Researchers at the University of Warwick and Monash University have uncovered a molecular basis for combinatorial biosynthesis, a strategy to create multiple versions of powerful cancer therapies. By understanding how bacterial enzymes interact, they can design new therapies with improved potency and selectivity.
The Ludwig Institute for Cancer Research has appointed three Clinical Scholars, Bernhard Gentner, Caroline Arber, and Christian Hinrichs, to advance cancer research and clinical interventions. The new scholars will focus on translating scientific discoveries into clinical trials and partnerships with leading clinical facilities.
The American College of Medical Genetics and Genomics (ACMG) has published a statement providing recommendations for the reporting of variants of uncertain significance (VUS) in germline genetic and genomic testing. The guidance aims to promote clarity, consistency, and best practices in the reporting of VUS findings, supporting approp...
Recent studies have analyzed the residues of fireworks, providing insights into their potential impacts on human health and the environment. The research also highlights the need for better management of pyrotechnics' fallout, including litter, particulate matter, and airborne compounds.
A new study suggests that several COVID-19 drugs can be toxic to marine organisms, even at low concentrations. The research found that ivermectin and other pharmaceuticals caused significant mortality in brine shrimp, highlighting an environmental concern.
A 15-year study found that extreme weather events, particularly sudden spring frosts and wildfires, have a significant impact on White Stork survival. Juvenile storks are most vulnerable to these conditions, with only 33% of fire-related incidents resulting in rehabilitation.
The new Ph.D. program in cybersecurity at Old Dominion University highlights the interdisciplinary nature of the field, incorporating emerging technologies like artificial intelligence. Students from diverse backgrounds are encouraged to contribute to advancing cybersecurity research and education.
The Institute for Quality and Efficiency in Health Care (IQWiG) has released its revised General Methods version 8.0, which aims to improve transparency and scientific recognition in its assessment methods. The new version includes a separate chapter on involving people affected by diseases or interventions in the assessment process.
This study defines IFRD1's disease-protective function and elucidates its molecular regulatory mechanism, which suppresses de novo hepatic lipogenesis by boosting α-KG production. Clinical correlations and translational potential are also established for therapeutic interventions targeting the GLUD1/α-KG axis.
Researchers developed a biomimetic water-harvesting system that extracts clean drinking water from contaminated soil using the desert horned lizard's skin and jaw motion. The system uses a porous medium and motor-driven artificial jaw to collect water, achieving more energy efficiency than conventional methods.
MDPI has acquired three Swiss journals, including SANPP, PHC, and Cardiovascular Medicine, to expand its healthcare portfolio. The journals will be free to read and share via MDPI's OA platform, promoting discussions and integrative clinical care in neurology, psychiatry, and primary healthcare.
Researchers found that COVID-19 vaccine boosters provide protection against some future coronaviruses that risk spreading from animals to humans. The study also showed that the immune response 'locks in' after the first exposure to SARS-CoV-2, impeding the ability to respond to future variants.
A modular system designed by Worcester Polytechnic Institute Assistant Professor Jiawei Yang enables the creation of customized hydrogel implants with tailored stiffness and functionality. The system addresses critical challenges in implant design, including adhesion and immune rejection, to improve long-term performance.
A study published in Frontiers in Psychology found that the time it takes for a therapist and patient to reach peak heart-rate synchrony during a music therapy session is around 25 minutes. This suggests that therapy sessions may need to allow sufficient time for this synchronization to develop.
The International Conference on Advanced (Nano)composites 2027 will bring together researchers from around the world to exchange ideas and present new research in composites and nanocomposites. The conference aims to provide an international platform for academic exchange, interdisciplinary collaboration, and industry engagement.
Researchers identified disrupted neural circuits behind Huntington's disease and used optogenetics to selectively activate key neurons, restoring function and improving motor skills. The study provides hope for future therapies targeting specific brain circuit imbalances.
The study reveals how genetic mutations disrupt muscle signaling in CMS, a family of genetic disorders that weaken communication between nerves and muscles. Researchers identified promising new therapeutic opportunities, including a potential use for an existing antidepressant.
A Korean research team created an underwater acoustic lens capable of focusing sound precisely at a desired point while reducing weight by about 40% compared to conventional designs. The findings have significant implications for underwater communication, marine environmental monitoring, and acoustic energy transfer.
The TESS mission has discovered a planet orbiting a distant star through microlensing, revealing a world about 1.63 times as massive as Jupiter at an orbital distance similar to Jupiter's. This finding suggests additional microlensing planets may be hidden within archived TESS observations.
A new imaging technology at UH helps scientists study exosomes, tiny particles released by human cells that may be targets for diseases. The technology uses advanced lighting at the nanoscale to analyze exosomes one at a time, measuring features to pinpoint good drug targets.
Nearly half of dementia cases can be prevented by addressing modifiable risk factors like physical inactivity and smoking. A new review found that large-scale awareness campaigns often lead to limited behavior change, highlighting the need for more personalized and community-driven approaches.
Researchers developed an AI-guided strategy to identify bioactive nucleoside hydrogels for periodontal therapy, using machine learning-based predictive models and experimental validation. The study identified two promising candidates, guanosine monophosphate and deoxyguanosine monophosphate, which successfully formed stable hydrogels w...
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
A new scientific study reveals Lake Chad's exceptional biodiversity despite conflict in the region. The research estimates that approximately 2.48 million waterbirds use the site, making it likely the largest concentration of wetland birds on the African continent.
A new study by Swansea University introduces a One Health Sustainability Framework linking biodiversity, ecological condition, and environmental sustainability with wellbeing outcomes in nature prescribing. The framework highlights the need to understand what kinds of nature and how much are needed to support health in a sustainable way.
Researchers found that dobutamine blocks the growth of cancer cells in bone tumours, stomach cancer, and multiple myeloma by inhibiting the ROCK2 protein. The study provides a practical path forward for developing targeted and potent ROCK2 inhibitors.
A new study by Tsinghua University Press proposes a dual dopant approach using iron and zirconium to improve the stability of cobalt-free Ni-rich layered oxides under high-voltage cycling. The Fe/Zr codoped cathode delivers enhanced rate capability, reduced charge-transfer resistance, and improved lithium-ion diffusion behavior.
Scientists at The University of Osaka have created a multipath synergistic strategy to toughen elastomers by sequentially activating three energy dissipation pathways. This approach enhances the material's toughness while maintaining its elasticity, making it suitable for various applications such as tires, gloves, and adhesives.
Researchers developed a method using chirped power oscillation waves to track high-speed motion with sub-micrometer accuracy. This technique directly uses time-domain intensity signals to eliminate frequency resolution limitations in short time windows.
Biochar improves soil physical and chemical properties by increasing water retention, enhancing soil aggregation, raising organic matter content, and regulating pH and nutrient availability. Biochar also reduces allelopathic autotoxicity and supports healthier plant development by adsorbing or degrading harmful compounds.
A Danish study found a small increased short-term risk of blood clots among inpatients at psychiatric hospitals who underwent mechanical restraint. The absolute risk remains low, but the findings support ongoing efforts to reduce the use and duration of mechanical restraint where feasible.
A new study reveals that sponges may use photosynthesis, increasing the productivity of tropical coral reefs. Sponges were found to account for 11% of gross primary productivity, surprising researchers who previously considered them as pure consumers.
Researchers at Hiroshima University have applied black-box optimization algorithms to model rainfall minimization through weather control. They demonstrated that Bayesian optimization can effectively design weather interventions, even under a limited budget of expensive weather simulations, by optimizing only a small number of trials.
Researchers developed an ensemble deep learning approach to detect cracks and cold flows on aluminum gas meter lids with over 97% accuracy. The system combines three AI models, significantly outperforming traditional manual checks.
A new ESO study warns that over 1.7 million proposed satellites could devastate astronomy by making the night sky brighter. Simulations show hundreds of satellites would be visible at any given time, polluting the sky with light and hindering observations of faint cosmic targets.
Researchers at the University of Texas at Austin have developed a comprehensive database for underground natural gas storage sites across the US. The study provides insights into geological assessments, reservoir engineering, and operational data to inform future expansion and optimization of existing storage facilities.
Researchers developed a one-pot synthesis strategy for hierarchical ZSM-5 catalysts that can improve catalyst lifetime during microwave-assisted catalytic pyrolysis of plastic waste. The study found that crystallization temperature strongly controlled the catalyst's pore structure, acidity, morphology, and lifetime.
Researchers at Chalmers University of Technology have developed a safer metal recycling method for the battery industry using renewable biomass, reducing the risk of fire and hazardous substance exposure. The new method performs just as well as conventional processes in extracting important metals.
MARVEL has transformed materials research by combining simulations, machine learning, and experiments to predict and design novel materials. Its open-source codes and computational infrastructures have strengthened the field, enabling reproducible and collaborative discoveries.
Alexandre Detappe has been awarded an ERC Proof of Concept grant to develop nanoparticles that promote interactions between immune cells and cancer cells, aiming to improve the effectiveness of immunotherapy for solid tumors. The project will provide preclinical validations and prepare its next stages of development.