Tumor cells develop resistance to immunotherapy by downregulating MHC class I molecules and triggering immunosuppressive processes. Inhibiting the epigenetic control protein Ezh2 improves treatment efficacy, leading to increased tumor mass shrinkage and extended tumor-free survival.
Researchers developed nanoparticles loaded with curcumin, a common spice compound, to target and destroy treatment-resistant neuroblastoma tumor cells. The study showed promising results in killing cancer cells while producing minimal toxicity in healthy cells.
The University of Sydney and Microsoft have partnered to create a premier centre for quantum computing, focusing on scaling up the technology and its applications. The partnership aims to build a rich and robust local quantum economy, attracting skilled people and investing in new equipment.
Scientists will use twin telescopes on NASA's WB-57F jet planes to capture high-resolution images of the Sun's outer atmosphere and thermal images of Mercury. The observations aim to study coronal heating and temperature variation across Mercury's surface.
Researchers from an international collaboration have analyzed data from the Venus Express spacecraft to investigate Venus's complex atmosphere. They found that stationary gravity waves at higher altitudes are related to surface elevations, suggesting wind currents caused by topographical obstacles contribute to the planet's superrotation.
A study published in mBio found a ten-fold increase in certain bacteria under the foreskin can increase HIV risk, suggesting that penile microbiome may be a previously unrecognized risk factor. The researchers also suggest that this risk factor may be sexually transmissible and could lead to novel ways to protect against HIV infection.
A team of UC Berkeley researchers has developed a new technique for real-time user-guided colorization using deep neural networks. The system enables novice users to quickly produce reasonable results by learning common colors for different objects and making recommendations in real-time.
Scientists have developed a new technique to produce high-density clusters of aligned quantum sensors in diamond, just nanometers from the surface. This enables submolecular sensitivity for microscopy, allowing researchers to detect changes in protein concentration within single cells.
Children start recognizing and following important rules governing English letter patterns, even before learning how letters represent sounds, around 3-5 years old. As they get older, their invented spellings improve, becoming more word-like in appearance.
Researchers at the University of East Anglia have discovered a gene that regulates the size of diatom cells, which contribute 20% to global primary production. The discovery could have significant implications for understanding the effects of climate change on future food webs and the potential impact on phytoplankton cell sizes.
Researchers developed a novel, tough, and triggerable hydrogel material that addresses safety concerns of traditional swallowable drug delivery systems. The new material can withstand gastrointestinal forces and release medication in a controlled manner.
A randomized trial found that same-day ART initiation improved retention (80% vs. 72%) and evidence of ART working (53% vs. 44%), with further improvements needed to hit UNAIDS 90-90-90 targets. The study supports accelerating HIV testing and treatment processes.
Researchers found that bonobos do not copy actions as children do, highlighting the unique nature of human imitation. The study suggests that over-imitation in young children may be a critical factor in explaining why human cultures differ from those of great apes.
The NRG-RTOG 0436 trial found that adding an epidermal growth factor receptor (EGFR) inhibitor to a chemo-radiation regimen does not improve overall survival for patients with locally advanced esophageal cancer. The trial showed no significant benefit from the addition of EGFR inhibitor cetuximab to standard treatment.
Researchers from KIT developed a novel material based on porphyrin to speed up rechargeable battery charging. The new material allows for high-performance energy storage and supercapacitors with exceptional properties.
A study conducted in the US has found that adolescent girls can safely use a dapivirine vaginal ring to prevent HIV. The ring, which contains an antiretroviral drug, was shown to be highly acceptable and easy to use, with high adherence rates among participants.
Researchers at the University of British Columbia developed a smart surface that can repel and absorb liquids, controlled by applying electric potential. The copper-based surface exhibits rapid and reversible changes in wetting behavior, making it suitable for various industrial and consumer applications.
A study found that total weed density was greatest when soil was tilled early in the growing season, while late-season tillage resulted in fewer weeds. This suggests that adjusting tillage timing can improve weed management and crop yields.
A new study found that children raised in rural households have a lower risk of developing inflammatory bowel disease, particularly those under the age of 10. The study identified 45,567 patients diagnosed with IBD and found that rural residents had a significantly lower incidence of the disease compared to urban residents.
A two-year clinic-based HIV testing program in Zimbabwe failed to identify many cases of HIV in children. The study found that 37.7% of HIV-positive children were undiagnosed, highlighting the need for alternative testing methods to reach these vulnerable populations.
Researchers found that mindfulness and hypnotic suggestion significantly reduced acute pain levels in hospital patients, with patients experiencing a 29% and 23% reduction in pain respectively. These brief mind-body therapies also led to a significant decrease in the perceived need for opioid medication.
A genetic predisposition to higher blood calcium levels is associated with an increased risk of coronary artery disease and heart attack. The study used mendelian randomization to examine the association between serum calcium levels and CAD, finding a link between the two.
Researchers developed a gene therapy using microdystrophin to treat Duchenne muscular dystrophy in dogs. The treatment restored muscle function and stabilized clinical symptoms for over 2 years. This breakthrough could lead to a new treatment for children with the disease.
Researchers analyzed Trump's 3200 tweets to find that he exhibits strong features of a Schumpeterian personality, characteristic of successful entrepreneurs. He shows creative and change-oriented behavior, but also struggles with emotional stability.
Researchers have successfully manipulated the 'valley' property in electrons using light, a crucial step towards realizing valleytronics technology. This breakthrough has potential applications in logic gates and is a major advancement in the field of materials science.
Tropical Storm Greg is weakening due to wind shear in the Eastern Pacific Ocean, with convection confined to its northwestern quadrant. The storm is expected to move towards the northwest and then west, leading to a gradual decline in its strength.
Tropical Depression Kulap is a waning storm moving west-southwest at 12.6 mph, affected by dry air and northerly wind shear. The Joint Typhoon Warning Center predicts the storm to dissipate late on July 26.
A recent study found that men with hepatitis B are more than twice as likely to develop severe liver disease as women, even when accounting for lifestyle and environmental factors. Drinking alcohol significantly increases liver disease risk in both men and women, but sex remains the strongest indicator of liver disease severity.
Researchers have produced new maps of dark matter dynamics in the Universe, revealing detailed information about matter streams and velocities. This study uses legacy survey data to build on previous research and provides insights into the nature of dark matter.
Researchers argue that basic legal and ethical principles surrounding consent are unclear, threatening the validity of large-scale biobanking projects. The authors call for explicit policy action to address these issues.
The Massachusetts General Hospital team, led by J. Keith Joung, is developing more sensitive methods of measuring and controlling on-target gene-editing activity and detecting off-target mutations induced by CRISPR-Cas9 technology.
A new study published in Radiology uses a combination of MRI techniques to identify brain regions associated with cognitive impairment in active professional fighters. The researchers found that lower gray matter volume and white matter tract integrity at baseline measurements were linked to increased risk of cognitive decline over time.
A comprehensive study reveals a 52.4% decline in sperm concentration and a 59.3% decline in total sperm count among Western men, highlighting impaired male health and decreasing fertility. The study suggests environmental and lifestyle influences may be contributing factors.
Individuals with high levels of psychopathic traits are better at learning to lie than those with few psychopathic traits, according to a study. After practicing a lying task, individuals with high psychopathic traits showed significant improvements in response time, whereas those with low psychopathic traits did not.
Eating Mediterranean and MIND-style diets is linked to lower risks for memory difficulties and cognitive impairment in older adults. The studies found that participants who ate these healthy diets scored significantly better on cognitive function tests, with a 35% lower risk of poor performance.
Researchers at Duke University discovered how fungal spores use the power of merging water droplets to launch themselves. The team used high-speed cameras and an inkjet printer to study the mechanism, which involves the release of energy from the merged drop causing the spore to break away.
A new study found that calves born to cows experiencing heat stress during early pregnancy exhibit related effects throughout their lives. Milk production and fat yield are higher for winter-conceived calves compared to summer-conceived calves.
Researchers at UCLA have discovered a link between brain wave frequency and nonverbal IQ in children with autism. The study found that lower peak alpha frequency corresponds to lower non-verbal IQ, suggesting a potential biomarker for detecting autism severity.
Researchers at Princeton University have successfully tested a cell-culture system that allows for the long-term study of hepatitis B virus (HBV) infections. This breakthrough may aid in the development of antiviral drugs to cure chronic HBV, which can cause severe liver disease and cancer.
The HPTN 077 study found that long-acting injectable cabotegravir was well-tolerated by men and women, with consistent levels in the bloodstream and good acceptance. The 600mg dose every 8 weeks showed promising results for HIV prevention.
Cachexia, a deadly weight loss condition in cancer patients, is caused by systemic inflammatory reactions triggered by cancer cells. Researchers discovered that autophagic stimuling compounds and pro-inflammatory cytokine IL-6 are associated with muscle mass loss, providing potential treatment options.
A two-year project will use drones and high-resolution imagery to estimate koala abundance, providing a robust survey method for detecting the native fauna. The State Government has committed additional $12.1 million for koala conservation, including ongoing funding for protection.
UCSB researchers are evaluating urban wildfire patterns and resilience strategies using a $1.5 million National Science Foundation grant, integrating atmospheric, fire-spread, and transportation models to enhance the understanding of extreme fire weather regimes and wildfire behavior in the wildland-urban interface.
Researchers at the University of Adelaide and Lund University have discovered brain cells that enable dragonflies to predict the movement of their prey, allowing them to hunt successfully. This knowledge could lead to advances in fields like robot vision and artificial intelligence.
A new model suggests that police should use confrontational tactics in areas with high gang violence to deter crime, while avoiding them in areas with low community trust. The model also highlights vast racial disparities in police stops and arrests.
Researchers at Aalto University developed a chemical method to create graphene nanoribbons with embedded electronic components, including diodes and tunnel barriers. The precision of the structures was achieved through atomic-level control over the chemical reaction process.
Researchers at Tohoku University have created a new synthesis route for alternative catalysts of noble metals, overcoming stability issues with organic-based and carbonaceous materials. This breakthrough could lead to more efficient and cost-effective eco-friendly technologies, including fuel cell vehicles and CO2 reduction.
Following terrorist attacks in Paris and Nice, French experts highlighted the importance of a coordinated medical response, including improved victim identification processes and equipment. The authors also emphasized the need for psychological care and support for those affected, as well as preparedness for future attacks with evolvin...
The Atmospheric Infrared Sounder instrument aboard NASA's Aqua satellite gathered data on Tropical Storm Irwin, revealing a large area of strong storms with cloud top temperatures as cold as minus 63 degrees Fahrenheit. This suggests that the storm has the potential to generate heavy rainfall and strengthen into a hurricane.
The Envirobot robot uses chemical, physical and biological sensors to map variations in water conductivity and temperature, detecting heavy metals like mercury. Biological sensors comprising bacteria, crustaceans and fish cells indicate water toxicity.
Ramesh Raskar has made significant impact in computational imaging, light transport and augmented reality with techniques like femto-photography. His work has led to applications such as EyeNetra, a low-cost technique to measure human refractive error and prescribe eyeglasses.
A 12-week yoga program significantly improves disability scores and reduces pain intensity in military veterans with chronic low back pain. Notably, these benefits persist even after six months, suggesting long-term potential for yoga as a non-drug treatment.
A high proportion of former NFL players had neuropathological evidence of CTE, with 110 out of 111 players diagnosed. The study also found a link between CTE and previous football participation, with severe pathology more common among professional players.
Researchers in Oklahoma compared measured soil moisture with the Keetch-Byram Drought index and found that high-quality soil moisture data consistently outperformed KBDI. Soil moisture conditions conducive to large wildfires were more narrowly defined, providing earlier warnings of extreme wildfire potential.
A new study found that Caribbean staghorn corals are benefiting from 'coral gardening,' which involves planting laboratory-raised coral fragments on reefs. The research provides important benchmarks for the long-term survival of coral reefs worldwide, which have been declining due to climate change and ocean pollution.
Typhoon Noru's eye was surrounded by powerful thunderstorms with cloud top temperatures as cold as 210 kelvin, indicating potential for heavy rainfall. NASA's infrared data will aid forecasters in tracking the storm's trajectory, predicting landfall on July 30 near Japan.
Researchers found an increased mutation rate in genes, including TP53, among African-American patients with smoking-related cancers. The study suggests that these genetic differences may contribute to resistance to chemotherapy and poorer outcomes.
Researchers at the Naval Research Laboratory have discovered a new phase change mechanism in monolayer Transition Metal Dichalcogenides (TMDs) that can be used to create highly sensitive chemical vapor sensors. The sensors can detect nerve agents and explosives with high selectivity and sensitivity.
Two clinical trials found that adolescents using oral Truvada and a vaginal ring for HIV prevention had high adherence rates, with most participants taking the medication as prescribed. The studies pave the way for larger trials of these interventions in this vulnerable age group.
Researchers at MIT and Brigham and Women's Hospital have developed triggerable tough hydrogels that can expand in the GI tract for days, slowly releasing medication. The materials, made from two intertwined polymer networks, can be triggered to self-destruct in case of an allergic reaction.