Coronary angiography is essential for detecting acutely occluded epicardial coronary arteries in resuscitated individuals with out-of-hospital cardiac arrest. Numerous cohort studies have shown an association between survival and early coronary angiography and/or percutaneous coronary intervention.
A new study from Duke University reveals racial wealth inequality is a key contributor to urban unrest. The racial wealth gap has worsened over the past 50 years, with black and Latino households holding significantly less wealth than white households.
Researchers discovered a link between BSEP inhibition and FXR activation, explaining the weak concordance between BSEP inhibition potency and cholestatic DILI incidence. The C-DILI assay has been shown to have high in vitro-in vivo correlation among compounds known to have a risk of DILI.
New research found that for every one-degree-Celsius increase in temperature, mountaintop species shift upslope by 100 metres, resulting in shrinking inhabited areas and dramatic population declines. This supports predictions of extinctions among top species due to global warming.
A study found that brain teaser questions give interviewers power and speak to their dark personality traits, such as narcissism and sadistic tendencies. Participants who support the use of these questions were less socially competent and relied heavily on intuition in the hiring process.
Researchers identified BAP1-regulated target genes and mechanisms linking ferroptosis to tumor suppression in various cancers. Treatment with ROS inducer resulted in increased ferroptosis-related cell death in BAP1 cancer cells, suggesting a potential new area of therapy research.
Researchers developed a predictive model to identify the most beneficial 3D distortions for controlling edge localized modes (ELMs) in tokamaks. The KSTAR facility validated these predictions with remarkable accuracy, paving the way for ITER's successful operation.
Scientists at Kyoto University have discovered a protein, AIP1, that plays a crucial role in regulating cell arrangement during wing development in fruitflies. The study reveals how cells sense and respond to tissue tension, which is essential for shaping tissues like wings.
A new study from St. Michael's Hospital examines health-care interventions to support patients seeking work and identifies key features of successful interventions. These include multidisciplinary teams, packages of services, one-on-one tailored services, comprehensive views of social needs, and communication with employers.
The project, called Playing & Learning Across a Year (PLAY), will create a digital library of videos of mothers going about their daily activities with their children. Researchers will gather video data from over 900 infants and their mothers, which will be transcribed, annotated, and uploaded to an open-source video library.
A novel nano material with electrical and magnetic properties has been synthesized by researchers at DTU Chemistry. The material, Chromium-Chloride-Pyrazine, is an organic/inorganic hybrid with promising prospects for quantum computing, superconductors, catalysts, batteries, fuel cells, and electronics.
Researchers analyzed climate change's effects on marine aquaculture production, finding it's already impacting producers today and will worsen unless proactive measures are taken. The study highlights the need for countries to prepare for climate change and develop adaptive measures to ensure sustainable seafood production worldwide.
A randomized clinical trial found that a Tai Ji Qan balance training program was more effective than other exercise programs in reducing falls among older adults at high risk. The study included 670 participants and lasted six months, with results suggesting improved fall prevention through the specific focus on balance training.
A new antimalarial drug called DM1157 is being tested in a Phase 1 clinical trial for its safety and efficacy. The trial aims to enroll up to 104 healthy volunteers and assess the drug's impact on the human body.
Hurricane Helene has strengthened and become highly organized, with maximum sustained winds reaching 105 mph. It is forecast to become a major hurricane by tonight and then undergo steady weakening by late Tuesday.
The automatic tool improves both inter-operator and intra-operator reliability, with a peak force sharper than the sliding hammer. Both tools have high learnability, but the automatic tool is 75% more efficient.
A team of researchers from the Moscow Institute of Physics and Technology has developed a model for predicting hand movement trajectories based on electrocorticogram data. This technology could enable exoskeletons that allow patients with impaired mobility to regain movement.
Hurricane Olivia is expected to affect Hawaii with strong winds and heavy rainfall, according to NASA. The Central Pacific Hurricane Center has issued Tropical Storm Warnings for Maui County and a Tropical Storm Watch for Oahu.
A team of scientists from Newcastle University has discovered three new species of snailfish in the Atacama Trench, a record-breaking 8000-metre-deep location. The fish, which are part of the Liparidae family, are highly adapted to living in extreme pressure and cold conditions.
A review paper published in the Journal of the American College of Cardiology found that high levels of optimism can lead to a reduced risk of heart disease. Optimistic patients were more likely to engage in healthy behaviors such as regular physical activity, healthy eating and not smoking.
The Global Leadership Initiative on Malnutrition has published a consensus report outlining five criteria for malnutrition diagnosis. The criteria include phenotypic and etiologic measures to assess malnutrition in adults. A two-step approach is recommended for diagnosis, involving screening and assessment.
Bilingual individuals exhibit unique brain activity when switching between languages, with increased cognitive control activity during disengagement. In contrast, engaging in a new language comes relatively cost-free from a neurobiological standpoint, suggesting that the burden of language-switching lies in disengagement.
A recent pilot study reveals that e-cigarette users are exposed to hazardous aldehydes like formaldehyde, which can cause cancer. The study found that concentrations of these chemicals increased tenfold after vaping sessions, suggesting a significant amount remains in the lungs.
A recent study published in the British Journal of General Practice found that prescribing antibiotics to children with cough does not significantly reduce the risk of hospitalization. However, a strategy of delayed antibiotic prescribing may help reduce unnecessary return visits to the GP.
Researchers found that mental imagery techniques can effectively regulate pain perception independently of the opioid system. The study used heat pain and visual cues to manipulate participants' expectations, showing that mental imagery is an opioid-independent approach to pain management.
A commentary suggests using smart technology and artificial intelligence to improve the detection of sepsis in children in Canada. The authors propose automating data combinations of sepsis symptoms and other relevant information to create more accurate and low-cost trigger tools.
A large Taiwanese study found that patients with sepsis are at increased risk of cardiovascular events, including stroke and heart attack, within the first 4 weeks after hospital discharge. Younger patients with sepsis aged 20 to 45 years were particularly at higher risk.
Researchers have developed a method to separate infected and uninfected cells, revealing how Zika virus manipulates the human immune system by suppressing gene production in macrophage cells. This approach provides a more accurate account of Zika's effect on macrophages and shows that the virus uses two methods to stop their function.
Researchers at the University of Edinburgh discovered that tiny vibrations can be used to heat small amounts of liquid, potentially improving systems that prevent ice build-up on aeroplanes and wind turbines. The findings could also lead to more efficient drying of clothes in appliances.
Researchers have demonstrated graphene's ability to convert electronic signals at gigahertz frequencies into signals at several times higher frequencies, paving the way for ultrafast graphene-based nanoelectronics. The breakthrough achieved using a novel terahertz radiation source enables efficient frequency multiplication in graphene.
Researchers discovered that highly robust regulatory proteins can acquire binding to new promoters in response to mutations, challenging the long-held assumption that robustness and evolvability are mutually exclusive. This finding has significant implications for understanding gene regulation and evolution.
Researchers found that people generally rate themselves more positively than others, but struggle to accurately estimate how much others like them. This 'liking gap' can hinder the formation of new relationships and has significant implications for personal and professional lives.
Researchers used a computer model to study the effect of increased cholesterol on a specific ion channel involved in regulating potassium levels in the heart. They found that increasing cholesterol levels made interactions with the channel more numerous, overwhelming it and interfering with its ability to open and close normally.
Researchers developed a new method for detecting hazardous nitrogen-containing substances using nuclear magnetic resonance (NMR) relaxometry. The technique analyzes 14N NMR relaxation signals to identify explosives and toxic substances, offering improved efficiency and accuracy compared to traditional methods.
Researchers have developed a new approach to conserving tree species, focusing on increasing genetic diversity and efficiency in protection. The method can be tailored for successful conservation of any species, including custom-tailored seed collection protocols.
A new study published in JAMA Internal Medicine found that one in four older adults prescribed benzodiazepines continue to use them long-term. The research highlights the need for better education and critical thinking among healthcare providers to reduce the risk of long-term use, particularly among low-income older adults.
A study published by the American Psychological Association suggests that focusing on feelings instead of logic in decision-making leads to increased attitude certainty and stronger advocacy for chosen options. This approach can also change behavior, as seen in experiments where participants who made intuitive decisions shared their ch...
Two DNA testing programs in Spain and UK successfully matched patient tumor profiles with targeted therapies, enabling new opportunities for personalized medicine. The programs use whole genome sequencing to identify specific genetic features of tumors and match them with early clinical trials.
A widely used drug has been identified as a contributor to skin cancer development, with researchers calling for enhanced sun protection advice. The study, published in Nature Communications, found a strong association between azathioprine use and a specific mutational signature in cutaneous squamous cell carcinoma.
A high-throughput screening study has identified six potent small-molecule inhibitors of α-synuclein aggregation, which could potentially halt Parkinson's disease development. The compounds target the monomeric state of αSN and share a common core structure.
The new California Climate Tracker tool provides more than 120 years of historical climate data, allowing users to analyze trends and patterns in temperature and precipitation. The updated version incorporates a user-friendly web interface, improved accuracy using PRISM data, and access to archived maps and data dating back to 1895.
Hurricane Florence's maximum sustained winds have increased to near 115 mph, making it a category 3 hurricane. Satellite data reveal powerful thunderstorms with cloud tops as cold as minus 63 degrees Fahrenheit, capable of generating heavy rainfall.
A new AI-powered workflow enables scientists to systematically and sustainably evaluate large amounts of high-resolution deep-sea images. The workflow, developed by GEOMAR researchers, uses machine learning algorithms to automatically detect features such as manganese nodules in the seafloor.
A new framework combines three existing methods to find large DNA mutations in cancer cells, providing a comprehensive view of the genome. The approach may help researchers understand how cancers begin and identify potential treatment targets.
Researchers at EMBL have developed an interactive map of proteins involved in human cell division, allowing users to track protein dynamics and identify critical vulnerabilities. The tool has the potential to advance our understanding of cellular processes and disease mechanisms.
Researchers found that nearly 9% of people who died by suicide in 18 states between 2003 and 2014 had chronic pain documented in their incident records. Chronic pain was associated with risk factors for suicide, but previous studies primarily examined nonfatal suicidal behaviors.
Researchers found that medical cannabis provides immediate symptom relief across various health conditions, including chronic pain and insomnia. Patients reported an average symptom reduction of nearly 4 points on a 1-10 scale following cannabis consumption.
A recent study by Alfred Wegener Institute researchers found that the loss of Arctic permafrost through coastal erosion led to significant increases in carbon dioxide concentrations in the atmosphere during the last glacial period. This phenomenon is now being studied to understand its potential impact on future climate warming.
A new study finds that rice farms emit 45 times more nitrous oxide than continuously flooded farms, which also predominantly emit methane. The authors call for scientists to map flooding regimes and measure emissions, as well as optimize water use to reduce climate impacts.
Researchers reconstruct relative sea level record from Mallorca island using phreatic overgrowths on speleothems, finding stability instead of fluctuations. This accurate record provides insight into future sea level rise due to global warming and challenges current estimates.
Two lunar transits were observed by NASA's Solar Dynamics Observatory in September 2018, with the first lasting one hour and obscuring 92% of the Sun. The second transit was shorter, lasting 49 minutes and showing a distinct view of the Moon's surface due to the lack of atmospheric distortion.
Researchers at Northwestern University developed a simple blood test called TimeSignature that can identify the body's precise internal time clock. The test measures gene expression markers and can be taken any time of day, allowing for more accurate diagnosis and treatment of diseases such as heart disease, diabetes, and Alzheimer's.
Researchers surveyed 1400 Kenyans affected by drought, finding that those who relocated are more likely to experience violence. However, migrants themselves do not express increased support for violence, suggesting a complex relationship between migration and conflict.
The authors explore clopidogrel's use in stable ischemic heart disease, acute coronary syndrome, stroke, and peripheral vascular disease. They evaluate the data behind its use in patients on oral anticoagulation, aiming to better understand its role in cardiovascular disease.
The Francis Crick Institute will run a new accelerator programme called KQ Labs to support data-driven biomedical start-ups, providing £40,000 each to ten companies to validate their proposals. The programme is part of a growing ecosystem around King's Cross, Euston and Bloomsbury.
A subpopulation of PD-1-expressing NK cells within tumors responds to checkpoint blockade, activating anti-cancer effects. These cells contribute significantly to the efficacy of checkpoint-targeting immunotherapies, suggesting new strategies for improving treatment outcomes.
Researchers found that papaverine reduces tumor oxygen consumption and hypoxia in mouse models, making tumors more sensitive to radiation. This suggests repurposing papaverine to enhance radiation therapy effectiveness.
Research finds cardiorespiratory fitness, high-intensity physical activity and low sedentary time all lower type 2 diabetes risk. The study, published in Diabetologia, suggests that a combination of these traits may be more beneficial than individual components.
Kessler Foundation will analyze the impact of its spatial neglect assessment and treatment protocols on stroke survivor recovery and independence. The two-year grant aims to confirm functional benefits and improve clinical benchmarks for stroke rehabilitation.
Pharmaceutical companies are adopting improved safety screening strategies to enhance the drug discovery process, including integrated screening paradigms and computational methods. These approaches aim to identify higher-quality drug candidates and mitigate off-target toxicity.