(New York, NY – June 8, 2025) – Sleep medicine experts from the Mount Sinai Health System are presenting new research at SLEEP 2025 , the 39 th annual meeting of the Associated Professional Sleep Societies, from June 8-11 in Seattle. Please let me know if you would like to coordinate an interview about their work. The doctors and researchers are also available to comment on other breaking news and trending topics.
The research appears in an online supplement of the journal, Sleep . These abstracts are available for immediate media coverage.
PRESENTATIONS
Tuesday, June 10
11:45 a.m. - 12:45 p.m. Pacific (2:45 - 3:45 p.m. Eastern)
3AB
Lunch Debate-02: Does the Failure of Brain Cleaning During Sleep Really Cause Alzheimer’s Disease?
Presenter: Andrew W. Varga, MD, PhD , Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
Wednesday, June 11
3:30 – 5:30 p.m. Pacific (6:30 – 9:30 p.m. Eastern)
Ballroom 6B
Symposia-32: Updates on Biomarkers in RBD: Neurophysiology, Actigraphy, and Biofluid Markers
Presenter: Emmanuel During, MD , Associate Professor of Neurology (Movement Disorders) and Medicine (Pulmonary Medicine, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
3:30 – 5:30 p.m. Pacific (6:30 – 8:30 p.m. Eastern)
Ballroom 6E
Symposia-33: Impact of Obstructive Sleep Apnea on Neurodegenerative & Alzheimer’s Disease Pathogenesis: Examining Physiologic, Race, and Sex Specific Mechanisms
Presenters: Korey Kam, PhD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai; Anna Mullins, PhD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
POSTERS
0112: Impact of REM OSA and Hypoxic Burden on Sleep-Dependent Spatial Navigational memory and White Matter Integrity in Cognitively Normal Elderly with OSA
Anjona Datta, MA, Graduate Student at the Icahn School of Medicine at Mount Sinai; Daphne Valencia, MA, Research Manager at the Mount Sinai Integrative Sleep Center
0114: Role of Encoding Opportunity and Change in Slow Wave Activity Across K-complexes on Sleep-Dependent Spatial Navigational Memory in Older Adults
Anna Mullins, PhD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
0135: Effects of Early-Adulthood Sleep Disruption on Longitudinal Spatial Learning, Neuroinflammation, and Late-Life Tau Pathology in the PS19 Mouse Model
Kerly Lozano, BA, Graduate Student at the Icahn School of Medicine at Mount Sinai
0460: A Foundational Transformer Leveraging Full-Night, Multichannel Sleep Study Representations Estimate Cardiovascular Mortality Risk
Benjamin Fox, MS, Graduate Student at the Icahn School of Medicine at Mount Sinai; Sajila Wickramaratne, PhD, Associate Scientist at the Icahn School of Medicine at Mount Sinai,
0604: Arousal threshold estimated by phenotyping using polysomnography is lower using automated arousal scoring compared to manual arousal scoring
Thomas M. Tolbert, MD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
0606: Demographic Differences in the Physiological Burdens of Sleep Apnea
Sarah Chu, MS, Clinical Research Coordinator at the Icahn School of Medicine at Mount Sinai
0612: OSA influences locus coeruleus structural integrity on 7T MRI in cognitively normal older adults
Korey Kam, PhD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
0619 : Shallower sleep by odds ratio product is associated with low arousal threshold when adjusted for confounding obstructive sleep apnea severity
Thomas M. Tolbert, MD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
0690: Examining the diagnostic validity of PAT device against concurrent nocturnal polysomnography recording in a community dwelling cohort of older adults
Daphne Valencia, MA, Research Manager at the Mount Sinai Integrative Sleep Center
1127: Actigraphy-Based Sleep Irregularity Measures and Cardiometabolic Imaging Biomarkers Using PET/MRI: A Descriptive Analysis
Bolong Xu, MD, Resident Physician at Mount Sinai Hospital
1157: The Impact of Chronic Rhinosinusitis on Insomnia Symptoms and Sleep Duration in World Trade Center Rescue and Recovery Workers
Horacio Romero Castillo, BA, Graduate Student at the Icahn School of Medicine at Mount Sinai
1271 : Cognitive impairment and sleep disturbances in World Trade Center (WTC) rescue and recovery workers and volunteers
Katarina Martillo, BA, Clinical Research Coordinator at Icahn School of Medicine at Mount Sinai
1253: Prevalence of Psychiatric Conditions in a Large Sleep Clinic Population
Ankit Parekh, PhD , Director of the Sleep And Circadian Analysis (SCAN) Group and Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
1265: Relationship Between Self-Reported Sleep Disturbances and Cognition in Older Chinese Americans: A Pilot Mediation Analysis
Li Zhou; MD, PhD, Postdoctoral Fellow at Icahn School of Medicine at Mount Sinai; Ankit Parekh, PhD , Director of the Sleep And Circadian Analysis (SCAN) Group and Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
1272: Longitudinal effect of slow wave sleep on plasma Alzheimer's disease biomarkers in cognitively normal older adults
Daphne Valencia, MA, Research Manager at the Mount Sinai Integrative Sleep Center
1307: External Validation of Actigraphy-based iRBD Classifier Using a Different Actigraph
Emmanuel During, MD , Associate Professor of Neurology (Movement Disorders) and Medicine (Pulmonary Medicine, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
LATE-BREAKING POSTERS
1597: Beyond CPAP Downloads: The Role of Effective AHI in Evaluating Treatment Burden
Joy Ayyoub, MBBCH, Sleep Medicine Fellow at the Mount Sinai Hospital; Korey Kam, PhD , Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
1604: Automated Severity Rating of REM Sleep Behavior Disorder with Computer Vision
Emmanuel During, MD , Associate Professor of Neurology (Movement Disorders) and Medicine (Pulmonary Medicine, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai
1639: Screening for Idiopathic REM Sleep Behavior Disorder Using a Synucleinopathy Prodrome Questionnaire and Machine Learning
Emmanuel During, MD , Associate Professor of Neurology (Movement Disorders) and Medicine (Pulmonary Medicine, Critical Care and Sleep Medicine) at the Icahn School of Medicine at Mount Sinaii
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