A comprehensive meta-analysis of adults with autism found significant impairments in four key domains: theory of mind, emotion perception and knowledge, processing speed, and verbal learning and memory. The study highlights the importance of a broader approach to treating autism in adults, including non-social cognitive domains.
A team of researchers discovered that APOL1 risk variants, previously known to affect African and African American populations, are also found at appreciable frequencies in Caribbean and Latin American populations. This finding could help physicians tailor treatment more closely to their needs through precision medicine.
Researchers have developed a novel way to streamline genetic analysis by utilizing the blacklist computing concept. This method has shown promise as a key to faster therapeutic innovation, enabling clinicians and researchers to focus on true disease-causing mutations., By removing non-pathogenic genetic variants from consideration, thi...
A large-scale study identified 14 gene variants associated with PCOS, including new variants linked to metabolic and reproductive features of the disorder. The findings also suggest links between PCOS and other conditions like obesity, depression, and male pattern baldness.
Researchers at Mount Sinai have discovered a novel combination of drugs that induces the highest rate of proliferation in adult human beta cells, increasing insulin production and potentially treating diabetes. The study found a 5-8% daily growth rate, which is significant progress toward a cure for the disease.
Researchers from Mount Sinai's Icahn School of Medicine published four scientific papers highlighting their work on brain genomics and psychiatric diseases. They analyzed over 2,000 brains to identify non-coding functional genomic elements associated with schizophrenia risk, autism spectrum disorder, and bipolar disorder.
Imagination has been shown to be an effective tool in treating anxiety and fear-related disorders. A recent study found that imagining a threat can help reduce neural and physiological responses associated with fear, making it a promising treatment option for conditions like post-traumatic stress disorder and phobias.
A study published in Pediatrics found that nearly half of children exposed to second-hand marijuana smoke had detectable levels of THC, a reliable indicator of exposure. Researchers also discovered that third-hand smoke exposure can occur when individuals smoke and the residue lingers on their skin, hair, or clothes.
BioJupies accelerates RNA sequencing data analysis, enabling researchers to share results in minutes. The cloud-based platform provides interactive reports and reduces costs to under one cent per sample.
Researchers develop nano-immunotherapy that prevents immune cells from activating and attacking transplanted organs, allowing for long-term acceptance. This approach could transform patient care and help overcome barriers to successful transplant outcomes.
Researchers found that AI models performed significantly worse on X-rays from outside their own network compared to those from within. The study highlights the importance of carefully testing AI performance in real-world clinical settings.
Researchers found that people with Alzheimer's disease who were treated with diabetes drugs showed fewer markers of the disease, including abnormal microvasculature and gene expressions. The study suggests targeting the brain's capillary system could have beneficial effects in Alzheimer's patients, opening opportunities for new therapies.
Researchers found that ezogabine, an FDA-approved anti-seizure medication, significantly reduced depressive symptoms in patients with Major Depressive Disorder. The study showed a 45% reduction in depression and improved resilience after treatment.
Research suggests that prenatal exposure to most common medications does not increase the risk of autism, contrary to previous studies. Instead, a mother's general health before pregnancy appears to play a more significant role in her child's development.
A study published in Science Advances reveals short-term lead exposure in ancient Neanderthals, with implications for understanding human evolution and the effects of environmental exposures. The research team analyzed teeth to reconstruct climate and developmental events during and after birth.
Researchers at Mount Sinai Hospital have successfully induced desensitization in the majority of children with wheat allergies through oral immunotherapy. After 52 weeks, 52% of children consumed a cumulative dose of 4,443mg of wheat protein without adverse reactions.
Researchers found that females without schizophrenia used more complex brain regions to identify others' mental states, while men used less complex regions. Both groups with schizophrenia showed reduced complexity in brain processing, suggesting a potential link between olfaction and emotional processing.
Researchers developed a novel technology to analyze hundreds of genes at single cell level, revealing critical immune system weakness in cancer. The Pro-Code technique identified disease-causing genes and potential drug targets for cancer immunotherapy.
Young adults exposed to cannabis during adolescence show altered brain structure and gene expression related to psychosis risk. The study suggests that adolescent cannabis use can induce long-term changes in brain cells and gene networks, potentially increasing psychiatric vulnerability.
Researchers at Mount Sinai have discovered a new way to determine whether breast cancer cells are dormant or soon to turn deadly. Patients with high levels of the NR2F1 protein in their bone marrow are less likely to develop metastatic cancer, allowing for more targeted treatment and improved survival rates.
A new approach integrates genomic and temporal information to infer causal relationships between genes, drugs, and their environment, allowing for a more accurate prediction of their interactions over time. The tool demonstrates the improvements in inferring genetic causes of disease enabled by higher-resolution molecular profiling.
A new study finds that mastectomies do not completely eliminate the need for postoperative imaging and biopsy. For 10% to 15.5% of patients, subsequent imaging is required, and 6-8% undergo biopsy, with low malignancy rates.
A comprehensive genome-wide map of RNA splicing variation in the aging brain has been created, offering new insights into genetic mechanisms underlying Alzheimer's disease progression. The study identified specific RNA splicing events linked to the disease and suggests a potential therapeutic strategy using antisense oligonucleotides.
Researchers discovered anti-a4b7 therapy significantly reduces lymphoid aggregates in the GI tract of HIV-1 infected patients. The study found that this therapy may have significant implications for HIV treatment.
A new pathology test using AI can accurately predict clinically significant prostate cancer disease progression following surgery, helping guide treatment decisions. The Precise MD post-op test reclassified 58% of intermediate risk patients as low risk and 42% as high risk for significant disease progression.
A specific protein called TEAD1 has been identified as a key regulator of tumor migration in glioblastoma, a devastating form of brain cancer. By deactivating this protein, researchers may be able to stop tumor cells from migrating away from the main tumor mass, increasing the success rate and overall survival time for patients.
Researchers at Mount Sinai Hospital have found a link between high doses of sildenafil citrate and irreversible damage to color vision. The study used advanced imaging technology to visualize the structural changes in the retina caused by excessive use of the drug.
Researchers found intravitreal treatments to be superior to periocular injections in reducing macular edema and improving visual acuity. The study suggests shifting towards intravitreal corticosteroid injections for treating uveitic macular edema.
Researchers at Mount Sinai discover that an antimicrobial protein in the gut can prevent graft-versus-host-disease, a common and lethal side effect of bone marrow transplants. The protein, REG3α, may lead to new treatments for inflammatory bowel disease and other GI illnesses.
A study published in JAMA Oncology found that patients treated with more-invasive surgical techniques for early-stage lung cancer were more likely to become chronic opioid users. In contrast, those who underwent minimally invasive VATS surgery were less likely to fill opioid prescriptions after surgery and in the long term.
Researchers have identified a novel gut-brain neural circuit establishing the vagus nerve as essential for regulating reward and motivation. The study reveals that stimulating the right branch of the vagus nerve can excite reward neurons in the brain, offering potential targets for therapy for eating and emotional disorders.
Researchers found that women who experienced higher levels of trauma and secreted higher levels of cortisol in late pregnancy had male infants with lower birth weights, averaging a 38-gram decrease. The study's results suggest that maternal trauma can have lasting effects on fetal development.
Researchers at Mount Sinai discovered that stromal cells in bladder cancer tumors prevent immune cells from attacking them, leading to low response rates with PD-1/PD-L1 inhibitors. The study identified genes linked to more aggressive cancers and found that tumors with these genes were less responsive to treatment.
Mount Sinai researchers discovered a novel epigenetic mechanism causing drug resistance in melanoma patients with BRAF gene mutations. A biomarker called IGFBP2 was also identified, which could benefit from combination therapies that inhibit BRAF and IGFBP2-driven pathways.
Researchers at Mount Sinai have successfully restored vision in mice by activating retinal stem cells, which could lead to treatments for patients with blinding diseases. The study found that new rod photoreceptor cells were generated and integrated into the existing retinal structure, restoring function of the visual pathway.
Scientists have identified a method to grow dendritic cells at scale in the lab, enabling more precise cancer vaccines and potentially improving organ transplant rejection outcomes. This discovery could lead to breakthroughs in cancer treatment and other immunological therapies.
A study published in The Lancet Psychiatry found that switching antipsychotic medications in patients with first-episode schizophrenia does not improve clinical outcomes. Instead, earlier treatment with clozapine, an effective antipsychotic medication, can be started earlier to potentially save time and reduce suffering.
An AI platform identified diseases in CT scans faster than human diagnosis, with a total processing and interpretation time of 1.2 seconds, significantly outperforming human triage systems.
Researchers at Mount Sinai will investigate the use of inhaled corticosteroids to treat sickle cell disease, a condition that affects 100,000 Americans and has high healthcare costs. The IMPROVE 2 study aims to improve patient outcomes and reduce ED visits.
The Icahn Institute is partnering with the National Institutes of Health to establish a center for reproducible biomedical modeling, aiming to accelerate development of predictive models for precision medicine and bioengineering. The center will provide much-needed model building resources to the research community.
A new RNA sequencing platform has been developed to match thousands of drugs with late-stage and drug-resistant multiple myeloma patients, providing a more accurate treatment approach. The platform's results showed that a majority of patients benefited from personalized treatment plans based on their cancer's RNA profile.
Researchers have discovered a novel way to enhance targeted cancer drugs by testing cocktail combinations on human cancer cell lines, fruit flies, and mice. The findings suggest that these cocktail combinations can be used with targeted therapy drugs or after failed attempts.
Researchers at Mount Sinai Hospital discovered a new gene, HIP1, linked to disease severity in rheumatoid arthritis. The study found that knocking out the gene reduced synovial fibroblast invasiveness and protected against arthritis progression.
Researchers discovered that brain microglia clearance activity in different regions goes hand in hand with natural neuronal degeneration. Microglia can mistakenly attack healthy neurons if their 'eating' behavior is turned on inappropriately, leading to cellular changes associated with neurodegenerative diseases.
Researchers at Mount Sinai have discovered two microRNA activity-based biomarkers that can predict patient outcomes and inform treatment decisions for p53-like bladder cancer. The findings hold promise for personalized treatment options, but further research is needed to translate the results into improved patient care.
Researchers have identified a new gene-activation pathway caused by lipids associated with coronary artery disease, which could help identify new directions in research and drug development. The study found that exposure to lipids activates the MTHFD2 gene in the walls of blood vessels.
Researchers identified adventitial CD90+ and mesenchymal stem cells in human arteries for the first time, providing a clear link to vascular diseases like coronary artery disease. These cells appear to play a key role in mediating vascular diseases.
A new study published in JAMA Internal Medicine finds that hospital at home (HaH) care reduces length of stay, hospital readmissions, emergency department visits, and transfers to skilled nursing facilities. HaH also improves patient experience and satisfaction rates compared to traditional inpatient care.
Research found that human herpesvirus 6A and 7 are present in Alzheimer's brains at higher levels than in those without the disease. The study identified previously unknown gene networks that could reveal novel targets for new drugs, and may help prevent or arrest the progression of the disease.
Researchers discovered a higher risk of major congenital malformations in fetuses exposed to lithium during the first trimester. The absolute risk was nearly one and one-half times higher than in unexposed babies.