A new clinical trial combines two immunotherapies, PD-1 antibody and poly-IC, to enhance T-cell response against solid tumors. The treatment aims to improve patient outcomes for a wide range of cancers, including lung, liver, colon, and others.
A new model predicts landslide locations and runouts in near real-time, helping first responders plan reconnaissance flights and evacuate affected areas. However, the approach overpredicts landslides, limiting its use for exact location determination.
A Master's student at FAU has developed a method to assign blue-green algae fossils to specific species using crystallography. By comparing fossil structures with microfossils, researchers found that blue-green algae have a less structured pattern with many misorientations in crystals.
A meta-analysis by Case Western Reserve University researcher Nathan Berger reveals that obesity increases risk of 13 different cancers in young adults, with certain cancers now reported in people under 50. Obesity can alter cellular mechanisms promoting cancer and increase cancer rates as it rises among younger demographics.
A recent study suggests that information security managers can motivate employees to act more securely by providing relatable messages and offering options. Employees may not realize they're putting company data at risk, but giving them choices can encourage better behavior.
A computer program called CLEESE enables researchers to visualize the mental representations of others' personalities according to acoustic qualities of their voices. The study found that a descending pitch with emphasis on the second syllable makes a hello sound sincere, while a rising pitch inspires trust.
Researchers at Saint Louis University discovered a method to block chemotherapy-induced neuropathic pain by supplementing a key signaling pathway. The study found that oxaliplatin, a widely used cancer drug, causes debilitating side effects due to increased adenosine kinase expression in astrocytes.
The study highlights the significant burden of hepatitis B virus globally, with 292 million individuals living with the virus in 2016. Only 5% of eligible patients received antiviral therapy, and less than 1% of expectant mothers with high viral load received prophylaxis to prevent mother-to-child transmission.
The Laramie Foothills Bison Conservation Herd has welcomed its first IVF-calved female, conceived using eggs and sperm from Yellowstone genetics. The breakthrough could provide a solution for conserving endangered species like the Northern white rhinoceros.
A new study in the Hudson-Raritan Estuary found that support for oyster restoration is linked to perceived risks to public health and the economy, rather than group membership. The research suggests that both conservationists and industry members may be receptive to similar appeals for oyster restoration projects.
A new laser technique can detect even trace amounts of chemicals in the air, making it possible to alert communities to biological or chemical attacks. The technology is accurate and sensitive enough to determine if there is a molecule of any chemical present at concentrations as low as one part per billion.
Researchers at the University of South Florida have developed a mobile version of ELISA, enabling point-of-care testing in doctor's offices and clinics. The new MELISA device measures progesterone levels and other hormones, making biomedical testing simple and affordable.
Stanford researchers found that aquatic mammal size is bounded by the need to retain heat and difficulties getting enough food. The group analyzed body masses for over 3,800 species and found a convergent evolution toward around 1,000 pounds.
Researchers have developed a novel technique that enables them to visualize biological targets in deep tissues without damaging tissues or labeling with fluorescent molecules. The method, which uses selectively guided light waves, overcomes the limitations of current optical imaging techniques.
Aquatic mammals are bounded by need to retain heat and difficulties gathering food, limiting their size. The study found that smaller ancestors like dog relatives increased in size more than larger ancestors like hippos to reach an optimal weight of around 1,000 pounds.
A study published in CMAJ Open found that use of the program increased three-fold and total government spending rose by 735 percent, with a significant increase in biologic drug claims. The rise in high-cost medications, including biologics, is seen as a major factor contributing to the growth of the program.
A study published in the British Journal of Ophthalmology reveals that around half of vision impairment in Western Europe is preventable. The UK has a relatively low prevalence of blindness, but higher rates of moderate to severe vision impairment compared to some non-EU countries.
Researchers found that changing the scheduling of drug administration can improve outcomes in mouse models of melanoma, leading to more complete responses. A combination of MEK inhibitor given continuously with intermittent CDK4/6 inhibitor was the most effective schedule in mice.
Research from Bar-Ilan University suggests that excessive focus on self-control can lead to inflexible behavioral patterns, over-emphasis on norm-adherence, and strict rational thinking. This can result in problems with information processing, decision-making, and social behavior.
Researchers at Osaka University have created a new form of art illumination that uses synchronized fluctuations in light to mimic natural rhythms, creating a unique and cozy setting. This technology has the potential to enhance quality of life by providing a more human-friendly and nature-inspired lighting solution.
A University of Oklahoma study analyzes 370,000 Landsat images to reveal divergent trends in US surface water bodies from 1984 to 2016. Climate was the primary driver behind decreasing trends in southwest and northwest states and increasing trends in southeast and northern Great Plains states.
Barts and The London School of Medicine and Dentistry has been allocated additional 32 new places for local medical students, providing opportunities for students from diverse backgrounds. This expansion aims to increase the number of primary care staff in the area following graduation.
Children as young as four years old with ADHD symptoms showed reduced brain volumes in regions essential for behavioral control. The study provides an indication that anomalous brain structure is evident in the early stages of development and could help predict which children are most at risk for developing ADHD.
A team of researchers has successfully extended the search range of an exotic gravity to short distances, demonstrating the highest sensitivity reported to date. The study uses a high-intensity pulsed neutron beam at the J-PARC facility, allowing for precise measurements of gravitational interactions.
A study by the University of Jyväskylä found that Finnish drivers use their smartphones extensively while driving, with WhatsApp being the most heavily used app. Heavier users even increase their phone use in dense traffic, highlighting a lack of moderation among some drivers.
A team of researchers from Nagoya University has discovered superconductivity in a quasicrystal alloy, which challenges conventional theories. The alloy's properties were found to be similar to those of weak-coupling superconductors, ruling out the role of critical eigenstates.
Many NHS trusts in England fail to log, track, or disclose conflicts of interest for their staff, potentially undermining public trust in health professionals. Researchers recommend a statutory body like the US model to ensure strong policies are in place, similar to the Physician Payment Sunshine Act.
A study found that 90% of coastal freshwater turtle species will be affected by sea level rise by 2100, with some species losing up to 30% of their range. Researchers warn that turtles may not be able to adapt quickly enough to changing environments, threatening their survival.
Fabrice Barresi has been awarded the Heine H. Hansen Award by European Society for Medical Oncology (ESMO) and International Association for the Study of Lung Cancer (IASLC). This award is presented annually at the European Lung Cancer Congress to a lung cancer investigator who has made a special contribution to this field.
Scientists found that meeting temperature targets without overshooting may not require zero emissions, while drastic cuts in emissions can stabilize warming at 1.5 or 2 degrees C. The timing of emission reductions matters significantly.
Researchers from Saarland University have developed self-monitoring conveyor rollers that precisely control each roller to respond to changing operating conditions. This technology can speed up parcel sorting operations while delivering greater flexibility, reducing costs and improving efficiency.
A new process enables 3D biofabrication of hollow and complex objects with excellent fidelity, facilitating the development of sustainable materials and biomedical applications. The method uses superhydrophobic interfaces to engineer bacterial access to oxygen in three dimensions.
A trained navigator with a degree in social work helped increase access to the transplant waitlist among patients who needed a longer time to get through the transplant evaluation process. Nearly 70,000 US patients have end-stage renal disease and most benefit from kidney transplantation.
Researchers at MIT have developed a new approach to designing battery materials that could lead to improved ion mobility and reduced reactivity. By analyzing the lattice properties of solid materials, they found a correlation between vibrational frequency and conductivity, allowing for accurate predictions of material properties.
Rare amphibian species on rocky plateaux in western India are threatened by erosion and disease. The research highlights the need for greater protection of these habitats to preserve the species.
A new study published in Annals of Internal Medicine found that hospital quality report cards and readmission penalties may not tell the whole story. The research revealed that when non-Medicare patients and unreported conditions are taken into account, half of hospitals would be subject to a change in their financial penalty status.
A team of scientists has found a way to trap the rice blast fungus within a single plant cell, stopping its spread. The breakthrough discovery reveals how the fungus manipulates natural channels to evade the plant's immune system.
A new method has been developed to determine the crystal structures of organic salts, significantly speeding up the development of medications. This breakthrough is expected to reduce the time and cost associated with screening organic salts, leading to a faster discovery of effective pharmaceutical ingredients.
A recent study by Lund University found that chance plays a significant role in local species survival, sometimes overriding conservation initiatives. The researchers also discovered negative frequency-dependence, which counteracts the role of chance and helps rare species recover.
A recent study found that receptivity to e-cigarette advertising significantly increased the odds of 12-21 year-olds who have never smoked trying cigarette smoking within a year. This association was independent of receptivity to cigarette advertising.
Physicists at MSU used high harmonics spectroscopy to study the behavior of electrons in a dielectric material. They found that ultra-short laser pulses can turn the material into a conductor by increasing its kinetic energy and changing its many-body state.
A new study from Johns Hopkins Bloomberg School of Public Health found that frequent public drug users who witness more overdoses are likely to be good candidates for naloxone training. These users tend to engage in riskier drug use and use drugs in a wider range of settings.
Scientists at Linköping University have developed a method to generate electricity from the natural fluctuations in temperature caused by sunlight and shade. By combining plasmonic antennas with pyroelectric materials, they can harness energy from light fluctuations. This innovative technology has the potential to be used in various ap...
Researchers at DESY's NanoLab found that nanoparticles with a large number of edges are more efficient in catalytic reactions. The study revealed that the different facets of the nanoparticles become inactive due to growing oxide islands, leaving active sites for the reaction.
The UK Centre for Research on Energy Demand (UKCRED) will focus on systemic and socio-technical perspectives to develop internationally leading research on energy demand. Led by Professor Nick Eyre at the University of Oxford, the centre aims to reduce energy demand, decarbonize it, and make it more flexible.
A new study published in the American Journal of Preventive Medicine found that the CUSFTA led to an increase in caloric availability of approximately 170 kilocalories per person per day in Canada. This rise coincided with a US$1.82 billion increase in US investment in the Canadian food and beverage industry.
A new study by Kaiser Permanente researchers found that children with autism spectrum disorders and their younger siblings are less likely to receive full vaccinations. The study analyzed data from over 3,700 children with ASD and nearly 500,000 children without ASD, as well as their siblings born between 1995 and 2014.
A study at UNICAMP in Brazil has identified genetic factors associated with the severity of acute viral bronchiolitis, a leading cause of hospitalization in infants worldwide. The researchers found links between specific genes and viruses that can cause the disease, which could lead to personalized treatment.
Cyclone Iris is a low-end Category 1 cyclone moving south through the Coral Sea. It is likely to weaken back to a tropical low and stall in the Coral Sea area for a full week.
Research on marmoset monkeys found that both internal states, such as arousal levels, and external factors, like timing of another monkey's vocalizations, impact vocalization changes. The study suggests a complex relationship between vocal production in nonhuman primates, with potential implications for understanding human communication.
Researchers from The University of Tokyo's Institute of Industrial Science discovered that water's tetrahedral structure is key to its unique properties. The study found that the delicate balance between order and disorder in water allows it to exhibit high structural flexibility, resulting in unusual behavior such as expansion upon fr...
A new study found a staggering 433% increase in U.S. infants diagnosed with opioid withdrawal symptoms between 2004 and 2014. Medicaid-covered infants showed even more severe symptoms, resulting in $462 million in healthcare costs and approximately $2 billion in excess Medicaid costs over 10 years.
A new study by UC Santa Barbara marine biologists shows that female purple sea urchins can condition their offspring to withstand stress induced by low pH levels, commonly caused by ocean acidification. The researchers found that the females' exposure to stressful conditions resulted in harder and larger offspring.
A study of aquatic mammal body size evolution found that environments constrain body size more than terrestrial habitats do. The analysis suggested that thermoregulation and metabolism force aquatic mammals to grow larger than their terrestrial counterparts.
A novel blueprint for faster implementation of more evidence-based healthcare solutions has been designed and implemented. The Agile Implementation methodology provides a catalytic platform for transforming the current healthcare delivery system into a patient- and family-centric, high-reliability model.
A new study using drones to track caribou movement found significant variation in sociality within herds, challenging the classic assumption of uniform behavior among group members. The research also showed that caribou follow isotropic interaction rules, with individuals influenced more by those in front of them than beside them.
Scientists at Michigan State University have discovered a promising new drug that targets the c-Myc gene, which is linked to obesity and various cancers. The drug, I-BET-762, delays the development of existing cancers by inhibiting critical proteins involved in cancer cell growth.
A new study reveals that US drug-related mortality rates are not randomly distributed across the country, but rather are influenced by economic and social factors. The research found significant geographic differences in overdose rates, with some regions bearing heavier burdens than others.
A recent study published in Cell Reports sheds light on the poorly-understood part of vesicle recycling at synapses. The researchers found that refilling vesicles with neurotransmitters like GABA takes longer than reforming them, and this process is crucial for maintaining important brain functions.
Researchers at Saarland University develop a new generation of electroactive polymers, which can act as sensors and actuators, requiring minimal energy and resources. The technology has potential applications in various industries, including self-metering valves, motorless pumps, and tactile aids for touchscreens.