Articles tagged with Viral Infections
A new study published in the Journal of Medical Entomology found that West Nile virus infection risk varies with neighborhood income in Baltimore. The research revealed that lower-income urban neighborhoods are more prone to mosquito-borne diseases due to environmental factors.
Research at the University of Chicago found that pre-existing flu immunity shapes antibody responses to influenza infections and vaccinations. The quality of these responses differs between individuals who are vaccinated or naturally infected, with vaccinated individuals generating more adaptable antibodies that target conserved regions.
A study found that Zika virus can remain in the mouse brain for extended periods, leading to lasting cognitive impairment and increased risk of psychological disorders. The infection caused long-term deficits in motor function and coordination, as well as anxiety and hyperactivity.
Researchers have developed an efficient method to study phage-microbe interactions, which can reveal bacterial receptors exploited by phages and cellular mechanisms used to respond to infection. The approach has implications for understanding microbiomes, developing new medicines and addressing antibiotic-resistant infections.
The University of Huddersfield's Antimicrobial Stewardship in Wound Management course has been honoured at the Antibiotic Guardian Awards. Over 8000 healthcare professionals have completed the course with high praise, exploring antimicrobial resistance and implementing infection control measures.
Two Luxembourg Institute of Health researchers have been recognized with the prestigious 2019 Galien Prize in Pharmacology for their groundbreaking research on atypical chemokine receptors. Their work has significant implications for understanding various physiological and pathological processes, including immune responses and cancer.
Researchers identified coral GSDME as a pyroptosis-inducing protein in reef-building corals, revealing its role in pathogen-induced coral death. Activation of coral GSDME triggers rapid cell swelling and cytoplasmic content release, leading to necrotic tissue damage.
Researchers have developed an AI-based algorithm called OxyGAN to accurately measure tissue oxygenation from single snapshots. This approach uses a conditional generative adversarial network to learn realistic output images and determine correct reconstructions for given input data, demonstrating robustness in measuring oxygen levels.
A DNA-based vaccine candidate has been found to be effective in protecting cynomolgus macaques from the Crimean-Congo hemorrhagic fever virus. The vaccine generated protective antibodies and prevented signs of disease in infected animals, offering a promising potential treatment for human patients.
Researchers found that multiple forms of a viral protein increase the virus's competitive advantage and replication rate. The study suggests that this may be why foot-and-mouth disease is so successful in infecting its hosts.
Researchers found that methacycline, a widely used tetracycline-based antibiotic, is effective at preventing brain infections and reducing neurological problems associated with Zika virus infections. The study also identified other potential candidates, including anti-inflammatory medicines and failed anti-Alzheimer's disease drugs.
Vaccination of endangered tiger population against canine distemper virus could reduce extinction probability from 15.8% to 5.7%
A genetic mutation in the 'coat' of a brain infection-causing virus may allow it to escape neutralizing antibodies, increasing the risk of developing a fatal brain disease. Researchers have identified this mutation in the mouse equivalent of JC polyomavirus and found that it prevents monoclonal antibodies from interacting with the virus.
Rotavirus-infected cells release signaling molecules adenosine diphosphate (ADP) that bind to P2Y1 receptors on neighboring uninfected cells, triggering intercellular calcium waves and disrupting normal function. This discovery provides a new potential strategy for treating viral diarrhea.
A new study of over seven million births from four countries found that cesarean-born babies are at increased risk of infection-related hospitalisation during early childhood. The study recorded a small but consistent increase in the absolute risk of infection-related hospitalisation rates in children up to five years of age compared w...
Researchers found that domesticated Aedes aegypti mosquitoes in Asia, Africa, and the Americas are more susceptible to acquiring Zika virus than their African counterparts. Genetic differences on chromosome 2 are believed to be the cause of this increased susceptibility.
Researchers discovered a unique RNA polymerase in crAss-like phages that helps transcribe its genes. The enzyme was found to be inactive in standard tests but active when exposed to specific conditions, revealing new insights into the mechanism of viral infections.
Researchers at Harvard Medical School have identified a group of gut microbes and a specific molecule that modulate immune responses to viral infections. The study found that these microbes, particularly Bacteroides fragilis, trigger the release of interferon-beta, which confers antiviral protection.
A molecule called Ldlrad3 has been identified as a key player in the virus's ability to infect cells. By creating a decoy version of this protein, scientists have found that it can prevent the virus from causing deadly brain infections in mice.
A German study confirms rats can transmit hantavirus to humans, with a young patient infected after contact with her pet rat. The virus, commonly found in Asia, poses severe disease risks and highlights the need for caution when keeping rats.
A Harvard Medical School study found that clinicians who prescribe unnecessary antibiotics for viral infections increase the likelihood of patients seeking care for similar infections in the future. This leads to a significant increase in antibiotic prescriptions, exacerbating the problem of antibiotic resistance and unnecessary spending.
Researchers have discovered a potential broad-spectrum anti-viral drug target by identifying how encapsulated viruses hijack the protein manufacturing and distribution pathways in cells. This approach offers an attractive alternative to developing individual drugs for each virus, with the same compound targeting multiple viruses.
Research at the University of Zurich reveals that host genetic differences explain most of the variation in virus community composition. Genetic diversity within species is crucial for immune system function and should be prioritized in agriculture to improve pathogen resistance.
Researchers at the Weizmann Institute of Science reveal retrons, hybrid structures found in many bacterial species, are 'guards' that prevent viruses from spreading. These retrons activate a programmed cell death mechanism to protect the bacterial colony.
A Duke Health-led research team has identified a key marker that will help speed effective vaccine designs for cytomegalovirus (CMV). The finding provides an immune surrogate to test the effectiveness of vaccine candidates, which could aid in vaccine evaluation and predict potential efficacy.
Researchers have found that some plant viruses can hijack the plant's defence system, using a viral protein to block gene silencing and promote its own replication. However, studying naturally resistant plants and employing modern breeding techniques like CRISPR/Cas9 may help regain control over the virus.
Researchers at Texas A&M AgriLife Communications have discovered that some phages can stop bacteria from sharing genes for antibiotic resistance by attaching to and disarming pili on bacterial surface. This discovery may lead to new treatments for infections, reducing the need for antibiotics or gentler alternatives.
Scientists at The Wistar Institute have developed a synthetic DNA vaccine against Powassan virus, which causes a deadly tick-borne disease with neurological consequences. The vaccine elicits broad immune responses in mice and provides protection in a challenge animal model.
Researchers at Northwestern University developed a new face mask concept that aims to deactivate viruses in respiratory droplets, making the wearer less infectious. The masks feature anti-viral chemicals like phosphoric acid and copper salt that alter escaped droplets, reducing viral spread.
Scientists used CRISPR interference to study virulence genes in a mouse model of pneumonia, observing surprising variability in disease progression. The results point to several genes as having important roles in pneumococcal infections, including the bacterial capsule genes and the gene for pneumolysin.
Researchers identified genes associated with decreased placental invasion and increased chemokine production in babies born with microcephaly. This finding provides insight into why only some babies exposed to Zika virus during pregnancy develop anomalies.
A study suggests that Ontario's current vaccination strategy for hepatitis B is inadequate, as many children are infected before receiving the vaccine. The authors recommend that all women be screened for HBV during pregnancy and that newborns receive the vaccine at birth.
A study led by University of Zurich researchers found that the HLA-DR15 gene variant plays a significant role in developing multiple sclerosis. People with this genetic predisposition can develop an immune response against their own brain tissue if infected with certain viruses or bacteria, leading to the disease.
Researchers have identified a novel immune defence mechanism orchestrated by lipid droplets that attracts and eliminates invading pathogens, providing a broad-spectrum response. This strategy could be used to develop new therapeutic approaches in the era of antibiotic resistance.
Researchers at Oregon State University found that viral infection is involved in coral bleaching, with bleached corals having a higher abundance of eukaryotic viruses and giant viruses. These findings suggest that viral assemblages shift between coral bleaching states.
Researchers found that WUSCHEL proteins inhibit viral protein production, preventing replication and keeping plants virus-free. The discovery could lead to breeding broad-spectrum antiviral crop varieties in the future.
Researchers have identified two new relatives of the rubella virus, ruhugu and rustrela, found in bats and mice in Uganda and Germany. These viruses are similar to rubella but differ in key regions, raising concerns about potential zoonotic transmission.
Primate lentiviruses, such as HIV-1, overcome species barriers through viral infectivity factor (Vif) and APOBEC3 protein interactions. A study by the University of Tokyo found that gorilla APOBEC3G can restrict SIVcpz replication but a specific amino acid substitution in Vif can evade this restriction.
Biomedical researchers at Georgia State University have identified a novel method for eradicating rotavirus and other viral infections using interleukin-18 and interleukin-22. The study shows that these cytokines can rapidly and completely eliminate viruses from intestinal epithelial cells, even in compromised immune systems.
Researchers identified a previously unknown strain of Paenibacillus thiaminolyticus bacteria as the primary cause of post-infectious hydrocephalus in Ugandan infants. The bacteria is linked to cytomegalovirus (CMV) infection, which causes neurological damage and can lead to severe cognitive and physical disabilities.
Scientists discovered a key transcription factor regulating T cell survival and immunological memory. Overexpressing this factor in CAR-T cells improved therapy efficiency for cancer treatments. Improved therapies could benefit patients with B cell lymphoma and other diseases.
Researchers found viral sequences associated with choanozoans and picozoans, which were not linked to bacterial DNA, suggesting these protists eat viruses. The removal of viruses from the water could potentially reduce the number of viruses available to infect other organisms.
Scientists found that ocean viruses infect algae without killing them immediately, instead allowing cells to multiply and bloom before dying. This discovery changes how scientists view viral infections of algae and their impact on ecosystem processes like algal bloom formation and carbon cycling.
Researchers found that middle-aged individuals have different H3N2 flu virus antibody specificities, which can leave them more susceptible to infection. Early childhood infections can elicit strong, long-lasting memory immune responses, but these may not be effective against newer strains of the virus.
Researchers found that certain human norovirus strains are more resistant to the body's natural defenses than others. This study highlights the importance of considering strain differences when studying norovirus biology and designing therapies.
The article reviews recent insights into feline leukaemia virus (FeLV) infection pathogenesis using molecular techniques. It explains the various outcomes of FeLV infection, including progressive, regressive, focal, and abortive infections, highlighting the importance of understanding the cat's immune response and the virus.
Researchers from Massachusetts General Hospital have successfully treated hepatitis C-infected kidneys in transplant patients using glecaprevir and pibrentasvir. The study shows that early antiviral intervention can cure the virus without serious side effects, paving the way for a significant increase in organ availability.
Researchers found that olfactory sensory neurons can activate antiviral genes to fight off the virus, but at a higher level than other cell types. This unique response may be a brain-protective mechanism, allowing these cells to avoid being destroyed by the infection.
A new study has shown that Zika virus can create a robust inflammatory environment in the placenta, leading to pathological changes and impact on fetal development. The findings provide valuable insights into mother-to-baby transmission of Zika virus and may lead to the development of detection methods and treatments.
Researchers found that prior exposure to powdery mildew makes plants more susceptible to subsequent disease. In experiments and in the wild, early infection facilitated later infection, with some pathogen strains promoting infections from later-arriving strains. The findings highlight the importance of understanding interactions among ...
Novel agents targeting viral production and immune response show promising results in early clinical trials. Four studies presented at DILC 2020 evaluated the strategy of disrupting viral protein synthesis using RNA interference and antisense oligonucleotides, with two combining NRTIs with novel therapies achieving significant HBsAg re...
A study published in Science found that prior Zika virus infection significantly increases the risk of both symptomatic and more severe forms of dengue disease. This interaction, known as antibody-dependent enhancement, could make it harder to design a safe and effective vaccine.
A new study found that transmission risk of the PPRV virus increases with specific husbandry practices, including introducing sheep or goats to herds and attending seasonal grazing camps. In contrast, herd size was not related to transmission risk, but rather social cliques formed within individual compounds.
Researchers at the University of Queensland discovered that neurons can fuse together, disrupting electrical circuits and leading to behavioral impairments in nematode worms. The study provides a novel cause for malfunction of brain's electrical circuits and a possible underlying cause of neurological diseases.
Researchers have discovered a region of viral protein LANA that is crucial for KSHV persistence in human cells, which could potentially be used to develop therapy for KSHV tumors. The study found that this LANA region interacts with p53 and other unacetylated proteins, allowing the virus to persist in tumor cells.
A QUT study has developed a new model to track the probability of banana plant infection by aphids carrying the BBTV virus. The findings suggest that mathematical and statistical models can help predict areas of risk of infection and aid in disease management strategies.
A study by researchers at the University of California, Berkeley, found that warmer temperatures increase the likelihood of capturing infected mosquitoes in Los Angeles neighborhoods. Sustained warm temperatures over weeks allow mosquitoes to acquire and spread the infection.
The new database covers 219 pathogens that infect plants in Brazil, including many agriculturally important species. It presents information on diseases caused by the viruses and their occurrence in native, cultivated, and ornamental plants.
Researchers found that influenza A virus (IAV) infection leads to changes in eosinophil surface markers, antigen presentation, and survival. Eosinophils play an active role in resolving viral infections by recognizing IAV antigens and inducing epigenetic changes in CD8+ T-cells.
Researchers found that a pre-epidemic Zika virus mutation enhanced virulence and fitness for transmission, increasing maternal-to-fetal transmission in nonhuman primates. The mutation did not affect mosquito-borne infection but increased the virus's ability to spread through human populations.