A team of researchers at Duke University has determined the structure of a concentrative nucleoside transporter, which works by moving nucleosides from outside to inside of cells. This discovery may lead to more effective drugs with fewer effects on healthy tissue.
Researchers found that the Moon's synchronous rotation with Earth is due to its geophysical properties, not a result of chance. The near side of the Moon resembles the Man in the Moon due to volcanic material, while the far side has higher mountainous regions.
Researchers used whole genome sequencing to reveal that Chlamydia strains can swap DNA, making it harder to detect new strains and track re-infections. This knowledge is crucial for improving Chlamydia testing and implementing health policies to combat the spread of this common STI.
The High Level Panel will discuss a 'nexus' approach to water management, planning projects with input from stakeholders in the food, water, and energy sectors. This approach aims to reduce conflicts between these sectors over dwindling water resources as global food and energy production intensify.
A Michigan State University researcher found that the US Citizenship and Immigration Services (USCIS) test is not reliable in measuring civics knowledge. The test questions are randomly selected from a pool of 100, but no data has been released on their reliability or validity.
A team of Australian scientists has bred salt tolerance into a variety of durum wheat, showing improved grain yield by 25% on salty soils. The research uses non-GM crop breeding techniques and introduces a salt-tolerant gene that works by excluding sodium from the leaves.
Cedars-Sinai researchers identified the mechanism that leads to interleukin-1beta production, a major contributor to inflammation in conditions like atherosclerotic heart disease and strokes. This discovery could lead to treatments that prevent its production, resulting in more effective medications for inflammatory diseases.
A team of researchers has found that an antidepressant called tranylcypromine (TCP) can harness the power of a vitamin A-derivative to treat acute myeloid leukemia (AML). The study reveals that inhibiting an enzyme called LSD1 with TCP can switch genes on, making cancer cells susceptible to ATRA.
Researchers found that telomeres send out a molecular SOS signal when cells take too long to divide, leading to the activation of DNA damage pathways and cell death. This discovery has implications for cancer chemotherapy, suggesting ways to make therapy more potent by combining mitotic inhibitors with other drugs.
Researchers have found a protein called pregnane X receptor (PXR) that can sense harmful substances in the blood and activate protective pathways in blood vessels. This discovery has major implications for preventing cardiovascular disease, the UK's biggest killer.
Researchers found that insulin and nutritional factors help maintain the 'stemness' of blood stem cells in fruit flies. The study's implications include a potential connection between metabolic disruptions and chronic inflammation in humans.
A new study suggests the Greenland ice sheet may melt completely within 500 years under 8 degrees Celsius global warming, while a 2-degree limit would take 50,000 years to achieve. The melting could accelerate due to feedbacks between climate and the ice sheet, with significant consequences for sea levels.
A study by Columbia researchers suggests that intestinal progenitor cells can be coaxed into producing insulin, offering a potential new treatment for type I diabetes. The technique involves knocking out the Foxo1 gene in these cells, which then produce functional insulin-producing cells.
Researchers at Mount Sinai School of Medicine have identified HIPK2 as a crucial regulator protein in kidney fibrosis, leading to improved conditions when eliminated or inhibited. The study provides a new therapeutic target for the treatment of kidney failure, affecting millions of Americans.