Researchers discovered a novel molecular mechanism that maintains glioma stem cells, which are responsible for tumorigenesis, treatment resistance, and tumor recurrence in glioblastoma. A small molecule inhibitor CMP3a selectively inhibits NEK2 kinase activity to promote tumor growth and radiation resistance.
Researchers discover moss sperm uses glutamate receptors to navigate towards female organs, fertilize eggs and develop spores. The study also shows that glutamate receptors play a crucial role in controlling gene expression essential for spore development.
The Indian summer monsoons have strengthened in the last 15 years over north central India, reversing a 50-year drying period. This increase in monsoon rainfall is attributed to a shift in India's land and sea temperatures, with higher land temperatures combining with lower ocean temperatures.
Researchers found that Medicaid expansion under the ACA reduced total emergency department visits in Maryland by nearly 36,000, with a 6% increase in Medicaid-covered visits and a 6% decrease in uninsured patient visits. The study suggests that while the ACA did not immediately reduce emergency department utilization, it provides incre...
A hospital implemented a water intake improvement project to increase patient hydration, resulting in increased water intake among patients undergoing bariatric surgery. The study found that standardizing the intake process led to significant improvements in hydration and reduced variability in postoperative fluid progression.
Researchers at UMD developed a new battery type that produces ionic electrical energy used by humans, powering brain functions and muscle movements. The battery uses grass to store energy and can be run at any voltage, making it suitable for medical devices and potential applications in neuroscience.
Researchers at The Wistar Institute have discovered a potential new therapeutic strategy for ovarian clear cell carcinoma, a difficult-to-treat form of ovarian cancer. By targeting the activity of histone deacetylase 6, a protein that suppresses tumor suppressive functions, they were able to increase apoptosis in tumor cells and reduce...
Researchers identified a cellular signaling pathway blocking immune cell infiltration into bladder tumors, explaining the limited success of checkpoint immunotherapy. The finding suggests targeting this pathway could enhance treatment effectiveness when combined with checkpoint immunotherapy.
A new study has found a link between adolescent obesity and an increased risk of developing colon and rectal cancer in adulthood. The study analyzed data from over 1.7 million Israeli males and females, finding that being overweight or obese at age 17 was associated with a significantly higher risk of colorectal cancer.
Researchers have revised the understanding of a large group of Neotropical 'club-tailed' scorpions, revealing two new genera and three new species. The findings provide insight into the evolution and classification of these ancient arthropods, which are among the oldest living terrestrial species on Earth.
Childhood dementia, an inherited disorder affecting brain metabolism, shows promise in treating with immunomodulators. Inflammation of the brain is a key feature, and drugs like fingolimod and teriflunomide have shown therapeutic effects in mouse models.
A study published in PNAS found that exposure to violent episodes hinders short-term memory and cognitive control, with significant impacts on school performance, job prospects, and overall life success. Researchers examined civilians in Colombia, finding long-lasting effects of violence on cognition and memory recall.
A new American College of Surgeons quality improvement program linked to a two-thirds decrease in smoking rates in patients undergoing cervical and lumbar spine procedures. The program, Strong for Surgery, helps patients prepare for surgery by identifying and evaluating evidence-based practices to optimize their health.
A new phylogenetic tree resolves key relationships among vertebrates, including the identification of lungfishes as closest living relatives of land vertebrates. The study uses a novel set of analyses for building large-scale genomic datasets.
Researchers found that rats partially recovered hind limb movement using cycling, semi-load bearing treadmill training, and serotonin treatment without healing the spinal cord break. The body re-routes nerve cell outputs to control muscles and stiffens back muscles to support weight and independent steps.
A new study synthesizes research on coastal armoring and its ecological effects, revealing gaps in knowledge and highlighting the need for more studies. The study evaluates a conceptual model that predicts ecological responses to armoring across various soft sediment ecosystems.
Scientists at Nagoya University developed a new material that conducts electricity and emits white light when exposed to electricity. The 'responsive porous host' method allows for predictable synthesis of stimuli-responsive materials with potential applications in memory devices, artificial muscles, and drug delivery systems.
Researchers discovered that a specific neural signal in the brain regulates young animals' ability to learn behavioral patterns from adults, particularly in zebra finches. The findings suggest that disruptions in this protein complex may be involved in neurodevelopmental disorders, such as autism spectrum disorder.
Researchers at UNC are testing a therapeutic vaccine to target HIV reservoirs and boost the immune system's response. The goal is to potentially pair the vaccine with latency-reversing agents to clear the virus.
Research by LSU Health New Orleans scientists may lead to a treatment for long-term sensory problems in cardiac arrest survivors. The study used rodent models and computer modeling to show that cardiac arrest damages the cerebral cortex, leading to decreased sensory responsiveness.
A phase 2 trial found that an injectable antiretroviral therapy was as effective in maintaining viral suppression in patients with HIV as a daily oral dose over 96 weeks. The long-acting injections had similar efficacy to the daily oral medication in preventing treatment failure and drug-resistant mutations.
Research from the University of Illinois found that soybean meal produced in different countries has varying levels of digestible protein and amino acids. The study suggests that US, Indian, and Brazilian soybean meals have higher concentrations of these nutrients compared to Argentine and Chinese alternatives.
Researchers at Friedrich Schiller University Jena reconstructed a 300 million-year-old beetle from Australia, shedding new light on the earliest developments in beetles. The 'Bad Boy' exhibits an unorthodox mix of ancestral and modern characteristics, challenging traditional beetle classification.
Research at the University of British Columbia and Harvard Business School found that spending money on time-saving purchases leads to greater life satisfaction. The study surveyed over 6,000 adults across four countries and controlled for income, revealing that buying time has similar benefits as having more money.
Researchers found that dog owners who walk their pets regularly are more active and less sedentary on rainy days than those without dogs. Dog ownership is linked to increased physical activity levels, reduced daily sitting time, and improved health outcomes.
A new study predicts that habitat loss on wintering grounds will be the greatest threat to eastern forest birds, exacerbated by climate change. The research found that bird species spend up to 60% of their year in Central America's wintering grounds, where habitat conversion and land-use changes will have a significant impact.
A new study found that over half of HIV-positive transgender women are concerned about combining antiretroviral therapy with feminizing hormone therapy due to unknown drug interactions. This concern affects their adherence to medication and treatment, highlighting the need for better health care optimization.
A study found that pregnant women who took antidepressants were 45% more likely to have children diagnosed with autism, but the effect was limited. The research suggests that only a small proportion of cases would be prevented if antidepressant use was completely cut off during pregnancy.
Researchers at Vanderbilt University have developed a method to produce patterned monolayers that can perform multiple functions, such as catalyzing chemical reactions and sensing molecules. These materials offer a new option for device designers, allowing for the creation of single materials with two functionalities.
Tropical Depression Roke made landfall in Hong Kong on July 23, weakening from a tropical storm earlier that day. After the landfall, NASA's Terra satellite captured visible light images of the depression, showing an elongated area of clouds and thunderstorms along the southeastern coast of China.
Jessica Hodgins, a pioneer in character animation and robotics, has been recognized with the prestigious Steven Anson Coons Award for her outstanding contributions to computer graphics. Her work on physical simulation and control has advanced the development of realistic computer animations and human-robot interaction.
Researchers from Mass Eye and Ear successfully prevented mice from developing retinal angiogenesis using CRISPR-Cas9 gene-editing techniques. The technique targets VEGFR2, a critical protein responsible for angiogenesis, and showed promising results in preclinical models.
Researchers found that people with insecure attachment styles have weaker social networks, struggle to form new relationships, and are more likely to dissolve ties. Primes can improve attachment security and relationship maintenance on social networks.
Two undergraduate students from the University of Illinois improved plant carbon-cycle models by discovering variation in stomata behavior among different tree species. Their findings reduced error rates by 30-60%, increasing model accuracy and improving predictions of crop growth, biomass production, and ecosystem dynamics.
Researchers develop method to directly observe dynamic fracture in metals, shedding light on material properties and behavior under stress. The technique enables real-time observation of atomic structure deformation and determination of stress required for fracture.
Inlighta Biosciences is developing a novel, protein-based MRI contrast agent called ProCA32 to detect early stages of liver cancers and other metastatic tumors. The agent has shown improved imaging contrast compared to conventional agents, enabling earlier detection and characterization of cancerous lesions.
A comprehensive study published in Nature Communications reveals that lean body mass is highly heritable and can be attributed to specific genes. The research may lead to the development of future therapies to prevent the loss of lean mass and associated disabilities such as sarcopenia.
A new study published in Nature Communications suggests that the Tibetan Plateau's unique shape may be explained by the strength of the tectonic plates involved in its formation. The research found that a strong Asian plate results in a narrow plateau, while a weak Asian plate produces a broad one.
Researchers from MIT's CSAIL have developed InstantCAD, a tool that enables designers to interactively edit and optimize CAD models using a streamlined workflow. This allows for real-time improvements and optimizations, reducing the time required to test and refine complex designs.
A University of Exeter study found that drinking alcohol boosts memory recall for information learned before the drinking episode began. Those who consumed more alcohol showed stronger effects on memory performance.
A new study reveals a significant increase in calls to poison control centers regarding dietary supplement exposures, with yohimbe and energy products posing serious health risks. The study's findings support the need for improved regulation, child-resistant packaging, and caregiver education.
NC State researchers pinpoint a specific gene, caffeoyl-CoA O-methyltransferase, associated with partial resistance to Southern leaf blight and gray leaf spot, and possibly Northern leaf blight. The gene is involved in lignin production and can be used to build disease-resistant corn plants.
Researchers developed an algorithm that identifies the most influential people in social networks, known as 'hubs', and targeting them can effectively isolate a contagion. The approach shows promising results in controlling diseases like parasitic worm infections by treating fewer households.
A new classification system, AIR score, based on patient symptoms and lab tests reduces diagnostic imaging, hospital admissions, and surgery needs. The system was tested in a study of 1068 patients with suspected appendicitis, resulting in improved care outcomes.
Babraham Institute group leader Dr Rahul Roychoudhuri has been selected for the £200,000 Lister Institute Research Prize Fellowship to support his research on immune system regulation and suppression. His goal is to better understand how gene regulators affect T cells and potentially treat autoimmune diseases.
A protocol called Enhanced Recovery After Colorectal Surgery (ERACS) has improved outcomes for colorectal surgical patients by reducing hospital stays by over half and complications by more than one-third. The study also found significant cost savings of up to $11,000 per procedure.
A new study reveals that neighboring deep-sea vents host drastically different animal communities, contradicting the common assumption that similar habitats share animal species. The research highlights the significance of local geology and vent fluid chemistry in shaping these communities.
A new clinical decision support tool calculates and displays kidney failure risk based on criteria identified from a large cohort study. The tool automatically calculates and displays a risk score within the health record, making it easier for physicians to spot disease progression and take action.
Scientists have discovered a novel way to create superconductors at higher temperatures using boron-doped Q-carbon, with a transition temperature of 57K. This breakthrough could lead to practical applications in fields like energy and transportation.
A new study using physics to predict where and how dialects occur suggests that dialects tend to move outwards from population centers. This theory explains why cities have their own dialects and how language boundaries get smoother over time.
A recent study found that the scent of a praying mantis can cause fruit flies to spend less time eating, more time being vigilant, and produce fewer offspring, leading to increased extinction risk. The study sheds light on the Allee effect, a long-standing biological conundrum related to population size and extinction.
A recent study published in Frontiers in Public Health found that up to 90% of adult males and 50% of children in the US may be overfat. The condition is linked to various health problems, including hypertension, coronary heart disease, and Type 2 diabetes.
A study found that excessive chemical applications in Bangladeshi lychee orchards may have triggered acute encephalitis syndrome, killing 13 children. The chemicals, including the banned endosulfan, were applied liberally and included residues on clothing worn into homes.
A new NASA study using data from the Van Allen Probes spacecraft has discovered that plasmaspheric hiss waves are more complex than previously understood. Low-frequency hiss waves interact with high-energy particles and can efficiently remove them from the radiation belts, protecting satellites.
A team from HZB and EMPA successfully realized direct electron beam writing of silver nanocrystals using Electron-Beam-Induced Deposition. This breakthrough enables the creation of complex features onto a substrate in a single step, promising applications in nano-optics and information technology.
A new study published in CMAJ found that people who survive a stroke or mini-stroke without early complications have an increased risk of death and stroke for at least 5 years following the initial event. Researchers recommend long-term management of modifiable risks, such as high blood pressure and physical activity, to reduce this risk.
Tropical Storm Sonca is forecast to strengthen to 57 mph before making landfall in central Vietnam on July 25. The storm appeared elongated due to wind shear but is expected to make landfall just south of the city of Vinh.
Research reveals that fathers with a record are nearly 50% less involved in their child's education, linked to distrust and avoidance of 'surveilling institutions'. This can lead to poor educational outcomes and transfer feelings of institutional distrust, setting up disadvantage from early childhood.
Researchers at Duke University have developed a new way to produce the seasonal flu vaccine that could speed up production and provide better protection against infection. By keeping the human influenza virus from mutating during production, they generate a perfect match to the target vaccine in a shorter time frame.
A new study found that individuals with higher cognitive abilities are more likely to learn and apply social stereotypes. However, they also tend to update their stereotypes more quickly when presented with new information.