Lund University researchers have developed a fluorescent variant of salinomycin to understand its mechanism against cancer stem cells. The molecule rapidly passes through the outer cell membrane and acts as an ion transporter in the endoplasmic reticulum, leading to a reduction in cancer stem cells
Researchers have developed a novel approach to pretargeted radioimmunotherapy, which has shown complete responses in several solid tumor types using the beta-emitting lutetium-177 and alpha-emitting actinium-225. The new approach offers greater versatility of treatment for various solid tumors and clinical situations.
A study evaluates ocean characteristics that influence fisheries bycatch on the US west coast, threatening ecological and economic sustainability. The analysis revealed an increased bycatch risk for protected species, including cetaceans and sea turtles, in areas with dynamic physical structures.
Researchers have developed a new approach for studying Cryptosporidium using lung and intestinal organoids, which support the complete life cycle of the parasite. This tool enables the testing of drugs and identification of vaccine candidates, providing hope for developing effective treatments.
ORNL's invisible micro-taggant technology uses an infrared marker for identification, providing a unique coding system that can identify item source, type, production, and composition. The taggant can be implemented in various products, including textiles, with a low production cost per taggant.
Researchers found that early ocean organisms grew tall to disperse their offspring and colonize their surroundings. The study suggests that reproduction was the main reason life on Earth got big during the Ediacaran period.
Researchers at QUT have developed a real-time, object-independent grasp synthesis method for closed-loop grasping that achieves high accuracy rates of up to 88% in dynamic environments. The approach uses a Generative Grasping Convolutional Neural Network to predict the quality and pose of a two-fingered grasp at every pixel.
A study found domesticated rabbits have smaller amygdalas and larger medial prefrontal cortices, suggesting genetic changes may reduce fear processing. Reduced white matter anisotropy indicates compromised information processing, supporting the link between domestication and altered brain architecture.
The study reveals the atomic structure of tropoelastin, a protein responsible for living tissues' flexibility. Researchers decoded the molecular structure using a combination of molecular modeling and experimental observation.
A new study from MIT finds that piano lessons enhance word discrimination in kindergartners, particularly with consonants, without improving overall cognitive ability. The researchers suggest that music education is at least as beneficial for language skills and possibly more beneficial than additional reading instruction.
A series of studies found no correlation between people's belief in free will and their moral behavior, including generosity and honesty. The researchers suggest that the field needs to rethink the connection between free will and morality.
A team of researchers from Purdue University has found that twisting cracks in certain animal materials make them incredibly strong and resistant to failure. This phenomenon, observed in the mantis shrimp's club, is now being replicated in new composite materials.
Scientists have created an 'electrogeochemical' method that captures carbon dioxide from the atmosphere while producing hydrogen gas for use as fuel. The technology also counteracts ocean acidification by converting carbon dioxide into a dissolved mineral bicarbonate already abundant in the ocean.
Researchers at Johns Hopkins Medicine discovered that combining chemical compounds to activate specific nerve cell receptors may reduce the risk of opioid tolerance and side effects by minimizing the amount of opioids needed. The study used mice models, suggesting that this approach could lead to a lower-risk pain treatment option.
Researchers found no association between efavirenz and depression or suicidal ideation in Ugandan HIV patients. Efavirenz, a commonly used HIV cocktail worldwide, was previously linked to adverse psychiatric side effects in US and European populations.
Researchers at Imperial College London have developed a more efficient enzyme that can break down plant-based biomass 30 times faster than current methods. This breakthrough could lead to cheaper and more environmentally friendly biofuel production, as well as more efficient plastic recycling.
Researchers have discovered a new type of small-cell lung cancer (SCLC) with distinct biological signatures, paving the way for developing personalized treatments. The discovery involves a novel transcription factor called POU2F3, which is expressed in a specific subset of SCLC tumors and may be targeted by specific drugs.
Researchers at ETH Zurich have developed a solid catalyst for a major chemical reaction, reducing waste and increasing efficiency by 20 times compared to traditional soluble catalysts. The new palladium-carbon-nitrogen material is more stable and cost-effective, making it suitable for commercial-scale production.
The EXIOBASE 3 database provides new clarity on the links between international trade, consumption, and environmental impact. Researchers found some level of decoupling between economic growth and environmental impact, but efficiency was reduced for material use increasing at a faster rate than GDP.
A study using high-resolution MRI found that domesticated rabbits have reduced amygdala size and enlarged medial prefrontal cortex compared to wild rabbits. This led to a diminished flight response and slower reaction time, as the brain's white matter structure was also compromised.
A new study found that Transcendental Meditation significantly improves psychological distress and brain functioning in school administrators and staff, with enhanced performance and well-being. The study, published in Brain and Cognition, is the largest randomized control trial investigating the impact of TM on brain functioning.
A new long-lasting type of radionuclide therapy has been proven effective in treating advanced neuroendocrine tumors, with the treatment lasting up to 4 times longer than previous options. The therapy, Lutathera-177 (Lu-DOTA-EB-TATE), was well-tolerated and showed promising results in a Phase I trial.
A study of 5,366 US flight attendants found a higher lifetime prevalence of breast, melanoma, and non-melanoma skin cancers compared to the general population. The authors suggest that factors such as circadian rhythm disruption and exposure to cosmic ionizing radiation may contribute to these increased cancer rates.
Rice University's NESMD technology uses nanoparticles and sunlight to desalinate water in one step, reducing energy costs compared to traditional methods. The technology has shown promising results in laboratory-scale tests, with the potential for further optimization and scaling up for field testing.
Researchers at Ural Federal University have discovered that controlling intrinsic defects in nanoparticles can enhance their energy conversion capabilities. This breakthrough could lead to improved solar cell efficiency by up to 50%.
Researchers at Cleveland Clinic found that a common prostate cancer drug, abiraterone, yields high levels of a testosterone-like byproduct in men with advanced disease who have a specific genetic variant. This byproduct may trick androgen receptors into turning on pro-cancer pathways.
Researchers found temperatures as low as -98 degrees Celsius in small valleys near the top of Antarctica's ice sheet, driven by persistent clear skies and extremely dry air. The study challenges current understanding of Earth's surface temperatures, suggesting a limit to how cold it can get.
The James Webb Space Telescope will create multispectral maps of the Great Red Spot, analyzing its thermal, chemical, and cloud structures. Scientists hope to observe unique chemical byproducts of the storm, which could reveal its composition.
A RAND Corporation study found that medication-assisted treatment for opioid use disorders jumped by 62% among Medicaid recipients, but disparities emerged in poorer counties and areas with larger black and Hispanic populations. The expansion of this treatment led to new racial and ethnic disparities in healthcare.
A team of international researchers created a dynamic surface, FLIPS, that can sculpt and re-sculpt microscale to macroscale features, change friction and slipperiness based on magnetic fields. It has been shown to direct particle movement, remove biofilms, coat droplets, and act as an adhesive.
A major study found that medications used to treat diabetes in adults are not effective on youth. The disease is progressing rapidly in young people due to the growing obesity epidemic.
A team of microbiologists and plant scientists has identified a genetic weakness in the cholera pandemic that could lead to future treatments. The discovery reveals a new signaling network for cyclic GMP-AMP (cGAMP) in the human cholera pathogen, which is responsible for the seventh pandemic's ability to thrive.
A study suggests that Jupiter's surface jet streams could provide evidence for a rocky core at its center. Researchers used computer simulations to analyze data from NASA's Juno spacecraft, which found evidence of local variations in the planet's magnetic and gravity fields.
Researchers emphasize the importance of authentication in medical research/treatment, highlighting issues related to respect for autonomy, privacy protection, and trust establishment. They propose two-factor authentication as a solution to address these concerns.
Benjamin Jones, a UTA physicist, has been awarded $750,000 to develop a sensor for detecting neutrinos, which could help explain the universe's matter-antimatter imbalance. The award supports his research on neutrinoless double beta decay and its potential to illuminate the origin of neutrino particles' small mass.
A University of Colorado Cancer Center study shows that combining radiosurgery with immunotherapy, especially PD-1 inhibitors, can significantly improve cancer control and overall survival in melanoma patients. The study found that patients treated with anti-PD-1 therapies had a median brain metastasis-free survival of not reached, whe...
Researchers used CRISPR-Cas9 gene editing to reduce repetitive behavior in mice with fragile X syndrome, a common cause of autism spectrum disorder. The technique successfully edited the receptor responsible for excessive signaling between neurons, leading to reduced repetitive behaviors such as digging and leaping.
A team of researchers at Ohio State University has developed a painless microneedle technology inspired by the mosquito's proboscis. The new design incorporates four key elements: a numbing agent, a serrated design, vibration during insertion, and a combination of soft and hard parts on the proboscis.
A trio of leading academics warn that the Brussels Declaration, a key public health declaration, was developed with extensive involvement of tobacco and alcohol industry actors. This raises concerns about the potential for industry influence on policy-making and the advancement of corporate interests.
Researchers found a significant decrease in C. difficile infections across Canada, with the most common virulent strain, NAP1, associated with severe illness and deaths. Improved infection control practices, such as frequent handwashing and better cleaning, may have contributed to this decline.
Researchers at Linköping University found a common mistake in the DIP-seq method that can cause misleading results. This error affects up to 90% of detected DNA regions, highlighting the importance of experimental validation in high-throughput technologies.
A new study found that Medicare patients are more likely to die outside of acute-care hospitals, where they died at home or in assisted-living facilities. Since 2009, there has been a reduction in patient deaths within three days of hospital discharge, and ICU use during the last month of life has stabilized.
Researchers identified autoantibodies against adrenocorticotropic hormone (ACTH) in aggressive male prison inmates, showing altered cortisol secretion and decreased time to attack in mice. These findings suggest potential molecular mechanisms underlying human aggression and stress response.
A new oral insulin formulation based on ionic liquids has been successfully developed, showing stability at room temperature and under refrigeration. The formulation significantly reduces blood glucose levels in rats, with up to 45% decrease observed after oral delivery.
A study published in JNeurosci reveals how nicotine interacts with cells regulating the output of a brain region involved in habit formation. Nicotine reduces dorsal striatal output, an effect that persists even after the drug has been cleared from the brain, potentially underlining nicotine addiction.
Researchers use computer simulations to test dark matter's presence in satellite galaxies, finding a relationship that could clarify its existence. The study uses radial acceleration relation data from the Gaia spacecraft to make predictions about the behavior of dwarf galaxies.
Researchers used LiDAR technology to map carbon storage in urban forests, finding areas like Hampstead Heath store up to 178 tonnes of carbon per hectare. This study highlights the value of urban trees for mitigating climate change and demonstrates their potential as a vital resource for cities.
Researchers discover a protein that shields the PI3K pathway from targeted drugs, leading to improved efficacy with combination therapy. A new study reveals that blocking this protein restores cancer-killing potential in previously ineffective therapies.
Researchers found that individuals are more than twice as likely to use surnames when referring to male versus female professionals. In multiple experiments involving nearly 500 participants each, scientists who were referred to by surname were perceived as more famous and deserving of career awards.
Sanford Burnham Prebys Medical Discovery Institute has received four Padres Pedal the Cause collaborative grants to fund research projects in cancer and immunology. The projects aim to develop new insights into developing drugs and treatments designed to attack and kill cancer cells.
A new photocatalyst composed of an organic semiconductor material and an iron complex selectively reduces CO2 to CO under visible light, converting the major factor of global warming into a valuable carbon resource. The efficiency of this process is comparable to that of precious metal or rare metal complexes.
Researchers found that children in the 2000s waited an average of two minutes longer to receive a larger treat than those tested in the 1960s and 1980s. The study attributes this change to increased access to digital technology, preschool education, and parenting practices.
Gambhir's work on multimodality molecular imaging has advanced nuclear medicine and healthcare. He has developed strategies to study gene and cell therapies, and his lab has more than 625 publications and over 40 patents pending.
International team of researchers warns that even with stringent climate policies, residual fossil fuel emissions could still cause CO2 emissions to endanger the climate targets agreed on by the international community. The study highlights the need for accelerated energy efficiency improvements and widespread electrification of energy...
Experiments show that citizens provide less aid to refugees when it incurs a cost, but increase aid with higher prosocial orientation and greater refugee needs. The results suggest that factors such as costs and integration efforts play a significant role in shaping public attitudes towards refugees.
Boson sampling with photons faces major obstacle due to unavoidable photon loss, but researchers from USTC have confirmed experimentally that lost photons still produce useful output. This discovery allows for exponentially faster sampling rates and brings demonstration of quantum supremacy closer to reality.
Researchers found that children with multiple allergies are nine times more likely to develop eosinophilic esophagitis. The study suggests a common underlying biological cause among these allergies and implies that early treatment of one allergy may prevent later disorders.
Researchers revealed the structural fold of S. agalactiae CAMP factor, composed of 5+3 helix bundles, with N-terminal bundle responsible for membrane permeabilization and C-terminal bundle for host receptor binding. The study clarifies the molecular mechanism of co-hemolytic activity.
Researchers found that brains selectively treat gaining knowledge about favorable outcomes as a reward, but not unfavorable ones. People tend to spend money on advance knowledge of good events and avoid information about bad ones.
Volunteers in the Galaxy Zoo project develop extensive expertise about galaxy images and instruments, surprising researchers with their knowledge. Through online discussions, participants learn about artefacts and how to identify them, creating a culture of shared learning.