Articles tagged with Viral Infections
Researchers at NIAID can detect infectious prion protein in mouse brains within a week of inoculation, surpassing prior detection times of six weeks. The study found that the protein was generated outside blood vessels in a specific brain region where drug treatment could be targeted.
A virulent strain of BVDV-2c virus affected over 5,000 cattle in Germany, causing severe symptoms and significant economic losses. The study suggests that farmers and people who visit farms should take biosecurity measures to prevent disease transmission.
Researchers found significant antigenic difference within each dengue serotype, suggesting individuals infected with one type may not be protected against different strains. The study's findings have implications for vaccine design and understanding of the virus's evolution.
Researchers analyzed breast tissue from 239 women, comparing samples with and without breast cancer for the presence of bovine leukemia virus. They found a significant association between BLV infection and an increased risk of breast cancer, with odds ratio higher than obesity, alcohol consumption, and post-menopausal hormone use.
Genetic mutations in Ebola virus appear to block antibody-based treatments from warding off infection. The mutations, or 'escape variants,' have implications for the continued development of therapeutics to treat Ebola virus disease, which has claimed over 11,000 lives in West Africa.
Scientists created a detailed model of the NS3 helicase enzyme, which facilitates viral replication. The study provides insights into how this protein interacts with RNA and could lead to the development of new treatments that target only the hepatitis C virus without harming human cells.
Researchers have discovered that the dengue virus NS1 protein acts as a toxin, similar to bacterial cell wall products. This finding allows them to re-purpose existing drugs for a potential dengue treatment.
Researchers at UC Berkeley have identified nonstructural protein 1 (NS1) as a key culprit responsible for fluid loss and resulting shock in severe dengue virus infections. Blocking this protein in mice protected them from lethal effects, suggesting it could be a prime target for drugs and vaccines.
A new study reveals how immune cells, such as neutrophils and T cells, coordinate their efforts to fight infections. By understanding this teamwork, scientists hope to develop new ways to control and improve the body's response to illnesses like multiple sclerosis and lupus.
Leptospirosis is a poorly understood and often misdiagnosed bacterial disease with a high case fatality rate. The researchers aim to develop an inexpensive, sensitive, and efficient diagnostic test for leptospirosis, which could lead to improved clinical outcomes and reduced mortality.
Researchers at the Salk Institute have identified a critical difference in how cells respond to DNA breaks versus viral infections. The discovery reveals that cells can selectively neutralize viral DNA without triggering a global response, which could lead to the development of new cancer-selective viral therapies.
A team of researchers from Pitt, Drexel, and NIH found that the Ebola virus can survive in detectable concentrations in wastewater for at least a week or longer. The study suggests that procedures for disposing of contaminated liquid waste might underestimate the virus' ability to persist.
Scientists have discovered a new virus in seals that is closely related to human hepatitis A virus, raising concerns about the emergence of hepatitis A. The researchers found the virus in harbor seals off the coast of New England and suggest it may be present in other wildlife species.
Researchers identified a new virus, phopivirus, in seals genetically similar to hepatitis A, suggesting it may have originated in animals. The discovery provides clues on the emergence of hepatitis A and highlights the importance of studying wildlife reservoirs of zoonotic viruses.
A recent study found that labeling a child's symptoms as 'pink eye' can mislead parents into wanting antibiotics, even when they're not necessary. The study suggests that physicians should be aware of the effect of words on parents' expectations for treatment.
Research detects RSV on personal clothing and high-touch areas of NICU, highlighting the need for frequent cleaning and visitor screening. Hand hygiene practices are crucial in mitigating transmission of respiratory viruses like RSV.
Scientists discovered that helper T cells boost killer cell reproduction and provide memory, enabling them to remember previous infections. This understanding could lead to the development of new vaccines that activate killer cells with harmless fragments of disease pathogens.
SLU researchers suggest approach to fight common virus in immunosuppressed patients by targeting Type 1 interferon pathway. The study found that disrupting the STAT2 gene in Syrian hamsters resulted in 100-1,000 times more virus replication compared to wild-type control animals.
Researchers created a vomiting device to study the aerosolization of virus particles similar to human norovirus. They found that only 0.02% of the total virus in the vomit was aerosolized, but this can still amount to thousands of infectious particles.
A new genomic catalog of nearly 200 viral genomes provides insight into the origins and transmission of Lassa virus. The data set confirms rodent-to-human transmission as the primary mode of infection.
The discovery sheds light on how the virus evolved and spread across West Africa, revealing that most cases are caused by spillover infections from wild rodents to humans.
Researchers developed an EBV vaccine using nanoparticles that induce potent neutralizing antibodies in mice and nonhuman primates. This approach is promising for developing an effective EBV vaccine for humans.
Researchers have discovered a way to trigger a preventive response to flu infections by boosting the level of IFITM3 protein in cells, preventing cell infection. The method involves inhibiting NEDD4 enzyme, which degrades IFITM3, allowing for sustained production and enhanced resistance to flu viruses.
A preclinical study found that a new Ebola vaccine, VSV-EBOV, provides complete protection against the disease when given 7 days before infection in macaques. The vaccine also induces a strong innate immune response, helping to limit virus replication and eventually clearing the virus.
A web-based programme to encourage frequent handwashing reduces respiratory tract infections in UK households, with a 14% risk reduction and lower demand for consultations and antibiotic prescriptions. The study suggests PRIMIT could play an important role in reducing flu spread and strain on NHS services during winter months.
A study found that 10.3% of patients tested positive for HCV, with 70% confirmed as chronically infected, while only 24% had prior knowledge of the infection. Hepatitis C is a leading cause of end-stage liver disease and liver cancer.
A single dose of the experimental Ebola virus (EBOV) vaccine VSV-EBOV has been shown to completely protect cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona. The vaccine triggers both innate and adaptive immunity, providing partial protection if given three days prior to exposure.
Researchers at University of Edinburgh's Roslin Institute discovered that prions build up in Peyer's patches before spreading to the brain. This finding could enable earlier detection and treatment of prion diseases, including variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.
Researchers have devised a new approach to vaccines that creates immunity without standard approaches, offering a rapid solution to deadly diseases like dengue fever. The DMAb platform produces antibodies that do not bind to cell receptors, eliminating the chance for infection and disease.
A University of Texas at Arlington study reveals that sea stars have an immune response characterized by various types of immunities, including the first melanin gene ever recorded in a sea star. The team also found changes in genes related to collagen and nervous system function, which may contribute to the disease's effects.
A study published in PLOS Pathogens found that older individuals are more susceptible to West Nile virus due to impaired immune responses. The researchers discovered that older mice had delayed antibody responses, reduced helper T cells, and lower chemokine levels, leading to higher viral loads and increased brain damage.
A study published in The New England Journal of Medicine reports that an experimental compound, AVI-7288, protected nonhuman primates against the deadly Marburg virus. The compound showed efficacy even when administered after exposure to the virus. Phase I clinical trial results also indicated safety and tolerability.
Researchers found that feeding high concentrations of soybean meal improved growth and immune response in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). The study suggests that isoflavones in soybean meal may have antiviral properties, helping to alleviate the effects of PRRSV.
A new study found that nearly all people in Chennai, India have been exposed to dengue and 44% to chikungunya, but only a small percentage report symptoms. The research highlights the need for better awareness and control measures to combat these mosquito-borne diseases.
The Oxford Vaccine Group is conducting a Phase II study of an Ebola vaccine regimen, recruiting over 600 healthy adult volunteers in the UK and France. The study aims to assess the safety and immunogenicity of the vaccine, as well as determine the best timing for each dose.
A collaborative team from UTMB and NIH develop an inhalable vaccine that protects primates against Ebola. The aerosol delivery method has shown promising results, with a single vaccination providing protection against the severe disease and death caused by lethal Ebola infection.
Researchers found that adenoviruses use ceramide lipids to trigger an infection by creating small pores in the cell membrane. The virus then multiplies in the nucleus and infects other cells. This discovery could lead to new anti-viral agents for gene therapy and vaccination.
Vanderbilt University Medical Center researchers have developed a large panel of antibody treatments against chikungunya, a flu-like illness with debilitating joint pain. The antibodies can be used to treat infected individuals early in the infection, potentially preventing severe symptoms.
A new investigational vaccine designed to protect against West Nile Virus infection is being tested in a Phase 1 clinical trial. The vaccine was developed with a novel, hydrogen peroxide-based process that renders the virus inactive while maintaining key immune-system triggering surface structures.
Researchers discovered that dengue virus adapts by interacting with host RNA and proteins, allowing it to bypass the immune response. This finding explains the 1994 Puerto Rico epidemic and may help predict future outbreaks.
Researchers have determined the structure of a human monoclonal antibody that strongly neutralizes a type of the potentially lethal dengue virus in an animal model. This finding could lead to effective therapies and vaccines against dengue, a complex of four distinct mosquito-borne viruses causing illness and death in the tropics.
Scientists at the University of Pittsburgh Center for Vaccine Research are developing vaccines and therapies against deadly mosquito-borne diseases, including eastern equine encephalitis virus (EEEV) and alphavirus. The research aims to limit brain entry by these viruses and identify biological markers of disease severity.
A new method is being used to screen primates in remote locations without invasive sampling techniques. Saliva from discarded ropes is collected and tested for viral diseases, providing valuable information on zoonotic pathogens.
A team led by Associate Professor Shee-Mei Lok at Duke-NUS Medical School discovered an antibody that neutralizes dengue virus serotype 2 (DENV-2), making it harder to kill. The finding could help develop dengue therapeutics and is a significant step towards addressing the global dengue pandemic.
A $1.35 million grant will fund research on predicting deadly avian flu outbreaks by understanding the influenza virus's transmission from birds to humans. The team, led by Lukas Tamm of the University of Virginia School of Medicine, aims to develop a new tool for predicting outbreak risk based on viral envelope changes.
Researchers found that hantaviruses are highly dependent on cholesterol in cell membranes to gain access into cells. Disrupting the S1P pathway reduced their ability to infect cells, suggesting potential therapeutic targets. However, further studies are needed to fully understand the viruses' dependence on cholesterol.
Researchers at Scripps Research Institute identify new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The study provides ingredients needed to develop treatments for future Marburg outbreaks.
A single mutation in the H3N2 virus helped it evade the immune system's defenses, making last year's flu vaccine less effective. Researchers have identified this mutation as a key factor in the mismatch between the vaccine strain and circulating strains.
Researchers at The Wistar Institute identified specific mutations in H3N2 viruses that made the 2014-2015 flu vaccine less effective. Antigenic drift, a phenomenon where viruses accumulate mutations to evade immune response, was found to be a key factor.
The American Association for the Study of Liver Diseases (AASLD) has updated its guidance on testing, managing, and treating hepatitis C virus (HCV). The new recommendations focus on direct-acting antiviral drugs, which have shown high efficacy in curing HCV. With these updates, millions of Americans living with chronic HCV may now hav...
Researchers report that statins and angiotensin receptor blockers, commonly used for heart disease, can stabilize endothelial cells lining blood vessels in Ebola patients. This approach may improve survival rates in infected individuals by bolstering the immune system.
Engineers at Lehigh University are developing stochastic models to study the dynamics of Ebola virus infection in bats and its potential human transmission. The goal is to quantify the risk associated with the virus's spread and provide a basis for resource allocation and epidemic response strategies.
A study published in the Proceedings of the National Academy of Sciences found that people with roseola virus DNA in their chromosomes are three times more likely to suffer from angina. The virus's genetic material can be transmitted like human genes, and its presence may lead to premature aging and inflammation.
Researchers found that EBV-infected B cells evade immune system using the viral protein LMP2A. The protein interferes with recognition by CD8+ T cells, allowing infected cells to escape detection and elimination.
A new study by NIH researchers compares the Makona strain of Ebola virus to the original 1976 Mayinga strain, revealing a decreased ability to cause disease in West Africa, with liver damage and rash appearing two days later than in the 1976 strain.
Researchers developed a new technology called VirScan to identify all viruses an individual has been exposed to over their life. The study found that people are exposed to around 10 viral species on average, but some individuals encountered up to 84 different viral species.
Dr. Steven Schiff aims to reduce infant mortality from neonatal sepsis by identifying infection causes and developing predictive models for optimal antimicrobial treatment. His research seeks to apply engineering control principles to prevent infections, with potential applications worldwide.
Scientists at the University of Bonn discovered two new groups of viruses, Jonchet and Ferak, which are believed to have originated from insect viruses. The researchers found that these viruses are phylogenetically independent and do not multiply above 32 degrees Celsius, making human infection unlikely.
A prospective study found that telbivudine prevented perinatal transmission of hepatitis B virus (HBV) in pregnant women with high viral loads. The study showed a significant reduction in HBV transmission in infants whose mothers received telbivudine, with almost no positive tests after six months.
Scientists discovered the molecular lock of Ebola virus's cellular entry, which could lead to the development of antiviral drugs blocking its interaction with Niemann-Pick C1. The study found mice lacking NPC1 gene were completely resistant to infection, suggesting a potential treatment for Ebola.