Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
Researchers found that shrinking ferroelectric tunnel junctions significantly boosts their performance, producing larger resistance contrasts between 'ON' and 'OFF' states. This enables efficient and reliable memory technologies for emerging applications in AI, edge computing, and IoT.
Researchers show enzymes can actively shift reactions away from equilibrium, controlling directionality and fine metabolic regulation. Enzyme diffusion enables 'memory' of past reaction events, driving system to new steady state.
Researchers developed a compact, low-power FMCW radar signal generator chip for edge and IoT devices, enabling high-speed sensing and precise distance measurement. The chip successfully overcomes the trade-off between chirp speed and signal linearity, bringing us closer to a seamlessly connected 6G society.
Researchers developed antibody–drug conjugates that combine CD4 mimic and neutralizing antibodies to target HIV entry, showing seven times better efficacy than existing approaches. The strategy aims to block HIV before it enters the host cell, offering a more targeted therapeutic profile and potentially reducing adverse effects.
A recent study reveals that hydration and terminal chemistry of poly(ethylene) glycol (PEG) polymers influence immune recognition, providing insights into why some PEGylated drug coatings fail to evade the immune system. The findings pave the way for novel drug coatings with improved performance.
Researchers developed an AI-driven pipeline to create functional intracellular antibodies, overcoming major barriers in intrabody development. The approach successfully redesigned structures compatible within the cellular environment, enabling high target specificity and stability.
A new ceramic material overcomes long-standing limits in proton conductivity, achieving record-high performance at intermediate temperatures. The innovative donor co-doping strategy combines increased proton concentration and mobility with chemical stability under various environments.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
Researchers discovered that ATG triggers rapid clotting and inflammation in the liver by activating a complement activation system and TGF-β pathway, leading to severe side effects. The study used human organoid models and imaging analysis to reveal the biphasic mechanism of ATG-induced liver injury.
Researchers achieve highly regio-, stereo-, and enantioselective 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds using an iron catalyst with a chiral N-heterocyclic carbene ligand. The achievement offers new opportunities for drug discovery, materials chemistry, and fine-chemical synthesis.
Researchers at Science Tokyo discover that a single amino acid deletion in the antibody's lower hinge transforms it into a stable half-IgG1 molecule with altered immune activity. This finding provides a blueprint for engineering next-generation antibody therapies.
Research suggests that lower oral microbiota diversity is associated with poorer cognitive function in people with schizophrenia. The study also identified specific microbial metabolic pathways potentially linked to this relationship.
A team of researchers has observed the Einstein–de Haas effect in a Bose–Einstein condensate, demonstrating the transfer of angular momentum from atomic spins to fluid motion. This finding highlights the conservation of angular momentum between microscopic spin and macroscopic mechanical rotation in the quantum world.
Researchers developed a miniaturized solid oxide fuel cell microreactor to power edge devices like drones and AI hardware with high energy density. The device features an innovative structural design with thermal insulation and a multilayered insulation system, solving thermal stress and safety concerns.
Researchers from Mitsubishi Electric and University of Tsukuba discovered a defect complex that generates free electrons when hydrogen is present, improving IGBTs efficiency by up to 20% in power loss. The mechanism could also be applied to ultra-wide bandgap materials.
A team of researchers from Institute of Science Tokyo developed a novel enzyme, MAN, that efficiently converts common nucleotide substrates into RNA nucleotides with remarkable efficiency. This method simplifies the production of RNA building blocks by using inexpensive and stable polyphosphate as a phosphate donor.
Researchers developed an AI model called DiaCardia that accurately identifies individuals with prediabetes using only ECG data. The model achieves impressive accuracy and generalizability, even in single-lead ECG data, opening possibilities for home-based screening.
A new study suggests that physical properties guided life before genes did. Phospholipids with more unsaturated bonds were more likely to merge and grow under freeze-thaw cycles.
Researchers present novel theoretical framework explaining non-monotonic temperature dependence and sign reversal of chirality-related AHE in highly conductive metals. The study reveals clear picture of unusual transport phenomena, forming foundation for rational design of next-generation spintronic devices and magnetic quantum materials.
A new 3D model of the fault beneath the Marmara Sea reveals where a future major earthquake could take place, helping improve earthquake forecasts. The study uses magnetotelluric measurements to identify distinct high-resistivity and low-resistivity zones, shedding light on ongoing processes of fault mechanics.
Researchers have discovered a new solid-state hydrogen carrier called layered hydrogen silicane (L-HSi) that can release hydrogen under ambient temperature and pressure. L-HSi exhibits high gravimetric hydrogen capacity and is stable, making it a promising alternative to conventional hydrogen storage systems.
Researchers at Science Tokyo have elucidated the molecular mechanism of Golgi membrane-associated degradation (GOMED), a selective protein cleanup system. They found that GOMED recognizes substrates using K33-linked ubiquitin chains and employs optineurin (OPTN) as an adaptor molecule to guide them for degradation.
Researchers found that gut microbes in Asian elephants digest pectin, reducing bitter compounds and giving Black Ivory coffee its smooth flavor. This process may lead to new methods for processing coffee beans, exploring animal-microbiome interactions in food fermentation.
Research highlights overlooked social mechanisms connecting oral health, eating and speaking difficulties, and cognitive decline. A six-year longitudinal study found poor oral health is a strong predictor of weight loss in older adults.
Scientists successfully observed a quinoxalinyl radical forming within nanoseconds using µSR spectroscopy. The technique enabled real-time detection of highly reactive aromatic heterocyclic radicals in isocyanide insertion reactions.
Researchers at Institute of Science Tokyo have discovered a stable superfluid that inherently hosts singularities known as exceptional points. The study reveals how dissipation can stabilize this unique superfluid phase, which features a finite order parameter and emerges deep inside a strongly interacting phase.
A novel osmium-based photocatalyst effectively captures long-wavelength visible light, improving solar-to-hydrogen energy conversion efficiency. The new material can harness a broader range of sunlight, generating more excited electrons to enhance hydrogen-evolution performance.
A recent study using Drosophila as a model organism reveals the involvement of linear ubiquitination in T-tubule biogenesis. The findings highlight LUBEL's role in triggering Amph-mediated T-tubule formation, which promotes membrane tubulation and curvature through self-ubiquitination and positive feedback loops.
The Global Workshop on Green Transformation brings together international experts from MIT, EPRI, and DLR to discuss decarbonization and renewable energy systems. The event focuses on the development and implementation of green transformation technologies for a sustainable future.
Researchers at Institute of Science Tokyo have developed a method to manipulate material chirality using electricity, enabling reversible and tunable chiral electronic states. This approach opens new possibilities for advanced spintronic devices and the emerging field of 'chiral iontronics'.
Researchers from Japan successfully downscaled a total ferroelectric memory capacitor stack to just 30 nm, maintaining high remanent polarization and paving the way for compact and efficient on-chip memory. This breakthrough demonstrates compatibility with semiconductor devices and paves the way for future technologies.
A newly designed mechanophore, called DAANAC, was developed to provide early warning against mechanical failure while resisting heat and UV. It features a stable and fluorescent diarylacetonitrile radical coupled to an alkoxycarbonyl radical that quenches fluorescence.
Composite copper oxides La₂CuO₄ and Y₂Cu₂O₅ demonstrate exceptionally high antiviral activity against non-enveloped viruses, outperforming individual constituent oxides. The oxides' cation-rich surfaces enhance electrostatic adsorption of viruses, leading to protein inactivation and viral neutralization.
Researchers developed CatDRX, a novel AI framework that integrates reaction data with catalyst performance to design new catalysts. The model accurately predicts catalytic activity and generates candidate structures worth testing in laboratory experiments.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Researchers develop a method to tune thermal conductivity in thin films using femtosecond lasers, achieving unprecedented throughput and nanoscale resolution. The technique enables laboratory-scale precision and industrial-scale production of phononic nanostructures.
Scientists successfully introduce ferromagnetism into bismuth ferrite at room temperature through dual-cation substitution, enabling potential use in low-power memory devices. Negative thermal expansion is also observed, which could help solve problems caused by thermal expansion in electronic components.
Researchers developed a novel magnetic biosensing technique using polydopamine-coated magnetoliposomes to monitor lectin-glycan binding. The technique provides insight into the dynamics of sugar-protein interactions and holds promise for medical diagnostics, glycoscience research, and drug discovery.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
Researchers have developed silver-based atomic switches that create stable electrical connections between individual molecules and electrodes, enabling the scalable integration of molecular components. This breakthrough paves the way for ultra-compact and energy-efficient circuits built from single molecules.
Scientists at Institute of Science Tokyo have developed an artificial metalloenzyme-based platform that enables dynamic control of artificial membranes, mimicking the behavior of natural biological membranes. The researchers successfully induced phase-separated domain disappearance and membrane division in artificial membranes using a ...
A new AI system can accurately reconstruct hand muscle activity without sensors, enabling precise estimation of fine motor control. The technology has potential applications in sports science, rehabilitation, and human-machine interaction.
Researchers at Institute of Science Tokyo developed a neural-network-based 3D imaging technique that can precisely measure moving objects. The new method reconstructs high-resolution 3D shapes using only three projection patterns, enabling dynamic 3D measurement across various applications.
Researchers developed a model using DNA methylation biomarkers and CT imaging to predict lymph node metastasis in early-stage gastric cancer patients. The tool helped reduce unnecessary invasive surgeries by up to 44%.
Researchers discovered that ferroelectric fluids can harness a previously overlooked transverse electrostatic force to rise over 80 mm without magnets or high voltages. This breakthrough enables the creation of lightweight, magnet-free motors with low-voltage operation.
A study conducted in a Japanese ICU found that healthcare workers experience reduced satisfaction and concentration due to poor lighting and excessive noise. The findings suggest that designing ICUs with improved natural light and mitigating noise can enhance worker satisfaction, productivity, and quality of patient care.
Researchers have developed an innovative antibody-based enzyme switch called 'Switchbody', which is activated upon antigen binding. The switch's mechanism relies on a 'trap-and-release' process, offering new opportunities in diagnostics and therapeutics.
Scientists at Institute of Science Tokyo developed an automatic and adaptive LED-based optical wireless power transmission system that can efficiently power multiple devices without interruption. The system overcomes limitations of traditional OWPT systems by adapting to varying lighting conditions and ensuring stable power delivery.
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.