Researchers have discovered a new solid-state hydrogen carrier called layered hydrogen silicane (L-HSi) that can release hydrogen under ambient temperature and pressure. L-HSi exhibits high gravimetric hydrogen capacity and is stable, making it a promising alternative to conventional hydrogen storage systems.
Researchers at Science Tokyo have elucidated the molecular mechanism of Golgi membrane-associated degradation (GOMED), a selective protein cleanup system. They found that GOMED recognizes substrates using K33-linked ubiquitin chains and employs optineurin (OPTN) as an adaptor molecule to guide them for degradation.
Researchers found that gut microbes in Asian elephants digest pectin, reducing bitter compounds and giving Black Ivory coffee its smooth flavor. This process may lead to new methods for processing coffee beans, exploring animal-microbiome interactions in food fermentation.
Research highlights overlooked social mechanisms connecting oral health, eating and speaking difficulties, and cognitive decline. A six-year longitudinal study found poor oral health is a strong predictor of weight loss in older adults.
Scientists successfully observed a quinoxalinyl radical forming within nanoseconds using µSR spectroscopy. The technique enabled real-time detection of highly reactive aromatic heterocyclic radicals in isocyanide insertion reactions.
Researchers at Institute of Science Tokyo have discovered a stable superfluid that inherently hosts singularities known as exceptional points. The study reveals how dissipation can stabilize this unique superfluid phase, which features a finite order parameter and emerges deep inside a strongly interacting phase.
A novel osmium-based photocatalyst effectively captures long-wavelength visible light, improving solar-to-hydrogen energy conversion efficiency. The new material can harness a broader range of sunlight, generating more excited electrons to enhance hydrogen-evolution performance.
A recent study using Drosophila as a model organism reveals the involvement of linear ubiquitination in T-tubule biogenesis. The findings highlight LUBEL's role in triggering Amph-mediated T-tubule formation, which promotes membrane tubulation and curvature through self-ubiquitination and positive feedback loops.
The Global Workshop on Green Transformation brings together international experts from MIT, EPRI, and DLR to discuss decarbonization and renewable energy systems. The event focuses on the development and implementation of green transformation technologies for a sustainable future.
Researchers at Institute of Science Tokyo have developed a method to manipulate material chirality using electricity, enabling reversible and tunable chiral electronic states. This approach opens new possibilities for advanced spintronic devices and the emerging field of 'chiral iontronics'.
Researchers from Japan successfully downscaled a total ferroelectric memory capacitor stack to just 30 nm, maintaining high remanent polarization and paving the way for compact and efficient on-chip memory. This breakthrough demonstrates compatibility with semiconductor devices and paves the way for future technologies.
A newly designed mechanophore, called DAANAC, was developed to provide early warning against mechanical failure while resisting heat and UV. It features a stable and fluorescent diarylacetonitrile radical coupled to an alkoxycarbonyl radical that quenches fluorescence.
Composite copper oxides La₂CuO₄ and Y₂Cu₂O₅ demonstrate exceptionally high antiviral activity against non-enveloped viruses, outperforming individual constituent oxides. The oxides' cation-rich surfaces enhance electrostatic adsorption of viruses, leading to protein inactivation and viral neutralization.
Researchers developed CatDRX, a novel AI framework that integrates reaction data with catalyst performance to design new catalysts. The model accurately predicts catalytic activity and generates candidate structures worth testing in laboratory experiments.
Researchers from Institute of Science Tokyo developed 'tubuloids' to capture the slow progression of chronic kidney disease (CKD), replicating key features such as DNA damage, cellular senescence, inflammation, and fibrosis. This realistic platform provides a new way to develop and test treatments for millions globally.
Researchers develop a method to tune thermal conductivity in thin films using femtosecond lasers, achieving unprecedented throughput and nanoscale resolution. The technique enables laboratory-scale precision and industrial-scale production of phononic nanostructures.
Scientists successfully introduce ferromagnetism into bismuth ferrite at room temperature through dual-cation substitution, enabling potential use in low-power memory devices. Negative thermal expansion is also observed, which could help solve problems caused by thermal expansion in electronic components.
Researchers developed a novel magnetic biosensing technique using polydopamine-coated magnetoliposomes to monitor lectin-glycan binding. The technique provides insight into the dynamics of sugar-protein interactions and holds promise for medical diagnostics, glycoscience research, and drug discovery.
Researchers at Science Tokyo have developed a tunable deterministic lateral displacement (DLD) cell-sorting platform using poly(N-isopropylacrylamide) hydrogel arrays. The device sorts cancer cells of defined sizes from blood samples with high-resolution size-based sorting, offering a promising tool for biomedical applications.
Researchers have developed silver-based atomic switches that create stable electrical connections between individual molecules and electrodes, enabling the scalable integration of molecular components. This breakthrough paves the way for ultra-compact and energy-efficient circuits built from single molecules.
Scientists at Institute of Science Tokyo have developed an artificial metalloenzyme-based platform that enables dynamic control of artificial membranes, mimicking the behavior of natural biological membranes. The researchers successfully induced phase-separated domain disappearance and membrane division in artificial membranes using a ...
A new AI system can accurately reconstruct hand muscle activity without sensors, enabling precise estimation of fine motor control. The technology has potential applications in sports science, rehabilitation, and human-machine interaction.
Researchers at Institute of Science Tokyo developed a neural-network-based 3D imaging technique that can precisely measure moving objects. The new method reconstructs high-resolution 3D shapes using only three projection patterns, enabling dynamic 3D measurement across various applications.
Researchers developed a model using DNA methylation biomarkers and CT imaging to predict lymph node metastasis in early-stage gastric cancer patients. The tool helped reduce unnecessary invasive surgeries by up to 44%.
Researchers discovered that ferroelectric fluids can harness a previously overlooked transverse electrostatic force to rise over 80 mm without magnets or high voltages. This breakthrough enables the creation of lightweight, magnet-free motors with low-voltage operation.
A study conducted in a Japanese ICU found that healthcare workers experience reduced satisfaction and concentration due to poor lighting and excessive noise. The findings suggest that designing ICUs with improved natural light and mitigating noise can enhance worker satisfaction, productivity, and quality of patient care.
Researchers have developed an innovative antibody-based enzyme switch called 'Switchbody', which is activated upon antigen binding. The switch's mechanism relies on a 'trap-and-release' process, offering new opportunities in diagnostics and therapeutics.
Scientists at Institute of Science Tokyo developed an automatic and adaptive LED-based optical wireless power transmission system that can efficiently power multiple devices without interruption. The system overcomes limitations of traditional OWPT systems by adapting to varying lighting conditions and ensuring stable power delivery.
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
Researchers at Institute of Science Tokyo found that European eels have restored aquaporin proteins with broad solute permeability through a recent gene duplication event. The study revealed that the genes Aqp10.2b2 and b3 acquired functional diversification, enabling them to transport urea and boric acid similar to Aqp10.1.
Researchers developed a novel mouse model to visualize RNA Polymerase II during elongation, shedding light on gene expression dynamics. The study revealed dynamic patterns of gene transcription activity in various tissues and developmental states, with implications for understanding development, differentiation, and disease mechanisms.
Researchers have identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant. The global constraint principle unifies two classic biological laws and provides a fresh perspective for looking at growth across all forms of life.
Researchers uncover tandem allosteric effect enabling efficient deacetylation of proteins by Sir2, a key enzyme for biological processes. This finding reveals new target for modulating Sir2, potentially leading to novel cancer treatments and therapeutic applications.
Researchers found that selective enrichment of adhesion proteins like fibronectin and vitronectin maximizes optimal cell adhesion on plastic surfaces. The optimal UVO treatment time creates a mix of hydrophilic and hydrophobic regions, promoting attachment protein replacement and secure cell binding.
Scientists discovered that eIF1A and eIF5B suppress toxic protein synthesis implicated in frontotemporal dementia and amyotrophic lateral sclerosis. The study sheds light on the mechanisms behind RAN translation, a process linked to neurodegenerative disorders.
The Earth-Life Science Institute (ELSI) will host the first Public Communication of Science and Technology (PCST) symposium in Japan, bringing together researchers and practitioners to explore science communication strategies in non-Western contexts. The event aims to develop formal education and training programs and bridge the gap be...
A team of researchers proposes a theoretical framework to induce non-reciprocal interactions in solid-state systems using light. By applying dissipation-engineering scheme, they predict a non-equilibrium phase transition called non-reciprocal phase transition, leading to a spontaneous and continuous rotation of magnetization.
Researchers have developed a lab-grown organoid that replicates a regenerating liver, recreating interactions between hepatocytes and hepatic stellate cells. This model provides a platform to study fibrosis, test anti-fibrotic therapies, and identify drugs that could prevent or reverse liver damage.
Researchers at Institute of Science Tokyo developed a rapid cell-free method to capture detailed 3D structures of flexible sugar molecules, including the first atomic-resolution image of melezitose. The study offers a powerful tool for accelerating research in drug discovery and molecular biology.
Researchers discovered that Shigella flexneri uses three effectors to disable host defense pathways, allowing the pathogen to replicate and evade the immune system. This study offers new insights into developing vaccines and targeted therapies for inflammatory colitis, a significant public health challenge.
Researchers at Science Tokyo have provided the first mathematical proof that reentrance implies temperature chaos in spin glasses. The breakthrough enhances understanding of disordered systems and has potential applications in machine learning and quantum technologies.
Researchers developed a deep blue organic light-emitting diode (OLED) capable of producing sharp blue emission meeting BT.2020 standards with just a single 1.5 V battery. The device operates by introducing a new molecular dopant that prevents charge trapping, a problem that previously hampered the performance of low-voltage OLEDs.
A 6-year cohort study found that people living in rental flats and owner-occupied detached houses face higher risks of cardiovascular death compared to those in owner-occupied flats. Improving housing quality to address colder indoor temperatures could lower cardiovascular mortality, particularly among men.
A new MOF, APF-80, enables the crystalline sponge method to capture and analyze nucleophilic compounds like alkaloids. This development opens possibilities for structural analysis in drug development and biochemistry.
A team of researchers from Japan has developed a novel approach to convert waste heat into electricity with higher efficiency than traditional methods, leveraging non-thermal Tomonaga-Luttinger liquid. This breakthrough could pave the way for more sustainable low-power electronics and quantum computing.
A new spinel-type sulfide semiconductor, (Zn,Mg)Sc2S4, has been developed by researchers at Science Tokyo. The material can be chemically tuned to switch between n-type and p-type conduction, making it suitable for pn homojunction devices in next-generation LEDs and solar cells.
Researchers developed a novel spectroscopic approach to precisely analyze molecular interfaces at material surfaces. The technique uses gap-controlled infrared absorption spectroscopy, combining conventional ATR-IR with advanced data analysis, allowing for the isolation of interfacial molecular signals.
A large-scale observational study found that patients who continued taking ACEis or ARBs had a significantly lower risk of mortality and functional decline after non-cardiac surgeries. These benefits were most evident among patients undergoing orthopedic or gastrointestinal surgeries.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
Researchers discovered bulky amino acids reduce pore size, blocking transport of certain molecules in aquaporin 10.2. This provides a framework for predicting functions of uncharacterized aquaglyceroporins.