Articles tagged with Dementia
A study by Kyoto University researchers found that hospital admissions for persons with dementia result in higher healthcare spending, with a $2,500 increase in 30-day costs after an emergency room visit. However, there was no conclusive evidence linking hospital admission to 30 or 90-day mortality rates.
A new AI tool, AIDD, combines brain scans with machine learning to accurately diagnose two common forms of dementia. The tool showed near-perfect accuracy in identifying Alzheimer's disease and dementia with Lewy bodies, offering a promising future for clinicians.
A large Japanese study found that maintaining a healthier profile with lower lifestyle and health risks can significantly lower dementia risk in people with one or no APOE ε4 alleles. However, individuals carrying two APOE ε4 alleles may require different preventive or therapeutic approaches.
A new University of Arizona study has found that several common sleep behaviors may be linked to signs of brain aging. Sleeping outside the recommended seven-to-nine-hour range, frequent daytime napping, and sleeplessness were distinctly associated with greater volume of white matter lesions in healthy people.
A new study by researchers at UC Davis Health and Kaiser Permanente found that long-term exposure to fine air pollution particles (PM2.5) is associated with lower semantic memory, a type of brain's encyclopedia. The study analyzed data from 740 adults aged 53-94 and found no impact on executive function or verbal episodic memory.
A study found an association between genetic variants for high pulse pressure and an increased risk of dementia as a contributing cause of death. Researchers constructed polygenic risk scores to calculate predisposition to disease, and found a 16% increased risk with higher scores.
Dr. Owen Carmichael received the James W. and Neil Ann Parks Professorship for Dementia Research, Prevention and Treatment at Pennington Biomedical. His work focuses on developing advanced biomedical imaging techniques to better understand Alzheimer's disease and brain aging.
A groundbreaking study created a world's first pure cerebral microbleed model by targeting brain vascular collagen IV using CRISPR/Cas9 gene editing. The research implicated dysfunctional collagen in tiny brain hemorrhages, which are strongly associated with dementia and cognitive decline.
Institutional Special Needs Plan (I-SNP) enrollment was associated with significantly fewer hospitalizations for nursing home residents with dementia at the end of life, according to a retrospective cohort study. Effect sizes were larger for UnitedHealthcare (UHC) I-SNPs vs non-UHC plans. Plan maturity and volume likely impact success.
A large multisite study found that Black and Hispanic people with cognitive impairment are less likely to show Alzheimer's pathology on brain scans compared to other racial and ethnic groups. The study highlights ethnoracial differences in dementia and underscores the need for further research into underlying causes of dementia symptoms.
A nine-session weekly group program in rural Spain improved caregiver burden, quality of life, and self-efficacy. Key factors associated with greater burden include personal health problems and extended caregiving hours.
Researchers developed an experimental gene therapy that protects brain cells from toxic protein damage caused by TDP-43, which is linked to neurodegenerative diseases such as frontotemporal dementia and Alzheimer's disease. The approach strengthens the neuron's resilience and helps preserve brain function.
A new preclinical study finds that estrogen loss in the extracellular matrix of the hippocampus may contribute to memory decline and increased risk of Alzheimer's disease in postmenopausal women. The study suggests a possible new treatment approach focused on restoring the brain's supportive environment.
Researchers at UC Riverside have identified a key neural circuit, the locus coeruleus, which plays a central role in cognitive flexibility and adapting to new rules. Disrupting this circuit impairs the brain's ability to reorganize neural networks during complex decision-making.
A new UC San Diego study reveals that women are more vulnerable to dementia risk factors affecting cognition, with some risk factors having stronger impacts on women than men. The findings suggest a greater need for targeted interventions, such as managing depression and improving cardiovascular health.
A Peking University study found that population ageing, not just air pollution, contributes to rising dementia deaths in China. Lower PM2.5 levels have brought health benefits, but the rapid growth of China's older population offsets progress.
A new study by Curtin University found that millions of dementia cases across the Western Pacific Region could be prevented by implementing country-specific strategies to address key risk factors. The research highlights a major opportunity for prevention, showing how different countries' economic and social contexts affect risk factors.
A new study found that at-home blood tests combined with online brain tests can accurately predict dementia risk. The study used a finger-prick blood test and performance on brain tests to categorize participants into low, medium, or high risk groups.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Researchers at Mass General Brigham developed an ultrasensitive test to detect abnormal clumps of TDP-43 protein in cerebrospinal fluid, a biomarker for specific form of dementia called FTLD-TDP. The test shows promise in diagnosing patients with the correct pathology and tracking disease progression.
A cohort study found that poor housing affordability was associated with higher risks of frailty, disability, dementia, and mortality, while poor housing quality was linked to increased risks of frailty, disability, and mortality. Housing insecurity is identified as a clinically relevant social determinant of health among older persons.
A new study investigates plasma biomarkers' role in early-onset Alzheimer's disease and frontotemporal dementia. The findings suggest distinct trajectories and clinical associations, supporting their potential utility for risk stratification.
A recent study published in JAMA Network Open found that half of older patients with dementia remain on psychotropic drugs a year after starting them. The medications, including antipsychotics and benzodiazepines, are often prescribed in acute and post-acute settings such as emergency rooms and skilled nursing facilities. This raises c...
Researchers found three distinct trajectories of cognitive decline: stable, slow and fast decline. Biomarker data showed that participants who declined faster had higher P-tau217 levels and smaller hippocampi.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.
A new study found comprehensive evidence that weight-loss GLP-1 receptor agonists like semaglutide reduce amyloid-beta and tau buildup in the brain. Consistent reductions were seen in animal and cell studies, with liraglutide showing the most positive effects.
A UC San Diego study found that diabetes is associated with changes in biological signals in the blood linked to Alzheimer's disease and brain damage in Latino adults. Researchers suggest that metabolic health may play a role in shaping future dementia risk.
A recent study published in Neurology found that people with epilepsy who experience poor sleep are at a higher risk of developing dementia compared to those without epilepsy. Optimal sleep, defined as six to eight hours per day, is associated with better cognitive function and lower dementia risk.
A new study suggests that a digital platform called Living Memory Home for Dementia Care Pairs (LMH-4-DCP) can help reduce grief severity and improve relationships between caregivers and individuals with dementia. The platform facilitates reminiscing and shared memories, promoting dignity and respect for care recipients.
A web tool called Living Memory Home for Dementia Care Pairs facilitates collaborative reminiscence therapy, reducing feelings of pre-death grief and improving relationship quality. The app promotes well-being and connection between dementia patients and caregivers, leading to better care outcomes.
Researchers from Johns Hopkins Medicine have developed mini brain-like structures grown in the lab that could be used to evaluate how patients with Alzheimer's disease respond to certain drugs. The study found that tiny particles secreted by these brain tissues may contain cellular information that could help scientists find new biomar...
A study by UC San Diego researchers identified CgA-centered stress-response pathways as key drivers of cognitive resilience in individuals with asymptomatic Alzheimer's disease. The findings also introduce a new framework to accelerate the discovery of preventive therapies for Alzheimer's disease.
A new Cochrane review of 17 clinical trials found that anti-amyloid Alzheimer's drugs have no significant impact on cognitive decline or dementia severity, but may increase the risk of brain swelling and bleeding. The evidence suggests that these drugs are unlikely to provide clear benefit to patients.
Researchers at Case Western Reserve University will use AI and machine learning to analyze over 1,800 potential genes that have been identified as suitable new targets for treating Alzheimer's disease. The goal is to deliver a prioritized list of genetically validated drug targets to pharmaceutical developers and clinicians.
Researchers at UT Arlington are working to improve dementia care through education and support initiatives. The university has received a grant to develop best practices and new developments in care, bridging the gap between research and real-world practice.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A study found that weaker, more fragmented daily rhythms were associated with smaller memory-related brain regions and faster brain atrophy. The study suggests that a weaker circadian rhythm can be an early sign of adverse neurological changes and contribute to the underlying neurodegenerative process.
A study published by the American Academy of Neurology found that a higher quality plant-based diet is associated with a lower risk of Alzheimer's disease and other dementias. Researchers compared participants based on their diet scores, finding that those who followed healthier plant-based diets had a lower risk of dementia.
A recent study published in Journal of the American Geriatrics Society found that individuals with higher optimism have a lower risk of developing dementia. After analyzing data from the Health and Retirement Study, researchers discovered a 15% lower risk associated with a one-standard-deviation increase in optimism.
A new study from the University of Chicago suggests that smoking may be linked to dementia through a previously unmapped route between the lungs and brain, involving pulmonary neuroendocrine cells and exosomes that disrupt iron balance in neurons.
A meta-analysis of millions of community-dwelling adults found that regular physical activity, less sedentary time, and appropriate nightly sleep (7-8 hours) were associated with a lower subsequent risk of dementia. Conversely, too little or too much sleep was linked to an increased risk, highlighting the importance of optimal sleep du...
The Dementia Trials Accelerator is revolutionizing dementia research by streamlining the recruitment process for clinical trials. With over 10,000 participants expected to be recruited by 2027, this initiative aims to accelerate diagnosis and treatment development for those affected by dementia.
Gladstone Institutes investigator Ryan Corces receives $750,000 to investigate unknown genetic variants contributing to Alzheimer's disease. He aims to identify new drivers and therapeutic targets using artificial intelligence and CRISPR tools.
A study by Concordia University found that individuals with hearing loss exhibit worse dual-task performance, including slower walking and less stable gait. Exercise and cognitive training can improve these outcomes, but the effects vary by sex and severity of hearing loss.
Scientists have found that the APOE4 gene variant causes hyperactivity in two regions of the hippocampus, an important memory center of the brain, even before middle age. In mice with the APOE4 gene, reducing Nell2 levels reverses neuronal changes and improves cognitive function.
A new study found that older people who forego necessary dental procedures due to financial barriers may experience heart failure, a heart attack, a stroke, or dementia. The researchers suggest that alleviating upstream factors such as financial constraints could prevent chronic disease.
The NIH grant will support the creation of a comprehensive long-term dataset on Hispanic and Latino brain aging, examining the factors that matter most for healthy cognitive aging. The study aims to understand how Alzheimer's disease, vascular injury, and other brain changes develop over time in Latino adults.
The NIH has renewed support for the USC-led AI4AD initiative, expanding its efforts to better classify Alzheimer's and related diseases, predict progression, and identify new treatment targets. The $12.6 million award will develop AI tools to uncover biological causes of Alzheimer's and improve disease diagnosis.
Researchers found that a novel compound can clear harmful protein from human neurons modeling frontotemporal dementia, preventing neuron death. Enhancing autophagy with the compound showed promise as a treatment strategy for neurodegenerative diseases.
Researchers discovered subtle changes in the blood can reveal early signs of cognitive decline caused by chemicals produced by gut bacteria. A blood test may one day transform how we detect dementia, potentially identifying people at risk years before symptoms appear.
Research found that people who spend a higher proportion of their total physical activity doing vigorous activity have substantially lower risks of all eight serious health conditions. The benefits of vigorous activity remained even when the amount of time was modest.
Adults who engaged in extended durations of mentally passive sedentary behaviors had a higher risk of dementia. Replacing passive with mentally active sedentary behaviors was shown to reduce the risk of dementia onset in later life.