Researchers discovered bulky amino acids reduce pore size, blocking transport of certain molecules in aquaporin 10.2. This provides a framework for predicting functions of uncharacterized aquaglyceroporins.
Researchers at Institute of Science Tokyo developed a new framework for generative diffusion models by reinterpreting Schrödinger bridge models as variational autoencoders. This approach reduces computational costs and prevents overfitting, enabling more efficient generative AI models with broad applicability.
Scientists develop novel LDPC quantum error correction codes that can handle hundreds of thousands of logical qubits and approach the theoretical hashing bound. The new codes achieve extremely high decoding performance, demonstrating a frame error rate as low as 10^-4, even for large-scale numerical simulations.
Researchers developed an mRNA vaccine that suppresses abnormal blood vessel growth in mouse models of age-related macular degeneration. The vaccine is as effective as current therapies and offers a convenient alternative to frequent eye injections.
A recent study from Japan explores ancient microbial life on Earth by analyzing iron-rich hot springs that mimic the chemistry of early oceans. Microaerophilic iron-oxidising bacteria were found to be dominant, using ferrous iron as an energy source before photosynthesis became dominant.
Scientists have found a new way to manipulate electron transport by exploiting the orbital magnetization of ferromagnetic oxide films. This discovery reveals unexpected electronic behaviors and opens new avenues for designing materials like magnetic sensors with tailored properties.
Scientists from Institute of Science Tokyo have created a solid electrolyte-based hydrogen battery that stores and releases hydrogen at temperatures below 100 °C, overcoming high-temperature and low-capacity limitations. The battery offers practical solutions for hydrogen-powered vehicles and clean energy systems.
A study reveals how PGC-1α protein and estrogen work together to boost thermogenesis in females, outperforming males. This finding highlights a sex-specific mechanism of energy metabolism and suggests new therapeutic targets for obesity and diabetes prevention.
A self-powered analytical device has been developed to detect toxic amines in water using electrochemiluminescence. The device generates its own voltage from liquid flow and produces light signals to indicate contamination, making water quality testing more accessible and portable.
A team of researchers from Japan has synthesized a novel 2D material, 2H-NbO2, which exhibits strongly correlated electronic properties with two-dimensional flexibility. The discovery paves the way for realizing advanced quantum materials in next-generation electronic devices.
Researchers created a new material platform for non-volatile memories using covalent organic frameworks (COFs) and successfully installed electric-field-responsive dipolar rotors. The COFs' unique sln topology allows the rotors to flip without steric hindrance, enabling high thermal durability up to near 400°C.
Researchers discover how heme bound proteins catalyze hydrogen sulfide signaling in bacteria, leading to stress tolerance and antibiotic resistance. Disrupting this mechanism could inspire new antibiotic strategies against drug-resistant infections.
The study found that DLDG1 regulates NPQ by controlling proton conductivity within the thylakoid membrane through CFo-CF1 ATP synthase activity. The dldg1hope2 double mutant showed faster NPQ induction than the hope2 mutant, indicating a complex relationship between DLDG1 and NPQ regulation.
Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Researchers discovered that disordered regions enhance specific RNA interactions in FUS protein-RNA complexes, revealing a breakthrough strategy for nucleic acid binding. The study suggests that intrinsically disordered regions actively contribute to the RNA-binding mechanism.
Physicists have observed the elusive giant anomalous Hall effect in a nonmagnetic material for the first time using high-quality thin films of Cd3As2. This breakthrough challenges long-held assumptions and opens up new pathways to advanced electronic devices based on nonmagnetic materials.
A new study finds that PAD2-mediated histone citrullination promotes tumor cell proliferation in pancreatic ductal adenocarcinoma. Knocking down the PAD2 gene reduces cell growth and increases survival rates. The researchers identify PAD inhibitors as potential therapeutic targets for treating PDAC.
Researchers from Japan and USA discover midline tissues use formation control to grow harmoniously, with the notochord leading elongation and adjacent tissues migrating together through fibroblast growth factor gradients and cell adhesion. Computer simulations confirm this mechanism is essential for synchronized tissue development.
Research reveals that hypoxia reduces alveolar bone levels and osteoblast differentiation after orthodontic tooth movement, while increasing osteoclastic activity. This study provides critical insights into the bone remodeling process under hypoxia.
Researchers developed modified ilmenite oxygen carriers that improve hydrogen yields and redox reaction efficiency in chemical looping systems. The new carriers enable simultaneous hydrogen production, carbon dioxide capture, and power generation, paving the way for scalable, carbon-neutral energy systems.
Researchers developed a borate-water-based electrolyte that enables safe, fast-charging lithium-ion batteries under ambient conditions. The new technology also offers direct recycling of active materials through water dispersal, ensuring a sustainable approach to battery production.
Researchers at Institute of Science Tokyo found that exposure to water vapor enhances oxide-ion mobility by increasing interstitial oxygen ions, nearly doubling the oxide-ion conductivity at 500 °C. This breakthrough could advance the development of efficient and durable fuel cells for clean energy applications.
Newly developed DNA nanostructures form flexible, fluid, and stimuli-responsive condensates without chemical cross-linking. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.
Researchers developed a machine learning model to predict liquid crystalline polyimides with high thermal conductivity, achieving 96% accuracy. The model identified six promising candidates, which demonstrated up to 1.26 W/mK thermal conductivities, accelerating the development of efficient thermal materials.
Researchers developed molecular capsules that can impart strong chiral properties to inherently non-chiral metal-containing dyes. The capsules create flexible, adaptable chiral cavities that induce chirality without requiring chemical modifications.
Researchers developed a white organic light-emitting diode that operates at an unprecedentedly low voltage of less than 1.5 volts. This breakthrough could contribute to reducing energy consumption in state-of-the-art displays, including television backlights and lighting devices.
Researchers developed nanosized, porous oxyhalide photocatalysts that achieve record performance in producing hydrogen from water and converting carbon dioxide to formic acid using sunlight. The breakthrough offers a scalable, eco-friendly approach to solar fuel production by carefully controlling particle size and structure.
Researchers from Japan studied DJ-1's catalytic mechanism, revealing key amino acids involved in cPGA hydrolysis. Mutations in these residues revoked cPGA hydrolase activity, confirming the pathophysiological implications of DJ-1.
Researchers develop efficient template-guided method for synthesizing endo-functionalized oligophenylene cages with yields up to 68%. The approach enables precise control over internal environments, leading to selective molecular encapsulation and recognition capabilities.
Researchers at Institute of Science Tokyo discovered that metal sulfides with seven to eight d electrons show superior catalytic activity. This volcano-shaped relationship provides guidelines for designing more effective catalysts, accelerating the development of efficient water-splitting catalysts for green hydrogen production.
Laminin-411 protein and its derived peptide A4G47 exhibit pro-myelinating activity in oligodendrocytes, promoting myelin sheath formation. This discovery advances understanding of myelin sheath formation and potential applications for treating demyelinating diseases.
Researchers developed a hybrid approach combining molecular dynamics simulations and Helfrich theory to evaluate bending rigidities of graphene nanosheets with lattice defects. The study reveals insights for designing novel materials with tailored mechanical properties.
Scientists create a new class of mechanochromic mechanophores that can detect and respond to mechanical stress in polymeric materials through fluorescence. The developed molecule exhibits excellent stress-sensing with high durability, offering a powerful tool for real-time monitoring of mechanical damage.
Conventional dendritic cells have been found to originate from both myeloid and lymphoid progenitors, revealing their unique functions and developmental pathways. These lymphoid-derived cDCs exhibit potent functions in immune suppression and allergy induction, and follow diverse developmental pathways.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers from Science Tokyo developed analog relay stations to extend mmWave coverage, achieving over 1 Gbps throughput and enhancing stability in previously unreachable zones. The innovative solution utilizes distributed relay diversity to maintain signal strength and throughput even with blockage.
The study successfully demonstrated impedance tuning of a 250 GHz waveguide transition, validating the effectiveness of mechanical tuning as a method to compensate for fabrication-induced performance variation. Terahertz frequencies above 100 GHz offer extremely wide bandwidths suitable for next-generation wireless communications.
Researchers developed Localizatome to study oxidative stress-related changes in protein localization. The database provides comprehensive information on subcellular protein localization and dynamic localization changes under stress.
A new palladium-loaded a-IGZO catalyst achieved over 91% selectivity when converting CO2 to methanol, leveraging electronic properties of semiconductors. The study demonstrates novel design principles for sustainable catalysis based on electronic structure engineering.
Researchers developed a controlled 'living' click polymerization system to achieve well-defined polymers with narrow dispersity, enabling bidirectional synthesis of ABA-type block copolymers. The method leverages copper-catalyzed azide–alkyne cycloaddition and initiators to selectively drive monomer addition in a controlled manner.
Researchers from Institute of Science Tokyo have developed (Al,Ga,Sc)N thin films with record-high scandium levels, enabling efficient data storage and reducing power consumption. The films also show promise for noise filters and optical computing applications.
Researchers developed Group Encoding (GE) to forecast electricity demand using On/Off device status, improving prediction accuracy and efficiency in smart energy operation. The method simplifies complex datasets while retaining key information for optimal energy management.
Researchers have developed novel three-dimensional liver organoids using bile acids, which retain hepatocyte-like features and can be sustained in long-term cultures. These organoids demonstrate a unique gene expression profile similar to fetal hepatocytes and support replication of hepatitis viruses.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
A new computational method combines 4D flow MRI, CFD, and data assimilation to estimate blood flow in brain aneurysms with greater accuracy and efficiency. The approach focuses on the aneurysm region, reducing computational cost while improving flow estimation.
A study published in Neurobiology of Disease found that melanin degradation is impaired in genetically engineered mice lacking the SLC26A4 gene, leading to chronic inflammation and macrophage activation. The researchers propose a novel pathological cascade where melanin accumulation exacerbates hearing loss in pigmented individuals.
Researchers have identified a gene signature indicative of hepatic ferroptosis using an iron overload-induced mouse model and validated it in human liver injury systems. The study highlights the role of ferroptosis in liver injuries and offers potential therapeutic targets.
A comparative whole genome analysis of 240 fish species found a strong correlation between loss of the chorion-hardening system and parental egg-care. The team's findings suggest that the loss of key genes, such as alveolin, contributes to this evolutionary bias.
Scientists from Institute of Science Tokyo create photo-switchable binding of DNA nanostructures that generate two distinct directional motions. The research paves the way for innovative fluid-based diagnostic chips and molecular computers.
BingoCGN accelerates real-time large-scale graph neural network inference through cross-partition message quantization and a novel training algorithm, achieving up to 65-fold speedup and 107-fold increase in energy efficiency compared to state-of-the-art accelerators.