Researchers identify a subpopulation of cancer stem cells that display resistance to chemotherapy and contribute to tumor progression. The study suggests a new therapeutic strategy by targeting these cancer stem cells with a combination of standard chemotherapy and signaling pathway inhibitors.
A study found that 25% of Medicare recipients spent more on out-of-pocket healthcare expenses than their total assets during the last five years of life. The average spending was $38,688, with the top quarter of participants spending $101,791.
Researchers at Mount Sinai School of Medicine have identified the genetic cause of Winchester syndrome, a rare and fatal bone disease, by studying frozen skin cells taken from a child in 1969. The MT1-MMP gene mutation leads to severe arthritis and osteoporosis, rendering patients incapable of movement without assistance.
A new study suggests that a dual-action polyclonal antibody may offer more effective protection against osteoporosis by slowing bone destruction and building bone. This novel approach has the potential to be safer than existing treatments.
Researchers found that mice exposed to methyl-glyoxal, a heat-processed food compound, developed abdominal weight gain, insulin resistance, and type 2 diabetes. A diet high in MG reduced SIRT1 and AGER1 levels, impairing glucose metabolism.
Researchers at Mount Sinai School of Medicine discovered that an enzyme called HDAC2 is involved in reducing the efficacy of antipsychotic drugs in schizophrenic patients. The team found that inhibiting HDAC2 can improve therapeutic effects of antipsychotics and prevent drug resistance.
Latrepirdine, a compound initially rejected for Alzheimer's treatment, shows promise in animal models by reducing neurodegeneration-related proteins and activating autophagy. The study suggests potential benefits in treating or preventing disorders associated with high levels of alpha-synuclein.
A team of researchers at Mount Sinai School of Medicine found that Aurora A (Aurka) activates p53 by phosphorylation, promoting ESC self-renewal. The study provides insight into the role of Aurka in embryonic stem cell regulation and cancer development.
A study published by researchers at Mount Sinai School of Medicine suggests that latrepirdine, a previously failed Alzheimer's drug, may be successful if tested on patients with earlier stages of the disease. The compound effectively stopped progression of memory deterioration and brain pathology in mouse models.
Researchers at Mount Sinai School of Medicine presented data on transoral robotic surgery outcomes for patients with head and neck cancer. The study found significant benefits in progression-free and overall survival rates for both smokers and nonsmokers, suggesting a promising treatment modality.
Researchers developed a new computational method to identify novel connections between genes, drugs and scientists. The approach analyzed large datasets to create gene-gene networks, connected co-prescribed drugs and side effects, and identified collaborations.
Mount Sinai researchers found that neutrophils boost antibody production and reprogram B-cells to create a potent immune response. This discovery has significant promise for developing vaccines against blood-borne infections and HIV.
A multi-center study of 55 children found that oral immunotherapy reduced allergic reactions, allowing most to consume eggs without symptoms. The therapy showed promise in desensitizing children to egg allergies, representing a promising therapeutic intervention.
Researchers at Mount Sinai Hospital found a link between increased risk of autism spectrum disorder (ASD) and family history of schizophrenia or bipolar disorder. The study suggests shared etiologic risk factors among these disorders, potentially leading to more similar understanding and treatment approaches.
A patient registry has yielded crucial data on the clinical features and outcomes of fibromuscular dysplasia (FMD), a non-inflammatory vascular disease. The study found that 91% of patients are women diagnosed in their prime of life, with an average delay in diagnosis of four years from symptom onset.
A study found that a simpler lifestyle with fresh foods and limited use of environmental chemicals can reduce exposure to EDCs. Researchers analyzed urine samples from OOM women and compared them to NHANES data, finding lower levels of BPA and phthalates in the former group.
A recent study found that young children with food allergies experience almost one allergic reaction per year, despite parental instructions on food avoidance. The study highlights the importance of educating parents and caregivers about avoiding allergenic foods and using epinephrine to treat severe reactions.
A study by Mount Sinai researchers found that the timing of ADHD medication impact on children's performance on standardized tests. The findings showed that starting medication within 12 months after fourth-grade test led to a decline of 0.3 percent in math compared to 9.4 percent for those who started treatment later.
A new intestinal gel formulation of levodopa/carbidopa has improved the duration of treatment benefits in people with advanced Parkinson's disease, reducing 'off' time and dyskinesia. The study found that the continuous delivery reduced 'off' time by nearly four hours, two hours more than standard oral formulations.
Researchers developed a multi-target approach to treat tumors using fruit flies, creating an investigational compound AD80 that targets multiple cancer genes. Tested in mouse models, AD80 proved far more effective and less toxic than standard cancer drugs.
Researchers at Mount Sinai School of Medicine are pioneering a new way to diagnose heart disease by focusing on fluid dynamics, not muscle mechanics. This approach uses advanced ultrasound techniques to visualize blood flow in the heart, providing clues for early detection and effective therapeutic interventions.
Researchers from Mount Sinai presented several landmark studies on late-stage cancer treatment trends, a promising multiple myeloma vaccine, and predictive models of soft tissue sarcomas, prostate, and bladder cancer. The studies aimed to identify factors associated with lack of treatment and explore new treatments for various cancers.
Researchers at Mount Sinai School of Medicine have found a potential treatment for craniosynostosis and acanthosis nigricans, two birth defects associated with Beare-Stevenson cutis gyrata syndrome. Inhibiting the protein p38 improved skull and skin defect outcomes in mouse models.
Researchers at Mount Sinai School of Medicine have developed a biosynthetic polyphenol that improves cognitive function in mice with Alzheimer's disease. The compound reduces brain neuropathology by preventing abnormal protein accumulation, promoting plasticity and benefits in learning and memory functions.
A research group led by Giulio Maria Pasinetti has discovered that misfolded tau released by neurons can spread to surrounding cells, promoting the progression of neurodegenerative disorders. A grape-seed extract enriched in polyphenols was also found to prevent cell-to-cell spread of tau pathology.
The RSNA Image Share project uses cloud computing to store and distribute medical images, making them accessible to physicians and patients. Patients can create an account to upload their images and access them securely.
Mount Sinai researchers identify top 10 toxic chemicals suspected to contribute to autism and learning disabilities, including lead, methylmercury, and PCBs. The list aims to guide research into preventable environmental causes of these conditions.
Scientists discovered that repeated cocaine exposure decreases a crucial brain protein's activity, enhancing reward for cocaine use and stimulating addiction. The study also found that blocking this protein's light-activated form can prevent addiction.
A study published in Archives of Otolaryngology – Head & Neck Surgery suggests that targeted swallowing exercises can alleviate debilitating side effects in people undergoing chemoradiation therapy for head and neck cancer. Patients who performed five targeted swallowing exercises throughout their CRT showed significantly better scores...
Researchers use groundbreaking gene sequencing technology to rapidly detect FLT3 mutations in AML patients who have relapsed on therapy. This discovery may help develop new therapies to treat AML, a type of leukemia characterized by rapid white blood cell growth.
Researchers developed a method to derive DNA information from RNA, allowing for identification of individuals in massive research repositories. This technique raises questions about DNA and RNA data bank privacy issues, and may enable tracking of individual characteristics like age, sex, and disease risks.
Researchers identified CHD8, SNC2A, and KATNAL2 gene mutations as risk factors for autism. The studies provide a better understanding of the genetic changes and biological pathways involved in autism spectrum disorders.
A new study found that lung cancers detected by annual CT screening grow as fast as those found with traditional methods, making early detection more effective. Non-small-cell lung cancer accounted for most cases, and solid nodules required less aggressive diagnosis and treatment.
Researchers from Mount Sinai School of Medicine presented several studies at the American College of Cardiology's annual scientific session. One study found that aggressive statin therapy reduced fat content in coronary blockage by 22 percent, while another showed that cardiovascular disease screening can identify risk factors and symp...
Researchers at Mount Sinai School of Medicine discovered that marijuana-like chemicals trigger receptors on human immune cells that directly inhibit a type of human immunodeficiency virus (HIV) found in late-stage AIDS. This finding could lead to the development of new drugs to slow the progression of disease.
Ingenol mebutate, a new topical gel, is applied for just a few days and shows comparable results to current therapies. The treatment significantly reduces the time needed to treat actinic keratosis, a common precursor to sun-related squamous-cell carcinoma.
A survey of over 1,000 gastroenterologists found that pressure to increase colonoscopy volume negatively affects procedure quality and safety. Gastroenterologists reported reducing time examining the colon wall or aborting difficult procedures due to production pressures.
Researchers at Mount Sinai School of Medicine have identified HIPK2 as a crucial regulator protein in kidney fibrosis, leading to improved conditions when eliminated or inhibited. The study provides a new therapeutic target for the treatment of kidney failure, affecting millions of Americans.
A new study has identified five genetic mutations associated with Crohn's disease in Ashkenazi Jews, who are nearly four times more likely to develop the condition. The findings provide insights into the unique risk factors driving this higher prevalence rate.
Researchers from Mount Sinai School of Medicine found that post-operative radiation therapy does not prolong life in older adults with locally advanced non-small cell lung cancer. The study analyzed data from over 1,300 patients and found no significant improvement in one-year or three-year survival rates.
Researchers found laws permitting young adults to stay on their parents' health insurance until age 26 result in improved access to healthcare. The study analyzed data from the U.S. Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System survey, comparing periods before and after state laws were enacted.
Researchers found that decaffeinated coffee improves glucose utilization in the brain, reducing the risk of neurocognitive problems associated with type 2 diabetes. The study suggests that decaffeinated coffee may have preventive benefits for cognitive decline caused by aging and neurodegenerative disorders.
Researchers at The Mount Sinai Hospital found an association between phthalate exposure and increased body mass index (BMI) and waist circumference in young children. Greater than 97% of study participants had been exposed to phthalates, which are man-made chemicals that mimic the body's natural hormones.
A study found that maternal gestational diabetes and low socioeconomic status significantly increase the risk of attention deficit hyperactivity disorder (ADHD) in six year olds. The risk doubles with either factor alone, but increases exponentially when both are present.
Researchers from Mount Sinai School of Medicine identified the pattern of cell signaling induced by antipsychotic drugs in a complex composed of two brain receptors linked to schizophrenia. This discovery may allow for the prediction of novel compounds' effectiveness and accelerate the development of better antipsychotic drugs.
Researchers found that responders with high exposure to the dust cloud had high-risk features of atherosclerosis and impaired vascular reactivity. The study used MRI imaging to evaluate cardiovascular risk in WTC first responders.
Researchers at Mount Sinai School of Medicine discovered fetal stem cells in the placenta can migrate to and repair damaged maternal hearts after a heart attack. The study found that these cells reprogram into beating heart cells, providing a potential therapeutic agent for cardiac regeneration.
The IPAL-EM initiative aims to integrate palliative care into emergency departments, reducing symptoms and anxiety while improving patient safety and satisfaction. By providing access to palliative care, the initiative seeks to improve quality of life for both patients and their families.
A study has discovered four gene variants that contribute to early stent thrombosis in people with coronary artery disease. These variants affect blood thinner clopidogrel sensitivity and platelet receptor function, increasing the risk of deadly complications after stent implantation.
Researchers found elevated levels of Advanced Glycation End products (AGEs) in infant blood, associated with early insulin resistance and diabetes. Cutting back on processed foods can improve insulin levels and reduce disease risk in adults.