Researchers identified a gene mutation associated with chronic neuroblastoma that typically affects adolescents and young adults. The discovery provides clues about the genetic basis of treatment outcome and age at diagnosis.
Researchers found that healthcare provider attitudes toward vaccinating young males against HPV can influence the implementation of new guidelines. Targeted education on HPV's association with certain cancers in men is crucial for achieving vaccination goals.
The Spine Patient Outcomes Research Trial (SPORT) found surgical treatment significantly favored outcomes for IDH, DS, and LSS, while vitamin D deficiency is critical to musculoskeletal health. A new study urges orthopaedic surgeons to proactively diagnose and treat vitamin D deficiency, which can improve treatment results for various ...
Researchers have discovered a novel link between lithium and body clocks in treating bipolar disorder. Lithium salts increase the strength of clock rhythms, which may lead to more effective treatments with fewer side effects.
African Americans in Georgia have poorer survival rates from cancer compared to national averages, with racial disparities widening rural areas. The study found that MIRs were higher for African Americans than whites across all cancer sites, particularly prostate, cervical, and oral cancers.
A new endoscopic procedure, transgastric necrosectomy, has been shown to reduce major complications and death in patients with infected severe pancreatitis compared to traditional surgical methods. The study found that the procedure resulted in lower proinflammatory response and reduced rates of multiple organ failure.
A study by Jessi Witt and coauthors found that visual illusions can improve sports performance, particularly in free throws. By projecting a ring of circles around the basket, players sank more putts when the hole looked bigger—about 10 percent more.
Researchers call for linking guideline development and policy development to improve global health systems guidance. A panel can ensure output is used for both policy and guidance development, addressing complexity of health systems and contexts.
Researchers have discovered that administering FTY720, an oral drug shown promise for multiple sclerosis, significantly improves motor function recovery in mice with spinal cord injuries. The study suggests targeting sphingosine 1-phosphate receptors may be a new avenue to counteract the degeneration of the spinal cord in human SCI.
Recent study in Molecular Ecology reveals spotted hyenas exhibit strong kinship relationships, affected by resource reduction. The San Diego Zoo Global Wildlife Conservancy's conservation efforts focus on understanding and conserving these social systems.
A new technique published in JoVE uses MRI-guided microbubbles and focused ultrasound to disrupt the blood-brain barrier, potentially opening new treatment avenues for devastating conditions like Alzheimer's and brain cancers. The method is safer than current methods, which can leave large areas of the barrier exposed to toxins.
A major study led by the University of Adelaide found that women who had one prior cesarean can lower the risk of death and serious complications for their next baby. Infants born to these women had a significantly lower risk of serious complications compared to those born after a vaginal birth following a prior cesarean.
Women farmers produce a lower yield on their crops than male farmers by an average of 25 percent. A recent report shows differences in yield in the same household, with female farmers facing restrictions on access to labor and basic farm inputs.
A study published in the Journal of Neuroscience shows that EpoD prevents further neurological damage and improves cognitive performance in a mouse model of Alzheimer's disease. The drug acts by stabilizing microtubules, potentially improving nerve-cell function in AD and other diseases.
Tropical Cyclone Lua has strengthened to a minimum tropical storm with maximum sustained winds near 35 knots, while System 96P is getting organized in the Southern Pacific Ocean. Both systems are affecting coastal areas in northern Australia and are expected to bring heavy rainfall, gusty winds, and rough surf.
A cancer compound called epothilone D has been found to slow neurological damage and improve memory in a mouse model of Alzheimer's disease. The treatment prevented tau tangle formation and improved learning and memory tests, suggesting potential therapeutic benefits.
A recent study discovered an association between the ATRX gene mutation and age at diagnosis in children with advanced-stage neuroblastoma. The research found that ATRX mutations were more common in adolescents and young adults, suggesting a potential molecular marker and therapeutic target for this age group.
A UK study published in PLOS Medicine found that uterine rupture is rare but increases with the number of previous caesarean deliveries. Women planning vaginal delivery after a previous caesarean section are at higher risk, especially if labor is induced or has a short interval since the last surgery.
Two large meta-analyses found a genetic variation in the interleukin-6 receptor associated with lower levels of inflammatory biomarkers and reduced coronary heart disease risk. A single-nucleotide polymorphism was linked to effects consistent with known benefits of IL6R blockade in patients with rheumatoid arthritis.
A new study reveals China's groundwater irrigation system is responsible for releasing over 30 million tonnes of CO2 into the atmosphere every year. This significant pollution is caused by the energy needed to pump water from underground, with some areas requiring pumps that run for miles.
A NASA experiment aboard the International Space Station has demonstrated remotely controlled robots can perform precise satellite-servicing tasks in space, marking a milestone in technology test bed use. The project is expected to reduce risks and encourage future robotic servicing missions, paving the way for satellite repair, refuel...
Researchers found that lowering the HbA1c cutoff from 6.4% to 5.7% increases the health benefits of preventive interventions, while also being cost-effective with a higher threshold.
JBEI researchers have engineered Escherichia coli bacteria to generate significant quantities of methyl ketone compounds from glucose, which yielded high cetane numbers comparable to gasoline. The findings add flexibility and options for the biofuels industry, with potential applications in producing advanced biofuels.
A study found that hospitals in Ontario with higher spending on intensive care and specialists had lower death rates, hospital readmissions, and better quality of care for severely ill patients. Higher-spending hospitals also saw longer lengths of stay and more medical specialist visits.
Gene Kritsky will give the Entomology Founders' Memorial Award lecture at Entomology 2012, honoring Charles Darwin's theory of evolution by natural selection. Dr. Kritsky's research has significantly contributed to understanding periodical cicadas and apiculture.
A recent study found that the protein Mer resides in the nucleus of leukemia cells, suggesting it may influence gene expression and contribute to cancer development. This discovery opens up new avenues for targeted treatments and potentially more accurate diagnoses.
Researchers at the Catholic University of Rome found that high concentrations of NF-kB cause degeneration of intervertebral discs, leading to chronic low back pain. They developed an experimental drug, NBD peptide, to inhibit NF-kB and tested its success in mice.
The Optics Express Focus Issue on Modular Ultrafast Lasers showcases state-of-the-art developments in femtosecond lasers, enabling new applications in biology, medicine, chemistry, and energy research. Key findings include the generation of broad-bandwidth frequency combs for precision metrology and spectroscopy.
Stephanie Turner Chen has received the Larry Sandler Memorial Award for her research on the detection of carbon dioxide in fruit flies and mosquitoes. Her work provides a novel approach to mosquito control, revealing odors that inhibit their ability to detect carbon dioxide.
Scientists have recorded unprecedented deformation within Santorini's caldera, with movement of up to nine centimeters between GPS stations. The volcano's magma chamber has expanded by 14 million cubic meters since January, raising concerns about a potential eruption.
Scientists at UC San Diego School of Medicine developed a new strategy for faster anticancer drug discovery by analyzing the genetic pathway of disease. They identified Peruvoside, a cardiac glycoside, as a potential treatment for prostate cancer with minimal side effects.
A new study from Rice University and Baylor College of Medicine has developed a computer program called EpiPredictor to rapidly identify genes targeted by epigenetic proteins. The program, which was funded in part by the Cancer Prevention Research Institute of Texas, shows promise for speeding up research in cancer epigenetics.
Cartilage transplant tissue can now be stored for up to 63 days, compared to 28 days previously, using a new method developed by researchers at the University of Missouri. This increase in storage time is expected to greatly improve the success rate of joint grafting procedures.
The publication brings together the latest knowledge on eastern big-eared bats, a group of species at risk due to habitat loss and environmental contaminants. The research provides guidance on securing or improving habitat for these bats, including discussions of conservation and management strategies.
A genetic study found that targeting the interleukin-6 receptor (IL6R) signalling pathway could be an effective way to combat heart disease. The research, led by the University of Cambridge, discovered a genetic variant that reduces the risk of coronary heart disease.
Aaron E. Carroll, a renowned health policy expert, will provide insight into the political aspects of health care via The JAMA Forum, analyzing presidential campaign proposals and Supreme Court decisions.
A study published in PLOS ONE found that dietary trans fatty acids are associated with irritability and aggression in both men and women of all ages. The research, which analyzed data from nearly 1,000 adults, suggests a strong link between trans fat consumption and aggressive behaviors.
A new EU project, TargetBraIn, is investigating the potential of the immune system to aid in stroke recovery. The research seeks to balance the positive and negative effects of inflammation, with the goal of developing more effective treatments for this growing health issue.
Patients with high alcohol screening scores experience longer hospital stays, more ICU days, and increased return to the operating room compared to low-risk drinkers. Preoperative alcohol screening may identify patients at risk for increased postoperative healthcare resource usage.
The Planet under Pressure conference brings together 2,500 specialists to present scientific knowledge on the planet's state and potential solutions. Public events at science centers and museums worldwide will take place concurrently, giving the public a snapshot of the planet's state and scientific concern.
Prolonged space travel has been found to cause brain and eye abnormalities in astronauts, similar to those seen in intracranial hypertension of unknown cause. MRI scans revealed optic nerve expansion, eyeball flattening, and pituitary gland changes in astronauts exposed to microgravity for extended periods.
A German study found that antibiotic treatment with azithromycin significantly reduced the number of patients carrying E. coli bacteria and the duration of shedding in stool specimens. Long-term carriers were more common among untreated patients.
A Kessler Foundation study found that people with multiple sclerosis perform poorly in memory and processing speed tests on hotter days. The research suggests a link between outdoor temperature and cognitive performance, which could impact clinical trials and treatment decisions.
Asthma action plans are developed by experts without patient input, leading to poor understanding and adherence. A new approach using wikis empowers patients to co-create their own plans, improving engagement and outcomes.
A study of 99 men found an association between high total fat intake and lower total sperm count and concentration. Men who consumed more omega-3 polyunsaturated fats had better formed sperm than those who consumed less.
A University of Connecticut study reveals that growing economic uncertainty leads to decreased public belief in man-made global warming. Research found a strong correlation between unemployment rates and climate change skepticism, with jobless rates dropping skepticism among the public.
A Mayo Clinic study found that people with rapid eye movement sleep behavior disorder are twice as likely to develop mild cognitive impairment or Parkinson's disease within four years. Researchers used the Mayo Sleep Questionnaire to diagnose probable RBD in neurologically normal individuals.
A study published in PLOS Medicine suggests that women who have a previous caesarean section may benefit from a planned repeat caesarean section in terms of reduced bleeding and infant mortality. The research found that elective repeat caesarean sections were associated with lower risks of severe bleeding and serious infant morbidity.
Worcester Polytechnic Institute (WPI) has received a $277,044 grant from the Bill & Melinda Gates Foundation to develop software tools detecting student engagement in educational software. The project aims to improve learning outcomes by identifying specific types of disengagement.
Scientists have identified a new compound, Factor Qunolinone Inhibitor 1 (FQI1), that rapidly kills hepatocellular carcinoma (HCC) cells by inhibiting an oncogene, while sparing healthy tissue. Laboratory experiments and mouse models demonstrate the compound's effectiveness without observable toxicity.
Biologists at Bielefeld University have developed a new method to quantify the impact of non-native species on ecosystem functioning. The study found that invasive species like the Sydney Golden Wattle can fertilize surrounding soil with nitrogen, extending beyond their occupied area and affecting native plants.
A study presented at the American Heart Association's 2012 Scientific Sessions found that cooling the palms of the hands during exercise improved exercise tolerance and cardiovascular fitness in obese women. Holding a cold bottle or using a cooling device may help exercisers work out longer and stick with their regimen.
A UC Davis report reveals that over 90% of human-generated nitrate contamination comes from agricultural activity, posing health risks to 1 in 10 people in the state's most productive agricultural areas. Fixes for drinking water systems could cost $20-35 million per year.
The Penn State Applied Research Laboratory and Sciaky, Inc. have established the Center for Innovative Metal Processing through Direct Digital Deposition as a Manufacturing Demonstration Facility. The center aims to provide an advanced design and simulation tool in a shared network for industry participants to evaluate the technology.
A University of Michigan team has identified a synthetic small molecule that can activate lysosome calcium channels, potentially treating rare inherited metabolic disorders and neurodegenerative diseases. The discovery could also provide insights into the aging process.
A study published in PLOS Medicine finds that the revised DSM-5 has been influenced by the pharmaceutical industry, despite a policy to disclose financial conflicts of interest. The authors argue that transparency alone cannot mitigate bias and recommend stricter safeguards to protect the revision process.
Researchers identified five distinct dietary patterns among US adults based on demographic factors such as age, race, region, gender, income, and education. These patterns include the Southern, Traditional, Healthy, Sweets, and Alcohol diets, which have clear differences in food choices across demographic groups.
A Wayne State University study found that children of parents with schizophrenia exhibit reduced brain network communication and disordered responses to emotional faces. These findings suggest a potential predictor for the onset of emotional problems in later life.
The book reveals startling neuroscientific and genetic findings that explain how clusters of mental illness traverse family generations. Victoria Costello shares her personal journey and discovers the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren.
A new study found that a brief, daily yoga meditation program reduced depressive symptoms and improved mental health in caregivers. The program also showed increased telomerase activity, slowing cellular aging.
Scientists have discovered an invisible wave interacting with Jupiter's jet streams, revealing a connection to Earth's atmosphere and influencing the planet's weather. The Cassini spacecraft's high-resolution images showed the wave's oscillation, tied to Rossby waves and gravity inertia waves.
Researchers at the University of Wisconsin-Madison have created early retina structures containing proliferating neuroretinal progenitor cells using induced pluripotent stem cells derived from human blood. The structures showed the capacity to form layers of cells, which possessed the machinery to communicate information.
A study by Dr. Lorraine Hope found that less than 60 seconds of physical exertion can severely impair a police officer's ability to remember details of an incident, including recognizing the person involved. This can lead to inaccuracies in witness accounts and potentially affect an officer's credibility.
A new research center, AU RECEIV, will study the impact of maternity/paternity and health visitor schemes on infant health and development. The center aims to understand how these schemes affect parental involvement, daycare institutions, and long-term child outcomes.
A team of scientists has identified a key player in the amplification of pain signals in the spinal cord, which could lead to the development of novel treatments for chronic pain. By removing an enzyme called PKG-1 from pain-sensing nerves, researchers found that LTP was abolished and pain-related memory and behavior were also altered.
US Army researchers have successfully tested antibody-based therapies in monkeys infected with Ebola and Marburg viruses, demonstrating full protection even when treatment was delayed until two days post-infection. This breakthrough provides proof-of-concept for developing filovirus therapies for human use.
The NIH and Lilly are collaborating to create a publicly available resource profiling thousands of approved and investigational medicines. This comprehensive database will enable researchers to better predict treatment outcomes and improve drug development.
Scientists have identified a paradoxical function of the gene Chk1, which is typically known for its anti-cancer properties. In this study, researchers found that extra copies of Chk1 actually facilitate tumor growth in mice, highlighting the complex role of this gene.
Researchers at Vanderbilt University have identified a major barrier to faster graphene devices, finding that charged impurities on the surface of graphene scatter electrons. By using electrically neutral liquids, they achieved record-levels of room-temperature electron mobility, three times greater than previous graphene-based devices.
Researchers have found that both humans and rats make more accurate decisions when presented with combined multisensory information, suggesting a statistically optimal combination of sensory stimuli. This discovery could provide insights into how the brain processes multisensory information in individuals with autism spectrum disorders.