The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
A study found that even advanced AI models can default to intuitive answers, overlooking critical details in health care settings. Researchers tested commercially available LLMs using creative lateral thinking puzzles and modified well-known medical ethics cases, revealing blind spots that clinicians can't afford.
A new study led by Mount Sinai researchers has identified distinct biological signatures in patients with mild Crohn's disease, which may help avoid overtreatment and guide more personalized care. The findings suggest that these biomarkers can distinguish mild disease from more aggressive forms, potentially allowing for safer treatment...
A new study found that exposure to PFAS, a class of synthetic chemicals, may increase the risk of developing type 2 diabetes. Higher levels of PFAS were associated with a significantly greater risk of developing T2D in the future.
The study found that guselkumab significantly improved endoscopic response and deep remission in patients with Crohn's disease. The therapy also demonstrated a corticosteroid-sparing effect, making it a valuable alternative to long-term steroid use.
A study from Mount Sinai Hospital found that patients with heart failure and atrial fibrillation who undergo mitral edge-to-edge repair have a doubled risk of death or rehospitalization for heart failure compared to those without AF. The researchers recommend aggressive treatment of AF before the procedure to improve outcomes.
Researchers at Mount Sinai identified Epac1 as a key driver of idiopathic pulmonary fibrosis, a chronic and progressive lung-scarring disease. Blocking Epac1 with a small-molecule drug may slow the progression of the disease, offering new treatment options for patients.
A new study led by Mount Sinai researchers discovered that the brain's response to regret is sex-dependent, with female brains more sensitive to sunk costs and regret. The study sheds light on how biological mechanisms underlying depression vulnerabilities differ between sexes.
Researchers developed an AI model that accurately predicts genetic mutations from routine pathology slides, reducing the need for rapid genetic testing by over 40% in lung adenocarcinoma patients. This innovation streamlines clinical decision-making and accelerates access to targeted therapies.
Dr. Andy Jagoda has received the Edward W. Gilmore Lifetime Achievement Award for his significant contributions to emergency medicine education, leadership, and quality improvement. The award recognizes his lifelong commitment to advancing emergency medicine in New York City.
A study published in Science Advances found that higher childhood lead levels are significantly associated with a faster rate of forgetting, even at low median blood lead levels. Additionally, older children and those with higher maternal IQs showed better memory retention.
The Mount Sinai Hospital has implemented the American Orthopaedic Association’s Own the Bone program to improve patient care for fragility fracture patients. The program offers a fracture liaison service to document and track individualized care, and incorporates 10 prevention measures to improve patient outcomes.
The study found a statistically significant increase in hospital admissions due to pediatric clavicular fractures over the 10-year period, suggesting an increase in severity of those injuries. This calls for better injury prevention and management strategies for doctors, parents, and patients.
Forensic pathologists play a crucial role in monitoring public health threats, advancing disease research, and providing support to families who have lost loved ones. They operate independently of law enforcement and courts, performing final diagnostic evaluations and providing objective facts for the justice system.
The study found that significant changes in sleep metrics occurred only when inflammation was present in the body, with symptoms alone not resulting in any notable sleep disruption. Sleep disturbances worsened leading up to inflammatory flares and improved afterward, suggesting that sleep changes may signal upcoming disease activity.
A Mount Sinai study found a post-pandemic increase in head and shoulder injuries among female and male youth hockey players, with higher rates of hospitalizations and fractures. The research highlights the importance of safer equipment standards, injury prevention strategies, and education to protect young athletes.
Mount Sinai Health System will participate at the 2025 Aspen Ideas: Health festival, discussing emerging science of aging and inflammation, and harnessing AI for healthcare innovation. The system will also provide complimentary dermatologic screenings for attendees.
A new study found that gut microbiome composition is associated with cognitive impairment in adults, and that food insecurity may jointly influence brain function. Adults with lower microbial diversity and specific imbalances in gut bacteria were more likely to experience cognitive impairment.
Researchers will analyze course of illness, confirm ingested substances, and provide real-time data for better care. The study aims to predict effects of emerging opioids and deliver timely alerts to doctors and public health agencies.
Mount Sinai Health System has received three prestigious awards from Practice Greenhealth for its commitment to environmental sustainability. The system's Mount Sinai Green program aims to reduce waste, improve energy efficiency, and create healthier environments. Recent initiatives include reducing emissions by 50% by 2030 and improvi...
Researchers from the Mount Sinai Health System are presenting new studies on the impact of sleep on neurodegenerative diseases like Alzheimer's. The studies explore the relationship between obstructive sleep apnea and Alzheimer's pathogenesis, as well as the effects of sleep disruption on spatial learning and neuroinflammation.
The New York Eye and Ear Infirmary of Mount Sinai has opened a comprehensive center for refractive solutions, providing innovative treatment options for patients requiring refractive correction. The center offers streamlined care for premium cataract and corneal refractive procedures, including LASIK and custom LASIK.
Individual incarceration is strongly associated with increased mortality in the US, as well as higher all-cause mortality among people living in counties with high incarceration rates. Incarcerated individuals face a 39% higher risk of dying from any cause and are three times more likely to die from drug overdose.
Exposure to lingering fine particulate matter from wildfire smoke was associated with increased hospitalization risks for various cardiorespiratory conditions, including ischemic heart disease and respiratory diseases. The study's findings highlight the need for research into the long-term health impacts of wildfire smoke.
A new machine learning tool called GLUCOSE helps doctors manage blood sugar levels in patients recovering from heart surgery by recommending tailored insulin doses. The model outperformed experienced clinicians in keeping blood sugar levels within a safe range, despite using only current patient data.
Researchers will present AI models that predict chronic respiratory failure and detect airway obstruction, with key findings on asthma susceptibility, small airway disease, and lung inflammation. The studies use nasal epithelial gene expression analyses and bronchoscopy to identify potential biomarkers for ICU patient outcomes.
Researchers have identified a mechanism involving potassium channels that could provide a new approach to treating depression. The study, led by Dr. James Murrough, found that ezogabine improved depression symptoms and anhedonia in patients, normalizing brain activity in key regions.
Surgeons at Mount Sinai performed the world's first heart-liver-kidney triple organ transplants in New York State, with two patients making full recoveries after the surgeries. The procedures were led by Anelechi Anyanwu and Sander S. Florman and represent a significant milestone in complex organ transplantation.
Research found that women whose sister experienced postpartum psychosis are over 10 times more likely to experience it themselves. The study highlights genetic and shared environmental influences and suggests early recognition and prevention are crucial.
Dr. Miriam Merad has been recognized for her groundbreaking research on macrophage biology and immunology, with a focus on cancer and chronic inflammatory disease. Her work has led to the development of novel therapeutic targets and has improved treatment outcomes for patients with lung cancer.
Researchers will discuss increasing the use of low-dose aspirin for preeclampsia prevention through universal implementation. Additionally, experts will present on the impact of doula care on social determinants of health, exploring its potential to address non-medical healthcare disparities within the system.
A study published in Brain found that the orbitofrontal cortex responds more strongly to drug content than other stimuli, even after treatment and abstinence. The researchers used an Academy Award-nominated movie to assess brain responses in individuals with heroin use disorder and healthy controls.
Dr. Charney will retire at the end of his current term on June 30; Eric J. Nestler, MD, PhD, appointed interim dean. Under his leadership, the Icahn School of Medicine advanced its reputation as an international leader in biomedical education and research.
The Mount Sinai team's NYC-Vita trial combines lifestyle and pharmaceutical interventions to rebalance the immune system and restore health in older adults. The ambitious effort aims to develop practical, science-driven interventions that extend life and restore energy, focus, and strength.
Researchers discovered distinct roles for dopamine receptors in the ventral hippocampus, a region involved in emotions and stress responses. The study highlights the importance of dopamine signaling in anxiety and mood disorders.
A novel AI model developed by researchers at Mount Sinai improved delirium detection by quadrupling the rate of identification and treatment in hospitalized patients. The model accurately calculates delirium risk in real-time and integrates smoothly into clinical workflows, helping staff catch and treat more patients with delirium.
Researchers found persistent inflammation in heart and lungs of patients with long COVID, even after standard tests return normal results. This study uses advanced PET/MRI imaging to detect abnormal patterns that could serve as early warning signs of future cardiac and pulmonary conditions.
Eric J. Nestler, a world-leading expert on addiction and depression, has been elected to the National Academy of Sciences (NAS) for his distinguished achievements in original research. The recognition is a testament to his extensive scientific experience and impact on the field of neuroscience.
The Icahn School of Medicine at Mount Sinai is providing all medical and graduate students with access to OpenAI's ChatGPT Edu private and secure platform. This move enhances its educational toolkit, equipping students with cutting-edge AI solutions to succeed in the rapidly evolving healthcare ecosystem.
Researchers identified how the brain assigns positivity or negativity to social experiences through a complex neural circuitry involving the hippocampus. They discovered that serotonin and neurotensin release opposing signals in the ventral CA1 region, which can be leveraged for future therapies.
A new AI algorithm, Viz HCM, can quickly and specifically identify high-risk heart patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The algorithm's findings can help doctors prioritize the highest-risk patients for earlier appointments and treatment.
A new AI algorithm has been calibrated to quickly identify patients with hypertrophic cardiomyopathy (HCM) and provide individualized risk assessments. The tool can help prioritize high-risk patients for earlier appointments and treatment, leading to better patient outcomes.
The Mount Sinai Fuster Heart Hospital cardiology faculty practice has received the 2024 Human Experience Pinnacle of Excellence Award from Press Ganey, a leading patient experience organization. The hospital ranks among the top 5% of healthcare providers in delivering patient experience over three years.
Using intravascular imaging (IVI) to guide stent implantation reduces death, stent thrombosis, and repeat procedures in severely calcified lesions. IVI outperforms conventional angiography in improving patient outcomes.
A new study reveals that inherited germline genetic variants significantly influence the biology of tumors, altering protein activity, gene expression, and tumor interactions with the immune system. The research suggests that considering a patient's inherited DNA could refine diagnosis, risk prediction, and therapy selection.
Researchers at Mount Sinai School of Medicine have identified a new genetic cause of neurodevelopmental disorders (NDDs), including mutations in the previously overlooked non-coding gene RNU2-2. The discovery offers hope to potentially thousands of families worldwide, providing closure and support for those affected by these conditions.
A study by researchers at Mount Sinai reveals that generative AI models may recommend different treatments for the same condition based solely on a patient's demographic background. The study highlights the need for early detection and intervention to ensure safe, effective, and appropriate care.
The Playbook Workflow Builder simplifies data analysis and streamlines collaboration for biomedical researchers. Researchers can design custom workflows using pre-built analytical components, removing a major barrier to data-driven discovery.
The Mount Sinai Hospital has launched an AI Small Molecule Drug Discovery Center to revolutionize the creation of life-saving medicines. The center will use cutting-edge AI to design and optimize novel therapeutics with unprecedented speed and precision.
Dr. Brian Brown is recognized for his groundbreaking work in gene therapy and functional genomics, which has helped transform the fields and contributed to key advancements in medicine and biotechnology. His innovations have been broadly used across biomedical fields, including cancer, immunology, and genetic disease research.