heart's cellular diversity. The findings provide valuable knowledge gaps about heart composition and function, shedding light on genetic risk factors for cardiac health.
Researchers used single-nucleus sequencing to investigate COVID-19's effects on the heart, discovering that the SARS-CoV-2 receptor is upregulated in patients with pre-existing cardiac conditions only in cardiomyocytes. The study also found no significant impact of hypertension medications on ACE2 levels.