Researchers developed a non-invasive ocular imaging method to detect flavoprotein fluorescence in the eye, indicating mitochondrial oxidative stress. This technique may predict glaucoma progression earlier than current methods, with similar sensitivity to visual field changes.
A new study found that Black patients are six times more likely to have advanced vision loss after a glaucoma diagnosis, highlighting the need for early eye screening in this population. The research analyzed nearly 210,000 participants and used artificial intelligence to identify visual field loss patterns.
Hospitalized COVID-19 patients with high blood viscosity have a 60% higher death rate than those with low blood viscosity. The study suggests that checking for blood viscosity early on could help determine the best treatment course and improve outcomes.
The Mount Sinai Hospital has been awarded $4.2 million over five years to establish a Proteogenomic Data Analysis Center, which will help identify potential biomarkers and drug targets for cancer and new insights into cancer biology.
A study found that patients with a specific form of age-related macular degeneration are at significant risk for cardiovascular disease and stroke. Researchers discovered a strong association between the disorder's subretinal drusenoid deposits and high-risk vascular diseases.
The study found that patients with severe stress-induced myocardial ischemia are likely to benefit from heart bypass surgery or angioplasty, while those with mild or no ischemia are not. Early revascularization was associated with a more than 30 percent reduction in mortality compared to patients treated with medication.
A new Mount Sinai study reveals that young Black adults are twice as likely to have atherosclerosis as their Hispanic counterparts. Researchers used comprehensive questionnaires and 3D vascular ultrasounds to determine cardiovascular risk scores, finding significant discrepancies between the groups.
A comprehensive study found that prenatal exposure to endocrine-disrupting chemicals is associated with non-alcoholic fatty liver disease in children. The researchers measured 45 chemicals in pregnant women and found elevated levels of biomarkers indicating risk for liver disease in children who were more highly exposed.
Researchers have discovered llama-derived immune particles that provide strong protection against a vast array of SARS-like viruses, including COVID-19. These 'super-immunity' molecules, known as nanobodies, could be used to develop a fast-acting, inhalable antiviral treatment or spray.
A new study found that exposure to air pollution and indoor burning without ventilation significantly increases the risk of heart disease mortality. Researchers created maps of eight environmental risk factors across Golestan Province, Iran, and identified associations between death and these factors, controlling for traditional risk f...
Researchers from Mount Sinai found a significant connection between the immune system and amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. The study analyzed mice and human samples using state-of-the-art technologies, revealing peculiar immune signatures that distinguish different forms of ALS.
Researchers identified a three-gene signature in multiple myeloma tumors that predicts a positive response to selinexor-based therapy. The discovery could improve patient selection for targeted agents and expand the use of the drug into patients who haven't failed other therapies.
Researchers developed a rapid blood assay that measures the magnitude and duration of immunity to SARS-CoV-2, allowing large-scale monitoring of population immunity. The test takes less than 24 hours to perform and is scalable to use broadly in the population.
A new study from Mount Sinai Heart found that heart failure patients unvaccinated against COVID-19 are three times more likely to die from it than those who are fully vaccinated and boosted. The research also shows that these unvaccinated patients face higher risks of hospitalization and ICU admission if infected with the virus.
Researchers validated a liquid biopsy test as a better predictor of immunotherapy response in lung cancer patients compared to traditional tumor biopsies. The test measures the PD-L1 biomarker in blood, showing improved accuracy in predicting treatment outcomes and survival.
Researchers developed an in vitro stem cell model to map disease risk variants in human neurons, which could provide insights into the biological mechanisms underlying neuropsychiatric disorders. The study focuses on mapping cis-regulatory elements linked to psychiatric disease heritability.
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
The Mount Sinai Hospital will recruit eight postdoctoral trainees for a five-year fellowship program in emergency care research. The program aims to investigate complex medical questions and lead to studies transforming patient care.
The Mount Sinai Microbiome Lab will use advanced methods to study the microbiome's role in autoimmune diseases such as rheumatoid arthritis and systemic lupus. The lab aims to identify microbial features that can help find more precise matches between diseases and treatments.
Researchers found signs of concussions and head trauma in the brains of deceased headbutting muskoxen and bighorn sheep. The study provides insights into human injuries and opens the possibility that studying these animals could help researchers understand and reduce traumatic brain injuries.
A cohort study of nearly 1,000 pregnant persons in NYC found that neighborhoods most affected by racism and economic inequality had higher rates of COVID-19 infection and preterm births. The researchers linked structural racism and community unemployment to increased risk of preterm birth.
Research at Mount Sinai Hospital found a significant difference in the prevalence of occult hypoxemia among Black, Hispanic, and White patients undergoing anesthesia. The study showed that Black and Hispanic patients experienced higher rates of unrecognized low oxygen levels despite normal pulse oximeter values.
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
Researchers at Mount Sinai have developed a reproducible method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes, which support heart muscle contraction. The new protocol enables efficient energy generation from both carbohydrates and fatty acids, improving disease modeling and regenerative therapies.
Researchers have identified a gene mutation in ARID2 that signals the development of aggressively metastatic melanoma. The study suggests patients with this mutation may require different treatment approaches to manage their cancer effectively. Further research is underway to refine this understanding and improve patient outcomes.
A third dose of COVID-19 vaccine significantly increases immune responses in patients with multiple myeloma, but a subset remains vulnerable. The study found that 88% of patients developed antibodies after the third dose, leading to improved neutralization of the wild-type virus.
Research finds that late-onset alcohol abuse may be a presenting symptom of dementia, particularly in patients with frontotemporal dementia. The study identified that up to 7% of patients with frontotemporal dementia started abusing alcohol late in life, and 5% did so as the first symptom of the disease.
Dr. Valentin Fuster is receiving the inaugural 'Valentin Fuster Award for Innovation in Science' at the ACC's 71st Annual Scientific Session. The award honors his contributions to cardiovascular medicine and scientific research.
The SAVE program, a NIH initiative, provides real-time risk assessment of SARS-CoV-2 variants on immune protection. It uses a coordinated approach to identify and curate data about these variants, their impact on immunity, and their effects on vaccine protection.
Researchers developed a method to identify aggressive early-stage lung cancers and target drugs to tumors likely to respond. They used genomics network models and identified signature genes associated with tumor invasiveness.
A study of over 7,000 adolescents found that consuming a high-quality diet, such as the Mediterranean diet, was associated with significantly lower wheezing odds among those exposed to environmental tobacco smoke. This suggests that targeted public health interventions focused on improving access to higher quality foods may be effectiv...
Researchers developed a novel genetic barcode system to mark cancer cells with different gene modifications and image their characteristics. The Perturb-map platform identified specific genes controlling lung tumor growth, immune composition, and response to immunotherapy, offering new approaches for targeting anti-cancer drugs.
A recent study published in Obstetrics and Gynecology found that birthing parents are at a higher risk of financial burden due to out-of-pocket medical costs, with low-income families facing the highest risks. Public health insurance, including Medicaid, was associated with lower risks of catastrophic health expenditures.
Researchers found that a community-based approach to reporting APOL1 genetic test results resulted in lower blood pressure readings among hypertensive patients. This trial suggests that involving communities in genetic testing could be beneficial for reducing the risks of chronic kidney disease.
A new study has found that research participation is associated with greater use of and adherence to medications for dementia, while also revealing significant racial/ethnic disparities. The research suggests that Black and Latino participants had lower rates of medication uptake and persistent use compared to White participants.
A new study found that women with bulimia nervosa exhibited reduced activation of the medial and lateral prefrontal cortices during attempts to control eating behavior. This deficiency in inhibitory control-related activation may contribute to more severe binge eating episodes.
The Ross procedure is associated with improved survival and fewer complications compared to biological or mechanical aortic valve replacement. Patients undergoing the Ross procedure have significantly better long-term survival rates, comparable to those in the general population without surgery.
A new study analyzed data from over 27,000 patients with multiple sclerosis to understand the impact of relapses on long-term outcomes. The research found that progression independent of relapse activity can start early in relapsing remitting MS and becomes the dominant driver of disability accumulation as the disease evolves.
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
Researchers analyzed DNA sequences and electronic health records of thousands of individuals to discover that the chance a pathogenic genetic variant may cause a disease is relatively low, about 7 percent. However, some variants are linked to wide range of risks for disease.
A large study has found that COVID-19 vaccination does not affect fertility outcomes in patients undergoing IVF, providing reassurance to those trying to conceive. The study compared rates of fertilization, pregnancy, and early miscarriage in vaccinated and non-vaccinated patients, with no significant differences observed.
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
A new study led by Mount Sinai researchers found that microglia may play a critical role in some cases of brain disease, and provides a comprehensive guide for future studies. The study identified two new genes linked to brain disorders, including Alzheimer's and Parkinson's diseases.
Researchers found that distributed codes among larger populations of neurons in the prefrontal cortex make information more reliable and robust. This discovery could support advanced cognitive abilities and potentially treat disorders of memory and cognition.
A pilot study suggests that machine learning algorithms combining EKG and electronic health record data can more effectively screen for pulmonary embolisms than current tests. The fusion model was found to be 15-30% more effective at accurately identifying cases, especially severe ones.
A recent study found that a substantial decline in lung cancer deaths is associated with earlier diagnosis of lung cancer through increased screening via computed tomography (CT) and follow-up scans. This approach can lead to surgical interventions, which can often be curative for precancerous nodules.
Cancer cells secrete type III collagen to stay dormant, and when levels decrease, they wake up and create metastatic cancer. Researchers found that enriching the environment with collagen can force cells to remain in a dormant state and prevent tumor recurrence.
Researchers found a novel therapy called AVID200 safe and well-tolerated, with modest improvements in symptom burden, anemia, and spleen enlargement. The therapy needs to be combined with other drugs to optimize impact in patients.
A case study published in Nature Medicine reports a patient experiencing progressive neurological features resembling Parkinson's disease after CAR-T cell therapy, suggesting potential neurotoxicity. The study highlights the importance of monitoring for neurotoxicity in patients receiving BCMA-targeted CAR-T therapies.