Researchers at Mount Sinai developed a clinical index to evaluate muscle-related symptoms associated with statin use. The team proposes re-challenging or switching statins, adopting healthy lifestyle changes, and exploring non-statin pharmacotherapies to optimize cholesterol treatment for patients experiencing adverse muscle symptoms.
A study by researchers at Mount Sinai identified a brain mechanism that makes siblings of bipolar patients resilient to the disease. The brain can adapt to its biological risk, opening new avenues for research on enhancing resilience.
A study examined the risk of intellectual disability (ID) in children born to mothers treated with antidepressants and found a slightly elevated risk, but it was not statistically significant. The researchers suggest that other factors such as parental age and psychiatric history may contribute to the risk.
A study applying machine learning techniques to the Look AHEAD Trial data found that 85% of participants experienced a clinically meaningful reduction in cardiovascular mortality and morbidity through intensive weight loss intervention. However, 15% of subjects had an increased risk of cardiovascular events due to weight loss.
A new study found that dying adults in the US receive almost twice as much caregiving support per week compared to those not at the end of life. Unpaid family caregivers, particularly spouses, report high levels of physical difficulty and time constraints.
The study found that men have a higher plaque burden than women, and that it increases with age. The 3D vascular ultrasound technique has the potential to become a key screening tool for identifying at-risk individuals.
Researchers at Mount Sinai Hospital have developed a novel technique to continuously monitor laryngeal and vagus nerve function during otolaryngology and neurosurgery procedures. This non-invasive method uses a special breathing tube to stimulate and record nerve responses, allowing surgeons to adjust their approach in real-time.
Researchers discovered an ancient antiviral defense system in human cells that could be used to deliver targeted therapies using engineered viruses or simple self-replicating RNAs. This system, which dates back billions of years, was originally designed to defend against viral infection and may hold the key to new treatments for diseases.
Researchers found that wire-free electrodes and the round window surgical approach improved long-term hearing preservation in cochlear implant patients. The study's lead investigator notes that these findings have major implications for doctors and patients seeking to restore their hearing.
Researchers identified a network of genes expressed in myeloid cells that contribute to Alzheimer's disease pathogenesis. A protein called PU.1 regulates this gene network, which may hold promise for therapeutic targets.
Researchers identify early stress as a molecular basis for lifelong depression susceptibility, revealing a critical role for the developmental transcription factor Otx2. Mice stressed in early life exhibit suppressed Otx2 levels and increased depression-like behavior in adulthood, highlighting a sensitive period for brain development.
A treatment for depression using the Emotional Faces Memory Task resulted in a significantly greater reduction of major depressive disorder symptoms compared to a control group. The digital therapeutic targets an imbalance in brain regions involved in emotion processing and cognitive control.
A new study published in Nature Communications found that differences in toxin and nutrient uptake during critical developmental windows increase autism risk. Researchers analyzed baby teeth to identify associations between metal exposure and ASD severity, suggesting a potential pathway for interplay between genes and environment.
A study found that repeated exposure to anesthesia during infancy results in impaired visual recognition memory, which emerges after the first year of life. The research used a rhesus monkey model and confirmed that multiple anesthesia exposures alone lead to memory impairment, with deficits not apparent until later developmental stages.
Researchers analyzed orangutan teeth to reconstruct diet histories and determine nursing patterns, shedding light on the evolution of human breast-feeding. Orangutans' cycles of milk consumption may inform models of population growth and resilience in humans.
A study published in JAMA found that systemic therapy with oral corticosteroids and immunosuppression can preserve or improve vision in the long term, better than regional implant therapy, for patients with severe uveitis. The treatment approach showed fewer ocular side effects and no significant increase in systemic side effects.
A research team identified a mechanism by which influenza A viruses hijack cellular machinery to replicate, including the RNA exosome. This process is linked to congenital defects and neurodegeneration in people with rare mutations. The study offers future insight into common brain disorders such as Alzheimer's and Parkinson's diseases.
A new study maps immune system components in early lung cancer, identifying potential targets for immunotherapy and suggesting a possible cure. The research reveals that early lesions are heavily infiltrated with immune cells, making immunotherapy a promising treatment option.
Patients operated on by high-volume mitral valve surgeons experience lower one-year mortality and reoperation rates compared to those performed by lower-volume surgeons. High-volume surgeons are more likely to perform durable repairs, with repair rates ranging from 77% for 51+ cases to 48% for fewer than 10 cases.
Researchers identified cyclic GMP-AMP synthase (cGAS) as the protein responsible for detecting viral infection, but dengue virus counteracts this by degrading cGAS. This study sheds light on a novel mechanism by which viruses evade immune detection and may inform techniques to dampen pro-inflammatory responses.
A new study from the Icahn School of Medicine at Mount Sinai suggests that the sympathetic nervous system, not macrophages, is the main driver of thermogenesis. The research team found that catecholamines released by the sympathetic nervous system can convert white fat tissue into a tissue resembling brown fat.
Researchers found that the prefrontal cortex teaches the hippocampus to differentiate goal-related memories, enabling rapid integration of memories with goals. This cognitive flexibility is disrupted in neuropsychiatric conditions like schizophrenia and depression.
Researchers found that pre-existing immunity to dengue and West Nile viruses can cause increased risk of severe Zika virus infection. High concentrations of antibodies from these infections offered protection, while lower concentrations led to enhanced morbidity and mortality.
A study led by Mount Sinai researchers found that knee replacement surgery provides only small improvements in quality of life, especially in patients with less severe physical function. The procedure's economic attractiveness increases when offered to those with more severe symptoms.
A genome sequencing study for rare parathyroid carcinoma has identified mutations in known cancer-related genes and pathways, providing a clear view of genetic mechanisms involved. This in-depth characterization could lead to the first therapy options for patients with this deadly cancer.
Research at The Mount Sinai Hospital found excessive histone acetylation in heroin users, leading to increased gene expression and addiction behavior. Treatment with JQ1 reduced heroin self-administration and drug-seeking behavior, suggesting potential therapeutic benefits.
A new study led by researchers at Mount Sinai Hospital found that early referrals to palliative care reduced healthcare utilization and increased use of support services after discharge. The study also showed significant improvements in 30-day readmission rates, hospice referral, and chemotherapy receipt.
Researchers from Mount Sinai Health System will present their study on the predictive value of the Fuster-BEWAT score for predicting the extent of subclinical atherosclerosis in healthy individuals, and another study exploring determinants of subclinical atherosclerosis in the absence of cardiovascular risk factors.
The Asthma Mobile Health Study demonstrates a successful, large-scale participant enrollment approach using iPhones and the Apple ResearchKit framework. The study collected rich research data from thousands of individuals, providing a comprehensive view of 'real-world' patterns of disease, wellness, and behavior.
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
A rheumatoid arthritis drug has been found to block a metabolic pathway that drives tumor growth in aggressive cancers with the PTEN gene mutation. Leflunomide kills human breast cancer cells in mice by damaging DNA produced through the pathway.
A research team at Mount Sinai has identified biological pathways involved in diabetic kidney disease, providing a potential diagnostic test and therapeutic strategy. The study found that blocking a cellular receptor can prevent kidney damage in mice with diabetic kidney failure.
A novel agent has significantly reduced episodes of swelling in patients with a rare genetic disorder. The drug, lanadelumab, works by suppressing the production of bradykinin, which causes swelling, and has been shown to be well-tolerated in a phase 1b clinical trial.
Researchers created a model showing the progression from normal blood cells to leukemia, allowing for testing of therapeutic interventions at each stage. The model enabled the transplantation of leukemia from humans to mice, paving the way for valuable research into therapies for blood cancer patients.
A study published in Nature Communications identifies a population of cells expressing Foxa2 that gives rise to cardiovascular cells of both left and right ventricular chambers. The research sheds light on the formation of heart chambers and may lead to new protocols for generating ventricular cardiomyocytes in cell culture.
Researchers at Mount Sinai Health System have developed an algorithm that predicts bone marrow transplant patients' risk of developing graft-versus-host disease. The 'MAGIC algorithm' uses two proteins in blood samples to determine a patient's risk, allowing for early intervention and potentially saving lives.
Researchers created a genetically modified rat model of autism and intellectual disability to study Phelan-McDermid syndrome. The study found that oxytocin improved social memory, attention, and nerve cell activity in the rat model.
A complete clinical and genetic profile of steroid 11-hydroxylase deficiency has been identified, a rare inherited disorder causing genital masculinization in females. The study may lead to prenatal diagnosis and treatment to prevent genital ambiguity.
Researchers at Mount Sinai discovered that specific signals in primary tumors induce dormant cancer cells that can evade chemotherapy. These 'dormant' cells are found in hypoxic regions of the tumor and may lead to disease relapse and poor prognosis.
A large study published in Depression and Anxiety found that gestational diabetes increases the risk of postpartum depression (PPD) in first-time mothers. Women with a history of depression are more than 20 times more likely to experience PPD, highlighting the importance of considering these conditions together.
A phase 3 trial found regorafenib significantly improved overall survival in patients with advanced hepatocellular carcinoma (HCC), a form of liver cancer. The study showed that regorafenib can improve survival in patients whose HCC progressed during treatment with sorafenib, an existing drug.
Researchers found that RGS9-2 promotes addiction to oxycodone in both pain-free and chronic pain states. The protein also plays a protective role against oxycodone tolerance. Understanding the mechanisms of oxycodone action can help develop new, less addictive pain management strategies.
Researchers found that estrogen intensifies the brain's dopamine reward pathway, leading to increased pleasurable effects of cocaine. The study suggests using birth control pills or similar strategies to adjust the hormonal cycle as a possible addiction intervention.
A study found gun violence research receives significantly less funding and publication volume than other leading causes of death, including sepsis and motor vehicle accidents. This disparity affects vulnerable communities disproportionately.
Researchers discovered cancer-driving gene mutations in uterine lavage fluid of women with and without endometrial cancer. The study's findings suggest that these pre-cancerous mutations can be detected using advanced genomic technologies, potentially leading to earlier diagnosis and improved treatment outcomes.
A team of investigators found that breast cancer cells with a few defined molecular alterations can spread to organs and form aggressive metastasis without a primary tumor. Most early spread cells remain dormant until a growth switch is activated.
Researchers at Mount Sinai have found measurable amounts of THC in the urine of young children exposed to secondhand marijuana smoke. The study highlights the need for education and awareness about the dangers of secondhand smoke to children in areas where marijuana use is common.
Researchers from Mount Sinai Health System presented various studies on multiple myeloma and other hematological disorders at the American Society of Hematology's Annual Meeting. The studies focused on treatment protocols, biomarkers, and gene expression in these diseases.
A team of surgeons at Mount Sinai Beth Israel has performed the first endoscopic transoral thyroidectomy in New York, removing the thyroid gland through three small incisions inside the mouth. The minimally-invasive procedure preserves critical structures and leaves a hidden scar.
Researchers developed a machine-learning model that can distinguish between pathological hypertrophic cardiomyopathy (HCM) and physiological changes in athletes' hearts, enabling easier diagnoses. The model demonstrated superior diagnostic ability comparable to conventional 2D echocardiographic and Doppler-derived parameters.