Researchers developed key technologies for precise and high-speed bonding and adhesive technology to address demands of high-performance computing applications. They successfully integrated chips onto a 300 mm waffle wafer, achieving enhanced bonding speed without chip-detachment failures.
Researchers discovered genes related to extracellular matrix and Wnt signaling pathway drive lip hypertrophy in East African Great Lakes cichlids. The study provides insights into the evolutionary biology of lip hypertrophy, highlighting the importance of proteoglycans and Wnt signaling pathway.
A new time-division MIMO technology enables phased-array receivers to operate at high speeds while reducing power and circuit area, addressing limitations in traditional systems. The innovation achieves a record-setting 38.4 Gbps data rate across eight streams, paving the way for practical large-scale MIMO systems.
Researchers developed a five-dimensional Langevin model to accurately predict fission fragment distributions and kinetic energies in medium-mass mercury isotopes. The model captures unusual 'double-humped' fragment mass distribution observed in mercury-180, providing new insights into nuclear shell effects.
Researchers discover iguratimod, a rheumatoid arthritis drug, effectively treats excessive COVID-19 inflammation in mice by maintaining antiviral immune responses. The study provides hope for patients with severe COVID-19-related cytokine storms.
A team of researchers from Japan has developed an ultra-compact, low-power 150 GHz radio module enabling high data rates in mobile devices. The proposed design integrates a phased-array transceiver with several key innovations to overcome the main challenges of operating at frequencies in the 150 GHz band.
A team from Institute of Science Tokyo has developed a postfunctionalization technique allowing for the incorporation of phosphonate esters under visible light conditions. This breakthrough paves the way for a broader range of polymer modifications, enabling the creation of novel polymer architectures with unique properties.
A revolutionary AI model has been developed to diagnose lung cancer without relying on costly GPU servers or massive datasets. The ultra-lightweight model achieved a discrimination performance corresponding to an AUC value of 0.92, outperforming state-of-the-art large-scale AI systems.
Researchers developed a patient-derived organoid library to study chemotherapy resistance in esophageal cancer. Lab-grown mini-tumors showed increased activity in the NRF2 pathway, suggesting potential biomarkers for predicting chemotherapy resistance.
Scientists from Institute of Science Tokyo successfully solubilize porous aromatic polymers (PAPs) in water using aromatic micelles, forming giant polycavity materials with high incorporation functions. The method enables the preparation of rare multi-component materials with potential applications in advanced functional materials.
Researchers demonstrate a new strategy for magnetization reversal in multiferroic materials, allowing for more energy-efficient electronics. The study achieves this breakthrough by growing thin films in an unconventional crystallographic orientation, enabling the application of electric fields perpendicular to the film surface.
Researchers discovered a specialized histone arrangement, called the CENP-A–H4 octasome, in centromeric regions. This unique structure likely contributes to proper kinetochore formation and mitosis.
Researchers have developed a new tool using quartz crystal microbalance with dissipation monitoring to study DNA-lipid interactions. The technique revealed insights into the attachment and integration of DNA nanostructures with lipid membranes, influencing cellular functions such as drug delivery and treatment precision.
Researchers identify five distinct immunotypes in tongue squamous cell carcinoma, shedding light on why current immunotherapies fail. The study's findings highlight the need for immune-based assessments to guide treatment decisions and suggest a new approach to personalized medicine.
Researchers developed a novel method to analyze energy losses in soft magnetic materials, using diamond quantum sensors and protocols for kHz and MHz frequencies. The study reveals near-zero phase delay up to 2.3 MHz in high-frequency inductors, indicating negligible energy losses.
Researchers have discovered that hydrogen boride nanosheets can inactivate a wide range of pathogens, including viruses, bacteria, and fungi, without the need for light activation. The nanosheets' ability to denature microbial proteins through strong physicochemical interactions confirms their effectiveness in combating various microbi...
Scientists develop high-quality (Ga,Fe)Sb ferromagnetic semiconductor with a record-high Curie temperature of up to 530 K, exceeding previous limits and enabling stable operation at room temperature. The material exhibits excellent crystallinity and superior magnetic properties, making it suitable for spintronics applications.
Scientists create ferritin structures with precisely arranged histidine residues to drive oxidation reactions in a highly effective metal-free peroxidase. This approach eliminates the need for metal cofactors and enhances catalytic activity.
A study by Mr. Shun Saito and Associate Professor Taro Sugihara from Institute of Science Tokyo explored the experiences of bereaved family members and healthcare professionals in end-of-life care, revealing three types of 'unintended, percolated work' that hinder collaboration between stakeholders.
Researchers developed a novel CMOS chip-based phased-array receiver that maximizes satellite performance by supporting dual-polarized beams, enabling greater communication flexibility. The innovation doubles the number of controllable beams and improves system capacity, making it crucial for real-world deployments.
A team of scientists has developed a new method for desalination that uses liquid tin to simultaneously purify water and recover valuable metals. The process, powered by concentrated solar energy, can transform desalination brine into a valuable resource.
Researchers from Institute of Science Tokyo developed a novel catalyst that efficiently produces sulfones at low temperatures, achieving high selectivity and reducing precious metal consumption. The new SrMn₁₋xRu_xO₃ catalyst offers significant advantages over conventional systems, making it suitable for various industries.
Researchers successfully constructed a large molecular spherical shell structure with the geometric topology of a regular dodecahedron through entanglement of peptides with metal ions. The resulting M60L60 metal-peptide shell exhibits remarkable stability against heat, dilution, and oxidative conditions, making it a promising platform ...
A study found that microRNA-27a promotes dental tissue regeneration by suppressing inflammation and activating Wnt/BMP signaling pathways. The researchers used human dental pulp stem cells to overexpress miRNA-27a, which led to the formation of new bone-like tissue in mice.
A recent study developed a VR game that combines olfactory stimulation with immersive gameplay to improve cognitive function in older adults. After just 20 minutes of play, participants showed significant improvements in visuospatial rotation and memory tasks.
Scientists at Institute of Science Tokyo develop first-ever wurtzite-structured MgSiN2 thin films, exhibiting piezoelectric properties. The material's unique electronic and bandgap properties make it a promising candidate for next-generation electronics and potential applications in ultrasonic transducers and energy harvesters.
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
Researchers developed an AI model called Odor Generative Diffusion (OGDiffusion) to automate fragrance creation, generating essential oil blends based on user input of scent descriptors. The system produced fragrances that met people's expectations in human sensory tests.
Researchers identified five consumer segments in Japan's CSA market, with 'Sustainable Food Seekers' showing the highest interest. The study highlights the importance of promoting CSA's educational, environmental, and social benefits over organic certifications. Japanese consumers prioritize food education, environmental issues, and so...
Researchers develop a novel 'zeolite blending' method to synthesize CON-type zeolites with unprecedentedly high aluminum content. This approach enables precise control over Al content, opening possibilities for catalyst development in various industrial applications.
A new study by researchers at the Institute of Science Tokyo hints that calcium ions played a crucial role in shaping life's earliest molecular structures. The team discovered that calcium dramatically alters how tartaric acid molecules link together, favoring homochiral polymers and potentially influencing the emergence of life.
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
Researchers discovered how bacterial swarms transition from organized movement to chaotic flow as confinement radius increases. The study reveals intermediate states between order and turbulence through large-scale experiments, computer modeling, and mathematical analysis. These findings provide insights into the universal properties o...
Researchers developed CeSPIACE, a 39-amino-acid peptide drug candidate that binds to the spike protein, blocking viral entry. It demonstrates strong binding to major SARS-CoV-2 variants and shows efficacy against multiple strains in vivo and in vitro experiments.
Scientists developed a novel solvatochromic fluorescent dye that enables high-precision temperature measurements through changes in fluorescence properties. The researchers achieved exceptional sensitivity and resolution, ideal for bioimaging applications.
Researchers from Institute of Science Tokyo developed a pentanuclear iron complex that achieves up to 99% Faradaic efficiency and exceptional stability in water oxidation, paving the way for sustainable energy solutions.
Researchers at Institute of Science Tokyo designed a protein cage system that can control and visualize orientational changes in aromatic side chains through strategic binding of fluorescent ligands. This approach enables precise control over protein dynamics while enhancing fluorescence properties, with potential applications in biomo...
Researchers developed heteroepitaxial diamond quantum sensors with high sensitivity and accuracy for monitoring electric vehicle battery systems. The breakthrough could pave the way for widespread adoption in industries related to sustainable development.
Researchers at Institute of Science Tokyo have discovered a rubidium-containing material with exceptionally high conductivity, paving the way for solid oxide fuel cells. The material's superior performance is attributed to low activation energy, large free volume, and tetrahedral motion.
Researchers developed innovative techniques and optical solutions to overcome long-standing challenges in facial projection mapping. They achieved unprecedented speed in dynamic facial projection mapping while maintaining high accuracy, and proposed methods to simulate video annotations and minimize alignment artifacts.
Research advances higher-order networks to capture multi-agent interactions, enabling accurate modeling of biological, social, and physical systems. The Dirac-Bianconi operator provides a powerful generalization of the graph Laplacian, encoding local and global interactions across different topological dimensions.
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
Researchers at Institute of Science Tokyo developed novel carbon-based materials to remove harmful 'forever chemicals' from water. The materials, utilizing lignin and glucose as carbon sources, effectively trap PFAS on their surface, allowing for efficient purification using membrane distillation.
Researchers unveil Ba-Si orthosilicate oxynitride-hydride as a transition metal-free catalyst, offering a more sustainable approach to ammonia production. The novel catalyst demonstrates exceptional stability and higher activity than conventional ruthenium-loaded MgO catalysts.
Researchers from Science Tokyo developed three design techniques to enhance power efficiency and data rates in wireless transmitters, enabling synergistic operation of electronic devices. The techniques avoid the power-hungry CORDIC circuit block and ensure linearity in amplitude and phase modulation.
Researchers at Institute of Science Tokyo developed porous organic crystals with ultrahigh-density amines, achieving fast CO2 adsorption and high thermal stability. The unique 2.5-dimensional skeleton reduces the cost for CO2 separation from flue gases.
Researchers found a high agreement between EEG and fMRI in identifying brain regions activated during language tasks. EEG-guided tDCS improved picture-naming speed in participants, suggesting its potential for innovative therapies.
A recent study found that polyester microdroplets can form in salt-rich environments, at low alpha-hydroxy acid concentrations, and in small reaction volumes. This expands on previous research and suggests that polyester protocells were likely more common on early Earth than previously thought.
PairMap overcomes limitations of traditional methods by introducing intermediate compounds to predict binding affinities with high accuracy. The approach minimizes calculation errors, improves convergence, and reduces computational costs for complex transformations.
Researchers utilized muon spin rotation spectroscopy to investigate the regioselective muoniation of peri-trifluoromethylated 12-phosphatetraphene 1, revealing a highly reactive muoniated radical at the phosphorus site. The study provided detailed insights into the structure and dynamics of the radical.