Mount Sinai physicians will offer expert guidance and resources to keep pickleball players safe and healthy at more locations than ever before. The partnership aims to promote physical and mental well-being, as well as boost longevity through pickleball.
Researchers discovered that mezigdomide can reinvigorate exhausted T cells and enhance immunotherapies. The drug works by degrading key gene regulators Ikaros and Aiolos, which sustain genetic and epigenetic programs keeping T cells in an exhausted state.
Researchers at Mount Sinai have identified a promising new strategy to overcome resistance to immunotherapy in colorectal cancer. The approach, which restores communication between key immune cells, achieved up to 100% tumor clearance in some models.
Dr. Lisa M. Satlin, a renowned pediatrician-scientist, has been awarded the ASPN Founders' Award for her lifetime contributions to pediatric nephrology through research, education, and clinical care. She has advanced understanding of kidney function and development, with significant implications for hypertension and kidney disease.
The program honors Marilyn Monroe's legacy and provides dedicated mental health services for artists at the Samuel J. Friedman Health Center in Manhattan's Theater District. It offers training, resources, and care to address the unique psychological demands of the entertainment industry.
Researchers present findings on sociodemographic disparities in hypertensive disorders of pregnancy, highlighting the need for better characterization and management of these conditions. Dr. Basma S. Faris discusses reframing PCOS as a chronic disease requiring longitudinal care.
The new 21-bed ICU will increase access to advanced care and enable more Queens residents to receive care locally. Construction is expected to take approximately 16 months and will be funded in part by New York City and State as well as through Mount Sinai’s capital resources.
A new study by researchers at Mount Sinai overturns the assumption that immune cells are essential for generating immunity from mRNA vaccines. Instead, non-immune cells such as muscle and liver cells play a role in shaping the immune response.
A Mount Sinai study reveals that early-life exposure to common environmental metals may shape brain development and behavioral health more than a decade later. The research combined baby teeth with advanced brain imaging, pinpointing specific weeks during pregnancy and infancy when the developing brain appears most vulnerable.
The study provides a roadmap for understanding and treating liver cancer by identifying key biological processes that enable tumors to grow and spread. It highlights the potential for precision medicine approaches, including immunotherapy and targeted therapies, to improve outcomes for patients with liver cancer.
Researchers developed an analytic tool using machine learning to predict how CPAP affects cardiovascular disease risk in patients with obstructive sleep apnea. The study found significant variation in treatment response across the cohort, identifying subgroups who benefited or were harmed by the therapy.
Mount Sinai ophthalmologist has developed a groundbreaking device enabling precise measurement of aqueous outflow during eye surgery. The technology offers improved accuracy and reduced complications, potentially transforming the field of ophthalmology.
The Adams Valve Institute aims to expand the treatment of valvular heart disease, focusing on complex surgeries and underserved populations. The Institute will promote innovation in advanced imaging, reconstructive surgical techniques, and breakthrough research.
A study published in The Lancet Regional Health – Americas found that carefully selected older adults can safely undergo surgery and achieve outcomes comparable to younger patients. The research challenges longstanding assumptions about age and cancer treatment, suggesting that older adults should not be excluded from potentially curat...
The Mount Sinai Hospital has pioneered a new minimally invasive liver cancer treatment method that allows doctors to treat patients on more days of the week, improving access and reducing wait times. This breakthrough innovation, called TheraSphere Y-90 Any Day Dosing, enables flexible scheduling and seamless care coordination.
Researchers are testing whether SAINT, a non-invasive brain stimulation therapy, can quickly relieve symptoms of postpartum depression. The study aims to find faster and more effective treatments for women experiencing depression after childbirth.
A new study reveals that blocking the aryl hydrocarbon receptor (AHR) helps neurons regrow damaged axons and recover motor and sensory function. AHR acts as a key regulator that determines how neurons respond after injury, slowing down axon growth.
Researchers found that an extra copy of chromosome 21 leads to increased levels of the ADARB1 enzyme, causing premature and excessive RNA editing in developing brain cells. This dysregulation affects how brain cells communicate and form circuits, potentially influencing neurological and behavioral outcomes in Down syndrome.
A study analyzing over 15,000 Latin American individuals identifies 35 genes significantly associated with autism, showing extensive overlap with previously identified genes in European-ancestry cohorts. The findings support the universal biological foundations of autism and highlight the need for diverse populations to be represented ...
The study identified a previously unknown recessive neurodevelopmental disorder caused by changes in the RNU2-2 gene, affecting thousands of individuals in the US. Symptoms vary widely, including developmental delays, limited speech, and seizures, and may be more common than previously thought.
Dr. Roxana Mehran was appointed President of the American College of Cardiology, focusing on innovation, equity, and global collaboration to advance cardiovascular care. She aims to improve heart health for all through partnerships with major organizations.
The MOMENTUM study found that 27% of patients with resistant hypertension have hypercortisolism, a condition characterized by elevated cortisol levels. This finding suggests that hypercortisolism may be an underlying cause of resistant hypertension, which impacts nearly 10 million patients in the US.
A new trial found that using a microaxial flow pump before and during cardiac stenting procedures for high-risk heart attack patients with severe heart attacks did not reduce heart damage. The study, published in the Journal of the American College of Cardiology, also showed increased bleeding complications.
The Mount Sinai team developed Biomni-AD, an AI-powered 'co-scientist' that reduces time required to generate scientific insights from complex biomedical data. The platform has already identified robust biological signals and helped prioritize promising drug targets with greater speed and confidence.
A study of over 14 million cardiovascular deaths found that colder temperatures are responsible for significantly more heart-related deaths than milder months. The optimal temperature for heart health is 74°F, with temperatures under this point accounting for approximately 40,000 deaths each year.
Researchers created a comprehensive mapping of over 1 million cells in normal adult human skin, identifying 45 unique cell types that vary across composition and arrangement. This study brings scientists closer to developing more targeted treatments for skin diseases like eczema and psoriasis.
Researchers have identified a distinct gene expression program associated with neurotransmission in the living human brain. The study combines molecular data with real-time physiological recordings, revealing a coordinated set of genes whose activity tracks with neuronal signaling.
A new study by Mount Sinai researchers found that distributed multi-agent AI systems can maintain superior accuracy levels while using significantly fewer computing resources compared to single-agent designs. This approach can help healthcare organizations scale AI without sacrificing quality or safety.
The collaboration aims to understand why IBD runs in some Saudi families and develop personalized treatment options. By studying well-characterized families with multiple members affected, researchers hope to identify exposure and biological markers that drive disease mechanisms and outcomes.
The ORIGIN study uses advanced molecular tools to identify risk factors and early warning signals in stored blood samples from up to 13,000 service members. By analyzing these data, researchers aim to predict and prevent diseases such as cancer, heart disease, and autoimmune disorders years before symptoms appear.
Researchers found that young mice developed strong skin inflammation in response to everyday allergens, revealing a brief window of vulnerability. The study suggests that early childhood represents a critical period for immune-driven skin disease, and that targeting this period may prevent allergic diseases from spreading.
A recent study has found that ChatGPT Health may fail to direct users appropriately to emergency care in serious cases, and its suicide-crisis safeguards are also concerning. The tool under-triaged more than half of cases that physicians determined required emergency care, highlighting the need for caution when relying on AI guidance.
Researchers developed a molecular monitoring approach to identify patients with muscle-invasive bladder cancer who can safely preserve their bladder without compromising cancer outcomes. The study found that ultra-sensitive testing of tumor-derived DNA in blood and urine may help predict metastatic risk and identify patients with an ex...
A Mount Sinai-led study developed an AI tool that analyzes ECGs to identify patients at risk for harmful heart changes, potentially reducing the need for expensive and time-consuming cardiac MRI scans. The tool could make lifelong heart monitoring more accessible and efficient for people born with congenital heart disease.
Researchers used advanced chemical detection to estimate a newborn's total PFAS exposure, detecting 42 confirmed or putatively identified PFAS chemicals in umbilical cord blood. The study found that infants are exposed to a wide range of PFAS before birth, including perfluorinated chemicals and fluorotelomers.
Researchers from The Mount Sinai Hospital have developed an AI-assisted tool to diagnose severe congenital heart defects from fetal scans with high sensitivity and specificity. Additionally, a machine learning model can predict placenta accreta spectrum based on preconception data, identifying novel predictors like anemia.
A new Mount Sinai study strengthens landmark evidence supporting lung-sparing surgery for pleural mesothelioma, a rare and aggressive cancer caused by asbestos exposure. The research found zero in-hospital and 30-day mortality rates, and a 90-day mortality rate of 4.2 percent in carefully selected patients.
Researchers found that patients with major depressive disorder share immune abnormalities with inflammatory skin diseases, including atopic dermatitis. The study suggests targeting the Th2 pathway and interleukin-4 receptor alpha as potential therapeutic strategies for psychiatric illness.
The study found that a novel subset of white blood cells becomes infected in the lung and produces type 1 interferon, which triggers cardiac damage. A modified mRNA treatment was shown to mitigate cardiac damage while preserving the immune system's protective response. The research offers great promise for developing new therapies to p...
A Mount Sinai study found that antibody-producing immune cells called IgG1 plasma cells help patients respond to PD-1 immune checkpoint inhibitors, which have transformed cancer care. The researchers identified IgG1 plasma cells as a critical factor in determining clinical outcomes.
Researchers provide radiation oncologists with practical guidance to identify and protect female sexual organs during pelvic cancer treatment. The study establishes a shared, standardized approach to identifying the bulboclitoris, enabling clinicians to measure radiation dose to these tissues.
Researchers at Mount Sinai detail how decades of cancer vaccine research have converged into more precise and effective immunotherapies. Decades-long clinical trials show personalized neoantigen vaccines are safe and capable of generating robust immune responses across various cancers.
Researchers have characterized the association between cellular senescence and human brain structure in both development and late life. The study found that senescence-related gene expression is linked to brain volume and cortical organization, with distinct roles depending on cell type and stage of life.
Scientists have developed a novel immunotherapy approach that targets tumor macrophages, converting them from immune suppressors to killers. The therapy, using engineered CAR T cells, has shown promising results in preclinical models of metastatic ovarian and lung cancer.
A recent study published in Nature identified over 100 new genetic regions linked to schizophrenia that had not been previously discovered. These findings show that while specific genetic variants may differ across populations, the core biological mechanisms underlying schizophrenia are shared worldwide.
Exposure to PFAS is associated with insulin resistance and altered insulin secretion, identifying pregnancy as a key vulnerable period. Gestational diabetes increases the risk of pregnancy complications and long-term health risks for both mother and child.
Researchers identified bradycardia as a symptom of xylazine-opioid overdose, particularly in the Northeast, where xylazine is more prevalent. This finding may aid emergency medicine physicians in detecting xylazine exposure and providing harm reduction counseling.
Researchers analyzed nearly 1.5 million immune cells from bone marrow samples of 335 newly diagnosed multiple myeloma patients, revealing previously hidden patterns in immune system behavior. The study provides unprecedented insight into immune dysfunction in myeloma and could lead to improved tools for predicting patient relapse risk.
The Mount Sinai Health System has launched an AI-powered clinical trial-matching platform, PRISM, to help connect patients with life-saving trials. The platform uses machine learning to match patients with trials based on their electronic health records and diagnosis.
The Mount Sinai Hospital has received an $8.5 million NIH grant renewal to continue groundbreaking research on long-term outcomes for children with congenital heart disease. The project will unite clinical leaders and registry data from all 25 congenital heart surgical centers across four states to study how differences in health care ...