The Ross Procedure offers long-term benefits and normal quality of life due to its living pulmonary valve replacement. Excellent durability and physiologic valve function are achieved, challenging traditional conceptions around the operation.
Researchers integrated social determinants of health with genetic information to predict disease risk. Social, behavioral, and environmental factors contributed as much as genetics to disease risk for four out of six studied conditions.
A new study suggests that wearable monitoring can detect cytokine release syndrome (CRS) hours before standard hospital monitoring, potentially reducing complications and improving patient outcomes. The findings support the use of wearable technology to expand access to CAR-T therapy and reduce reliance on prolonged hospital stays.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
Mount Sinai Health System experts will lead discussions on innovative community-based approaches to youth mental health and emerging scientific advances transforming healthspan. The conversations will explore how collaboration, research, technology, and personalized care can improve health and well-being for people across communities t...
Researchers found that Ebola virus can persist in cerebral organoids for up to 120 days, infecting various cell types, including neurons and astrocytes. The virus can trigger local inflammation and lead to disease relapses in survivors, highlighting the need for improved treatments.
A new study suggests a novel electronic health record-based marker, MLVI, can help identify transplant patients at high risk for organ rejection due to non-adherence. The study found that using MLVI as a risk marker reduced overall rejection rates by bringing them down to levels typically seen in low-risk patients.
Researchers identified distinct brain activity patterns in people with depression, which may contribute to the experience of feeling stuck. The study suggests depression involves a form of brain-state entrapment, where the brain becomes more likely to enter certain patterns of activity and less likely to transition out of them.
Researchers identified age-related genetic changes in microglia that may drive inflammation and neurodegeneration in Alzheimer's disease. Cancer-associated mutations were found in genes commonly linked to clonal hematopoiesis, promoting inflammatory activity.
Researchers used advanced MRI techniques to evaluate kidney blood flow, oxygen utilization, and inflammation in patients undergoing surgery for kidney tumors. The study found that MRI measurements could help predict both kidney function decline and the future development of chronic kidney disease.
Researchers discovered a previously unknown binding site in a cancer-related protein that could lead to more precise cancer drugs. The study reveals the power and limitations of AI tools for drug discovery, showing that even small chemical changes can dramatically alter how molecules bind to proteins.
Researchers developed a manufacturing platform for producing targeted mixtures of beneficial gut bacteria, demonstrating comparable safety and efficacy with fecal microbiota transplants. The new approach uses defined bacterial strains isolated from donor stool and grown under controlled conditions.
Researchers at Mount Sinai discovered that focused irradiation can help CAR-T cells survive longer and work more effectively inside tumors. Irradiation turns dendritic cells into a local source of stimulation for CAR-T cells, promoting durable control of advanced lung tumors.
Mount Sinai researchers have uncovered a substantial genetic component to postpartum psychosis, a rare psychiatric illness that occurs after childbirth. The study found rare damaging mutations in the HMGCR gene and significant genetic overlap with bipolar disorder, schizophrenia, and autoimmune diseases.
Deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks. The therapy helps patients recover from severe depression by increasing fractional anisotropy and myelination within specific pathways, suggesting a previously unrecognized mechanism.
A new study analyzes 240 health care AI-related policies, finding accelerated oversight efforts but a lack of unified framework for clinical AI deployment. Governance challenges are emerging as AI adoption accelerates, requiring strong oversight and internal governance structures.
Researchers at Mount Sinai have found that autoimmunity is responsible for the symptoms of long COVID in a subset of people. The study suggests that therapies already validated for managing autoimmunity, such as IVIG and FcRn inhibitors, could be effective in reducing symptom burden.
Researchers from Mount Sinai will present various studies on myelofibrosis, lung cancer, multiple myeloma, urothelial cancer, gynecologic cancers, and care innovation. Key findings include selinexor plus ruxolitinib in JAK inhibitor-naïve myelofibrosis and efficacy of HLX43 in advanced non-small cell lung cancer.
A study published in Nature suggests that individuals at the extremes of certain traits, such as cholesterol and blood glucose, are more likely to have rare genetic variants with larger effects. This discovery may lead to better preventive care and treatments for those with extreme trait values.
The Mount Sinai Health System has opened the Carolyn Rowan Center for Women’s Health and Wellness, which brings together multidisciplinary clinical expertise, structured care pathways, and leading-edge research to deliver personalized, comprehensive care for women. The Center offers guided multi-visit experiences and coordinated care o...
Physicians at Mount Sinai recommend a more patient-centered approach to evaluating skin toxicities in cancer treatments, prioritizing symptom burden and quality of life over treatment type. This new framework could enhance consistency across clinical trials and improve the accuracy of reporting.
Researchers created an AI model that maps how genes work together inside human cells, helping to understand biology and disease. The Gene Set Foundation Model (GSFM) learns patterns in gene groupings and interactions across thousands of biological contexts.
Experts from Mount Sinai will present a new AI model that predicts lung nodule risk and assesses the impact of air pollution during pregnancy. The researchers also explore cognitive consequences of sleep-disordered breathing and reevaluate asthma guidelines to integrate both conditions.
Researchers discovered a flexible survival strategy among beneficial gut bacteria, allowing them to switch between functional states to withstand changes. This reversible mechanism, known as 'bet-hedging,' may help explain microbiome resilience and variability.
Mount Sinai physicians will offer expert guidance and resources to keep pickleball players safe and healthy at more locations than ever before. The partnership aims to promote physical and mental well-being, as well as boost longevity through pickleball.
Researchers discovered that mezigdomide can reinvigorate exhausted T cells and enhance immunotherapies. The drug works by degrading key gene regulators Ikaros and Aiolos, which sustain genetic and epigenetic programs keeping T cells in an exhausted state.
Researchers at Mount Sinai have identified a promising new strategy to overcome resistance to immunotherapy in colorectal cancer. The approach, which restores communication between key immune cells, achieved up to 100% tumor clearance in some models.
Dr. Lisa M. Satlin, a renowned pediatrician-scientist, has been awarded the ASPN Founders' Award for her lifetime contributions to pediatric nephrology through research, education, and clinical care. She has advanced understanding of kidney function and development, with significant implications for hypertension and kidney disease.
The program honors Marilyn Monroe's legacy and provides dedicated mental health services for artists at the Samuel J. Friedman Health Center in Manhattan's Theater District. It offers training, resources, and care to address the unique psychological demands of the entertainment industry.
Researchers present findings on sociodemographic disparities in hypertensive disorders of pregnancy, highlighting the need for better characterization and management of these conditions. Dr. Basma S. Faris discusses reframing PCOS as a chronic disease requiring longitudinal care.
The new 21-bed ICU will increase access to advanced care and enable more Queens residents to receive care locally. Construction is expected to take approximately 16 months and will be funded in part by New York City and State as well as through Mount Sinai’s capital resources.
A new study by researchers at Mount Sinai overturns the assumption that immune cells are essential for generating immunity from mRNA vaccines. Instead, non-immune cells such as muscle and liver cells play a role in shaping the immune response.
A Mount Sinai study reveals that early-life exposure to common environmental metals may shape brain development and behavioral health more than a decade later. The research combined baby teeth with advanced brain imaging, pinpointing specific weeks during pregnancy and infancy when the developing brain appears most vulnerable.
The study provides a roadmap for understanding and treating liver cancer by identifying key biological processes that enable tumors to grow and spread. It highlights the potential for precision medicine approaches, including immunotherapy and targeted therapies, to improve outcomes for patients with liver cancer.
Researchers developed an analytic tool using machine learning to predict how CPAP affects cardiovascular disease risk in patients with obstructive sleep apnea. The study found significant variation in treatment response across the cohort, identifying subgroups who benefited or were harmed by the therapy.
Mount Sinai ophthalmologist has developed a groundbreaking device enabling precise measurement of aqueous outflow during eye surgery. The technology offers improved accuracy and reduced complications, potentially transforming the field of ophthalmology.
The Adams Valve Institute aims to expand the treatment of valvular heart disease, focusing on complex surgeries and underserved populations. The Institute will promote innovation in advanced imaging, reconstructive surgical techniques, and breakthrough research.
A study published in The Lancet Regional Health – Americas found that carefully selected older adults can safely undergo surgery and achieve outcomes comparable to younger patients. The research challenges longstanding assumptions about age and cancer treatment, suggesting that older adults should not be excluded from potentially curat...
The Mount Sinai Hospital has pioneered a new minimally invasive liver cancer treatment method that allows doctors to treat patients on more days of the week, improving access and reducing wait times. This breakthrough innovation, called TheraSphere Y-90 Any Day Dosing, enables flexible scheduling and seamless care coordination.
Researchers are testing whether SAINT, a non-invasive brain stimulation therapy, can quickly relieve symptoms of postpartum depression. The study aims to find faster and more effective treatments for women experiencing depression after childbirth.
A new study reveals that blocking the aryl hydrocarbon receptor (AHR) helps neurons regrow damaged axons and recover motor and sensory function. AHR acts as a key regulator that determines how neurons respond after injury, slowing down axon growth.
Researchers found that an extra copy of chromosome 21 leads to increased levels of the ADARB1 enzyme, causing premature and excessive RNA editing in developing brain cells. This dysregulation affects how brain cells communicate and form circuits, potentially influencing neurological and behavioral outcomes in Down syndrome.
A study analyzing over 15,000 Latin American individuals identifies 35 genes significantly associated with autism, showing extensive overlap with previously identified genes in European-ancestry cohorts. The findings support the universal biological foundations of autism and highlight the need for diverse populations to be represented ...
The study identified a previously unknown recessive neurodevelopmental disorder caused by changes in the RNU2-2 gene, affecting thousands of individuals in the US. Symptoms vary widely, including developmental delays, limited speech, and seizures, and may be more common than previously thought.
Dr. Roxana Mehran was appointed President of the American College of Cardiology, focusing on innovation, equity, and global collaboration to advance cardiovascular care. She aims to improve heart health for all through partnerships with major organizations.
The MOMENTUM study found that 27% of patients with resistant hypertension have hypercortisolism, a condition characterized by elevated cortisol levels. This finding suggests that hypercortisolism may be an underlying cause of resistant hypertension, which impacts nearly 10 million patients in the US.
A new trial found that using a microaxial flow pump before and during cardiac stenting procedures for high-risk heart attack patients with severe heart attacks did not reduce heart damage. The study, published in the Journal of the American College of Cardiology, also showed increased bleeding complications.
The Mount Sinai team developed Biomni-AD, an AI-powered 'co-scientist' that reduces time required to generate scientific insights from complex biomedical data. The platform has already identified robust biological signals and helped prioritize promising drug targets with greater speed and confidence.
A study of over 14 million cardiovascular deaths found that colder temperatures are responsible for significantly more heart-related deaths than milder months. The optimal temperature for heart health is 74°F, with temperatures under this point accounting for approximately 40,000 deaths each year.
Researchers created a comprehensive mapping of over 1 million cells in normal adult human skin, identifying 45 unique cell types that vary across composition and arrangement. This study brings scientists closer to developing more targeted treatments for skin diseases like eczema and psoriasis.