A new study by Scripps Research scientists found that activating GPR139, a receptor linked to alcohol addiction, can significantly decrease drinking in alcohol-addicted rats. The researchers also discovered that the drug helps mediate physical pain associated with withdrawal in severe cases of alcohol addiction.
Researchers found that a fight-or-flight response can trigger the overproduction of white blood cells, leading to inflammation and increased risk of heart attacks in people with diabetes. Beta 2 blockers may help reduce this risk by limiting the proliferation of inflammatory myeloid cells.
A new study found that Finnish forest management guidelines do not adequately protect old growth forests where flying squirrels live. The guidelines were compared to the recently amended Forest Act and resulted in an extremely low occurrence of female flying squirrels, highlighting a large gap between science and policy.
Researchers at the University of Münster have discovered a correlation between the spatial organization of a nerve cell and its process degeneration. The study found that specific arrangement of cytoskeleton components influences the direction of dendrite degeneration in fruit flies.
A recent study by researchers at the University of Arizona has found no evidence of domestic dog ancestry in the Mexican wolf population. The analysis of 87 Mexican wolves using genomic technology revealed a low percentage of genetic similarity with domestic dogs, suggesting that the species is genetically pure.
A recent study published in Nature Communications reveals that serotonin plays a crucial role in learning by influencing an animal's decision-making strategies. When the interval between trials was short, mice relied on their working memory, while longer intervals activated their long-term memory, allowing them to learn from past rewar...
A study of 49,287 women found that performing an abortion in an ambulatory surgery center was not associated with a significant difference in infection, hemorrhage, or other complications. The research aimed to address the lack of evidence on abortion-related complications at ASCs compared to office-based settings.
Research in Japan found that Asiatic black bears create arboreal feeding signs (AFS) on trees with large mast energy values, indicating a cost-benefit analysis for climbing. AFS are also more likely during poor mast years when competition for hard mast is high.
Researchers have developed a macroscale fluorescence imaging technique, known as macro-FLIM, that can analyze whole mouse tumors with cellular resolution. The new approach enables observation of biochemical processes taking place within the sample, and could potentially find use in clinical settings to identify tumor edges during surgery.
Two new studies highlight the critical need for evaluating and updating standards for infection preventionist (IP) staffing levels, citing severe gaps in staffing and outdated coverage benchmarks. The studies found that actual IP labor needs are 31-66% higher than current benchmarks, indicating a greater need for IP oversight.
A study by Yale School of Medicine researchers found that human insulin is comparable to insulin analogs in terms of safety and effectiveness. The use of more expensive analog insulins did not result in better blood sugar control or reduced risk of hypoglycemia, suggesting they may be unnecessary for many patients with type 2 diabetes.
Researchers at UCLA have developed synthetic T cells with near-perfect facsimiles of human T cells, which could lead to more effective treatments for cancer and autoimmune diseases. The artificial cells can boost the immune system and interact with immune cells, making them a promising tool in the fight against infections.
Researchers recorded methane bubbles from seafloor off Oregon coast using hydrophone, estimating bubble size and frequency related to methane content. The study aims to use sound to estimate volume and rate of methane gas exiting seafloor fields.
Scientists estimate that planets around almost every star in the galaxy may harbor life, prompting new research to identify biosignatures. Researchers propose solutions to detect gases and light signatures produced by life on exoplanets.
Researchers discovered that Fox genes play a crucial role in directing stem cells to form cartilage and teeth during facial development. The study found that mutations in these genes can cause diseases such as cancer and language disorders.
A new compound, DPM-1001, has shown promise in reducing copper levels in cells and improving symptoms of Wilson's disease. The study confirmed that the compound is orally available and specifically targets copper, reducing unwanted side effects.
A UBC study suggests that anger is a significant feature in postpartum mood disturbances, contributing to feelings of powerlessness and unmet expectations. Ignoring anger in women with postnatal mood disorders may exacerbate symptoms and negatively impact mothers, children, and families.
Researchers call for active woodland management to create a 'mosaic' of trees with varied ages and sizes. Dormouse numbers are falling in Britain due to changes in climate and habitat composition, with more broadleaf woodland needed to support the species.
A clinical trial found that 59% of patients with biochemical recurrence of prostate cancer had their clinical management changed by fluciclovine PET/CT imaging. The study detected disease in the prostate, pelvic lymph nodes, and less commonly, bone, guiding treatment decisions for men with recurrent prostate cancer.
A new capacitive sensor design created by Binghamton University professor Ron Miles allows for efficient sound sensing in devices without significant electrostatic forces. The flexible sensor can move with small air movements, addressing issues with existing sensors and expanding possibilities for applications.
A new study published in PLOS Medicine found that patients covered under Medicare's fee-for-service plan spent more time in nursing homes after hip fracture hospitalization, yet saw slightly worse health outcomes. In contrast, those covered under Medicare Advantage had shorter stays and similar or better health outcomes.
A study by the University of Kent found that mindfulness meditation can increase pain tolerance and mindful awareness in injured athletes. The research used Mindfulness-Based Stress Reduction (MBSR) as an intervention for recovery, showing promising results. The study has major implications for treating sporting injuries at all levels.
Scientists at the University at Buffalo have developed heated magnetic nanoparticles that can selectively target and destroy tumors with significant amounts of heat under low-magnetic fields. The new technology has potential benefits over other treatments, including minimal side effects and deeper penetration into hard-to-reach body pa...
A complex of powerful thunderstorms affected Oklahoma, with NASA's GPM core satellite analyzing storm intensity. More severe weather is forecasted for June 26, highlighting the importance of monitoring severe weather systems.
Researchers at Children's Hospital Los Angeles and USC have developed a minimally invasive micropacemaker system that can treat faulty heart rhythms in children and adults. The device, implanted through a single incision, offers a new approach to cardiac pacing without the need for traditional pacemakers.
Researchers found that resveratrol inhibits mutant p53 protein aggregation, preventing breast cancer cell migration and proliferation. This breakthrough could lead to a treatment for over half of malignant tumors, targeting novel strategic targets in cancer research.
Researchers identify epigenetic enzyme TET2 as a key player in controlling dormant tumor cells that can lead to cancer recurrence. A novel biomarker, 5-Hydroxymethylcytosine (5hmC), is also discovered to detect these treatment-resistant cells and predict patient outcomes.
Researchers found that Chlamydia trachomatis deactivates immune cells by activating a protein that cleaves key receptors, allowing the bacterium to evade detection. This discovery holds promise for developing targeted therapies against Chlamydia infections.
Researchers have developed a technique to determine the significance of gene variants of uncertain significance in patients with suspected heart conditions. By using advanced genetic-editing tools and stem cell technology, they were able to confirm that a patient had a mild case of long QT syndrome and rule out another condition.
Tropical Storm Daniel weakened as it passed over NASA's Terra satellite on June 24, revealing a small area of strong storms around its center. By the next day, the storm had degenerated into a remnant low-pressure area, forecast to dissipate by Wednesday night with maximum sustained winds near 30 mph
A subset of immune cells has been found to create and sustain chronic inflammatory bowel disease, a condition characterized by persistent diarrhea and abdominal pain. These cells could become therapeutic targets to treat Crohn's disease and ulcerative colitis.
A study by ISGlobal reveals the presence of proteins from hypnozoites in circulating extracellular vesicles, providing a potential diagnostic tool for asymptomatic patients. This breakthrough could help identify and stop malaria vivax transmission, an essential requirement to achieve the WHO's target of eliminating malaria by 2030.
Researchers found that using chopsticks while eating popcorn, finding novel ways to drink water, or watching a video with hand-goggles all intensified the experience and made it more enjoyable. These unconventional methods help focus on what's enjoyed about the product, making experiences feel brand new.
Researchers developed a computational model that found serotonin boosts learning rates in mice, particularly in slow decision-making systems. The study suggests a possible link between serotonin and cognitive behavioral therapy, which is often effective when combined with SSRIs.
A new study from the CDC estimates substantial numbers of people infected with HIV, but unaware of their infection, weren
Researchers developed a device that reflects sound in its original direction, more than doubling the effective range of previous technologies. The 'retroreflector' uses engineered materials to focus incoming sound waves onto a second layer, sending them back to their source.
Scientists have discovered an active volcanic heat source beneath the Pine Island Glacier in Antarctica, which plays a critical role in the glacier's movement and melting. The finding is significant as it suggests that volcanism is an additional factor contributing to ice sheet instability, alongside climate change.
PharmaMar and Chugai agree on an early termination of their license agreement for Zepsyre in Japan, allowing PharmaMar to regain rights to the compound. PharmaMar will receive €3,000,000 from Chugai and can now pursue new partnerships for the drug.
A new study found that even mild sleep disturbances can lead to elevated blood pressure in women, with nearly three times more common than severe sleep disturbances. Women who slept for seven to nine hours a night were significantly more likely to have high blood pressure.
A team of researchers has developed a minimal logic system to bridge the gap between mathematical proofs, algorithms, and real-world outcomes in control systems. The work, published in IEEE/CAA Journal of Automatica Sinica, aims to improve the realism of theoretical mathematics by focusing on computational certainty.
Researchers at UMass Amherst used advanced seismic imaging and data from the National Science Foundation's EarthScope program to construct a detailed model of the tectonic plate beneath the Adirondack Mountains. They discovered a 'pillow' of low-density, relatively light rock material that appears to have been squeezed up under the mou...
The USPSTF updates its recommendation on screening for osteoporosis to include bone measurement testing for prevention of osteoporotic fractures in eligible populations. Approximately 12 million individuals in the US older than 50 years are expected to have osteoporosis by 2020.
A study found that elderly patients with hip fractures who received rehabilitation under Medicare Advantage programs had shorter hospital stays and less therapy time. These patients also experienced a lower rate of readmission to the hospital within 30 days and higher successful discharge rates to the community.
Researchers compared CF-PWV and CAVI to assess vascular ageing, finding CAVI provides additional information on vessel wall state. Metabolic syndrome was found to increase CF-PWV levels but not affect CAVI.
Researchers have identified a new meteorite impact structure in Central Finland, measuring 2.6 km in diameter and 275 km north of Helsinki. The discovery is part of the country's growing list of confirmed impact structures, with Finland now ranking among the top countries to find these features.
Purdue University researchers have created the most accurate picture of Zika virus to date, finding probable drug-binding pockets on its surface. This breakthrough has the potential to lead to the development of vaccines and therapeutics for this mosquito-borne disease.
Researchers discovered that worms' behavior at the time of experiencing stimuli influenced how their brains interpreted information, leading to a more sophisticated understanding of mechanosensory circuitry. The study paves the way for further investigations into how simple brains interpret sensory signals and turn them into actions.
Researchers found female nipple sizes vary significantly due to functional use in breastfeeding, contradicting previous claims. The study's findings support the idea that highly variable features result from weak evolutionary selection.
A genetically modified poliovirus therapy developed at Duke Cancer Institute has shown significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent. The therapy preferentially targets tumor cells and ignites a targeted immune response.
Researchers discovered a molecular inhibitor that could help fight prostate cancer when resistance develops to CDK4/6 inhibitors. The study found that tumors become more aggressive and dependent on the MAPK-6 pathway when resistance occurs, making MEK inhibitors a potential therapeutic option.
Fatigue is a common symptom of endometriosis, affecting over half of diagnosed women, with links also found to childhood abuse and neglect. The study suggests that endometriosis may cause fatigue independently of other factors, possibly due to inflammation and immune system activation.
A team of scientists from McGill University discovered a key role for the GRIN2B gene in early neural stem cell development and autism. They used genetic engineering to reprogram skin cells into brain cells with the patient's mutation, showing how improper protein production leads to impaired brain development.
A new imaging technique using bioinspired camera technology will measure changes in the UCL during loading, providing insight into damage accumulation. The technique aims to improve microstructural evaluation of soft tissues and study biological damage in rotator cuff tendons.
Researchers at Tokyo Institute of Technology successfully formulated and experimentally verified a unified theory for controlling coherent optical phonons in diamond. The theory explains the generation and detection of coherent optical photons based on a model involving two states of electrons and the quantum harmonic oscillator.
Researchers at the University of Helsinki have identified a monoclonal antibody that inhibits capillary leakage in sepsis. The antibody targets β1-integrin, a key molecule in endothelial cells, and improves junctions between endothelial cells, decreasing vascular leakage and protecting against sepsis-induced heart failure.
Researchers found that maximal running shoes increase impact peak and loading rate in female runners, associated with higher injury risks like plantar fasciitis and tibial stress fractures. Maximal shoes feature increased cushioning, but this may lead runners to rely more on the shoe rather than their own internal structures.
Scientists have identified a new mechanism for the plant hormone auxin that enables rapid adaptation of root growth direction in response to gravity. This mechanism allows roots to quickly bend and grow deeper into the soil, where they can anchor themselves and find water and nutrients.
Lancaster County corn production may face significant declines due to projected climate change impacts. Rising temperatures and extreme heat stress threaten corn yields, forcing farmers to reconsider their growing strategies.
Researchers at Cornell University have developed a new battery design that could increase the power of lithium-ion batteries by confining dendrite growth in electrolytes, reducing instability and improving lifespan.
Researchers developed a computer game to examine relationships between countries and strategic environments. They found that having more allies can increase a country's responsibility, leading to decreased overall welfare. The study has potential implications for current events, including the China-US-North Korea conflict.