Over 75% of hospitalized AKI patients lack proper follow-up kidney health testing after discharge. Less than 25% have kidney function monitored with blood and urine tests within 90 days of discharge.
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
A recent study found that higher plant protein intake is associated with lower risk of chronic kidney disease. The UK Biobank study data revealed that participants consuming more plant-based protein had a reduced risk of developing CKD.
The 2017 American Academy of Pediatrics guideline shows higher levels of proteinuria in children with hypertensive range blood pressure. Clinicians should re-calculate BP percentiles using the new guidelines to accurately diagnose and treat hypertension in pediatric chronic kidney disease.
Regular follow-up clinic visits with a nephrologist after hospital discharge significantly reduce mortality risk in patients with acute kidney injury (AKI). This study found that such visits, focusing on cardiovascular disease and kidney complications management, lead to lower mortality rates by 29% compared to standard care.
A study of 510 children with chronic kidney disease found that declining hemoglobin levels were associated with significant growth impairment even when above guideline-targeted levels. Lower hemoglobin values are linked to poorer growth, independent of kidney function and age.
Researchers found that a one-year increase in retinal age was associated with a 10% higher risk of incident kidney failure over 11 years. Retinal age gap, a non-invasive biomarker based on retinal imaging, may help identify people at elevated risk for kidney failure.
A large South Korean cohort study found a five-fold increased risk of chronic kidney disease (CKD) for adults with persistent hematuria. Associations were stronger in men compared to women.
A higher urine-to-plasma urea ratio is associated with faster decline in eGFR and development of kidney failure in patients with common forms of CKD. This biomarker may improve risk prediction, particularly in low-cost, easily measurable assays.
Researchers found a significant association between extreme heat exposure and emergency room visits for acute kidney injury, kidney stones, and urinary tract infections. The impact of extreme heat exposure lasted up to a week, with stronger effects during transitional months.
A Swedish cohort study found that direct oral anticoagulants (DOACs) were associated with a lower risk of kidney function decline or kidney failure compared to vitamin K antagonists (VKA). DOACs also showed a lower risk of acute kidney injury.
A national US kidney disease registry found that 60% of participants were unaware of their kidney function level, hindering clinical trial recruitment. The National Kidney Foundation Patient Network aims to address this issue through real-world data collection and patient-centered research.
Anemia is common among adults with advanced kidney disease, associated with adverse outcomes and low eGFR levels. Effective iron supplementation is a low-risk intervention to address this issue, emphasizing the need for increased testing and treatment.
Reduced kidney function and increased urine albumin excretion are associated with brain volume reduction in regions typically affected by Alzheimer's disease and other dementia etiologies. Cognitive decline is common in patients with kidney disease, and this study provides new insights into the etiology and localization of brain damage.
The study found a significant decline in peritoneal dialysis-associated peritonitis rates over time, with consistent differences in risk by race and age. The decline suggests improvements in clinical practice and highlights the importance of uniform coding standards to identify additional risk factors.
A prespecified subgroup analysis of East Asian adults with lupus nephritis found that belimumab added to standard therapy improved kidney outcomes significantly. The study also showed no new safety concerns were raised in the subgroup.
A quality improvement program increased pneumococcal vaccination rates from 53% to 70% in adults aged 18-64 years with stage 4 and 5 chronic kidney disease. The intervention, which utilized electronic best practice alerts within the electronic medical record, improved vaccination rates primarily among this high-risk group.
A 12-month exercise program improved physical functioning and aerobic exercise capacity in adults with CKD stages G3b-4. The program, which included resistance and aerobic exercise, showed no significant impact on cardiovascular risk factors.
A qualitative study highlights the importance of timely and balanced information exchange in shared decision-making for vascular access placement. This collaborative approach involves presenting choices, sharing personalized knowledge, and eliciting patients' values and preferences to strengthen treatment plans.
A new clinical model predicts hospital mortality and major adverse kidney events in critically ill patients with acute kidney injury. The proposed model exhibits good performance for outcome prediction, enabling timely interventions to promote kidney recovery.
Lumasiran, an RNA interference therapeutic, has been shown to reduce oxalate levels in patients with primary hyperoxaluria type 1 (PH1) who have relatively preserved kidney function. In the ILLUMINATE-C study, lumasiran resulted in substantial reductions in plasma oxalate with acceptable safety in patients on hemodialysis.
A long-term study of 3,926 adults with CKD found that higher levels of physical activity reduced the risk of atherosclerotic events, new-onset heart failure, and death. The association was strongest for incident peripheral arterial disease and reinforces current guideline recommendations.
A study found that over 60% of parents of children with kidney disease or hypertension are unsure or unwilling to vaccinate their child against COVID-19. Effective vaccines exist to protect children from COVID-19, and the findings highlight the need for clear communication to address parental concerns.
A study found that US adults receiving hemodialysis with high air pollution exposure have more heart attacks and strokes compared to those with low exposure. The strongest associations were noted among patients who were Asian, older, or had chronic lung disease at dialysis initiation.
Patients with primary glomerular diseases have a significantly higher risk of cardiovascular events, including coronary artery disease and stroke. The study found that inclusion of kidney-specific risk factors improved the prediction of cardiovascular events.
A protocol-based potassium supplementation strategy resulted in a longer time to the first peritonitis episode and a lower hazard ratio of peritonitis compared to reactive supplementation. This approach also improved PD-related outcomes by significantly reducing the risk of peritonitis.
Patients with mild to moderate kidney disease and kidney transplant recipients had a higher risk of cancer. They also faced a higher risk of dying from cancer, particularly from cancers such as bladder, kidney, and multiple myeloma, compared to those with normal kidney function.
Researchers have discovered a significant association between acute kidney injury and an increased risk of developing dementia in patients hospitalized with AKI. Early detection and monitoring may lead to improved outcomes for this high-risk population.
Dialysis facilities referred more incident patients, transplant centers evaluated more, but fewer were placed on the waitlist following KAS implementation. This led to a decline in overall waitlisting nationwide.
A cost-effectiveness analysis found that adherence promotion programs like MAPS reduce costs and improve outcomes for adolescent kidney transplant recipients. Strategies with similar costs to MAPS can still be cost-effective if they decrease rejection episodes by a small amount.
Young adults are disproportionately excluded from kidney transplantation, with only 1.8% of Black and 4.4% of Hispanic patients receiving the treatment compared to 10.9% of White patients within this age group. The study highlights the need for targeted interventions to address these disparities.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.
The National Kidney Foundation has released a research roadmap to accelerate innovations in treatment and increase understanding of kidney disease. The report calls for increased funding in preclinical science, genetics, health equity, and implementation science to tackle the most vexing challenges in kidney disease.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Researchers propose reinstating waiting time for recipients experiencing early post-transplant allograft failure within an expanded timeframe to boost transplant numbers. This policy change could potentially reduce the perceived patient-level risk of transplanting marginal organs and improve organ utilization.
Referral guidelines for nephrology care are shifting towards identifying patients at higher risk of kidney failure. A study using Veterans Health Administration data found that referring patients with a two-year risk of kidney failure above 1% would identify those at highest median risk.
Ongoing acute kidney injury in deceased donor kidneys is linked to lower long-term graft survival. Notably, abnormal serum creatinine values during procurement also negatively impact graft outcomes.
A Korean population-based cohort study found that cancer, particularly multiple myeloma and leukemia, is associated with an increased risk of kidney failure. The study included approximately 825,000 patients with cancer compared to twice as many without cancer, matched on other characteristics.
A scoping review found that 80% of studies on acute kidney injury did not define recovery of kidney function, highlighting the need for clear application of standard definitions. Researchers recommend transparent reporting of how the Kidney Disease Improving Global Outcomes (KDIGO) definition is applied.
Researchers developed a new risk equation using 6 routinely available patient parameters to estimate the risk of CKD patients progressing to ESKD requiring KRT. The 6-variable risk score achieved high predictive performance and good calibration in validation cohorts.
Abbreviated lung ultrasound protocols show similar diagnostic sensitivity to 28-zone studies, suggesting they can efficiently diagnose volume overload. Researchers found no mortality differences between patients with mild and moderate-to-severe pulmonary congestion.
China's kidney disease burden is expected to increase significantly, with an estimated 874,373 patients receiving dialysis by 2025. The study used insurance claims data to estimate the national prevalence of dialysis in China.
Research identifies fetal APOL1 kidney risk alleles as contributing factors for preeclampsia in African-American mothers, while maternal-fetal genotype discordance is also linked to this risk. The study suggests a connection between APOL1 genetic variants and preeclampsia, particularly among mothers of African ancestry.
A large population-based family study found that individuals with an affected first-degree relative have a threefold higher risk of chronic kidney disease. Genetic factors play an important role in modulating susceptibility to kidney disease.
A single-center retrospective study found that 1-year kidney transplant outcomes are similar for HCV-negative recipients from HCV-positive or negative donors. The results suggest that transplantation of kidneys from HCV-infected donors to HCV-negative recipients is a viable option.
Researchers found that greater eGFR variability is associated with increased risk of all-cause mortality independent of other factors. In contrast, eGFR variability was not linked to cardiovascular disease events.
A nationwide registry study found frequent low blood pressure episodes during hemodialysis associated with a higher incidence of diagnosed peripheral arterial disease. Patients experiencing more intradialytic hypotension may warrant careful examination for PAD.