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Science News for August 12, 2010


Single neurons can detect sequences

Researchers at University College London found that single neurons and even individual dendrites can effectively distinguish between different temporal sequences of incoming information. This challenges the widely held view that large numbers of neurons working together are necessary for sequence processing in the brain.

SourceUniversity College London·JournalScience·DateAug 12, 2010

The cancer biomarker conundrum: Too many false discoveries

Despite advancements in cancer biomarker research, many initial breakthroughs fail to translate to clinical success due to issues with study design and interpretation. Seven biomarkers initially hailed as promising have been reevaluated, highlighting problems with pre-analytical, analytical, and post-analytical study design.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateAug 12, 2010

Immune overreaction may enable recurrent urinary tract infections

Severe inflammatory responses to initial UTI cause bladder damage and allow infection to persist longer. Immunodeficient mice lacking these acute inflammatory responses are protected from chronic bladder infection. Researchers hope to identify patients vulnerable to recurrent infection using markers discovered in the study.

SourcePLOS·JournalPLOS Pathogens·DateAug 12, 2010

Expensive new blood pressure meds no better than generics

A new study found that expensive brand-name medications for high blood pressure are no better than generic diuretics in preventing cardiovascular disease. The ALLHAT trial, which followed patients with high blood pressure for eight to 13 years, showed that the diuretic was superior in two measures: stroke death rate and hospitalization...

Poor kidney function common among HIV-infected injection drug users

A study reveals that HIV-infected injection drug users are more likely to develop proteinuria, a marker of kidney disease, which can lead to kidney failure. Clinicians should aggressively screen this population for proteinuria and consider them candidates for medical treatments that protect the heart and kidneys.

SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateAug 12, 2010

New rheumatoid arthritis criteria to stave off disabling disease for thousands of people

The new criteria redefine RA by classifying it based on the confirmed presence of synovitis in at least one joint, absence of alternative diagnoses, and a combined score from four domains. Early diagnosis and treatment can prevent destructive joint damage with the help of synthetic and biological disease-modifying antirheumatic drugs.

SourceBMJ Group·JournalAnnals of the Rheumatic Diseases·DateAug 12, 2010

New case series section in European Urology

A new case series in European Urology introduces a purely intrafascial approach for robot-assisted laparoscopic prostatectomy, aiming to avoid damage to critical structures. The study reports promising results with no perioperative major complications, but highlights the need for well-designed studies to evaluate its advantages.

SourceEuropean Association of Urology·JournalEuropean Urology·DateAug 12, 2010

An IRCM researcher pinpoints the cellular mechanism responsible for modulating the permeability of blood vessels

A new cellular mechanism has been identified for modulating blood vessel permeability, which could have a significant impact on the treatment of cancerous tumours. Nitrosylation of beta-catenin protein by nitric oxide increases vascular permeability, potentially leading to the blockage of tumour growth.

Trusting people make better lie detectors

Researchers discovered that trusting people are more accurate at detecting lies and make better hiring decisions. They were also less likely to be deceived themselves. High trust individuals formed a more accurate impression of interviewees and chose honest candidates over dishonest ones.

SourceSAGE·JournalSocial Psychological and Personality Science·DateAug 12, 2010

Potential novel genetic pathway for alcoholism

Researchers have identified a novel mutation in a mouse gene that may contribute to the genetic roots of alcoholism. The mutation, called Lightweight, affects sensitivity to alcohol and voluntarily consumed more alcohol by mutant mice. Further studies are needed to determine if this pathway is relevant to humans.

SourcePLOS·JournalPLOS Genetics·DateAug 12, 2010