Articles tagged with Alzheimer Disease
Lecanemab is approved to treat early Alzheimer's disease, but its clinical benefits are modest. The treatment carries serious adverse effects and requires resource-intensive monitoring with MRI scans.
Researchers at Niigata University conducted the first comprehensive reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes, finding a substantially lower risk than previously cited estimates. The study suggests that the risk is comparable to estimates reported in large studies of people with European ancestry.
Researchers discovered that a brain protein called Arc helps spread toxic Tau from sick brain cells to healthy ones in mice. This finding suggests that targeting the spread of Tau could be a powerful tool to stop Alzheimer's disease progression. The study also highlights the potential protective role of Arc in early stages of the disease.
A new study reveals ATOX1 as a key regulator of oxidative stress, neuroinflammation, and microglial survival in Alzheimer's disease. ATOX1 expression is downregulated in microglia associated with Aβ plaques, leading to copper accumulation and cellular toxicity.
This study reveals that Porphyromonas gingivalis induces neuroinflammation and cognitive impairment via microglial ferroptosis triggered by the NOX4/PPAR-α/PGC-1α pathway. The findings provide a molecular target for drug repurposing to intervene in periodontitis-associated Alzheimer's disease.
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
Researchers identified karyoptosis as a key link between toxic protein accumulation and neuron death in neurodegenerative diseases like Alzheimer's and frontotemporal dementia. The study found that targeting proteins acting as 'switches' in this pathway may slow or prevent cell death by karyoptosis.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
Salk Institute researchers discovered chronoferroptosis, a chronic stress pathway in cells that causes neurons to become less resilient over time and more susceptible to neurodegeneration. Iron accumulation was found to lower the cells' defenses, making them more vulnerable to stressors.
A new study finds that Alzheimer's disease and related dementias will cost the US $818 billion this year, driven by costs associated with care and loss of productivity. The study's comprehensive model accounts for often-overlooked factors like diminished quality of life and unpaid care provided by family members.
A new study published in Health Psychology reveals that individual personality traits play a significant role in how caregiving stress affects physical health. Caregivers with high neuroticism and low agreeableness experienced greater inflammation and poorer physical functioning, while others remained relatively resilient. The research...
Researchers developed RNovA algorithm to identify new PTMs in human cells, expanding capabilities of machine learning in basic biological research. The discovery aims to advance diagnostics and broaden biologists' horizons for cancer and other diseases.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
Researchers found a copper-based compound significantly reduces toxic Alzheimer's proteins and improves long-term spatial memory in laboratory experiments. The treatment repairs the brain's waste-clearing pump, allowing it to clear out trapped toxic proteins and reduce amyloid buildup by 42%.
Researchers identified age-related genetic changes in microglia that may drive inflammation and neurodegeneration in Alzheimer's disease. Cancer-associated mutations were found in genes commonly linked to clonal hematopoiesis, promoting inflammatory activity.
A study by DZNE shows that smartphone-based memory tests can detect subtle cognitive decline in people with mild cognitive impairment (MCI) more quickly than conventional testing. This approach has the potential to accelerate clinical trials for new dementia drugs and be used in routine care.
A large retrospective analysis found a significant association between glucosamine supplementation and increased likelihood of progressing from mild cognitive impairment to Alzheimer's disease. The study also revealed elevated sugar attachment in Alzheimer's brain specimens, suggesting metabolic dysfunction as a contributing driver.
The JTMF Foundation has expanded its footprint with a $3.3 million gift to fund three main initiatives: identifying early signs of Alzheimer's in adults with Down syndrome, expanding access to cutting-edge clinical research, and developing best-practice guidelines.
A new compound, compound 10, has shown promising effects in slowing the development of Alzheimer's disease by inhibiting GRK2 aggregation. This leads to improved mitochondrial function and reduced amyloid beta deposition, potentially breaking a vicious circle that contributes to dementia progression.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
A new University of Arizona study has found that several common sleep behaviors may be linked to signs of brain aging. Sleeping outside the recommended seven-to-nine-hour range, frequent daytime napping, and sleeplessness were distinctly associated with greater volume of white matter lesions in healthy people.
A new study by researchers at UC Davis Health and Kaiser Permanente found that long-term exposure to fine air pollution particles (PM2.5) is associated with lower semantic memory, a type of brain's encyclopedia. The study analyzed data from 740 adults aged 53-94 and found no impact on executive function or verbal episodic memory.
Researchers have identified an experimental molecule called OLE that helps restore microglia's protective function against Alzheimer's disease. The compound reduces beta-amyloid plaque size and toxicity, improving cognitive performance in memory tests.
Andrew Yang's research has reshaped scientific understanding of the blood-brain barrier and its role in brain health and disease. His latest study reveals new potential treatment targets for neurological diseases, normal aging, and sleep.
Scientists at Gladstone Institutes create new method to track brain waste exit points, revealing unexpected details on immune cell interaction and disease disruption. The 'nearest exit' model suggests that each brain region has a unique drainage system.
Researchers at Columbia University have discovered a key mechanism in the formation of toxic tau filaments that contribute to Alzheimer's disease. The findings suggest that disrupting neuroproteasomes can trigger misfolding of tau into highly similar filaments, and that APOE variants may play a role in modulating this process.
A blood test can identify signs of Alzheimer's Disease decades before symptoms appear, suggesting early detection and potential treatment. A new brain imaging test also detects Alzheimer's Disease biomarkers earlier than the current standard, improving diagnosis and treatment options.
Researchers found biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults. These biomarkers, measuring tau and amyloid plaque, were associated with a greater chance of cognitive decline, particularly in processing speed and executive function.
A new brain imaging test can detect Alzheimer's disease pathology in twice as many people before symptoms appear. The test uses a new tau PET tracer that identifies more tau-positive cases than the current standard, leading to better decisions about who is on an Alzheimer's trajectory.
Researchers found that impaired virtual reality path integration was closely tied to brain structure and biomarkers associated with neurodegeneration. This suggests that VR-based navigation errors may reveal hidden changes in the brain long before symptoms arise, making it a promising behavioral marker for preclinical Alzheimer's disease.
A new approach combines MRI scans and AI tools to measure fluid flow in the brain, shedding light on the glymphatic system’s mechanics. The study reveals two main ways the system washes away particles, with one way moving faster than the other.
A large multisite study found that Black and Hispanic people with cognitive impairment are less likely to show Alzheimer's pathology on brain scans compared to other racial and ethnic groups. The study highlights ethnoracial differences in dementia and underscores the need for further research into underlying causes of dementia symptoms.
A plasma-based staging model using eMTBR-tau243 and %p-tau217 demonstrated strong concordance with positron emission tomography-based staging and clinical severity of Alzheimer disease. This approach may provide a scalable, minimally invasive method for biological stratification and treatment selection.
Researchers developed an experimental gene therapy that protects brain cells from toxic protein damage caused by TDP-43, which is linked to neurodegenerative diseases such as frontotemporal dementia and Alzheimer's disease. The approach strengthens the neuron's resilience and helps preserve brain function.
A study proposes that sleep disruption may be connected to increased risk of dementia through the brain's waste clearance system. The glymphatic system, active during sleep, helps remove metabolic waste, and its disruption may lead to cognitive decline.
Researchers at UC Riverside have identified a key neural circuit, the locus coeruleus, which plays a central role in cognitive flexibility and adapting to new rules. Disrupting this circuit impairs the brain's ability to reorganize neural networks during complex decision-making.
A new study from UC San Diego found that poorer sleep quality is associated with greater memory difficulties and more Alzheimer's-related brain changes in older women with a higher genetic risk. The study suggests that improving sleep could become a target for future Alzheimer's prevention strategies.
A new study by Tohoku University researchers has identified dopamine dysfunction as a previously unrecognized mechanism underlying memory impairment in Alzheimer's disease. The discovery may lead to the development of targeted therapies to restore cognitive function and potentially reverse cognitive decline.
The APOE2 gene variant is linked to exceptional longevity and reduced Alzheimer's risk, thanks to its ability to help human neurons keep their DNA intact and resist cellular senescence. This study reveals a previously underappreciated function of the gene, shifting attention away from its role in cholesterol transport.
A study from the University of Eastern Finland reveals that lithium chloride may affect various cellular level changes in Alzheimer's disease, including Tau phosphorylation and Rho GTPase signaling. The researchers identified new AD-relevant phosphosites affected by lithium chloride treatment.
A new study found that at-home blood tests combined with online brain tests can accurately predict dementia risk. The study used a finger-prick blood test and performance on brain tests to categorize participants into low, medium, or high risk groups.
A study published in the Journal of Nutrition found that moderate egg consumption is associated with a lower risk of Alzheimer's disease. Researchers discovered that eating one egg per day for at least five days a week reduces the risk of Alzheimer's by up to 27%.
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Researchers developed a new photonic material using lead iodide, enabling high-speed data transmission in the terahertz frequency range. The material confines light within submicrometer regions, paving the way for integrated photonic circuits that could replace or complement electronic circuits.
Researchers studying RNA pollution's impact on aging brains seek to develop therapeutic strategies for neurodegenerative diseases like Alzheimer's. Sanford Burnham Prebys scientist Anne Bang will use advanced robotics to test thousands of compounds.
A new study from Mayo Clinic suggests that Alzheimer's disease may start as early as the late 50s, with subtle biological changes accelerating over time. Researchers analyzed data from 2,082 participants and found that biomarkers of tau pathology and neurodegeneration show more pronounced increases around ages 68 to 72.
Researchers at Indiana University School of Medicine developed a new method to analyze brain energy network patterns, revealing insights into Alzheimer's disease progression. The study found that brain networks reorganize as the disease progresses, with memory and language functions showing increased metabolic demand in early stages.
A study using mice and simulations found that abdominal contractions compress blood vessels connected to the spinal cord and brain, enabling gentle brain movement that facilitates cerebrospinal fluid flow and potentially removes neural waste. This mechanism may explain why exercise is thought to benefit brain health.
Researchers investigate how environmental stressors like jet lag and high-fat diets affect Alzheimer's risk. They aim to determine if restoring metabolic rhythms can prevent the progression of the disease, taking a holistic view of health and natural rhythms.
A randomized clinical trial examined the impact of Alzheimer's disease and related dementias (ADRD) screening in older adults on family members. The study found that primary care screenings did not worsen quality of life, depression, or anxiety over two years.
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data to discover multi-omic biomarkers for preclinical Alzheimer's. The model delivers 4× more accurate preclinical diagnosis and 130% better responder stratification than prior art.
Researchers found three distinct trajectories of cognitive decline: stable, slow and fast decline. Biomarker data showed that participants who declined faster had higher P-tau217 levels and smaller hippocampi.
Researchers at Scripps Research identify S-nitrosylation of protein STING as driver of chronic brain inflammation in Alzheimer's disease. Blocking this process protects brain cell connections and preserves synapses.