Researchers at Mount Sinai have developed an AI-powered ECG analysis tool that shows promise in detecting Chronic Obstructive Pulmonary Disease (COPD) early. The model achieved high accuracy rates across diverse populations, including a subgroup with irregular heartbeat and smoking exposure.
Researchers developed an AI tool, NutriSightT, to predict underfeeding in critically ill ICU patients. The model analyzed routine data to identify patients at risk on days 3-7 of ventilation, enabling clinicians to adjust care and provide targeted nutrition.
The Mount Sinai Health System has received a Level 9 designation from CHIME Digital Health Most Wired survey, recognizing its commitment to excellence in digital health. The organization is leveraging AI and digital tools to improve patient care and streamline operational processes.
The Icahn School of Medicine at Mount Sinai is advancing women's health through cutting-edge research and compassionate care, with a focus on addressing knowledge gaps and promoting seamless treatment journeys. The institution joins the Milken Institute's Women's Health Network to bring its expertise in clinical excellence, research in...
Researchers have created an mRNA system that activates therapeutic genes in specific cell populations, potentially leading to safer and more precise cancer treatments. The system uses microRNAs to recognize cancer cells and shuts off the treatment if it's not needed, reducing toxicity and expanding mRNA therapy's reach.
A novel AI tool called V2P has been developed to identify not just genetic mutations but also the diseases they may cause. The method accelerates genetic diagnostics and aids in discovering new treatments for complex and rare diseases by predicting disease outcomes.
Researchers from Mount Sinai present new discoveries in breast cancer biology, treatment, and real-world patient outcomes. The institution's contributions span artificial intelligence, triple-negative breast cancer, geriatric oncology, and novel therapeutic approaches.
A Mount Sinai study found that the timing of a genetic mutation in children with leukemia can significantly impact its aggressiveness. The researchers discovered that leukemia caused by mutations occurring before birth is often more aggressive and harder to treat than those occurring later in life.
A Mount Sinai study reveals PTSD may accelerate brain aging in World Trade Center responders, with longer exposure duration further amplifying the effect. The study uses deep learning-based brain age models to estimate brain age and provides new evidence for the long-term impact of trauma on neurological health.
The Mount Sinai Hospital is now using an FDA-approved AI tool that enhances fetal ultrasound screenings for congenital heart defects. The AI tool improved detection rates of suspicious findings to over 97%, while also reducing reading time and increasing confidence scores.
A novel mRNA-based therapy has been shown to slow bacterial growth, strengthen immune cell activity, and reduce lung tissue damage in models of multidrug-resistant pneumonia. The therapy works by giving the body a special protein that directly breaks down harmful bacteria and recruits immune cells to help clear them out.
Rocatinlimab shows durable improvements in skin clearance, itch, and quality of life by targeting OX40 immune receptor in patients with moderate-to-severe atopic dermatitis. The treatment led to significant reductions in eczema severity, itch, pain, and sleep disturbances.
Researchers at Mount Sinai discovered a technique to renew aged blood-forming stem cells by correcting defects in lysosomes. The breakthrough revealed that restoring lysosomal slow degradation can revitalize aged stem cells and enhance their regenerative capacity. This study may help prevent age-related blood disorders and improve stem...
A new electronic application highlights discrepancies between parents and children's views on the child's well-being, providing powerful insight into how children truly cope. This approach has broad implications beyond transplant medicine and may reshape patient-reported outcomes for pediatric chronic illnesses.
A new study found that current cardiac screening tools are not optimal and fail to identify half the people who are at risk of having a heart attack. The researchers assessed the accuracy of widely used tools, including ASCVD and PREVENT calculators, and found that nearly half of patients would not have been recommended for preventive ...
Researchers at the Icahn School of Medicine created a comprehensive map showing how antibodies attach to the SARS-CoV-2 virus and how viral mutations weaken that attachment. The study highlights the limits of current antibodies and suggests new strategies for building longer-lasting antibody therapies and vaccines.
The initiative aims to decipher the basic function of human genomic sequences, enabling personalized diagnosis and therapy. The partnership will analyze genomic regions to identify underlying mechanisms that contribute to disease and uncover potential therapeutic targets.
A nationwide analysis found that roughly 25% of patients with Bell's palsy received CT or MRI scans within 30 days of diagnosis, not aligned with current guidelines. This study highlights the need for initiatives to align clinical practice with evidence-based guidelines, promoting early treatment and minimizing unnecessary imaging.
A Mount Sinai study found that diverse T cells and low immunosuppressive myeloid cells are key to long-term remission after CAR T cell therapy. Patients with these immune features remained cancer-free for more than five years, while others relapsed sooner.
Renowned gastroenterologist Jean-Frédéric Colombel, MD, will deliver the 31st Anatomy Lesson on November 20, exploring Mount Sinai's pioneering work in IBD prevention and treatment. His presentation aims to highlight the growing problem of immune diseases, including Crohn's disease.
Researchers have identified a distinct population of neuroprotective microglia that may point to a new therapeutic approach for Alzheimer's disease. Microglia with reduced expression of PU.1 and co-expression of CD28 limit neuroinflammation and slow amyloid plaque build-up.
The Mount Sinai Health System will implement Microsoft Dragon Copilot, an AI-powered voice assistant designed to streamline clinical documentation and automate administrative tasks. The rollout aims to reduce burnout, improve patient experiences, and enhance clinical efficiency across the system.
A naturally occurring gene called Cyclin A2, normally silenced in humans, can make new functioning heart cells and aid in the heart's repair. The breakthrough discovery could lead to new techniques for repairing damaged hearts as an alternative to transplants or implanted cardiac devices.
A small phase I study has shown that directly injecting an immune-activating compound into prostate tumors before surgery appears safe and may help the immune system recognize and attack cancer cells. The therapy, called poly-ICLC, was well tolerated and appeared to jump-start immune activity.
The Mount Sinai Tisch Cancer Center has introduced a real-time data integration tool to automate the transfer of clinical data from its electronic health record system into clinical trial platforms. This technology streamlines data flow, reducing manual transcription time by up to 70% and improving data quality and workforce efficiency.
Dr. Bruce D. Gelb, MD, is selected as recipient of the 2026 APS John Howland Award for his groundbreaking work on congenital heart disease (CHD) and related developmental disorders. His research has significantly expanded the scientific understanding of CHD and opened new avenues for diagnostic approaches.
The Mount Sinai team will investigate neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.
Benjamin Abella, MD, receives Honorary Membership from ERC for his leadership and expertise in cardiac arrest and CPR. He has advanced resuscitation science through numerous clinical studies and publications.
A new drug-eluting balloon has been shown to match the outcomes of standard care for in-stent restenosis, offering a safer alternative for patients with multiple stent layers. The study's results suggest that patients with complex or multilayer ISR may benefit from sirolimus-eluting balloons as a viable treatment option.
Dr. Bethany Slater, a highly skilled and compassionate surgeon, has been appointed as Division Chief of Pediatric Surgery at Mount Sinai Kravis Children's Hospital. She will focus on advancing surgical excellence, expanding minimally invasive techniques, and enhancing multidisciplinary care for children and families.
Researchers at Mount Sinai found chronic traumatic encephalopathy (CTE) rare among individuals with isolated brain injuries. The study, published in the Journal of Neuropathology & Experimental Neurology, analyzed postmortem brain tissue from 47 donors and revealed that CTE is more common in those with extensive repetitive head impacts.
International Consortium of Women's Mental Health Experts recommend classifying postpartum psychosis as a distinct category within standardized medical coding systems. This classification is crucial for improving patient outcomes and saving lives, particularly due to the risks associated with the condition to both patients and infants.
The Mount Sinai Tisch Cancer Center has been named a Comprehensive Cancer Center by the National Cancer Institute, recognizing its breadth and depth of cancer research, clinical excellence, and commitment to health equity. The center will receive over $3 million annually in funding to support its research and innovation.
Researchers at Mount Sinai developed a new technology to track beneficial bacteria after fecal microbiota transplants, providing insights into how donor microbes adapt and persist in the gut. This approach may guide the design of safer and more effective microbiome-based therapies.
Dr. Elizabeth Haines brings a distinguished career in advancing patient safety, quality, and operational excellence to her new role at Mount Sinai. She will guide children’s health initiatives, ensure daily clinical operations excellence, and drive innovation across the Health System.
The Mount Sinai School of Medicine has received a $4.5 million NIH award to establish a pioneering program in women's environmental health research. The program, called LEAP, will train the next generation of leaders in this emerging field.
Researchers developed an AI system, InfEHR, that links unconnected medical events over time, revealing diagnostic insights. The system transforms millions of scattered data points into actionable patient-specific diagnostic insights.
New research papers from Mount Sinai present unprecedented evidence that brain tissue from living individuals has a unique molecular character, differing significantly from postmortem samples. These findings challenge the conventional practice of using postmortem brain tissue for studying the human brain and its diseases.
The study found that males have a narrower pelvis, resulting in a more medial starting point for S2AI screws and poorer rod alignment. Researchers aim to tailor treatment to patients' specific anatomy to improve surgical efficiency and outcomes.
Researchers developed Giotto Suite, a modular software platform that streamlines the study of tissue biology and disease mechanisms. The tool supports various analyses, including data integration across different types of measurements and resolutions.
Researchers identified specific ways to address religion and spirituality during radiation therapy, highlighting their importance in patient coping mechanisms. The study found that nearly all patients considered spiritual history questions helpful, especially those related to coping with stress.
A new study provides a comprehensive view of how brain cells interact in Alzheimer's disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities. The researchers discovered that disruptions in glia-neuron communication are closely linked to the progression of Alzheimer's disease.
A new study from Mount Sinai Health System suggests that a simple tweak to how AI assigns diagnostic codes can improve accuracy and even surpass physician performance. By allowing the model to reflect and review similar past cases, researchers found better results in reducing time spent on paperwork and billing errors.
The Mount Sinai Health System has received an $8 million grant from DataPhilanthropy to fuel urgently needed research into CADASIL, a genetic disease associated with migraines, strokes, cognitive decline, and dementia. The center will focus on extending brain healthspan and preventing dementia in individuals with genetic risk for cereb...
The new lab, led by Dr. Annapoorna Kini, will focus on leveraging AI in interventional cardiology, from procedural to educational aspects. The lab aims to optimize complex treatment decisions and improve patient outcomes through AI-powered insights.
A recent Mount Sinai study analyzed genetic data from over 452,000 individuals to identify genetic differences linked to higher body fat but better metabolic health. The researchers discovered eight distinct obesity subtypes, each associated with unique health risks, and developed a genetic risk score to predict individual outcomes.
Researchers found that nerves with a response to stimulation had a greater likelihood of recovering on their own, while those without a response had a low chance of functional recovery. The study uses intraoperative electrical nerve stimulation as a tool to distinguish between recoverable and non-recoverable nerve injuries.
Researchers at Mount Sinai are developing an AI-based predictive tool that can analyze complex sleep study data to predict cardiovascular event risk and treatment response among individuals with obstructive sleep apnea. The findings could help clinicians make more informed recommendations about OSA treatment for their patients.
The Mount Sinai Hospital has relocated its inpatient services to a newly renovated space at Mount Sinai Morningside, featuring lifts, larger rooms, and state-of-the-art equipment. The new facility aims to enhance care for patients with various rehabilitative needs, including brain and spinal cord injuries.
Researchers found that lung tumors reshape immune cells in the bone marrow before they reach the cancer, altering their function and leading to a stronger anti-cancer response. The study identified NRF2 as a key protein involved in this process and proposed blocking it as a potential strategy to enhance immunotherapy.