Researchers discovered a gene that enables bacteria to resist linezolid in cats and dogs at a UK animal hospital, suggesting potential transmission between animals and humans.
Researchers at MUSC found that procedure time is vital in thrombectomy success, with diminishing returns after the 60-minute mark. The study suggests that surgeons should pause and reassess if a procedure is worth continuing beyond this point.
A Phase 1 clinical trial of CAR-T therapy found an 88.2% overall response rate in patients with relapsed/refractory multiple myeloma. The treatment, called LCARB38M, targets the B-cell maturation antigen and achieved a stringent complete response in 13 patients.
Researchers successfully engineered and printed a 3D vascularised engineered heart with cells, blood vessels, ventricles, and chambers that matches the immunological, cellular, biochemical, and anatomical properties of the patient. The use of native patient-specific materials is crucial to eliminating implant rejection risks.
Activists argue that pre-treatment mental health assessments of trans people are dehumanizing and unjustified, treating self-reports of gender dysphoria as if it were a mental illness. Informed consent should replace these assessments, respecting patients' autonomy and lived experience.
A new CRISPR/Cas9 system allows for precise gene knock-in in live cancer mouse models, improving efficiency and control over gene insertion. The system was used to model intrahepatic cholangiocarcinoma, a type of liver cancer, and successfully induced tumor formation in mice.
Scientists successfully blocked cancer-fighting gene silencing protein UHRF1, restoring hundreds of protective genes in human colon cancer cells. The findings suggest a new strategy for fighting cancers by targeting this protein.
A recent study by Dr. David Munoz reveals the APOE ε4 allele affects sleep patterns differently in women and men with Alzheimer's disease. The research found carriers of this gene variant experience more nighttime disturbances than non-carriers, highlighting a gender-based effect on sleep behavior.
Researchers discovered that impaired FUS protein-protein interactions contribute to ALS degeneration, but drug-induced autophagy reduces pathological processes linked to aberrantly accumulated FUS. Stimulating autophagy rescued RNA-binding proteins and reduced neuronal death in cell culture experiments.
Researchers at SLAC National Accelerator Laboratory have made the first high-definition 'movie' of ring-shaped molecules breaking open in response to light. The results provide high-resolution details of the reaction, showing how bonds break and atoms jiggle around for extended periods of time.
A new study proposes a blueprint for conserving habitat across the Western Hemisphere to protect migratory birds. The research uses eBird data to calculate how much land must be conserved for each species, finding that working lands are more efficient than protected areas.
Researchers from Michigan State University used satellite imagery to quantify nitrogen losses in Midwestern corn fields. They found that nearly $1 billion worth of fertilizer is wasted annually, resulting in 6.8 million metric tons of greenhouse gas emissions.
Scientists at Hebrew University create decoy molecules that trick RNA-binding proteins into binding with them, inhibiting their cancer-promoting activity. The technology has shown promise in slowing or stopping the growth of brain and breast cancer cells in mice.
Researchers at TU Wien develop innovative light-emitting diode by harnessing radiative decay of exciton complexes in ultra-thin layers, enabling precise control over desired light wavelengths.
A new RAND Corporation study finds that primary care services account for only 2.12% to 4.88% of total medical and prescription spending among Medicare beneficiaries. This estimate is lower than previous studies, and highlights the importance of investing in primary care for better outcomes and lower costs.
The study found that suppression of glutamatergic pyramidal neurons in the medial prefrontal cortex inhibits both acquisition and expression of cocaine-associated memories. In contrast, GABAergic neurons were not affected. This suggests that mPFC pyramidal neurons are a potential therapeutic target for treating drug addiction.
A new study reveals that flowering plants employ different genetic strategies to maintain a 'core genetic circuitry' that ensures stem cell function, even in the presence of defects
Children born to mothers with gestational diabetes are nearly twice as likely to develop diabetes before age 22. Early detection is crucial, as many cases are diagnosed when symptoms like frequent urination and weight loss arise.
A landmark clinical trial shows that canagliflozin lowers the risk of kidney failure by 30% in people with Type 2 diabetes and kidney disease. The study also found a significant reduction in cardiovascular events, providing a promising new treatment option for patients at high risk.
Researchers have discovered that small molecule compounds can alter the spatial organization of the genome, potentially leading to new epigenetic cancer drugs. This breakthrough opens up a promising approach to treat cancer by changing the 3D genome structure.
Research by SDSU finance professors found that mutual fund managers invest more in firms with similar political leanings, leading to lower returns and higher volatility for clients. The study analyzed over 1,300 active mutual funds and 16,655 firms, revealing a partisan bias among fund managers' portfolios.
Measles and diphtheria have re-emerged in Venezuela with a disproportionate impact on indigenous populations, with over 7,500 measles cases reported and 100 deaths attributed to the disease. Diphtheria cases also surged, with 96% of reported cases originating from Venezuela, exposing 3 million vulnerable children to the disease.
A new study suggests that extreme heat and precipitation in early childhood can lead to lower educational attainment, even among better-off households. The research found that climatic conditions affect education negatively in multiple ways, particularly in Southeast Asia and West and Central Africa.
A new study found that leaders in groups of animals are more vulnerable to attack from predators due to their riskier position within the group. Researchers used virtual prey in aquarium tanks and found leaders were more likely to be attacked than followers, with isolated individuals also being at higher risk.
Researchers confirm a long-hypothesized limit for weather prediction, first proposed in the 1960s, which is approximately two weeks on average. They used state-of-the-art models to test this limit and found that reliable forecasts are now possible nine to 10 days out in mid-latitudes.
The study found that certain genes, specifically transcription factors, code for proteins that fine-tune gene expression during the medusa stage. Jellyfish have a unique genetic toolkit, distinct from corals and anemones, which enables their development and growth.
Researchers found a new, more powerful variant of an antimicrobial resistance gene in Staphylococcus epidermidis, making it harder for the bacteria to be killed by chlorhexidine bathing. The discovery was an unexpected result of a study on central venous catheter infections.
A new study from Stanford University's Immigration Policy Lab found that providing low-income immigrants with free access to application assistance boosts naturalization rates. The gentlest kind of nudge—simple, well-placed information—most effectively targets those who are less educated and have lower incomes.
A study published in Annals of Internal Medicine found that low scam awareness in older adults may be an early sign of impending mild cognitive impairment and dementia. The researchers observed a significant association between low scam awareness and Alzheimer disease pathology in the brain.
A comet fragment has been found inside a carbonaceous chondrite meteorite, La-Paz 02342, revealing unique properties of the cometary dust speck. The discovery provides insight into the formation of primitive materials and their preservation in meteorites, shedding light on the solar system's origins.
Researchers aim to identify effective strategies for reducing violence in internationalized civil wars, which have the most fatalities and are difficult to resolve. The project will analyze conflict management approaches, create a barometer to measure changes in conflict levels, and provide policy recommendations.
A team of MU neurobiologists have annotated the sequences of 47 ion channels across the lamprey genome, shedding light on their role in nervous system function and recovery from spinal cord injury. This advancement paves the way for further investigations into the molecular aspects of the nervous system.
Scientists have developed a novel strategy to extract and analyze membrane proteins, which are critical targets for therapy. Azo, a photocleavable surfactant, enables effective mass spectrometry analysis of whole proteins, opening up new opportunities to study membrane proteins.
A study found that state-level legalization of gay marriage led to a significant decrease in implicit and explicit anti-gay bias across the US. The effects were consistent across models, suggesting that legislation locality may moderate local biases.
Researchers at the University of Otago and Indian Statistical Institute have discovered distinct epigenetic markers in oral cancer tissues that are associated with patient survival. The findings, published in the journal Epigenomics, could help save thousands of lives by identifying cancer cells early.
Google searches have identified popular North American bird species, with large birds and those visiting feeders drawing more attention. The study found that owls were the subject of public curiosity, while conservationists can use this information to focus efforts on lesser-known species.
A new study published in the Journal of Hepatology reports that whole-exome sequencing (WES) can diagnose the genetic cause of liver disease in a significant proportion of adult patients. The analysis identified four monogenic disorders in five unrelated adults, enabling new treatment options and shedding light on underlying molecular ...
Booz Allen Hamilton received the 2019 INFORMS Prize for its pioneering integration of operations research (O.R.) and analytics programs. The company consolidated its O.R. talent into a single, centralized organization to enhance cross-disciplinary exchanges and accelerate internal research projects.
Scientists at NRL discovered a new method to passivate defects in next generation optical materials, improving optical quality and enabling miniaturization of light emitting diodes. The technique produces a 100-fold increase in material's optical emission efficiency, paving the way for high-efficiency optoelectronic devices.
Researchers found that tropical fire ants in Florida can coexist with both single- and multi-queen colonies. In multi-queen colonies, all reproductive queens are genetically identical and reproduce asexually.
Researchers at the University of Pittsburgh School of Medicine have found that responsive neurostimulation can remodel the brain to be less susceptible to seizures. By analyzing individual brain activity recordings over time, the study shows that stimulation changes brain networks, making it harder for seizures to spread.
A new study by McGill University researchers found that state legislation played a significant role in reducing anti-gay bias in the US. By analyzing data from over 1 million respondents, the team discovered that laws supporting same-sex marriage led to a sharp decline in biases, with the effect being roughly double the previous rate.
Research in a Washington river basin reveals that early 20th-century timber harvesting, particularly splash-damming, led to increased bedrock erosion and reduced floodplain areas. This study suggests that brief human activities can have lasting impacts on the landscape.
Research shows low-intensity ultrasound can modulate normal brain function, affecting counterfactual thinking and alternative choice. This technique may revolutionize non-invasive treatment for mental health conditions like depression and Parkinson's.
Daniela Rubatto's research provides a new way to connect minerals' ages to their formation conditions, reconstructing the speed and duration of rock travel within the Earth's crust. Her innovative method uses an ion microprobe to extract valuable information from minerals, contributing to better understanding geological processes.
Researchers found that being part of a group provides safer protection from predators, with prey positioned in the middle of schools having the safest position. The study revealed that predators are more likely to attack isolated individuals than those in groups, highlighting the benefits of collective behavior.
A £1.8m funding boost will help researchers at the University of Edinburgh improve diagnosis and treatment outcomes for Crohn's disease, a condition affecting 120,000 people in the UK. The study aims to develop a non-invasive test using blood or stool to determine if the inflamed bowel wall has healed after treatment.
A new study by the University of Stirling has identified a silence around suicidality among children and young people, with many feeling they cannot access help or are not listened to by healthcare professionals. The research emphasizes the importance of using explicit language, such as 'suicide,' in mental health conversations.
A new study published in Pediatrics found that adolescents with cognitive impairments and intellectual disabilities have similar weight-loss outcomes after bariatric surgery as those with typical cognitive function. The study's authors recommend a case-by-case approach to determining eligibility for weight-loss surgery.
Researchers found that older brains with low TRIM9 levels are prone to extensive swelling following stroke, but increasing the gene's expression improves recovery. The study aims to identify what triggers TRIM9 gene expression to develop potential treatments.
Researchers found that half of patients prescribed statins failed to achieve 'healthy' cholesterol levels within two years, increasing the risk of cardiovascular disease and stroke. Patients who did not respond well had a 22% higher risk of developing cardiovascular disease compared to those who reached the target.
Continuing PCV in Kenya is estimated to prevent over 100,000 cases and save 14,000 lives annually. The vaccine's full price is less than Kenya's GDP per person, making it a cost-effective option.
HRL Laboratories' breakthrough alloy is the world's first printable high-strength aluminum, registered with the Aluminum Association. The registration validates its commercial value and enables companies to access the alloy through specific powder numbers.
Researchers at Newcastle University found a significant discrepancy between reported and actual catches of vulnerable species like sharks and rays in small-scale fisheries. The study highlights the urgent need for global efforts to assess their impact on the environment.
Researchers found that reframing how students view food-marketing campaigns can spur adolescents to make healthier dietary choices for an extended period. Teenage boys reduced their daily purchases of unhealthy drinks and snacks in the school cafeteria by 31 percent, while girls' purchases remained similar.
Researchers at UNC and TMIMS discovered that IRF1 protein regulates RARRES3 enzyme, making liver cells hostile to hepatitis A infection. The study provides implications for cellular responses to other RNA viruses like dengue and Zika.
Moffitt researchers discovered that melanoma cells become resistant to BRAF inhibitors through a conserved stress response mechanism involving AP-1 activation and histone deacetylase 8. This finding suggests that HDAC inhibitors may be able to overcome resistance mechanisms, leading to potential new treatments.
A study found kin relationships among people buried in Neolithic megalith tombs, indicating a societal role for these enigmatic structures. The genomic data revealed affinity to farming groups with past admixture with hunter-gatherer groups, highlighting a previously unknown role for megaliths in Neolithic societies and families.
Biomedical engineers at Duke University developed a method to improve CRISPR accuracy by adding a short tail to the guide RNA, creating a 'lock' that prevents off-target activity. The approach increases accuracy by an average of 50-fold across five different CRISPR systems.
A new study published in Geosphere investigates how scientists perceive interactions with policy makers, revealing five distinct models: a beacon, collaborator, educator, outcast, and investigator. The researchers emphasize the importance of understanding individual perspectives to effectively engage scientists in policy decisions.