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Science News for November 9, 2009


News brief: Detecting overall survival benefit derived from progression-free survival

A new study suggests that progression-free survival (PFS) is a reasonable primary endpoint for clinical trials of metastatic cancer when the median survival post-progression (SPP) is less than 6 months. However, PFS benefit does not always translate to overall survival (OS) benefit in cases where SPP is longer than 12 months.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateNov 9, 2009

Physician bias might keep life-saving transplants from black and Hispanic patients

African Americans are less likely to receive kidney/pancreas transplants than similar patients in other racial groups, despite increased Medicare coverage. Physician bias may be a contributing factor, with doctors assuming African Americans have type 2 diabetes when they may actually qualify for type 1 diabetes.

SourceGeorgetown University Medical Center·JournalAmerican Journal of Transplantation·DateNov 9, 2009

JCI online early table of contents: Nov. 9, 2009

Research suggests that NSAIDs can prevent the early appearance of neuronal cell cycle events in a mouse model of Alzheimer's disease. However, treatment with NSAIDs does not reverse existing neuronal CCEs. Additionally, interstitial macrophages may play a role in preventing asthma by inhibiting LPS-induced immune responses.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 9, 2009

Scientists successfully reprogram blood cells

Researchers have successfully transplanted genetically modified hematopoietic stem cells into mice, allowing their developing red blood cells to produce a critical lysosomal enzyme and preventing or reducing organ and central nervous system damage from Hurler's syndrome. This approach has the potential to improve treatment options for ...

SourceCincinnati Children's Hospital Medical Center·JournalProceedings of the National Academy of Sciences·DateNov 9, 2009

Advance growing animal penile erectile tissue in lab may benefit patients

Researchers at Wake Forest University Baptist Medical Center have successfully grown replacement penile erectile tissue in rabbits, enabling normal sexual function and offspring production. The engineered tissue has the potential to benefit patients with congenital abnormalities, penile cancer, and some cases of erectile dysfunction.

SourceAtrium Health Wake Forest Baptist·JournalProceedings of the National Academy of Sciences·DateNov 9, 2009

Mood improves on low-fat, but not low-carb, diet plan

A one-year study found that participants on a low-fat diet experienced improved mood and well-being compared to those on a high-fat, low-carbohydrate diet. The study suggests that the low-carb diet may have detrimental effects on mood due to its structured nature and potential social challenges.

SourceJAMA Network·JournalArchives of Internal Medicine·DateNov 9, 2009

Look ma, no mercury in fillings!

Researchers at Southwest Research Institute have created a new proof-of-concept dental restorative material made with zirconia nanoplatelets, which are super hard due to the arrangement of atoms in the material. The new fillings aim to replace amalgam, containing mercury, and offer improved durability and ease of use.

The bizarre lives of bone-eating worms

Osedax marine worms feast on submerged bones using symbiotic bacteria, with unique sexual and digestive habits and diverse habitats across the world's oceans. Recent research discovered up to twelve further distinct evolutionary lineages exist beyond the five species already described.

SourceBMC (BioMed Central)·JournalBMC Biology·DateNov 9, 2009

Reduced muscle strength associated with risk for Alzheimer's

A study of 970 older adults found that those with weaker muscles were more likely to develop Alzheimer's disease and experience cognitive decline. Muscle strength was also linked to the development of mild cognitive impairment, suggesting a common pathogenesis underlying loss of muscle strength and cognition in aging.

SourceJAMA Network·JournalArchives of Neurology·DateNov 9, 2009

Squeak, squeak -- can you hear me now?

Researchers created a new strain of mice with outstanding hearing as they age, studying the phenomenon known as golden ears. The study offers clues about maintaining good hearing while aging and provides a new tool to explore protective factors that allow some organisms to retain their hearing for their whole lives.

SourceUniversity of Rochester Medical Center·JournalNeurobiology of Aging·DateNov 9, 2009

First Bose-Einstein condensation of strontium

Physicists from the Institute for Quantum Optics and Quantum Information produced a Bose-Einstein condensate of strontium atoms, outperforming competitors in an international race. The breakthrough was achieved using the isotope 84Sr, which has ideal scattering properties for this phenomenon.

SourceUniversity of Innsbruck·JournalPhysical Review Letters·DateNov 9, 2009

The Malawi government's program to cut childhood pneumonia deaths

The Malawi government has introduced a national program to deliver effective pneumonia treatment, known as standard case management, to children. This initiative aims to reduce the high mortality rate of childhood pneumonia in low-income countries by providing timely and appropriate antibiotic therapy and oxygen support.

SourcePLOS·JournalPLOS Medicine·DateNov 9, 2009

Words, gestures are translated by same brain regions, says new research

A recent study published in PNAS found that the brain regions responsible for decoding spoken words also process wordless gestures. This discovery challenges traditional theories about the evolution of language and suggests that these brain regions may play a broader role in symbol interpretation.

SourceNIH/National Institute on Deafness and Other Communication Disorders·JournalProceedings of the National Academy of Sciences·DateNov 9, 2009

Unravelling the pathology of dementia

A study published in PLOS Medicine found that dementia is often associated with mixed pathological changes, including Alzheimer's and vascular dementia. The researchers estimated that drugs targeting specific pathologies may have limited impact on the overall burden of dementia.

SourcePLOS·JournalPLOS Medicine·DateNov 9, 2009

Drought resistance explained

Scientists discovered how plant hormone ABA interacts with protein PYR1 to trigger drought response. This interaction enables PP2C molecules to be hijacked, allowing plants to increase water uptake and storage while decreasing water loss. The study offers new approaches for increasing crop tolerance to water shortages.

Mount Sinai finds those with more difficult to treat forms of HCV are half as likely to get treated

Researchers found that patients with more difficult-to-treat forms of hepatitis C are less likely to initiate treatment, with marital status and comorbidities being significant factors. Mount Sinai is now launching a program to increase support systems for patients, aiming to improve treatment rates.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalJournal of Health Care for the Poor and Underserved·DateNov 9, 2009

Scripps team shows diet switching can activate brain's stress system, lead to 'withdrawal' symptoms

Researchers from Scripps Research Institute found that cycling between sweet and regular food can activate the brain's stress system, generating overeating, anxiety, and withdrawal-like symptoms. The study suggests a vicious circle of compulsive eating and anxiety, where repeated dieting can lead to increased stress levels.

SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateNov 9, 2009

Elsevier sponsors 2009 Semantic Web Challenge

The 2009 Semantic Web Challenge recognized four outstanding applications that demonstrated practical applicability to real-world issues. The winners were awarded cash prizes sponsored by Elsevier, promoting the dissemination of knowledge from academia to society.

Darwin meets Facebook

Natural historians can now share and manage their data using the Scratchpads platform, which serves over 1100 users across 100 sites. The system allows users to create virtual workbenches to study aspects of organisms, promoting biodiversity informatics approaches.

SourceBMC (BioMed Central)·JournalBMC Bioinformatics·DateNov 9, 2009

Sniffing out memories

Researchers found that the first association between a smell and an experience leaves a lasting impression in the brain. After one week, they could predict which associations would be remembered based on brain activity alone.

SourceWeizmann Institute of Science·JournalCurrent Biology·DateNov 9, 2009

UCSD discovery allows scientists for the first time to experimentally annotate genomes

Researchers at UCSD have made a breakthrough discovery that enables the experimental annotation of genomes. By combining multiple genome-scale measurements, they can identify the location and use of genomic elements with precision. This innovation has significant implications for metabolic engineering, disease research, and drug design.

SourceUniversity of California - San Diego·JournalNature Biotechnology·DateNov 9, 2009

Yoga boosts heart health

A study published in International Journal of Medical Engineering and Informatics found that yoga practitioners exhibit higher heart rate variability compared to non-practitioners. This suggests a strengthening of parasympathetic control, indicative of better autonomic function and a healthier heart.

SourceInderscience Publishers·JournalInternational Journal of Medical Engineering and Informatics·DateNov 9, 2009

Study: Credit crisis, debt load a double whammy for investment

A University of Illinois study found that firms with heavy long-term debt that came due during the recent credit crisis slashed investment more than three times as much as companies whose paybacks dodged the meltdown. This can have a ripple effect on the overall economy, leading to reduced employment and profits in the future.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalReview of Financial Studies·DateNov 9, 2009

Amyloid beta protein gets bum rap

Researchers found that low doses of amyloid beta protein improved learning and memory in healthy mice, while blocking the protein caused learning impairment. The study suggests that the optimal amount of amyloid beta is crucial for maintaining cognitive function.