A new $4.4 million research project aims to improve diagnosis and therapies for obesity-related health problems, including coronary heart disease, endometrial cancer, type-2 diabetes, and degenerative joint disease. The project will utilize big data analytics and genomics to gain insights into the causes of obesity.
Researchers at Umeå University discovered that increased CO2 levels shifted photosynthetic metabolism in plants towards photosynthesis, contributing to global vegetation's ability to dampen climate change. The study used historic plant samples to quantify the impact of atmospheric CO2 levels on plant metabolism.
Researchers at Boston University School of Medicine used non-invasive Magnetic Resonance Imaging (MRI) to detect vulnerable atherosclerosis plaques, which can lead to heart attacks and strokes. The study showed that MRI can discriminate between high-risk and stable plaques at early stages.
A recent study by Ben-Gurion University researchers found that individuals with diabetic foot complications suffer from significantly impaired cognitive function. Cognitive abilities such as memory, concentration, and learning are affected, with patients exhibiting slower responses and decreased verbal fluency.
Dr. Donald Schomer, a Harvard Medical School professor, is recognized for his pioneering work in comprehensive epilepsy programs and training fellow clinicians worldwide. He has trained 46 fellows since establishing the fellowship program at Beth Israel Deaconess Medical Center.
Research reveals disrupted sleep in people with epilepsy can impede memory formation, impair cognitive performance, and influence daily life. Studies show links between sleep disturbances and seizure control, as well as the impact of nighttime seizures on memory retention.
Engineers at University of California, Santa Barbara developed a new tunnel field effect transistor that switches at only 0.1 volts and reduces power dissipation by over 90%, overcoming the fundamental limitations of conventional transistors.
A recent study by University of Edinburgh researchers has identified two molecules, Hif-1alpha and Hif-2alpha, that work together to prevent the development of Acute Myeloid Leukemia (AML) in an aggressive type of blood cancer. The findings suggest that therapies designed to block these molecules may have no impact or worsen the disease.
A new study in PLOS One analyzes tens of millions of tweets surrounding specific social protests and finds that a critical periphery of 'slacktivists' greatly amplify a movement's message, doubling its reach. The researchers argue that these peripheral players are essential to give protests resonance.
Global carbon emissions from fossil fuels and industry grew by just 0.6 per cent last year, marking a slowdown. China's decreased coal use is largely responsible for the break in global emissions growth, with emissions projected to decline by 0.6 per cent this year.
The OIST team developed an on-off switch with ultrathin optical fibers, using the quantum properties of rubidium atoms in the presence of different wavelengths of light. This proof-of-concept system could be used as a building block in a quantum network, enabling efficient data transfer and security.
Designers of Christmas cards employed fine art to divert attention from growing consumerism and promote art and aesthetic values. Rare cards held by a Devon-based private collector showcased high-quality artwork, bridging the boundary between fine and decorative arts.
A new study from the University of Exeter found that larger protected areas with irregular shapes tend to host more species. Habitat fragmentation, however, can reduce species diversity in these areas.
Virginia Tech researchers have discovered that plasmacytoid dendritic cells do not contribute to late-stage lupus in mice, contradicting years of previous research. The study's findings suggest that pDCs are only involved in the initiation of lupus, rather than its progression.
A recent study found that a reform model aimed at improving coordinated care for individuals with mental health diagnoses has yet to deliver desired results. The Blue Cross Blue Shield of Massachusetts Alternative Quality Contract, which began in 2009, was designed to encourage high-value care and improve quality coordination, but its ...
The Bill and Melinda Gates Foundation has granted $478,000 to researchers at the University of Massachusetts Amherst to develop a vaccine against trypanosomiasis, a fatal disease of cattle in sub-Saharan Africa. The vaccine aims to enhance the immune response of infected hosts to control the disease.
Dr. William Bottke will present on a relatively tranquil time between two violent bombardment phases in the early solar system, exploring evidence from various sources including planet formation models and ancient samples.
The new Cardiovascular Innovations and Applications (CVIA) journal has published its first issue, featuring a special focus on heart failure. Key findings include strategies to reduce heart failure readmission rates and the use of noninvasive hemodynamic monitoring for improved management.
Walter J. Arabasz received the Frank Press Public Service Award for his public service in modernizing seismic monitoring in the US. He led the development of Utah's regional seismic network and played a key role in informing state seismic safety policies.
Researchers developed a new index identifying concurrent but unrelated diseases among AYA cancer patients, highlighting prevalence of mental illness, obesity, and cardiovascular conditions. The AYA HOPE Comorbidity Index can predict service needs and improve treatment outcomes for young cancer patients.
Global carbon dioxide emissions from fossil fuels declined by 0.6% in 2015, marking a break from the rapid growth of the past decade. The largest contributor to this decline was a decrease in coal consumption in China, which slowed its emissions growth to 1.2%.
Researchers at MIT have developed a stretchy hydrogel material that can incorporate temperature sensors, LED lights, and drug-delivering reservoirs. The hydrogel can sense changes in skin temperature and release medicine as needed, making it a potential treatment for burns or other skin conditions.
A team of researchers has developed an open software platform to simulate a complete model of the adult fruit fly brain for the first time. The platform will enable global collaboration and accelerate model development, providing insights into diseases such as Alzheimer's and motor neurone disease.
A study of over 99,000 children found that weight increase during the first year of life is associated with a higher risk of developing type 1 diabetes. The average change in weight from birth to 12 months was linked to an increased risk, while length gain showed no association.
A new study has found that combining the blood thinner warfarin with certain diabetes medications increases hospitalizations for falls, altered mental state, and insulin shock among Medicare patients. The study's findings have significant implications for patient safety and healthcare costs.
Researchers at Case Western Reserve University School of Medicine received NIH grants to study Parkinson's disease, investigating gliptins for effective treatment. They also explored regenerating stem cells to heal the brain after a stroke and targeting brain tumor stem cells to develop new therapy strategies.
Researchers at Eindhoven University of Technology developed a tiny wireless temperature sensor that measures just 2 square millimeters and weighs 1.6 milligrams. The sensor operates beneath a layer of paint or concrete, consumes extremely low energy, and can be easily incorporated into buildings.
A recent study by Cornell University found that firefighter platoons who eat meals together have better group job performance compared to those who dine solo. This phenomenon is attributed to the social bonding and intimacy that comes with sharing meals, which spills over into improved work performance.
Research on invasive yellow crazy ants found they are more likely to attack native cruiser butterfly caterpillars than green tree ants. The study suggests a potential eradication program could mitigate ecological damage, but federal support is uncertain without state and local backing.
A new study by Princeton University researchers suggests that warmer nights may lead to more carbon being released into the atmosphere, exacerbating climate change. The research found a strong correlation between tropical nighttime temperatures and variations in plant respiration rates, which produce carbon dioxide.
The Target Validation Platform provides a single, robust infrastructure that integrates high-level information from key sources of evidence. It enables communities to work together, making the hand-off from basic research to drug discovery smoother, and is expected to grow substantially as it integrates experimental project data.
Scientists from Switzerland and the Netherlands have identified over 2,300 bacterial proteins in 22 different growth conditions, representing half of the bacterial genes. The dataset provides insight into protein function, expression levels, and post-translational adaptations.
A new randomized clinical trial found that acetaminophen does not provide benefits in fighting the flu or reducing symptoms. The trial involved adults with confirmed influenza infections, who were treated with paracetamol or placebo for five days.
A new study shows that Greenland's glaciers are retreating twice as fast as in the past 9,500 years, highlighting their acute temperature sensitivity. The sediment cores from a glacier-fed lake provide the first continuous observation of glacier change in southeastern Greenland.
Amol Aggarwal, a Harvard University PhD student, received the 2016 Morgan Prize for his exceptional work in combinatorics. He has already published four research papers and has been awarded several prestigious fellowships.
A Yale-led study finds that individuals with negative beliefs about aging are more likely to develop brain changes associated with Alzheimer's disease. Combatting these negative beliefs could potentially reduce the rising rate of Alzheimer's disease.
Four studies explore the interplay between epilepsy and aging, revealing unexpected consequences on the brain. Researchers found that uncontrolled epilepsy can lead to accelerated brain aging, while others discovered a link between traumatic brain injury and post-traumatic epilepsy in the elderly population.
A mindfulness-based stress reduction program has been shown to improve attention and reduce mistakes on difficult cognitive tasks in breast and colorectal cancer survivors. The program, known as MBSR, provides a creative solution for managing cancer-related cognitive impairment, which can be incapacitating.
Researchers at Imperial College London have genetically modified Anopheles gambiae mosquitoes to be infertile, using a gene drive technology that can spread the trait rapidly. The goal is to reduce the spread of malaria parasites, which infect over 200 million people annually and cause 430,000 deaths.
Researchers used a novel approach to measure the forces exerted by tumor cells on their surrounding connective tissue. By analyzing tissue deformations, they calculated cell forces with high accuracy, revealing key insights into tumour cell migration and behaviour.
A new study confirms that home-delivered meals provide more than just nutrition and food security for seniors. The research found that meal delivery significantly reduced feelings of loneliness among participants, particularly those who received daily deliveries.
A Stanford-led study predicts global carbon dioxide emissions from fossil fuels will drop slightly in 2015 due to a decrease in coal use in China. This slowdown contrasts with rapid growth in emissions before 2014 and highlights the need for action to stabilize CO2 emissions.
A pediatric chemotherapy regimen significantly improved outcomes for young adults with acute lymphoblastic leukemia (ALL), with a three-year overall survival rate of over 70%, according to Dana-Farber Cancer Institute scientists.
Studies by Dartmouth researchers found that mixing of sediments and microorganisms significantly impact methylmercury production, contradicting earlier assumptions about sediments as the primary source.
A study published in Arthritis Care & Research found that both prefabricated foot orthoses and rocker-sole shoes alleviate big toe joint pain, with orthoses potentially being the better option due to reduced discomfort and impaired balance. Additionally, these interventions also affect peak pressure under other toes and midfoot.
Researchers from University Health Network have found a specific cell type plays a key role in maintaining healthy arteries after inflammation. A group of tissue macrophages can self-replicate and help to heal the vessel after inflammation. This discovery could provide new treatment options for cardiovascular disease.
A new article published in Acta Paediatrica stresses the importance of direct interactions with family members for infants' cognitive and language development. The research suggests that screen-based activities like iPads or DVDs may actually hinder language skills, leading to potential delays.
A study of 261 children with severe epilepsy found significant seizure reduction after taking pharmaceutical CBD (cannabidiol) in combination with anti-epileptic drugs. The frequency of seizures was reduced by a median of 45% in all participants, with some patients experiencing a 50% or greater reduction.
A new messaging system, Vuvuzela, provides strong mathematical guarantees of user anonymity while allowing for fast communication. The system uses three servers and encryption layers to confuse adversaries and prevent them from inferring communication patterns.
Studies reveal that nearly a quarter of people who experienced SUDEP carried mutations linked to cardiac sudden death, suggesting irregular heart rhythms as a significant cause. Genetic testing could potentially identify people at high risk of SUDEP.
The Federal Emergency Management Agency has granted a $750,000 program to enhance coastal resilience in Texas. The program aims to improve community planning and outreach, using tools like CHARM, to mitigate the impact of weather hazards.
University of Washington researchers have developed a technology to capture the 'persona' of a well-photographed person like Tom Hanks from vast numbers of Internet images. The digital model can be animated to deliver speeches that the real actor never performed, and even transfer expressions and mannerisms onto another person's face.
A new RAND Corporation study found that home health visits can lead to a 14% reduction in hospital admissions and a lower risk of nursing home admissions among Medicare beneficiaries. The program, called HouseCalls, involves comprehensive geriatric assessments and referrals to community providers.
A study of 47 men with erectile dysfunction found that 79% were satisfied with the outcome of penile prosthesis surgery. The benefits included improved sexual function, enhanced male identity, and relationship improvements. Most men reported positive emotions, self-esteem, confidence, and increased desire after receiving the implant.
A study by the USDA Forest Service found that landscapes with 50-60% forest land use had statistically the same sink strength as those with 90-100% forest. This suggests that land use change is a substantial component of the forest carbon sink in the Eastern United States, and new approaches like establishing new forests may help seque...
Researchers studied gustatory computations in zebrafish brainstem circuits, revealing that taste categories are represented by dissimilar responses and generate different behaviors. The study proposed a central role for encoding category, concentration, and mixtures of taste in these circuits.
Research found that young men with greater interest in babies showed smaller increases in testosterone in response to sexually explicit stimuli, indicating a 'slow' life-history strategy. In contrast, men who didn't like babies as much were more physiologically aroused by novel sexual stimuli.
A new study suggests that global plant growth is not keeping up with CO2 emissions, contradicting expectations. The research indicates that satellite-based results and model-based estimates diverge due to limitations in water availability and nutrient supply.
Researchers at Eindhoven University of Technology have identified a novel site on the RORγt nuclear receptor that can be targeted by drugs without inducing resistance. This discovery could lead to new treatments for autoimmune diseases like rheumatism and Crohn's disease.
A new gene therapy platform uses a hydrogel and self-assembled nanoparticles to deliver microRNAs that suppress tumor tissue, increasing dosage at the site while reducing systemic side effects. The approach has shown promising results in shrinking tumors by nearly 90% in pre-clinical models.
Women with Type 2 diabetes face increased cardiovascular disease risk, including earlier heart attacks, higher mortality rates, and reduced access to treatments. Lifestyle changes like improved diet and exercise may help reduce this risk, but more research is needed to understand these differences and improve health equity.
RHIC scientists found that shape affects particle production and flow in collisions, enabling them to separate results by geometry. This discovery represents a paradigm shift in understanding quark-gluon plasma formation.
Young men with HIV who have sex with men are more likely to report condomless anal sex, particularly with a partner not infected with HIV. Behavioral approaches to improve engagement in care and medication adherence may need to occur in concert with interventions to reduce risky sexual behaviors.
Researchers have identified four potential treatment opportunities for acute myeloid leukemia, including compounds targeting metabolism, internal communications, and protein transport. These findings represent significant progress in seeking out new ways to approach an intractable cancer.
Researchers have uncovered the atomic-level structure of the bluetongue virus, providing a detailed understanding of its mechanism of entry into host cells. This breakthrough could lead to the development of more effective vaccines and treatments against this devastating disease.
A recent study published in Nature Genetics reveals that Short Tandem Repeats (STRs) regulate gene expression and modulate disease traits. STRs, previously thought to be neutral or 'junk' DNA, were found to act like springs or knobs that fine-tune nearby gene expression.
Researchers at Toyohashi University of Technology have developed a novel gene-transfection method that uses electrostatic manipulation in water-in-oil droplets. This technique increases transfection efficiency and cell viability compared to traditional methods, offering promising applications in regenerative medicine and gene therapy.
Researchers found that including plants' acclimation to changes in temperature improves climate model accuracy, especially for tropical forests. Adding formulas for acclimation increases carbon exchange simulations by 36%, leading to a better understanding of how regions will respond to warmer temperatures.
A study found that breast cancer survivors with therapy-related leukemia often have inherited cancer susceptibility and gene mutations. Researchers suggest a long-term follow-up study to understand the impact of these genes on leukemia risk, enabling personalized conversations about treatment benefits and risks.
Researchers have achieved unprecedented response rates of up to 93% and durable remissions of over two years in children with relapsed/refractory acute lymphoblastic leukemia. Similarly, patients with non-Hodgkin lymphoma responded well to personalized cellular therapy, with complete remissions seen in 14 patients.
Researchers at Dana-Farber Cancer Institute have conducted three studies demonstrating the effectiveness of new drug combinations in treating relapsed or treatment-resistant multiple myeloma. The trials showed impressive partial and complete remissions, as well as increased duration of remissions with tolerable side effects.
Researchers identified a nuclear receptor protein called RXRgamma, which promotes OPC differentiation and remyelination. A vitamin D-activating drug may enhance remyelination in MS patients by controlling myelin sheath regeneration.
A University of Eastern Finland study found that small gallstones are often caused by idiopathic pancreatitis and can be prevented by laparoscopic gallbladder removal surgery. Statin use was also associated with an increased risk of acute pancreatitis, especially during the first year of use.
A recent study from Australia found that urban environments contain disproportionately more threatened protected species in a given area than non-urban environments. Cities consistently supported a greater number of protected species than other areas, showcasing the importance of cities in tackling biodiversity loss.
Experts presented research on the complex relationship between diabetes and bone, highlighting increased risk of fragility fractures in people with type 2 diabetes. The studies found that diabetic patients may experience higher BMD but lower bone microstructure quality, leading to an increased risk of wrist fracture.
A recent survey by Drexel University researchers found that there is a lack of understanding about the costs and benefits of improving indoor air quality, even among building owners and designers. The study suggests that increasing ventilation and using better air filters can significantly improve health and productivity, but many peop...
A Stanford study found that infertile men have a higher risk of developing heart disease, diabetes, and other health problems. The research suggests that male infertility is associated with increased rates of mortality and general health issues, even after adjusting for obesity and smoking.
Young adults born preterm have a 40% increased risk of premature death compared with people born at term. Regular measurement of blood pressure and pulmonary function testing are recommended to help manage risks associated with preterm birth.
A new study found that a brief dissonance-based eating disorder prevention program alters how young women's brains respond to images of thin supermodels. The program reduces pursuit of unrealistic beauty standards and changes brain responsivity to normal-weight women, suggesting a shift in valuation towards healthy weight.
A study of medical records found that men taking androgen deprivation therapy for prostate cancer were almost twice as likely to be diagnosed with Alzheimer's disease as those who didn't undergo the therapy. The longer duration of ADT, the greater the risk of Alzheimer's disease.
Scientists have reevaluated the emergence of early dinosaur relatives and their connection to the first dinosaurs. The new findings suggest a shorter time gap between the two, dating back around 234-236 million years, contradicting previous estimates.
Brian Litt, M.D., receives the American Epilepsy Society's Research Recognition Award for Clinical Science for his pioneering work in neuroengineering and translational neuroengineering. His research focuses on developing new diagnostic and therapeutic technologies to improve epilepsy treatment outcomes.
A recent study published in Cancer Research reveals that obesity contributes to metastasis in ovarian cancer patients. Researchers from the University of Notre Dame found that tumor cells are better able to metastasize when grown in a high-fat environment, suggesting potential targets for dietary and therapeutic interventions.
Researchers have developed personal monitoring devices that can track seizure activity in the home environment, providing advance warning before seizures strike. These devices use biometric recording technology and can operate for seven days on a single charge, revolutionizing epilepsy therapy.
Research studies presented at the IOF regional meeting found significantly low levels of vitamin D in different population groups across the Middle East. The studies revealed high prevalence of vitamin D deficiency, affecting all age groups, sexes and local/non-local populations.
Researchers have found that continuous intravenous infusions may not be appropriate for all patients with drug-resistant status epilepticus, while a sedative called ketamine is increasingly used as a treatment option. The duration of status epilepticus in children depends on factors such as the length of time between seizure onset and ...
Professor Federico Rosei of INRS Énergie Matériaux Télécommunications Research Centre has received the 2016 John C. Polanyi Award from the Canadian Society for Chemistry. He is known for his research on nanostructured materials and has earned several national and international awards.
A new model has been developed to track animal movements using solar geolocators, providing more precise locations and behavioral data for migratory species. The FLightR R package enables accurate estimates of migration routes with increased precision than traditional methods.
A team of researchers discovered non-coding RNA molecules in cancer cells that stimulate an immune response by mimicking pathogens. The findings suggest these molecules may play a significant role in mediating immune responses against cancer.
Researchers identify NEK7 enzyme's switch-like activity in immunity, leading to potential new treatments for metabolic disorders and inflammatory conditions. The study provides insights into the inflammasome pathway and its connection to cancer.
The Rice researchers used experiments and simulations to study the stiffness of joined nanotubes and found that some types are tougher than others, with all having potential uses in macroscale structures. The team discovered that the X's were the stiffest and most able to bounce back to nearly their original shapes.
The study describes for the first time the developmental processes that differentiate Neanderthal facial skeletons from those of modern humans. The researchers found that Neanderthals' faces grow with extensive deposits by osteoblasts without a compensatory resorption, leading to a prognathic maxilla.
Researchers create spatiotemporal genomic analysis (SAGA) technique to study differences in cellular behavior, including cell migration and response to chemotherapy. This approach may lead to new treatments that hamper metastasis.
Researchers at the University of Warwick discovered that sperm tails rotate in a counter-clockwise motion to move through fluids. Approximately 50% of observed sperm moved to the right by distorting their bodies to counteract the left-turning force, suggesting two distinct physiologically subpopulations
Scientists have detected spin currents on a topological insulator at room temperature for the first time, enabling dissipationless spin currents. The breakthrough uses ferromagnetic tunnel contacts to measure the spin polarization of electrons on the surface.
A study published in Health Affairs found that the most crowded US hospital emergency departments did not adopt effective interventions to improve flow, leading to worse patient care and outcomes. Despite increased adoption of strategies to reduce crowding over four years, many hospitals still failed to implement proven interventions.
Researchers at the University of Missouri-Columbia found that TigerPlace residents who used sensor technology and onsite care coordination stayed in their apartments for an average of 4.3 years, nearly double the national median of 1.8 years.
Once-weekly GLP-1RAs lack clear-cut benefits and harms, making it challenging to choose the most suitable medication. The medications share similar outcomes for blood pressure and lipids but have differences in terms of HbA1c reduction and body weight, as well as risk of nausea and heart rate increase.
A new mobile biochip device, the HemeChip, can rapidly screen for sickle cell disease with just a few drops of blood, providing an easy-to-use and cost-effective tool for equitable diagnosis. This technology has the potential to make a huge difference in developing nations worldwide by enabling early treatment.
A UK-based research team aims to produce a yeast-derived substitute for palm oil using sustainably-sourced waste feedstocks, potentially mitigating environmental issues associated with palm oil production. The £4.4m grant-funded project will develop a novel yeast and apply innovative methods of depolymerizing waste materials.
Researchers harness molecular machinery of living systems to power integrated circuit from ATP, enabling new artificial systems with both biological and solid-state components. The system produces an electrical potential harvested by the IC in the presence of ATP.
Researchers at TUM developed a new method to produce extremely thin and robust, yet highly porous semiconductor layers using nanostructured germanium. These layers can be custom tailored with organic polymers to create hybrid materials suitable for small solar cells or batteries.
New research published in CMAJ found that older men taking alpha-blockers for prostate issues are at higher risk of ischemic stroke during the initiation phase. The study suggests caution when prescribing alpha-blockers to patients not already on other blood pressure medications.
A new study by Johns Hopkins Bloomberg School of Public Health researchers found that over 112,000 people exiting prison or jail got health care coverage through Medicaid in a single year. The programs that helped with enrollment primarily targeted low-income men, and the number of new enrollees likely far exceeds this total.
Researchers have developed a novel method to reposition an FDA-approved anti-cancer compound for targeting liver cancer tumors. The 'triple attack' technique uses nanobubbles filled with the drug to specifically target cancer cells, minimizing harm to healthy tissue.
Researchers use high-energy synchrotron X-rays to analyze cast iron structure, revealing insights into its mechanical and thermal properties. This technology enables the development of high-performance materials for fuel-efficient engines and engine parts.
A phase I/II clinical trial found that acalabrutinib promotes high response rates and durable results in patients with relapsed chronic lymphocytic leukemia while producing minimal side effects. The drug's selective blockade of the BTK pathway may offer improved tolerability compared to other treatments.
Researchers found support for Chomsky's decades-old theory that we possess an 'internal grammar' to comprehend nonsensical phrases. The study used magnetoencephalography and electrocorticography to isolate brain activity while subjects listened to linguistically manipulated sequences.
German cockroaches' gut bacteria produce pheromones that attract other roaches, promoting aggregation. The compounds are essential for nymphs to determine a safe place.
A £5.5m research project aims to tackle air pollution in Beijing, which poses a serious threat to human health, particularly among China's 500 million urban residents. The five four-year projects will investigate the concentrations and sources of urban air pollution, its effects on health, and potential solutions.
Midostaurin has been shown to improve the five-year survival rate of patients with high-risk acute myeloid leukemia (AML) who carry the FLT-3 gene mutation. The clinical trial found that midostaurin added to standard chemotherapy reduced the risk of death by 23% compared to placebo, resulting in a 50.9% five-year survival rate.
Researchers at Umea University discovered unique muscle fibers in the soft palate of humans, found in greater numbers in snorers and sleep apnea patients. These fibers have a distinct molecular build-up and are absent or modified in some key proteins.
A clinical trial showed midostaurin, a multi-kinase inhibitor, improved the five-year survival rate of patients with high-risk acute myeloid leukemia (AML) who carry the FLT-3 gene mutation. The treatment resulted in a 50.9% survival rate compared to 43.9% for those without the mutation.
Researchers have developed an innovative approach to treat drug addiction using RVG-exosome delivered RNAi against the opioid receptor mu (MOR). This method successfully down-regulates MOR in mouse brain and rescues opioid relapse. The study demonstrates the potential of this therapy for treating CNS diseases.
Researchers developed a simple method to track and predict viral evolution based on whole-genome sequences of influenza viruses. By identifying genetic variants that change the structure of influenza proteins, they found that many strains used in vaccines during previous seasons lacked these markers.
Researchers found that men use cardinal directions more efficiently and the hippocampus less than women, while women rely on local memory. Administering testosterone improved women's navigation skills, but not their performance.
A Phase I study combining natural killer cells with high-dose chemotherapy and stem cell transplantation showed promising results in treating multiple myeloma. The treatment resulted in no toxicity or graft-versus-host disease, offering a potential new approach for patients.
A new antivirus add-on can scan across computer networks and trap malicious activity missed by system firewalls, offering improved protection against malware. The system adds little computing overhead and can block malware before it causes harm or spreads to other machines.
Researchers at SLU are developing a biomarker to help diagnose sepsis early and improve treatment outcomes. Chlorinated lipids may hold the key to this discovery, as they appear under conditions of inflammation.
Researchers found that physical activity enhances neuroplasticity in the visual cortex of adult humans, paving the way for non-invasive therapeutic strategies. The study suggests exercise plays a crucial role in brain health and recovery, particularly for individuals with conditions like amblyopia.
A new study identifies brain processes in mice that may help explain how weak sensory inputs are interpreted differently in the same brain. Activity in higher-level perception areas of the brain is shaped by lower-level sensory input, adding a cellular layer to our understanding of perception.
Researchers found a 15-20% reduction in hospitalization risk for heart failure or death among patients with cardiac resynchronization therapy compared to those with implantable cardioverter defibrillators. The treatment is associated with improved outcomes, but further studies are needed.
Researchers found that winter temperatures drive synchrony in aphid flight timings, affecting commercial crops like alfalfa and wheat. Climate change influences spatial synchrony in many species, with implications for public health and commercial endeavors.
Recent research reveals that all dividing human skin cells have the potential to switch between two modes of cell division, one for maintenance and another for wound repair. This finding explains how skin grafts work and may lead to new treatments for wound healing and cancer.
A phase 1 clinical trial found that enzalutamide is active and well-tolerated alone and with fulvestrant in patients with advanced breast cancer. The study supports a larger trial of the combination, building on promising preclinical data and targeting androgen receptors in breast cancer.
Cavitation bubbles, formed by ultrasonic pressure waves, can cause severe damage to nearby cells. Duke researchers used high-speed cameras to study the effects of these powerful little bubbles on individual cells, finding that membranes can withstand higher strains than previously thought and reseal allowing target cells to fully recover.
Researchers discovered that ancient Puebloans used trees from the Zuni and Chuska Mountains to build massive structures in Chaco Canyon. The switch to Chuska Mountain trees coincides with significant cultural developments in Chacoan culture, including changes in masonry style and construction volume.
University of Oregon scientists have identified a molecular change in aging stem cells that stops them from making tumors. The discovery, detailed in the journal Current Biology, focuses on the larval stage of fruit fly development and reveals that a protein called Eyeless plays a crucial role in regulating Notch signaling.
Researchers have developed a new system to track nanometer-sized viruses at sub-millisecond time scales, shedding light on the spontaneous self-assembly of viruses. This breakthrough could help design drugs that prevent viruses from forming in the first place.
The American Epilepsy Society awarded Dr. Christian E. Elger the William G. Lennox Award for expanding his department into a leading program in epilepsy surgery and human brain research. Elger's pioneering work includes studying seizure prediction and developing pre-surgical cognitive outcomes.
A Stanford University study has found that men treated with androgen deprivation therapy for prostate cancer are nearly twice as likely to be diagnosed with Alzheimer's disease. The researchers analyzed electronic medical records of thousands of patients, revealing a significant increase in cognitive decline among those receiving ADT.
Researchers at the University at Buffalo have developed a method to convert skin cells into functional dopamine neurons by manipulating the expression of p53 and Tet1 enzymes. This breakthrough enables the efficient generation of patient-specific neurons that can be transplanted into the brain to repair faulty dopamine neurons.
Researchers found that hippos consume meat, challenging their dietary status as herbivores, and increasing their susceptibility to anthrax outbreaks. This behavior may be linked to the unique characteristics of antelope carcasses infected with anthrax.
A UCI study found that high doses of green tea polyphenols can cause developmental delays, reduced offspring output, and reproductive abnormalities in fruit fly larvae. The researchers recommend moderate consumption to avoid potential health risks.
Researchers presented landmark studies on newly diagnosed multiple myeloma, revealing key biological processes and disease mechanisms. Two combination therapy strategies showed high response rates in patients with difficult-to-treat myeloma.
A new model predicts that climate change impacts will worsen income growth for the poor, leading to a more unequal distribution of wealth. The researchers recommend lenient or sharp increases in carbon prices to mitigate these effects and protect vulnerable populations.
Research at Columbia University's Mailman School of Public Health found that young men with detectable HIV are more likely to engage in risky sexual behavior, particularly anal intercourse without condoms. This disproportionately affects vulnerable groups, such as those aged 13-29 and experiencing substance use issues.
Researchers discovered strikingly huge organs in tiny cave snails, including enormous kidneys and three-pointed teeth. These adaptations enable the snails to tolerate extreme conditions and survive in environments where others would perish.
Researchers at University at Buffalo find that motivational interviewing significantly reduces the risk of opioid misuse and abuse among older adults with chronic pain. The intervention increases motivation, self-efficacy, and confidence in changing behavior, while also decreasing depression and anxiety.
Researchers have invented a technique to dramatically accelerate protein evolution, allowing them to test millions of variants in hours or days. The technology, called µSCALE, enables the identification of promising variants and their DNA sequences, paving the way for breakthroughs in medicine, industry, and biosensors.
The Canadian Medical Association Journal recommends that the new Minister of Health enact a national pharmacare program, letting science guide health policy decisions. The editors also emphasize the importance of defending the Canada Health Act and focusing on social determinants of health.
Patients who discontinued ibrutinib or idelalisib due to side effects experienced durable responses after switching to another kinase inhibitor, with a 50% objective response rate and 11.9-month median progression-free survival.
Researchers found elevated levels of polycyclic aromatic hydrocarbons (PAHs) in NYC community garden soils, a concern due to air emissions. However, cultivating vegetables in beds may lower PAH concentrations, suggesting potential for reduction through gardening practices.
Hitachi and Tohoku University's Advanced Institute for Materials Research have developed a basic technology to reduce internal resistance in all-solid-state lithium-ion batteries, allowing them to operate at temperatures up to 150°C. This breakthrough enables the thermally durable battery to be used in various applications, such as lar...
Entomologists from the University of California, Riverside, discovered a new genus of plant bug, Restiophylus, and four new species from Australia. The new species are closely associated with Australian restiid clade (Poales). Detailed information on the insects is provided in the Annals of the Entomological Society of America.
Trees draw on stored carbon reserves when springtime sap begins to flow, integrating sugars from multiple growing seasons. This finding suggests that maple syrup production depends on long-term nutrient storage rather than just the last season.
Researchers found that losing CD73 enzyme promotes tumor growth and progression in endometrial cancer by disrupting adenosine signaling, which normally regulates tissue function. The study provides new insights into the role of CD73 in cancer development.
Kevin Staley, M.D., has made significant contributions to understanding neonatal seizures through his work on 'neuronal plumbing' and GABA receptors. His research will benefit patients with epilepsy for years to come.
Researchers at University of California, San Diego School of Medicine have discovered that the existing compound KD3010 offers hope for slowing Huntington's disease and its symptoms. The study found that KD3010 improved motor function, reduced neurodegeneration, and increased survival in a mouse model of HD.
A study by the University of Georgia found a correlation between certain patterns of connections on Facebook and drug and alcohol use among female students. Students with a history of childhood physical abuse were more likely to be part of densely interconnected groups, associated with higher risk for alcohol use. In contrast, those wi...
Researchers deciphered the atomic-scale structure of a botulism toxin-bound protein, revealing how it stays intact in acidic conditions and disassembles in neutral pH environments. This knowledge may help develop new vaccines or treatments targeting the deadly neurotoxin.
The Scripps Research Institute (TSRI) team has discovered a unique anti-diabetes compound that activates the GLP-1 receptor's G-protein pathway, potentially leading to a new type of diabetes treatment. The novel molecule P5 shows promise in boosting glucose tolerance with minimal insulin stimulation.
A study published in PLOS ONE found that treating ear mites in Santa Catalina Island foxes reduced ear tumor prevalence by 99% and inflammation by 90%. The success story highlights the impact of preventative treatments on wildlife populations, with improved conditions for foxes' ear canals and a notable decline in tumors.