A research group led by Giulio Maria Pasinetti has discovered that misfolded tau released by neurons can spread to surrounding cells, promoting the progression of neurodegenerative disorders. A grape-seed extract enriched in polyphenols was also found to prevent cell-to-cell spread of tau pathology.
The RSNA Image Share project uses cloud computing to store and distribute medical images, making them accessible to physicians and patients. Patients can create an account to upload their images and access them securely.
Mount Sinai researchers identify top 10 toxic chemicals suspected to contribute to autism and learning disabilities, including lead, methylmercury, and PCBs. The list aims to guide research into preventable environmental causes of these conditions.
Scientists discovered that repeated cocaine exposure decreases a crucial brain protein's activity, enhancing reward for cocaine use and stimulating addiction. The study also found that blocking this protein's light-activated form can prevent addiction.
A study published in Archives of Otolaryngology – Head & Neck Surgery suggests that targeted swallowing exercises can alleviate debilitating side effects in people undergoing chemoradiation therapy for head and neck cancer. Patients who performed five targeted swallowing exercises throughout their CRT showed significantly better scores...
Researchers use groundbreaking gene sequencing technology to rapidly detect FLT3 mutations in AML patients who have relapsed on therapy. This discovery may help develop new therapies to treat AML, a type of leukemia characterized by rapid white blood cell growth.
Researchers developed a method to derive DNA information from RNA, allowing for identification of individuals in massive research repositories. This technique raises questions about DNA and RNA data bank privacy issues, and may enable tracking of individual characteristics like age, sex, and disease risks.
Researchers identified CHD8, SNC2A, and KATNAL2 gene mutations as risk factors for autism. The studies provide a better understanding of the genetic changes and biological pathways involved in autism spectrum disorders.
A new study found that lung cancers detected by annual CT screening grow as fast as those found with traditional methods, making early detection more effective. Non-small-cell lung cancer accounted for most cases, and solid nodules required less aggressive diagnosis and treatment.
Researchers from Mount Sinai School of Medicine presented several studies at the American College of Cardiology's annual scientific session. One study found that aggressive statin therapy reduced fat content in coronary blockage by 22 percent, while another showed that cardiovascular disease screening can identify risk factors and symp...
Researchers at Mount Sinai School of Medicine discovered that marijuana-like chemicals trigger receptors on human immune cells that directly inhibit a type of human immunodeficiency virus (HIV) found in late-stage AIDS. This finding could lead to the development of new drugs to slow the progression of disease.
Ingenol mebutate, a new topical gel, is applied for just a few days and shows comparable results to current therapies. The treatment significantly reduces the time needed to treat actinic keratosis, a common precursor to sun-related squamous-cell carcinoma.
A survey of over 1,000 gastroenterologists found that pressure to increase colonoscopy volume negatively affects procedure quality and safety. Gastroenterologists reported reducing time examining the colon wall or aborting difficult procedures due to production pressures.
Researchers at Mount Sinai School of Medicine have identified HIPK2 as a crucial regulator protein in kidney fibrosis, leading to improved conditions when eliminated or inhibited. The study provides a new therapeutic target for the treatment of kidney failure, affecting millions of Americans.
A new study has identified five genetic mutations associated with Crohn's disease in Ashkenazi Jews, who are nearly four times more likely to develop the condition. The findings provide insights into the unique risk factors driving this higher prevalence rate.
Researchers from Mount Sinai School of Medicine found that post-operative radiation therapy does not prolong life in older adults with locally advanced non-small cell lung cancer. The study analyzed data from over 1,300 patients and found no significant improvement in one-year or three-year survival rates.
Researchers found laws permitting young adults to stay on their parents' health insurance until age 26 result in improved access to healthcare. The study analyzed data from the U.S. Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System survey, comparing periods before and after state laws were enacted.
Researchers found that decaffeinated coffee improves glucose utilization in the brain, reducing the risk of neurocognitive problems associated with type 2 diabetes. The study suggests that decaffeinated coffee may have preventive benefits for cognitive decline caused by aging and neurodegenerative disorders.
Researchers at The Mount Sinai Hospital found an association between phthalate exposure and increased body mass index (BMI) and waist circumference in young children. Greater than 97% of study participants had been exposed to phthalates, which are man-made chemicals that mimic the body's natural hormones.
A study found that maternal gestational diabetes and low socioeconomic status significantly increase the risk of attention deficit hyperactivity disorder (ADHD) in six year olds. The risk doubles with either factor alone, but increases exponentially when both are present.
Researchers from Mount Sinai School of Medicine identified the pattern of cell signaling induced by antipsychotic drugs in a complex composed of two brain receptors linked to schizophrenia. This discovery may allow for the prediction of novel compounds' effectiveness and accelerate the development of better antipsychotic drugs.
Researchers found that responders with high exposure to the dust cloud had high-risk features of atherosclerosis and impaired vascular reactivity. The study used MRI imaging to evaluate cardiovascular risk in WTC first responders.
Researchers at Mount Sinai School of Medicine discovered fetal stem cells in the placenta can migrate to and repair damaged maternal hearts after a heart attack. The study found that these cells reprogram into beating heart cells, providing a potential therapeutic agent for cardiac regeneration.
The IPAL-EM initiative aims to integrate palliative care into emergency departments, reducing symptoms and anxiety while improving patient safety and satisfaction. By providing access to palliative care, the initiative seeks to improve quality of life for both patients and their families.
A study has discovered four gene variants that contribute to early stent thrombosis in people with coronary artery disease. These variants affect blood thinner clopidogrel sensitivity and platelet receptor function, increasing the risk of deadly complications after stent implantation.
Researchers found elevated levels of Advanced Glycation End products (AGEs) in infant blood, associated with early insulin resistance and diabetes. Cutting back on processed foods can improve insulin levels and reduce disease risk in adults.
Researchers at Mount Sinai School of Medicine found that $6.7 billion was spent on unnecessary tests or medications, with brand-name statins accounting for 86% of the cost. Excess spending included blood work, bone density scans, and antibiotic prescriptions.
Research reveals 11 genomic regions associated with mental illness, including six previously unknown areas. The findings provide fresh insight into the causes of schizophrenia and bipolar disorder, potentially leading to new treatment options.
A new study from Mount Sinai School of Medicine reveals that thyroid-stimulating hormone (TSH) directly influences bone growth, contrary to its usual thyroid functions. The findings suggest TSH may be a novel method for addressing bone production and could lead to innovative treatments for osteoporosis.
Researchers used MRI and PET/CT to prove the efficacy of dalcetrapib in preventing atherosclerosis progression and reducing vascular inflammation over 24 months. The study found significant reductions in atherosclerotic disease progression and arterial inflammation, suggesting a promising new treatment for cardiovascular disease.
Researchers at Mount Sinai School of Medicine have identified SUMO1 as a potential therapeutic target for treating and preventing the progression of heart failure. Gene therapy with SUMO1 improved cardiac function in human and pig hearts, suggesting its critical role in pathogenesis.
A long-term study of WTC workers found a high incidence of asthma, PTSD, depression, and other conditions. Over one in five responders had multiple health problems, and nearly 10% experienced symptoms of all three.
A new study predicts a 7.3% increase in asthma-related emergency room visits for children in the NYC metropolitan area by 2030 due to climate change. The research, led by Dr. Perry Sheffield, used regional and atmospheric chemistry models to simulate ozone levels and their impact on air quality.
Researchers at Mount Sinai School of Medicine will identify genetic markers for each patient enrolled in the study, inputting them into electronic medical records for tailored treatment. The study aims to improve management of heart disease risk factors and prevent onset.
A study published in PLOS ONE found that pharmaceutical advertisements in biomedical journals are often non-compliant with FDA guidelines, failing to provide critical safety and efficacy information. The study's findings highlight the need for improved regulation of pharmaceutical marketing.
Researchers at Mount Sinai School of Medicine found that motion sickness on tilting trains can be eliminated by adjusting the timing of when cars tilt as they enter and leave curves. In a predictive mode based on GPS signals, passengers experienced no discomfort despite faster tilts.
Researchers have identified how the SorCS1 gene controls amyloid-beta generation in the brain, contributing to both Alzheimer's disease and type 2 diabetes. The study reveals that SorCS1 regulates the movement of amyloid precursor protein (APP) within cells.
A recent study conducted at Mount Sinai School of Medicine found that introducing baked milk products into the diets of children with milk allergies accelerated the rate at which they outgrew their allergy. After five years, 47% of children in the experimental group could tolerate unheated milk products, compared to 22% in a control gr...
Researchers at Mount Sinai School of Medicine developed a gene therapy called SERCA2a that stabilized or improved cardiac function in people with severe heart failure. Patients receiving the high-dose therapy experienced substantial clinical benefit and significantly reduced cardiovascular hospitalizations.
Researchers at Mount Sinai School of Medicine discovered a cellular signaling pathway governing fat tissue and vascular smooth muscle differentiation. Elevated PDGFRβ signaling inhibits the formation of fat cells, offering new therapeutic targets for preventing obesity and cardiovascular disease.
Researchers discovered a hyperactive Wnt signaling pathway in human sarcoma cells, which increases cell growth and proliferation by increasing CDC25A gene expression. This suggests that medications targeting the Wnt pathway may be effective in treating human sarcomas.
A recent study published in PLOS ONE found that ancestral genetic heritage is not fixed at the individual level for African-American and Hispanic patients, but rather varies widely within each group. This research challenges traditional ethnic labels and highlights the importance of considering individual genotypes in personalized medi...
New policy proposals aim to reduce toxic chemical exposure and subsequent burden of disease on children, with estimated annual costs of $76.6 billion. The studies also found a statistically significant association between air pollution and infectious respiratory illness in children.
Research found that prenatal exposure to organophosphates negatively impacts perceptual reasoning and nonverbal problem-solving skills in early childhood. Mothers with a specific genotype associated with less efficient PON1 enzyme metabolization were particularly at risk.
Researchers from Mount Sinai School of Medicine have found that a ketogenic diet may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. The study, published in PLoS ONE, also identified previously unreported genes associated with diabetes-related kidney failure whose expression was reversed by the diet.
Researchers found that a subgroup of PPMS patients can convert to PRMS, with faster disease progression and increased risk for sustained disability. The study emphasizes the need for clinicians to consider evaluating this subgroup differently in assessing prognosis and clinical course.
A consortium of researchers has identified four new genes associated with an increased risk of developing Alzheimer's disease. The study analyzed over 54,000 individuals and found that these genes contribute to the disease by disrupting brain biochemistry. Understanding the role of these genes could lead to the development of new treat...
Researchers at Mount Sinai School of Medicine found that patients with Alzheimer's disease have lower glucose utilization in the brain, detectable approximately 20 years prior to symptoms. The study suggests that novel therapies could prevent the onset of Alzheimer's by addressing mitochondrial impairment.
Researchers found that rhodopsin, a retina pigment, plays a role in detecting temperature sensations in fruit flies. The discovery reveals a new function of rhodopsin beyond its well-known role as a light sensor.
A study published in Cell reveals that lactate from astrocytes plays a crucial role in forming and maintaining long-term memories. The findings have significant implications for treating Alzheimer's disease, dementia, and diabetes.