New research from the University of Georgia found at least 479 people were injured and 28 died worldwide in more than 130 bounce house accidents due to weather events. Basic precautions such as securing bounce houses could have prevented many accidents.
A Rutgers study found that nonbinary and female college students, as well as those in their second year, are most affected by academic stress, leading to poor mental well-being. The researchers recommend colleges provide tailored mental health resources, stress-management strategies, and peer support groups to help build resilience.
A new mathematical framework predicts the most effective combinations of drugs to treat postmenopausal bone loss in patients. The model identifies optimal orderings that boost bone density and reduce long-term bone loss, improving treatment outcomes.
Researchers have modelled a key mechanism by which DNA replicates, revealing details about how helicases wrangle DNA during replication. The simulations showed each step of translocation can travel more than 12 nucleotides along the backbone, pinpointing interactions involved in long-distance movement.
A new study uses a biomimetic in-silico simulator to investigate the effect of body posture and stomach motility on oral drug bioavailability. The simulation reveals that stomach contractions can induce pressure, generating complex pill trajectories and affecting drug dissolution rates.
Researchers found that incorporating banana peel flour into sugar cookie batter makes the treats more healthful. The addition of banana peel flour resulted in cookies having less fat and protein, higher amounts of phenols, and better antioxidant activities compared to conventional cookies.
A new study found that neuronal cilia play a crucial role in ensuring proper signaling of dopamine receptors, which regulate motivated behavior and movement. Mice lacking functional cilia on dopamine receptor 1-expressing neurons became obese and sedentary, highlighting the importance of cilia in dopamine-dependent neural signaling.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
Researchers at IRB Barcelona have found that CRISPR/Cas9 gene editing can trigger cell toxicity and genomic instability, particularly in regions near the tumour suppressor protein p53. The study identified 3,300 targeted spots with strong toxic effects, highlighting the need for safer CRISPR reagents.
Researchers have found that spinosaurid dinosaurs had rapid tooth replacement, with up to three generations of teeth developing simultaneously. This trait likely contributed to their overabundance in Cretaceous sites.
A recent study suggests that the BCG vaccine is effective in preventing tuberculosis (TB) in children under 5 years old. However, adolescents and adults may require additional protection to maintain immunity beyond childhood. The researchers emphasize the need for booster vaccinations and new TB vaccines to supplement the BCG vaccine.
Scientists have discovered a new way to detect infection by sensing physical forces produced by bacterial invasion. Cells use mechanosensor protein PIEZO1 to detect changes in surface tension, triggering an early and fast immune response.
Research shows higher concentrations of pathogenic dust landing at lower elevations in the Sierra Nevada mountains, carrying fungi and bacteria that can cause crop failures and human respiratory disease. The study highlights the increasing threat of microbe-laden dust as the Earth dries out.
Researchers found that people with obesity gained an average of 4.3% of their body weight during the pandemic, with those reporting high levels of stress, anxiety, and depression experiencing the most weight gain.
Researchers have developed an ultrasound method that can screen for bucked shin in young horses, a condition that occurs in about 70% of animals during training. The technique uses axial transmission to detect irregularities in bone formation, allowing for early diagnosis and treatment.
A team of US scientists proposes a 'Western Rewilding Network' to conserve and restore ecosystems in the region. The plan aims to reintroduce keystone species like gray wolves and North American beavers to promote biodiversity and ecosystem health.
A research team at the University of Oklahoma has developed a new approach to triggering an adaptive immune response. The study presents a method to create molecules that can integrate into cells, cause stress on their membrane, and release signals that recruit immune cells to their location.
A WVU researcher is studying corollary discharge circuits in fruit flies to better understand how the brain integrates sensory information and coordinate movement. The goal of this research is to shed light on human disease and human performance, with potential applications for improving fighter pilot safety.
Researchers developed a new technique to track single blood stem cells in live organisms and describe their ultrastructure using electron microscopy. This allows for better understanding of cell-cell interactions and potential therapeutics for blood diseases and cancers.
A new nomogram has been developed to assess lung cancer risk in female non-smokers in China, using data from 151,834 patients. The model identified five independent risk factors, including age, chronic respiratory disease, and menopause, and showed good predictive discrimination.
Researchers developed nanoparticles to deliver anti-inflammatory payloads directly to inflamed blood vessels, significantly increasing survival chances and delaying rupture onset. Targeting specific NF-kappaB subunits improved therapeutic effects with fewer adverse effects.
Common noctule bats form mobile sensory networks to optimize prey localization, reducing foraging time by 40%. This collaborative strategy enables bats to effectively control agricultural insect pests and contribute to ecosystem balance.
A massive analysis of over 10,000 Mycobacterium tuberculosis isolates revealed new genes associated with resistance to 13 antibiotics. The study provides a comprehensive framework for understanding the genetic mechanisms of resistance and identifying diagnostic gaps.
Research reveals significant differences in earnings between white and ethnic minority workers within the same workplace. The study suggests that changes in pay-setting arrangements are needed to bring parity between workers.
A new study published in The Lancet Regional Health – Europe found that over 55% of respiratory disease hospitalisations during the pandemic's peak were caused by non-SARS-CoV-2 infections. Non-COVID-19 respiratory infections are expected to increase this winter, posing a significant burden on healthcare systems.
Researchers at Cedars-Sinai created complex computer models of individual brain cells using artificial intelligence. These models capture the electrical signals that neurons fire to communicate with each other, allowing researchers to replicate brain activity at the single-cell level.
The KEYNOTE-604 study shows that pembrolizumab-based combination with etoposide and platinum significantly improves progression-free survival and overall survival in patients with previously untreated ES-SCLC. Long-term follow-up data also reveal durable responses and manageable safety profiles.
Scientists created a robot that mimics rock ants' one-to-one tuition to understand teaching methods. The study found the robot successfully taught route to an apprentice ant, which then learned and led others, revealing key elements of teaching in these ants.
A recent study highlights uncomfortable social situations people with blindness face, as well as strategies they use to navigate them. Researchers found techniques for avoiding awkward encounters, recovering from them, and even constructive ways allies can support individuals with visual impairment.
A new study by Columbia University and MIT researchers found that expanding Medicaid coverage to adults can also help enroll children, a phenomenon known as the 'woodwork effect'. The study examined Oregon's 2008 Medicaid lottery and found that for every nine adults who gained coverage, one additional child also enrolled.
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
Researchers at Carnegie Mellon University have developed an AI pilot that can safely navigate crowded airspace by predicting the intent of other aircraft and avoiding collisions. The AI uses vision and natural language processing to communicate with other aircraft, enabling safe and socially compliant navigation.
A team of researchers at the University of Hawaii collected over 3,000 microbial samples from Waimea Valley's watershed, discovering that microbes follow the food web and are maintained within soil and stream water. The study also found that local distribution of a microbe predicts its global distribution.
A team of researchers has discovered a way to improve the water-use efficiency of field-grown plants by overexpressing a sugar-sensing enzyme in their leaves. This breakthrough could lead to increased crop yields and reduced reliance on irrigation, making it an attractive solution for farmers struggling with water scarcity.
The COVID-19 lockdowns led to a significant reduction in soot emissions in Europe, with an average decrease of 41% in the lower troposphere. This improvement in air quality is attributed to reduced fossil fuel burning and limited travel.
A large international trial found that sub-lobar surgery is non-inferior to lobectomy for patients with peripheral non-small cell lung cancer. The study, which enrolled 1,080 patients, showed similar disease-free survival rates between the two groups.
Researchers from the Institute of Industrial Science, The University of Tokyo, found that preordering significantly influences crystal growth and nucleation. Their study proposes modifications to address shortcomings in classical nucleation theory.
Atomic force microscopy studies reveal that chemical fixation leads to structural changes in cell surfaces, forming large protrusions with diameters of 20-100 nanometers. Membrane proteins aggregate during fixation, creating artefacts that can mislead experimental results.
Researchers have identified key molecular differences between cancer cells that cling to initial tumors and those that spread to distant sites. The study found unique properties in cells that gain migratory ability and survival advantages, leading to the development of new treatment targets.
Scientists have successfully implemented the world's fastest two-qubit gate in a quantum computer, achieving an impressive speed of 6.5 nanoseconds using cold atoms cooled to near absolute zero and optical tweezers. This breakthrough has significant implications for the development of ultrafast quantum computing hardware.
Researchers at Kanazawa University create a nanoparticle called nanoHT that can both generate heat and measure temperature, allowing for controlled manipulation of cellular activity. The technology shows promise in inducing cell death in cancer cells, with HeLa cells dying after heating by 11.4°C.
Researchers at University of the Basque Country have developed a convolutional neural network to predict flow characteristics around flow control devices on wind turbines. The model achieves accurate results with minimal computational time, reducing errors compared to traditional CFD simulations.
Researchers have developed an immunity-boosting postoperative treatment that could prevent glioblastoma relapse by targeting cancer stem cells with nanoparticles. The injectable gel promotes the cancer-killing immune response and reduces toxic side effects.
A new study predicts that climate change will cause a significant rise in mortality rates due to excessively hot nights, with an estimated 60% increase by the end of the century. The researchers used climate modeling scenarios to estimate the impact on 28 cities across three countries.
A comprehensive assessment of scientific literature found that more than 58% of human diseases caused by pathogens have been aggravated by climatic hazards. The research identified 218 out of 375 known human pathogenic diseases affected by at least one climatic hazard via 1,006 unique pathways.
A study found that LGBTQ+ youth in both highly supportive and less supportive communities experience high rates of depressive symptoms and stigma. The research suggests that systemic changes are needed to address the negative impact of broader social stigma on mental health.
The IMpower010 trial showed an overall survival trend in favor of atezolizumab in the PD-L1 TC ≥1% stage II-IIIA population, with a clinically meaningful improvement observed across most subgroups. The study found no separation for the ITT population or all-randomized, stage II–IIIA populations.
Researchers at Hokkaido University used computer simulations to discover a reaction that selectively adds two fluorine atoms to a difficult-to-access position on an N-heterocycle. The successful synthesis of 48 new compounds with unique alpha position fluorine substitutions has significant potential for novel drug development.
New research projects a southerly shift of suitable habitat for blue and sperm whales in New Zealand waters due to climate change. The study finds a 61% loss of suitable habitat for sperm whales, mostly in northern waters, with potential socioeconomic impacts on the local economy.
Scientists have created a robot that moves without pushing against anything in curved space, defying the law of conservation momentum. The research challenges physical laws and intuition designed for flat space, with potential applications in space navigation and robotics.
Researchers have developed a proof-of-concept model that uses artificial intelligence to combine multiple types of data from different sources to predict patient outcomes. The models demonstrate the ability to make prognostic determinations while uncovering the predictive bases of features used to predict patient risk.
The research team will analyze the remaining two enzymes necessary for riboflavin production and build a 'riboflavinator' in a test tube. This understanding could lead to improved methods for treating diseases and improving public health.
A 12-month exercise program improved physical functioning and aerobic exercise capacity in adults with CKD stages G3b-4. The program, which included resistance and aerobic exercise, showed no significant impact on cardiovascular risk factors.
Researchers at Australian National University and James Cook University identified a natural mechanism that enables plants to limit water loss without compromising CO2 uptake. This discovery has significant implications for the agricultural industry, potentially leading to drought-tolerant crops that can withstand extreme weather events.
A new study estimates the environmental impact of 57,000 food products in the UK and Ireland, providing a first step towards enabling informed decision-making. The research finds that many meat alternatives have significantly lower environmental impacts than their meat-based equivalents.
A Rutgers University study found that simultaneously focusing on kids, caregivers, and community members produces better outcomes than interventions targeting children in isolation. The study suggests that multilevel programs can strengthen mental and behavioral health of children affected by extreme adversity.
The DOLPHIN Study reports a high progression-free survival rate of 72.1% and an overall response rate of 90.9% for patients with unresectable locally advanced NSCLC treated with durvalumab plus concurrent radiotherapy.
A cohort study found that reinfection rates are low after successful hepatitis C virus (HCV) treatment in people who inject drugs, suggesting a benefit of treatment in this population. The risk for reinfection was highest among those with ongoing injecting drug use and needle sharing.
A new study published in Applied and Environmental Microbiology suggests that oil formulations with food-grade organic acids can kill dried Salmonella on stainless steel surfaces. This approach has the potential to replace water-based cleaning methods, which promote microbial growth and are often challenging to use.
A study by Medical College of Georgia at Augusta University found that fatigue and headache were the most common lingering symptoms after COVID-19, reported by 68.5% and 66.5% of participants, respectively. Cognitive impairment, depression, and anxiety were also prevalent among participants.