A Kansas State University-led study reveals that the TonB protein plays a central role in the uptake of iron by Gram-negative bacteria, which cause diseases like typhoid fever and meningitis. The research found that TonB acts as an electric motor that rotates in response to cellular energy flow, enabling iron acquisition into the cell.
The Fondation Leducq has awarded a $6 million grant to a new global research network focused on cardiac regeneration. The network, which includes researchers from the Cardiovascular Research Center at Mount Sinai, aims to identify cellular and molecular targets for advancing cardiac regenerative therapeutics.
Researchers discovered that Alzheimer's drugs designed to target amyloid plaques are ineffective against small Aβ clumps called oligomers. Future studies aim to develop new drugs specifically targeting these oligomers to potentially treat the disease.
Researchers at Arizona State University are developing a new DNA nanostructure-based vaccine to combat nicotine dependence. The approach uses precision control over the placement of antigenic components to stimulate an immune response and recruit antibodies capable of binding with nicotine, potentially improving efficacy and safety.
A new technique called 'renal denervation' has shown significant reductions in blood pressure and improved long-term stability. The procedure involves removing nerves connecting the kidney to the brain using radio-frequency energy, with minimal side effects and no need for tablets.
Typhoon Rumbia is bringing heavy rainfall, tropical-storm force winds, and flash flooding to southeastern China. The storm's western quadrant is interacting with Hainan Island, weakening the storm ahead of its expected landfall near Zhanjiang.
Researchers at UCLA's Eli and Edythe Broad Center have successfully established a foundation for using hematopoietic stem cells to treat sickle cell disease. The breakthrough technique uses anti-sickling genes to create healthy red blood cells that do not sickle, offering a revolutionary alternative to current treatments.
Researchers used biotechnologies to increase food production while lowering harmful gas emissions from cattle. The study found that biotechnology treatments improved milk production and reduced greenhouse gas emissions.
A study by Stanford researchers found that loud blasts can cause damage to the cochlea's hair cells and nerve cells, leading to permanent hearing loss. The researchers believe that treating the ear with certain medications after exposure to loud blasts may limit the damage.
Researchers are developing innovative systems to track infectious diseases, leveraging the internet and mobile phones. Digital epidemiology enhances transparency and understanding of outbreaks, predicting increased importance in future public health efforts.
A study published in The FASEB Journal found that moderate paternal exposures, such as cigarette smoking, increase the number of mutations transmitted to children and potentially future generations. DNA mutations were more frequent in families with low-income fathers who smoked cigarettes.
Valerie Hu's study reveals RORA regulates more than 2,500 genes, many involved in neuronal development and functions. The gene's expression is reduced in RORA-deficient brain tissues from individuals with autism.
The study found that it took a mean of 5.2 physician visits to obtain the correct diagnosis of cervical spondylotic myelopathy (CSM), highlighting delays in diagnosis due to lack of awareness among primary care physicians and community-based orthopedic surgeons.
A systematic analysis of acupuncture and in vitro fertilization (IVF) found that adding acupuncture to IVF treatment increased pregnancy success rates at fertility clinics with lower baseline pregnancy rates. The study, published in Human Reproduction Update, suggests that acupuncture may be beneficial as an add-on procedure for these ...
Researchers have developed a malaria vaccine using blood-stage parasites that are chemically attenuated, inducing immunity to multiple species. The study demonstrates protective immunity in mice for over 100 days, suggesting a promising approach to target human malaria species.
Researchers at the University of Leicester have made a groundbreaking discovery into the regulation of a key cancer drug target. The study, funded by £2.4 million from the Wellcome Trust, reveals that signalling molecules called inositol phosphates play a crucial role in controlling gene expression.
A study found that access to healthcare is a key driver in the increasing incidence of thyroid cancer. Insured individuals are more likely to be diagnosed with thyroid cancer than those without insurance, highlighting the need for targeted measures to prevent overdiagnosis.
A study published in Plastic and Reconstructive Surgery reveals that nearly half of cosmetic plastic surgery patients take herbal supplements, which can increase complication risk. The study advises patients to stop taking supplements at least two weeks before surgery to minimize risks.
A Yale team identified a key molecular mechanism underlying higher-order thinking, which is impaired in schizophrenia. The discovery of the alpha7 nicotinic receptor's role in cognitive function may lead to new treatments for cognitive disorders.
The foundation awarded six new Clinical Investigators, including Omar Abdel-Wahab and Himisha Beltran, for their cancer research programs. The recipients will receive $450,000 each, while three others received Continuation Grants worth $300,000 to support ongoing research.
A recent study has found a significant link between long-term night shifts and an increased risk of breast cancer. Women who worked night shifts for 30 or more years were twice as likely to develop the disease, highlighting the importance of workplace policy.
A new approach to getting kids to eat their veggies involves teaching them a conceptual framework for nutrition, which encourages understanding of why eating a variety of foods is ideal and increases vegetable consumption. The study found that preschoolers who were taught about nutrition showed more knowledge about nutrition and increa...
A study found that exercise-induced improvements in glycemic control are dependent on pre-training blood glucose levels and type 2 diabetes status. Moderate-intensity aerobic exercise improved body weight, body fat, fasting plasma glucose, and 2-hour oral glucose tolerance test results.
Researchers found widespread 'modern slavery' in England among refugees and asylum seekers, with coercion and abuse common, and calls for improved welfare support and workplace regulation to prevent exploitation. The study's findings highlight the need to recognize and address forced labor as a criminal offense.
Researchers found that neuroblastoma cells with low levels of HDAC10 enzyme are more resistant to chemotherapy, and blocking this enzyme using autophagy prevents cancer cell survival. The study suggests a new approach for treating aggressive neuroblastoma tumors.
Researchers discovered a common biochemical thread to multiple diseases and found that CD36 draws soluble particles inside cells, triggering an inflammatory response. Blocking the CD36 receptor reduces inflammation and improves symptoms in mice with atherosclerosis.
Researchers found that patients at low risk of clinical deterioration can safely forgo overnight vital sign monitoring without negative effects. The study suggests tailoring vital sign collection based on patient risk to improve patient experience and safety in hospitals.
A new study published in JAMA Pediatrics suggests that early childhood respiratory infections may be a potential risk factor for developing type 1 diabetes mellitus. The research found associations between respiratory infections during the first six months of life and later development of persistent islet autoimmunity.
Researchers used computer models to study the predatory behavior of Thylacosmilus atrox, a 3.5 million-year-old sabre-toothed super-predator. The results show that the animal relied on powerful forearms and precise neck muscles to kill its prey efficiently.
Scientists at the Potsdam Institute for Climate Impact Research have developed a novel approach to forecast El Niño events, extending the prediction time to one year or more. The method employs network analysis and was tested successfully, predicting the absence of an El Niño event in the last year.
A new University of Missouri study found that countries with freedom of information (FOI) laws tend to have lower corruption rates than those without. Having an FOI law is linked to higher levels of human development and can help prevent corruption over time.
Scientists found superconductivity in carbon disulfide at -449°F, a highly disordered state that defies conventional understanding of superconductivity. The discovery could lead to new insights into the interplay between superconductivity, magnetism, and structural disorder.
Replacing older sedentary electronic games with newer active versions significantly boosts daily physical activity levels among kids, with a 3-4 minute increase. Removing all devices also leads to a 4-5 minute decrease in sedentary time and a small but significant increase in moderate to vigorous physical activity.
Researchers found that inactivating taste genes TAS1R3 and GNAT3 caused male sterility in mice, leading to malformed and fewer sperm. The study suggests that certain compounds, such as fibrates, could be negatively impacting human fertility.
Computer scientists programmed ACT-R, a cognitive simulation, to play Concentration, improving computer security and understanding human thought processes. Human participants played 20 times each to compare with the AI model's performance.
The GPM Core satellite completed two pre-vibration solar array deployment tests, simulating the satellite's deployment in space. The successful tests showcased the satellite's support system and air cushion design, which reduce friction and mimic how the solar array would float in space.
A new study by RI-MUHC researchers identifies a previously unknown mode of cancer progression, where infection-fighting white blood cells activate cancer cells and facilitate their spread to secondary tumours. Medications already used for other non-cancer diseases may prevent this mechanism of cancer spread or metastasis.
Researchers at Washington State University have created a superconductor capable of transmitting electrical current with zero resistance. By compressing carbon disulfide under high pressure and cooling it to near absolute zero, they achieved a material that exhibits properties like magnetism and superhardness.
The program, MARC U STAR, will provide four undergraduates per year with tuition, fees, and a stipend to pursue doctoral study in the biomedical sciences. The initiative is part of MSU's goal to create a more diverse future for biomedicine.
A new study by the University of Chicago and Northwestern University expands the habitable zone for alien planets orbiting red dwarfs, doubling the number of potentially habitable planets. The research suggests that up to 60 billion planets may be habitable in the Milky Way galaxy.
Ecologists Monica Turner and Jiangxiao Qiu mapped ecosystem services in the Yahara River watershed, finding complex interactions between provisioning, cultural, and regulating services. The study identifies areas with high levels of multiple services, suggesting a holistic approach to land management.
A new method developed by researchers at the University of Exeter uses computational social science to measure the aesthetic value of ecosystems. The study found that areas in Cornwall with high levels of photographer activity, such as Kynance Cove and Port Issac, have the highest aesthetic value.
The University of Nottingham has established a leading £18 million national power electronics research centre to develop the next generation of power electronics components and devices. The centre will bring together academics and industry partners to create an environment for innovation and knowledge transfer.
Seventy percent of US plastic surgeons use fat grafting techniques for breast operations, with 88% using it for breast reconstruction. However, issues like mammography interference and unpredictable results are noted as potential obstacles.
Researchers at Rice University analyzed thousands of mutant worms to identify genes controlling movement, revealing 87 new links in the process. The study also uncovered evidence for a protein-signaling pathway regulating locomotion, with implications for prioritizing genetic tests in humans.
Researchers have successfully used a genetic vector to efficiently transduce bone marrow cells from SCD patients, suggesting a potential treatment method. The study's findings support the use of autologous HSC transplant with genetically modified patient cells to treat sickle cell disease.
A study analyzing 35,191 patients with coronary heart disease found that about one-third of those who achieved low-density lipoprotein cholesterol goals underwent repeat lipid testing. This may result in significant healthcare resource overuse and waste, estimated to cost around $203,990 annually in one VA network.
A new eight-week intervention involving Head Start children and their parents produced significant improvements in attention, brain functions, and parental stress. The program's focus on selective attention and positive parenting practices led to improved cognitive abilities and reduced stress levels.
A new study published in Adapted Physical Activity Quarterly found that children with autism who struggled with motor skills such as catching and throwing had more severe social and communication skills. Developing motor skills can be crucial for children, enabling them to participate in physical activities and socialize with peers.
Researchers at UCSF discovered that vitamin C helps release brakes on genes in mouse stem cells, potentially playing a key role in normal development. This finding may lead to the use of vitamin C in IVF and cancer treatments, as it can stimulate gene activity similar to early embryonic development.
The UNC team developed biomarkers for challenging molecular subtypes of human breast cancer using genetically engineered mouse models. They found that these models accurately predicted human response to chemotherapy drugs, providing valuable insights into breast cancer treatment.
Researchers found that DHA is converted into maresin 1 (MaR1), which inhibits inflammation and shifts macrophage phenotype, providing a potential lead for new drugs to treat chronic inflammation.
Researchers developed a highly accurate method to detect ALK-rearranged non-small cell lung cancer using immunocytochemistry. The study found that this method had high sensitivity and specificity, making it suitable for prescreening NSCLC patients.
Researchers found that simultaneously controlling high blood pressure and cholesterol can significantly reduce the risk of heart disease. The study suggests that prescribing medications and regular doctor visits can greatly benefit certain populations, including older adults and Hispanic-Americans.
Salsalate shows promise as a type 2 diabetes treatment, reducing A1C and fasting blood glucose levels, but increases risk of hypoglycemia. Black men are less likely to have advanced colorectal neoplasia found at screening than white men, with disparities attributed to access and modifiable risk factors.
The Silver Fire, burning in southern New Mexico's Gila National Forest, has consumed over 133,625 acres as of July 1. The fire, caused by a lightning strike on June 7, is partially contained at 50 percent.
Researchers found that partition dependence, where breaking down possible outcomes into specific intervals, leads people to overestimate the likelihood of certain events. This bias was observed in various prediction markets, including lab experiments and natural markets, such as horse racing.
A new online risk calculator estimates an individual's likelihood of treatment resistance to antidepressants, providing a graphical estimate based on statistical patterns from the STAR*D study. The calculator aims to help clinicians design personalized treatment plans for patients with depression.
New studies examine how people react to terrorist threats, gamble for money vs suspense, and the link between sex motivation and satisfaction. Additionally, research challenges traditional birth order theories and reveals attentional biases in shopping situations.
Researchers found lower dopamine levels in long-term cannabis users compared to non-users, suggesting a possible link between cannabis use and motivation issues. The study also suggests that cannabis use may be the cause of altered dopamine systems, which could explain increased risk of mental illnesses like schizophrenia.