Researchers at Mount Sinai Hospital discovered a unique elemental pattern in single hair strands that distinguishes people with ALS from healthy individuals. This finding suggests a simple, non-invasive hair-based test could speed up ALS diagnosis and improve patient care.
The Mount Sinai Hospital has completed a six-phase redesign of its Emergency Department, featuring innovative advancements and expanded clinical space. The new ED is equipped with cutting-edge technology and tools to enhance patient care and workflow.
A new method, AEquity, identifies and corrects bias in health care datasets used to train machine-learning algorithms. The tool can spot well-known and previously overlooked biases across different datasets.
Researchers discovered a brain-liver circuit that connects stress with increased glucose production, potentially linking to type 2 diabetes. Long-term elevations in glucose can cause hyperglycemia and increase the risk of developing type 2 diabetes.
Researchers developed a safe method to obtain prefrontal cortex biopsies during deep brain stimulation (DBS) surgery in living patients, demonstrating no increased risk of adverse events or cognitive decline. The study's findings establish the safety of this approach and open up new avenues for neuroscience research.
Dr. Michael J. Welsh has advanced understanding and treatment of cystic fibrosis through his pioneering research on chloride channels and CFTR function. He has developed new therapies, including a porcine model of CF, leading to improved treatments for 90% of people with the disease.
Researchers developed an AI model that makes individualized treatment recommendations for atrial fibrillation patients, potentially revolutionizing stroke and bleeding prevention. The model reclassified up to half of AF patients from receiving anticoagulants under current guidelines.
A new study published in The New England Journal of Medicine and the European Heart Journal finds that beta blockers, commonly prescribed after a heart attack, provide no clinical benefit for patients with preserved heart function. Women treated with beta blockers had a higher risk of death, heart attack, or hospitalization for heart f...
A study by Mount Sinai-Duke University identifies specific DNA variants in the DENND1A gene that increase testosterone production in PCOS patients. This finding could lead to new therapies targeting the genetic source of elevated testosterone levels in PCOS, which is a common condition affecting reproductive-age women.
Dr. Roxana Mehran is recognized for her exceptional contributions to cardiovascular medicine, including designing and implementing randomized clinical trials and outcomes research projects. She has also focused on personalized medicine and developed individual risk scores for bleeding and acute kidney injury.
Researchers at Mount Sinai use AI to analyze common data and gauge the risk of rare genetic variants contributing to disease. The new method offers a more accurate, data-driven view of genetic risk, enabling doctors to make informed decisions about patient care.
Dr. Valentin Fuster, a renowned cardiovascular expert, has been awarded the inaugural World Heart Federation oration lecture for his groundbreaking work in promoting global cardiovascular health. He will discuss early detection and education as key strategies for preventing heart disease, focusing on low- and middle-income countries.
A team of researchers at Mount Sinai discovered three powerful monoclonal antibodies that target the viral protein A35 and block viral spread in laboratory tests. These antibodies also protected rodents from severe disease and fully prevented death, suggesting they could be promising drug candidates for mpox treatment.
MARQO automates whole-slide image processing across multiple staining technologies, extracting detailed cellular and spatial information from tumor tissue slides. This enables faster and more accurate analysis of cancer tissues, paving the way for personalized treatments.
Researchers at Mount Sinai Hospital discovered that adding everolimus to standard chemotherapy improves outcomes for patients with advanced triple-negative breast cancer. The combination therapy reduces the risk of disease progression or death by 52%.
Researchers at The Mount Sinai Hospital successfully treated a rare and aggressive T-cell lymphoma that developed after CAR T-cell therapy for multiple myeloma. They identified a combination of compounds approved by the FDA that effectively targeted the lymphoma, with one compound, anti-CCR4, showing particular promise.
The Icahn School of Medicine at Mount Sinai has been awarded a five-year, $64 million grant to establish the Advancing the Science of Palliative Care Research Across the Lifespan (ASCENT) consortium. The consortium will support high-quality research for enhancing care for people living with serious illness and their caregivers.
Mount Sinai will provide orthopedics, sports medicine, emergency medicine, and musculoskeletal radiology services to world's top tennis stars. The institution has partnered with the USTA for 13 years, promoting health and wellness, preventing injuries, and catering to diverse populations.
A computational framework has been created to understand how the brain's striatum region influences everyday decisions and impaired decision-making in individuals with psychiatric disorders. The study suggests that modulating striosomal activity could be a new approach to addressing psychiatric abnormalities.
A new study suggests that prenatal exposure to acetaminophen may increase the risk of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD), in children. The research team calls for cautious use of acetaminophen during pregnancy under medical supervision.
The Mount Sinai Hospital has launched the country's first clinical manual for treating infection-associated chronic illnesses (IACIs), a comprehensive guide for diagnosis and care. The manual covers extensive learnings from the Cohen Center and provides practical strategies for clinicians to support patients with conditions such as lon...
The Mount Sinai Hospital has established the Cancer Health Research Center to address cancer-related health inequities across New York City. The center will conduct community-engaged research focused on social determinants of health, collaborating with local residents and trained community scientists.
A multi-hospital study by the Mount Sinai Health System found that AI can accurately predict hospital admissions hours earlier than current methods. The machine learning model performed reliably across diverse hospital settings, suggesting that it can support decision-making on the front lines of care.
A new study suggests that an AI-driven surgical education model can significantly improve the quality of resident training, reducing errors and costs. The model uses artificial intelligence algorithms and extended-reality headsets to simulate complex procedures without instructor presence.
Researchers found that AI chatbots can easily repeat and elaborate on false medical information, but a simple warning prompt can significantly reduce this risk. The study suggests that stronger safeguards are needed before these tools can be trusted in healthcare.
Researchers have gained a deeper understanding of the 5-HT1A serotonin receptor, a key player in regulating mood, emotion, and cognition. The study reveals that certain cellular signaling pathways are favored over others, and drugs can influence their strength of activation.
The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
A study found that even advanced AI models can default to intuitive answers, overlooking critical details in health care settings. Researchers tested commercially available LLMs using creative lateral thinking puzzles and modified well-known medical ethics cases, revealing blind spots that clinicians can't afford.
A new study led by Mount Sinai researchers has identified distinct biological signatures in patients with mild Crohn's disease, which may help avoid overtreatment and guide more personalized care. The findings suggest that these biomarkers can distinguish mild disease from more aggressive forms, potentially allowing for safer treatment...
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
The study found that guselkumab significantly improved endoscopic response and deep remission in patients with Crohn's disease. The therapy also demonstrated a corticosteroid-sparing effect, making it a valuable alternative to long-term steroid use.
A study from Mount Sinai Hospital found that patients with heart failure and atrial fibrillation who undergo mitral edge-to-edge repair have a doubled risk of death or rehospitalization for heart failure compared to those without AF. The researchers recommend aggressive treatment of AF before the procedure to improve outcomes.
Researchers at Mount Sinai identified Epac1 as a key driver of idiopathic pulmonary fibrosis, a chronic and progressive lung-scarring disease. Blocking Epac1 with a small-molecule drug may slow the progression of the disease, offering new treatment options for patients.
A new study led by Mount Sinai researchers discovered that the brain's response to regret is sex-dependent, with female brains more sensitive to sunk costs and regret. The study sheds light on how biological mechanisms underlying depression vulnerabilities differ between sexes.
Researchers developed an AI model that accurately predicts genetic mutations from routine pathology slides, reducing the need for rapid genetic testing by over 40% in lung adenocarcinoma patients. This innovation streamlines clinical decision-making and accelerates access to targeted therapies.
Dr. Andy Jagoda has received the Edward W. Gilmore Lifetime Achievement Award for his significant contributions to emergency medicine education, leadership, and quality improvement. The award recognizes his lifelong commitment to advancing emergency medicine in New York City.
A study published in Science Advances found that higher childhood lead levels are significantly associated with a faster rate of forgetting, even at low median blood lead levels. Additionally, older children and those with higher maternal IQs showed better memory retention.
The Mount Sinai Hospital has implemented the American Orthopaedic Association’s Own the Bone program to improve patient care for fragility fracture patients. The program offers a fracture liaison service to document and track individualized care, and incorporates 10 prevention measures to improve patient outcomes.
The study found a statistically significant increase in hospital admissions due to pediatric clavicular fractures over the 10-year period, suggesting an increase in severity of those injuries. This calls for better injury prevention and management strategies for doctors, parents, and patients.
Forensic pathologists play a crucial role in monitoring public health threats, advancing disease research, and providing support to families who have lost loved ones. They operate independently of law enforcement and courts, performing final diagnostic evaluations and providing objective facts for the justice system.
The study found that significant changes in sleep metrics occurred only when inflammation was present in the body, with symptoms alone not resulting in any notable sleep disruption. Sleep disturbances worsened leading up to inflammatory flares and improved afterward, suggesting that sleep changes may signal upcoming disease activity.
A Mount Sinai study found a post-pandemic increase in head and shoulder injuries among female and male youth hockey players, with higher rates of hospitalizations and fractures. The research highlights the importance of safer equipment standards, injury prevention strategies, and education to protect young athletes.
Mount Sinai Health System will participate at the 2025 Aspen Ideas: Health festival, discussing emerging science of aging and inflammation, and harnessing AI for healthcare innovation. The system will also provide complimentary dermatologic screenings for attendees.
A new study found that gut microbiome composition is associated with cognitive impairment in adults, and that food insecurity may jointly influence brain function. Adults with lower microbial diversity and specific imbalances in gut bacteria were more likely to experience cognitive impairment.
Researchers will analyze course of illness, confirm ingested substances, and provide real-time data for better care. The study aims to predict effects of emerging opioids and deliver timely alerts to doctors and public health agencies.
Mount Sinai Health System has received three prestigious awards from Practice Greenhealth for its commitment to environmental sustainability. The system's Mount Sinai Green program aims to reduce waste, improve energy efficiency, and create healthier environments. Recent initiatives include reducing emissions by 50% by 2030 and improvi...
Researchers from the Mount Sinai Health System are presenting new studies on the impact of sleep on neurodegenerative diseases like Alzheimer's. The studies explore the relationship between obstructive sleep apnea and Alzheimer's pathogenesis, as well as the effects of sleep disruption on spatial learning and neuroinflammation.
The New York Eye and Ear Infirmary of Mount Sinai has opened a comprehensive center for refractive solutions, providing innovative treatment options for patients requiring refractive correction. The center offers streamlined care for premium cataract and corneal refractive procedures, including LASIK and custom LASIK.
Individual incarceration is strongly associated with increased mortality in the US, as well as higher all-cause mortality among people living in counties with high incarceration rates. Incarcerated individuals face a 39% higher risk of dying from any cause and are three times more likely to die from drug overdose.
Exposure to lingering fine particulate matter from wildfire smoke was associated with increased hospitalization risks for various cardiorespiratory conditions, including ischemic heart disease and respiratory diseases. The study's findings highlight the need for research into the long-term health impacts of wildfire smoke.