A genome sequencing study for rare parathyroid carcinoma has identified mutations in known cancer-related genes and pathways, providing a clear view of genetic mechanisms involved. This in-depth characterization could lead to the first therapy options for patients with this deadly cancer.
Research at The Mount Sinai Hospital found excessive histone acetylation in heroin users, leading to increased gene expression and addiction behavior. Treatment with JQ1 reduced heroin self-administration and drug-seeking behavior, suggesting potential therapeutic benefits.
A new study led by researchers at Mount Sinai Hospital found that early referrals to palliative care reduced healthcare utilization and increased use of support services after discharge. The study also showed significant improvements in 30-day readmission rates, hospice referral, and chemotherapy receipt.
Researchers from Mount Sinai Health System will present their study on the predictive value of the Fuster-BEWAT score for predicting the extent of subclinical atherosclerosis in healthy individuals, and another study exploring determinants of subclinical atherosclerosis in the absence of cardiovascular risk factors.
The Asthma Mobile Health Study demonstrates a successful, large-scale participant enrollment approach using iPhones and the Apple ResearchKit framework. The study collected rich research data from thousands of individuals, providing a comprehensive view of 'real-world' patterns of disease, wellness, and behavior.
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
A rheumatoid arthritis drug has been found to block a metabolic pathway that drives tumor growth in aggressive cancers with the PTEN gene mutation. Leflunomide kills human breast cancer cells in mice by damaging DNA produced through the pathway.
A research team at Mount Sinai has identified biological pathways involved in diabetic kidney disease, providing a potential diagnostic test and therapeutic strategy. The study found that blocking a cellular receptor can prevent kidney damage in mice with diabetic kidney failure.
A novel agent has significantly reduced episodes of swelling in patients with a rare genetic disorder. The drug, lanadelumab, works by suppressing the production of bradykinin, which causes swelling, and has been shown to be well-tolerated in a phase 1b clinical trial.
Researchers created a model showing the progression from normal blood cells to leukemia, allowing for testing of therapeutic interventions at each stage. The model enabled the transplantation of leukemia from humans to mice, paving the way for valuable research into therapies for blood cancer patients.
A study published in Nature Communications identifies a population of cells expressing Foxa2 that gives rise to cardiovascular cells of both left and right ventricular chambers. The research sheds light on the formation of heart chambers and may lead to new protocols for generating ventricular cardiomyocytes in cell culture.
Researchers at Mount Sinai Health System have developed an algorithm that predicts bone marrow transplant patients' risk of developing graft-versus-host disease. The 'MAGIC algorithm' uses two proteins in blood samples to determine a patient's risk, allowing for early intervention and potentially saving lives.
Researchers created a genetically modified rat model of autism and intellectual disability to study Phelan-McDermid syndrome. The study found that oxytocin improved social memory, attention, and nerve cell activity in the rat model.
A complete clinical and genetic profile of steroid 11-hydroxylase deficiency has been identified, a rare inherited disorder causing genital masculinization in females. The study may lead to prenatal diagnosis and treatment to prevent genital ambiguity.
Researchers at Mount Sinai discovered that specific signals in primary tumors induce dormant cancer cells that can evade chemotherapy. These 'dormant' cells are found in hypoxic regions of the tumor and may lead to disease relapse and poor prognosis.
A large study published in Depression and Anxiety found that gestational diabetes increases the risk of postpartum depression (PPD) in first-time mothers. Women with a history of depression are more than 20 times more likely to experience PPD, highlighting the importance of considering these conditions together.
A phase 3 trial found regorafenib significantly improved overall survival in patients with advanced hepatocellular carcinoma (HCC), a form of liver cancer. The study showed that regorafenib can improve survival in patients whose HCC progressed during treatment with sorafenib, an existing drug.
Researchers found that RGS9-2 promotes addiction to oxycodone in both pain-free and chronic pain states. The protein also plays a protective role against oxycodone tolerance. Understanding the mechanisms of oxycodone action can help develop new, less addictive pain management strategies.
Researchers found that estrogen intensifies the brain's dopamine reward pathway, leading to increased pleasurable effects of cocaine. The study suggests using birth control pills or similar strategies to adjust the hormonal cycle as a possible addiction intervention.
A study found gun violence research receives significantly less funding and publication volume than other leading causes of death, including sepsis and motor vehicle accidents. This disparity affects vulnerable communities disproportionately.
Researchers discovered cancer-driving gene mutations in uterine lavage fluid of women with and without endometrial cancer. The study's findings suggest that these pre-cancerous mutations can be detected using advanced genomic technologies, potentially leading to earlier diagnosis and improved treatment outcomes.
A team of investigators found that breast cancer cells with a few defined molecular alterations can spread to organs and form aggressive metastasis without a primary tumor. Most early spread cells remain dormant until a growth switch is activated.
Researchers at Mount Sinai have found measurable amounts of THC in the urine of young children exposed to secondhand marijuana smoke. The study highlights the need for education and awareness about the dangers of secondhand smoke to children in areas where marijuana use is common.
Researchers from Mount Sinai Health System presented various studies on multiple myeloma and other hematological disorders at the American Society of Hematology's Annual Meeting. The studies focused on treatment protocols, biomarkers, and gene expression in these diseases.
A team of surgeons at Mount Sinai Beth Israel has performed the first endoscopic transoral thyroidectomy in New York, removing the thyroid gland through three small incisions inside the mouth. The minimally-invasive procedure preserves critical structures and leaves a hidden scar.
Researchers developed a machine-learning model that can distinguish between pathological hypertrophic cardiomyopathy (HCM) and physiological changes in athletes' hearts, enabling easier diagnoses. The model demonstrated superior diagnostic ability comparable to conventional 2D echocardiographic and Doppler-derived parameters.
A research team has solved the three-dimensional structure of PrimPol, a key protein that helps damaged cellular DNA repair itself. The knowledge gained from this study will likely aid in designing anti-cancer agents.
Researchers use optimal coherence tomography (OCT) angiography to identify characteristic patterns of different forms of glaucoma based on their vascular patterns. This breakthrough technology could lead to earlier diagnosis and potentially slow down the progression of vision loss.
Mount Sinai researchers used EEG to study cue-induced craving in cocaine addicts and found that vulnerability to relapse peaks between one and six months of abstinence. This period coincides with patients' release from treatment programs, highlighting the need for alternative interventions to prevent relapse.
Researchers created a human heart tissue model using induced pluripotent stem cells to study hypertrophic cardiomyopathy, an excessive thickening of the heart associated with rare genetic disorders. The model revealed a previously unknown role for fibroblasts in triggering cardiomyocyte hypertrophy, offering new therapeutic possibilities.
Researchers found that a resort vacation immediately impacts molecular networks associated with stress and immune pathways. Meditation retreats were associated with antiviral activity, while long-term meditators had distinct molecular signatures.
Researchers found that obese individuals with insulin resistance showed improvement by avoiding AGEs, a byproduct of dry heat-cooked foods. A diet low in AGEs reduced insulin resistance, body weight, and AGE levels.
Researchers from Mount Sinai and international partners have identified specific genes that contribute to cardiometabolic diseases, such as heart attack and stroke. The study analyzed gene-expression data from patients with coronary artery disease and found genes that regulate blood lipid levels in abdominal fat.
Researchers identify Polycomb Repressive Complex 2 (PRC2) as a key player in maintaining medium spiny neurons' identity and function throughout adulthood. The study reveals that PRC2's dysfunction contributes to Huntington's disease-like symptoms in mice, highlighting its potential role in neurodegenerative disorders.
Researchers developed a 'dual molecular tuner' to rapidly manipulate two proteins in mammalian cells, offering an easy way to perform in-depth analyses. The tool uses plant hormones to target specific proteins for degradation, allowing for reversible and controllable manipulation of protein levels.
Researchers have identified a panel of genes that can help predict whether a transplanted kidney will develop fibrosis, leading to organ failure. The study's findings have the potential to change how doctors monitor and manage renal transplant patients.
A new study found that buprenorphine implants are non-inferior to sublingual buprenorphine in maintaining abstinence from opioids. The implants reduced adherence issues and improved efficacy in stable patients, offering a potential solution for addressing opioid dependence.
A new method called MICSSS helps characterize human cells involved in immune responses at the tissue site, before and after treatment with immunotherapy. This technique enables views of co-expression of markers on the same cells while sparing material from tissues.
A study found that parvalbumin-interneurons in the amygdala regulate emotional reactivity by suppressing surrounding neurons. This inhibitory plasticity is a normal consequence of memory encoding, but dysregulation may lead to hyperexcitability and pathological fear expression.
Researchers linked traumatic brain injury with later development of Parkinson's disease, but not Alzheimer's disease or incident dementia. The study, involving over 7,000 participants, found an association between TBI and Parkinson's disease, contradicting common assumptions about the relationship between TBI and Alzheimer's.
A study at Mount Sinai Hospital found that brain reward circuits, specifically the basal forebrain and lateral habenula, mediate motivation to engage in or avoid bullying. The research used a mouse model to demonstrate that activating this circuit makes bullying behavior pleasurable for some individuals.
Researchers found the 2009 swine H1N1 flu virus originated from pigs in a small region in central Mexico, with genetic analysis revealing its precise location and molecular transformations. This discovery sheds light on how animal influenza viruses infect humans and spread globally.
Mount Sinai scientists identified CBX8 as a protein that promotes tumor growth in the most lethal forms of breast cancer. This study highlights the need to focus on epigenetic factors and suggests new strategies against these aggressive cancers.
Researchers found that patients who were asked about their preferred site of death and those in hospices with frequent symptom monitoring had lower hospitalization rates. For-profit hospices, however, showed persistently high hospitalization rates regardless of practice implementation.
Researchers at Mount Sinai have shown how infected immune cells directly transmit newly minted viral particles to uninfected sister cells, spreading the virus efficiently. This study highlights cell-to-cell transmission as a key route for HIV spread and may help develop new treatments.
A new study suggests that an avian influenza virus vaccine can trigger broad and durable protection against multiple flu strains, offering a promising path toward a universal flu vaccine. The research identifies unique epitopes on the virus and highlights the potential of non-neutralizing antibodies in providing protection.
A new study from Mount Sinai researchers reports a high success rate for a personalized medicine program that uses an integrated genomic approach to guide cancer treatment. The program led to therapeutic recommendations for 91% of patients, outperforming targeted cancer panels in clinical use.
Researchers at Mount Sinai Hospital have developed a strategy to create the first broad-spectrum antiviral drug, which could provide protection against seven deadly viruses, including Nipah and Ebola. By targeting a single gene, the approach boosts immunity against viral infections.
Using clinical data from over 7 million US armed forces members, researchers identified patients with Crohn's disease and found that specific antimicrobial antibodies in their serum samples were associated with increased risk of complications. These biomarkers could potentially predict IBD development and inform preventive strategies.
Scientists used gene therapy to halt pulmonary hypertension progression in a large animal model. The approach delivered SERCA2a gene via aerosol inhalation, slowing vascular changes and improving heart function. Further studies are needed to assess long-term efficacy and safety before human clinical trials.