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Science News for December 9, 2021


Catch me if you can: how mRNA therapeutics are delivered into cells

Researchers have visualized the entry routes of mRNA into cells and found that it must escape two barriers to reach the cytoplasm. The study reveals that late endosomes are counterproductive for delivery, increasing cell toxicity. Better vehicles for efficient mRNA delivery can now be developed.

SourceMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)·JournalJournal of Cell Biology·TypeExperimental study·DateDec 9, 2021

Common drugs affect our gut microbiome differently, with good and bad impacts on health

Research shows that common medicines have distinct effects on gut bacteria, with some having beneficial and others detrimental impacts. The study found associations between certain medications and changes to the gut microbiome, particularly with statins and gastric acid medication.

Effectiveness of COVID-19 vaccine incentive lottery programs

A recent study published in JAMA Network Open found that implementing lottery programs as an incentive for COVID-19 vaccination led to substantial increases in vaccine uptake. The study analyzed data from over 40 states and showed a strong correlation between the implementation of these programs and subsequent vaccine adoption.

SourceJAMA Network·JournalJAMA Network Open·DateDec 9, 2021

American College of Cardiology, American Heart Association issue coronary artery revascularization guideline

The new guideline recommends a patient-centric approach to managing patients with coronary artery disease, incorporating clinical indications and multidisciplinary team decision-making. The guideline aims to improve quality of care and reduce disparities in treatment, particularly among women and underrepresented racial or ethnic groups.

SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·DateDec 9, 2021

Review finds significant barriers in shift to remote mental health services during pandemic

A systematic review found that remote care presented challenges for new patients, those without a private space at home, and individuals with schizophrenia or severe anxiety. Despite the benefits of increased convenience and accessibility, concerns were raised about safety, privacy, and confidentiality in remote care.

SourceKing's College London·JournalJournal of Medical Internet Research·DateDec 9, 2021

Tropical forests can recover quickly on reclaimed agricultural lands

Tropical forests worldwide have disappeared rapidly due to deforestation. However, they can recover quickly on abandoned lands, with key forest functions rebounding within a decade. The study found that tropical forests can regain 78% of their old-growth values in just 20 years and near-total recovery occurs in less than 10 years.

New mathematical model to predict viruses

A new mathematical model developed by USC researchers uses a generator-based approach to analyze mutations in genomic datasets, allowing for the prediction of virus evolution and detection. This tool can be applied to various pathogens, including crops, enabling proactive protection measures.

SourceUniversity of Southern California·JournalScientific Reports·TypeObservational study·DateDec 9, 2021

Scientists show how bone-bordering cells may help shape a skull

A new study by researchers at Mount Sinai found that a specific gene, HHIP, helps regulate the development of the coronal suture, a fibrous joint that connects the front and middle bone plates. The study showed that embryos with a missing HHIP gene had misshapen skulls and fewer mesenchymal cells separating the bones.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature Communications·TypeExperimental study·DateDec 9, 2021

Violence increased most in marginalized neighborhoods early in the COVID-19 pandemic

A new UC Davis study tracks firearm violence, assault, and homicide in 13 major US cities by zip code, revealing stark disparities. Firearm violence increased 29.3%, homicides by 27.7%, while robberies decreased 23.3% and rapes by 31.4% during the first five months of the pandemic.

SourceUniversity of California - Davis Health·JournalAmerican Journal of Public Health·TypeData/statistical analysis·DateDec 9, 2021

NIH study traces molecular link from gene to late-onset retinal degeneration

A NIH study has identified a molecular link between a gene mutation and late-onset retinal degeneration, a rare eye disease. The researchers found that the diabetes drug metformin and gene therapy may be effective treatments for the condition, which can cause abnormal blood vessel growth and deposits of apolipoprotein E.

SourceNIH/National Eye Institute·JournalCommunications Biology·TypeExperimental study·DateDec 9, 2021

Circular economy: Researchers show how synthetic rubber raw material can be degraded

Researchers have successfully degraded synthetic polyisoprene using enzyme LCPK30, a breakthrough that could enable recycling of car tires and production of new plastics. The method involves creating an emulsion with the polymer, allowing the enzyme to break down long molecular chains into smaller fragments.

SourceMartin-Luther-Universität Halle-Wittenberg·JournalGreen Chemistry·TypeExperimental study·DateDec 9, 2021

New consensus care guideline will significantly improve quality of life for adults with Duchenne muscular dystrophy

The Adult North Star Network's guidelines aim to improve quality of life for adults with Duchenne muscular dystrophy by addressing complex medical needs such as cardiac failure, weight loss, and renal dysfunction. The consensus-based recommendations also highlight gaps in current care and call for further research.

SourceIOS Press·JournalJournal of Neuromuscular Diseases·TypeCommentary/editorial·DateDec 9, 2021

A new super-cooled microwave source boosts the scale-up of quantum computers

Researchers at Aalto University have developed a precise microwave source that operates at extremely low temperatures, potentially removing the need for high-frequency control cables. The new device could enable larger quantum processors with more qubits, increasing their potential applications in fields like computing and sensing.

SourceAalto University·JournalNature Electronics·TypeExperimental study·DateDec 9, 2021

Researchers identify brain signals associated with OCD symptoms, paving way for adaptive treatment

A team of researchers has recorded electrical signals in the human brain associated with ebbs and flows in OCD symptoms over an extended period. The study could lead to an emerging therapy called deep brain stimulation that adjusts to everyday changes in OCD symptoms, potentially providing more relief and fewer side effects for patients.

SourceBrown University·JournalNature Medicine·TypeExperimental study·DateDec 9, 2021

Natural variability in Pacific Ocean drives decade-long intensification in Pacific walker circulation

A new study reveals that natural decadal variability related to the Pacific Ocean played a significant role in modulating the Pacific Walker circulation change. The research found that the Interdecadal Pacific Oscillation (IPO) could explain 63% of the observed strengthening trend in the Walker circulation between 1980-2015.

Previously unrecorded Chilean tsunami identified

A large earthquake off the coast of south-central Chile in 1737 may have caused a substantial tsunami that was absent from historical records. Researchers analyzed sediments and found evidence of widespread sandy layers, dating to the same time as the earthquake, similar to deposits made by tsunami waves in other areas.

SourceNorthumbria University·JournalNature·TypeNews article·DateDec 9, 2021

Burrowing snakes have far worse eyesight than their ancestors

Scientists found that seven genes associated with bright-light vision are absent in burrowing snakes, demonstrating extensive vision gene loss over millions of years. This challenges the hypothesis that all modern snakes evolved from extreme burrowers, suggesting a different evolutionary path for these subterranean snakes.

SourceUniversity of Plymouth·JournalGenome Biology and Evolution·TypeExperimental study·DateDec 9, 2021

Breast cancer patients with estrogen receptor mutations may benefit from early switch to fulvestrant/palbociclib

A recent study found that patients with hormone receptor-positive breast cancer who experience rising ESR1 mutations before disease progression can benefit from an early switch to fulvestrant plus palbociclib. This approach yields a statistically and clinically significant gain in progression-free survival, potentially justifying its a...

A tool to speed development of new solar cells

Researchers at MIT and Google Brain developed a system that predicts how changing materials or designs will improve solar cell performance. The new simulator, called differentiable solar cell simulator, provides information on which changes will provide desired improvements, increasing the rate of discovery of new configurations.

SourceMassachusetts Institute of Technology·JournalComputer Physics Communications·DateDec 9, 2021

Scientists solve the grass leaf conundrum

Researchers used computational modeling and developmental genetic techniques to study grass leaf formation, finding that current theories are likely incorrect and a 19th-century proposal is closer to the truth. The discovery sheds light on how simple growth rules can generate diverse leaf shapes.

SourceJohn Innes Centre·JournalScience·TypeComputational simulation/modeling·DateDec 9, 2021

Chronic exposure to air pollution may increase risks for ICU admission or death among COVID-19 patients, study finds

Hospitalized COVID-19 patients with chronic exposure to higher particulate matter had increased risks for ICU admission and death. Chronic air pollution exposure was associated with an 11% higher risk of mortality and a 13% higher risk of ICU admission.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateDec 9, 2021

Dinosaurs’ last spring: Study pinpoints timing of Chicxulub asteroid impact

A groundbreaking study confirms the timing of the Chicxulub asteroid impact, which occurred during the spring-summer growth phase, leading to the extinction of dinosaurs and 75% of life on Earth. The research team used multiple lines of evidence, including fossil pollen, index fossils, and radiometric dating, to pinpoint the exact time...

SourceFlorida Atlantic University·JournalScientific Reports·TypeExperimental study·DateDec 9, 2021

Community of ethical hackers needed to prevent AI’s looming ‘crisis of trust’, experts argue

A global community of hackers and threat modellers is needed to stress-test the harm potential of new AI products. Companies can harness techniques like red team hacking, audit trails, and bias bounties to prove their integrity and earn public trust. The industry faces a 'crisis of trust' if it doesn't adopt these measures.

SourceUniversity of Cambridge·JournalScience·TypeCommentary/editorial·DateDec 9, 2021

Concerning rates of clarithromycin prescribing for H. pylori, despite increasing antibiotic resistance, uncovered in new Digestive Diseases & Sciences publication

A new study reveals widespread prescribing of clarithromycin-based regimens for H. pylori infection, defying increasing resistance and suboptimal eradication rates. Talicia, a rifabutin-based therapy, offers an alternative with higher eradication rates and fewer concerns over resistance.

SourceRedHill Biopharma·JournalDigestive Diseases and Sciences·TypeData/statistical analysis·DateDec 9, 2021

Family dynamics can motivate and prevent talking about health

A new study from Iowa State University finds that open dialogue and reciprocal information sharing between parents and emerging adults reduces barriers for talking about health, leading to better health outcomes. The researchers identified three significant factors affecting health disclosures: relational quality, reciprocity, and conf...

SourceIowa State University·JournalWestern Journal of Communication·TypeSurvey·DateDec 9, 2021

China’s crops at risk: Climate change boosts spread of crop pests and diseases

A recent study by the Potsdam Institute for Climate Impact Research found that climate change has contributed to a four-fold increase in crop pest and disease occurrence in China since the 1970s. The researchers attributed this rise to warmer night temperatures, which can foster an increased chance for pests and diseases.

SourcePotsdam Institute for Climate Impact Research (PIK)·JournalNature Food·TypeData/statistical analysis·DateDec 9, 2021

Use of generic heart meds in Medicare Part D could save more than $600 million a year

A new study published in Circulation: Cardiovascular Quality and Outcomes Journal found that increasing the use of generic medications for heart and blood vessel diseases in Medicare Part D could save more than $600 million per year. This would lead to lower out-of-pocket costs for patients and improved adherence rates.

SourceAmerican Heart Association·JournalCirculation Cardiovascular Quality and Outcomes·DateDec 9, 2021

DeepMind simulates matter on the nanoscale with AI

DeepMind's neural network approach accurately describes electron interactions in chemical systems, overcoming long-standing challenges. The company's breakthrough enables researchers to explore material design, medicines, and catalysts at the nanoscale level.

SourceDeepMind·JournalScience·DateDec 9, 2021

Childhood trauma increases risk of opioid abuse

A new study found that childhood trauma is a significant risk factor for prescription opioid misuse among young adults. Participants who reported four or more adverse childhood experiences were nearly three times more likely to be at risk for opioid misuse, with a 13% higher likelihood compared to those with zero to three ACEs.

SourceUniversity of Georgia·JournalJournal of American College Health·DateDec 9, 2021

Dinosaur faces and feet may have popped with color

A new study from the University of Texas at Austin suggests that extinct dinosaurs expressed bright colors on their beaks, legs, and around their eyes. The researchers analyzed data from living bird species and found a 50% chance that the common ancestor of birds and extinct dinosaurs had bright colors in its soft tissues.

SourceUniversity of Texas at Austin·JournalEvolution·TypeData/statistical analysis·DateDec 9, 2021

Making childbirth safer in Indonesia

The Safe Childbirth Checklist, adapted for local needs, increased communication of danger signs, improved baby feeding practices, and reduced stillbirth rates in Indonesian health facilities. The study suggests that long-term adherence to the tool requires continued support for midwives.

SourceUniversity of Göttingen·JournalJAMA Network Open·TypeSurvey·DateDec 9, 2021

Large future changes in climate variability

The study found that climate change impacts are apparent in nearly all aspects of climate variability, including temperature extremes, precipitation patterns, and ecosystem changes. These changes have important implications for sustainable resource management and future adaptation strategies.

SourceInstitute for Basic Science·JournalEarth System Dynamics·TypeMeta-analysis·DateDec 9, 2021

Towards quantum states of sound

A team of researchers at Imperial College London has generated and observed non-Gaussian states of high-frequency sound waves comprising over a trillion atoms. This breakthrough makes important strides towards generating macroscopic quantum states that will enable future quantum internet components to be developed.

SourceImperial College London·JournalPhysical Review Letters·DateDec 9, 2021

Stopping arthritis before it starts

Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.

SourceKeck School of Medicine of USC·Journalnpj Regenerative Medicine·TypeExperimental study·DateDec 9, 2021

LSU Health contributes to research suggesting late-onset retinal degeneration mechanism and potential Rx

A study led by LSU Health found how late-onset retinal degeneration develops and identified a surprising potential therapeutic, metformin. The research suggests that an enzyme called AMPK activates the protein CTRP5 to regulate fatty acid metabolism and energy stability.

SourceLouisiana State University Health Sciences Center·JournalCommunications Biology·TypeExperimental study·DateDec 9, 2021

Environmentally sustainable diet linked to health benefits

A large population study from Lund University found that a sustainable diet is associated with lower risks of premature death. The EAT-Lancet diet, which emphasizes whole grains, vegetables, and pulses, was linked to a 25% lower risk of total mortality and specific causes like cardiovascular disease and cancer.

SourceLund University·JournalAmerican Journal of Clinical Nutrition·DateDec 9, 2021

Modern slavery still not a priority for one in five Australian businesses

New research from UniSA finds that confusion, lack of knowledge and disinterest are hindering businesses' progress in addressing modern slavery. The study provides a framework to help companies improve their approaches, but warns that without effective measures, global efforts to stop modern slavery will be unlikely to succeed.

SourceUniversity of South Australia·JournalThe British Accounting Review·TypeData/statistical analysis·DateDec 9, 2021

Study estimates that more than half of US hospitals not in compliance with new pricing disclosure rules in first five months

A study by Johns Hopkins Bloomberg School of Public Health found that over half of US hospitals failed to comply with new pricing disclosure rules, despite 75% compliance in some regions and states. Hospitals' decisions on compliance were linked to peer hospital performance and health IT preparedness.

SourceJohns Hopkins Bloomberg School of Public Health·JournalJournal of General Internal Medicine·DateDec 9, 2021

A diet rich in plant-based products reduces the risk of cognitive impairment in the elderly

A study published in Molecular Nutrition & Food Research found a significant association between dietary polyphenols from plant-based foods and reduced cognitive impairment risk. The research analyzed the metabolism of dietary components, intestinal microbiota, and endogenous metabolism in relation to cognitive decline.

SourceUniversity of Barcelona·JournalMolecular Nutrition & Food Research·TypeRandomized controlled/clinical trial·DateDec 9, 2021

Ultra-thin 3D lensless fiber endoscopy using diffractive optical elements and deep neural networks

Researchers have developed a new method for 3D imaging without distal optics, enabling high-resolution endomicroscopy with diameters below 0.5 millimeters. The approach uses diffractive optical elements to compensate phase distortions in fiber bundles, allowing for robust and low-cost medical imaging.

‘Super trees’ may help save Houston … and beyond

A new study ranks live oaks and American sycamores as champions among 17 "super trees" that can mitigate air pollution and climate change in urban areas. The research provides a three-part framework for selecting suitable trees, identifying high-impact planting sites, and engaging with community leadership to make the project a reality.

SourceRice University·JournalPlants People Planet·TypeData/statistical analysis·DateDec 9, 2021