Articles tagged with Viral Infections
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A study found that daily chlorhexidine bathing in a trauma center reduced the rate of MRSA colonization and treatment-resistant bacteria infections. Patients who received chlorhexidine baths were less likely to acquire catheter-related bloodstream infections and ventilator-associated pneumonia caused by MRSA.
Researchers have discovered exactly how one type of New World hemorrhagic fever virus latches onto and infects human cells, offering a much-needed lead toward new treatments. The finding identifies the apical domain of the transferrin receptor as an attractive target for drugs.
Researchers have identified genes that predispose people to gluten intolerance, which is linked to the human immune system and inflammations rather than gluten breakdown. The findings suggest a possible connection between virus infections and the onset of gluten intolerance.
Researchers have developed an experimental vaccine for chikungunya virus, which has already infected millions of people in Asia, Africa, and Europe. The vaccine, composed of virus-like particles, successfully protected monkeys from infection.
Scientists have discovered a new form of prion disease that causes brain artery damage, distinct from the typical sponge-like brain deterioration. The study may hold clues for treating Alzheimer's disease, as researchers found that removing a specific anchor from prion protein could prevent plaque accumulation and block fluid drainage.
Researchers at Duke University have developed a new gene-expression test that can detect Candida fungal infections in patients. The test measures how a patient's genes respond to the infection and has shown promising results in mice, indicating it could be an early detector of life-threatening candidemia.
Researchers at HZI have discovered a new adjuvant, c-di-IMP, that enhances immune responses and provides long-lasting protection. The molecule has been shown to stimulate important effector mechanisms in mice, making it a promising candidate for improving existing vaccines.
A new study suggests that mosquitoes, particularly Culex tarsalis, played a significant role in spreading West Nile virus across the US. The findings reveal that mosquitoes' flight patterns mimic the actual path of the virus's spread, contradicting previous assumptions that birds were primarily responsible.
A study by researchers at Johns Hopkins Bloomberg School of Public Health suggests that mosquitoes played a primary role in spreading West Nile virus westward across the US. Genetic analysis detected widespread movement by Culex tarsalis populations, which were congruent with the pattern of West Nile virus infection across the country.
Researchers found that tall palm trees with debris should be targeted for Chagas disease surveillance and control. They suggest simple environmental management practices like removing organic debris can reduce the risk of vector-human contact.
Researchers at Stanford University School of Medicine have found that disrupting the SDF-1/CXCR4 interaction can prevent the recruitment of vasculogenic cells to the tumor site, blocking postirradiation development of functional tumor vasculature and tumor regrowth. This approach may be applicable to treating glioblastoma multiforme.
Researchers at UF's College of Veterinary Medicine have discovered that dolphins can harbor multiple infections of apillomaviruses, which are linked to cervical cancer in humans. The study suggests that dolphins may be an ideal model for studying human cervical cancer due to their genetic similarity to humans.
Researchers used population genetics approaches to identify gene variants that increase or decrease susceptibility to viral infections, finding 139 human genes with this effect. The study suggests these variants could be targeted for novel therapeutic approaches and vaccines.
Research reveals that flu-induced stress response is critical for resistance to secondary infection, involving increased production of glucocorticoids to control inflammation. The study found that mice without GCs were better able to suppress secondary bacterial infections, but lacking GCs led to a lethal excessive inflammatory response.
A Johns Hopkins Hospital campaign made seasonal flu vaccinations free and convenient, resulting in a double national average vaccine rate of 71.3% among staff. The hospital's policy requiring employees to wear face masks if not vaccinated also encouraged vaccination.
A new screening system for hepatitis C has been developed by Texas A&M University researchers, allowing for the study of all aspects of the virus's life cycle. The system enables the discovery of small, low-cost molecules that block the HCV life cycle, which could lead to more effective and affordable therapies.
Researchers identified specific mutations that enable a common plant virus to infect new species, shedding light on the viral-host interface. The study's findings could inform strategies for breeding resistant crops and understanding animal disease emergence.
Researchers have proven that subneutralizing levels of dengue virus antibodies exacerbate the disease, contradicting the normal function of antibodies. This finding has major implications for developing a vaccine against dengue virus, which annually infects 50-100 million people worldwide.
A study found that HBV genotype C is independently associated with a higher risk of cirrhosis in community-based residents in Eastern China. Logistic regression models identified age, sex, and viral load as major risk factors for probable cirrhosis.
Researchers found that two Lactobacillus strains improved Helicobacter pylori-infected gastritis by exhibiting anti-bacterial and anti-inflammatory effects. The study suggests using probiotics as an alternative to antibiotics for treating H. pylori-associated diseases.
Scientists successfully produced plant-based monoclonal antibodies that effectively combat West Nile virus infections, rivaling their mammalian cell counterparts. The production technique holds promise for making life-saving treatments more affordable in resource-constrained regions.
A targeted preventive approach using Tamiflu and strict hand hygiene measures contained the outbreak of H1N1 influenza among 171 campers. The plan, developed by Dr. David Kimberlin and implemented in 2009, successfully prevented illness in all campers, including those at high risk.
Researchers at Arizona State University have developed a plant-based therapeutic that effectively combats West Nile virus infection. The treatment, derived from tobacco plants, neutralizes the virus by binding to its surface protein, offering a promising alternative to existing treatments.
A common plant virus attracts aphids by elevating the odor cue of infected plants without changing it. The insects transmit the disease efficiently despite leaving quickly, implying a persistent mode of transmission beyond agriculture.
Researchers at National Jewish Health have discovered how Listeria monocytogenes triggers an endogenous pathway that dampens the host's own immune response. The bacteria makes infected immune cells release interferon-αβ, which reduces immune resistance to infection and causes food poisoning. This finding highlights the crosstalk betwee...
A recent study published in the Journal of Experimental Medicine reveals that type I interferons are essential for combating Chikungunya virus infection. The unexpected finding is that fibroblasts, not immune cells, produce the virus-fighting proteins during infection.
Scientists have developed an experimental VLP vaccine that protects macaques and mice against chikungunya virus, a debilitating disease with no current treatment. The vaccine, using non-infectious virus-like particles, elicits immune responses and provides complete protection from infection.
Researchers at Scripps Research Institute have discovered a potential new way to stimulate the immune system to prevent or clear a viral infection by blocking a key protein in mouse immune systems. This approach may enhance the effectiveness of human vaccines designed to prevent viral infections.
The viral hemorrhagic septicemia virus (VHSV) has been detected in fish from Lake Superior, Paradise, and Skanee in Michigan, and St. Louis Bay and Superior Bay in Wisconsin. The presence of the virus in all Great Lakes poses a significant threat to New York's $1.4 billion annual sport-fishing industry.
A new study suggests that flu can increase susceptibility to secondary bacterial super-infections, which can lead to high mortality rates. The research found a lethal synergy between the influenza virus and Haemophilus influenzae, mediated by innate immunity, and highlights the need for early antiviral and antibiotic treatment.
Scientists tested 2009 and 1918 H1N1 virus strains on chickens and ducks without causing disease or symptoms. The results suggest that birds played no role in the spread of these pandemic viruses.
Researchers discovered that the Ebola virus uses a protein called VP35 to mask its RNA, evading the host cell's immune response. This unique mechanism makes Ebola highly deadly and difficult to treat.
A new study by UT Southwestern Medical Center suggests that appendicitis may be caused by undetermined viral infection or infections. The researchers evaluated data over a 36-year period and found seasonal variations and clustering of cases, supporting the theory that appendicitis may be a viral disease.
A phase II study found that adding ketoprofen to pegylated-interferon (PEG-IFN) with or without ribavirin improves viral kinetics and early activation of the IFNa signaling pathway. This combination therapy shows promise for treating genotype 1 chronic hepatitis C.
Research by Dr. L Veijola and colleagues suggests H. pylori infection may trigger autoimmune gastritis, a condition that requires lifelong vitamin B12 supplementation. The study confirms previous findings that serum markers of autoimmune gastritis appear in patients with H. pylori, highlighting the potential for eradication therapy to ...
Researchers found that a master regulatory protein called KAP1 orchestrates silencing of viral sequences, preventing harm to the host. The discovery provides insights into evolution and suggests potential new therapies for fighting AIDS.
Researchers at Emory University have developed the Prokopack mosquito aspirator, a low-cost, efficient tool for monitoring adult mosquitoes and the diseases they carry. The device outperforms current gold standards in field and lab tests, providing insights into mosquito ecology and behavior.
Researchers have developed an early warning system to defend rare Jersey cows against the spread of bluetongue disease. By analyzing meteorological data and midge activity, the team can predict when the disease-carrying midges are likely to reach the UK and Channel Islands.
Researchers have identified two cellular proteins that are important factors in hepatitis C virus infection. The natural compound Quercetin inhibits the synthesis of these proteins, significantly inhibiting viral infection in tissue culture. A Phase I clinical trial will be launched to determine if the compound is safe and effective.
Prions, infectious protein particles devoid of DNA, can develop mutations and adapt through natural selection, leading to drug resistance. The study suggests that normal prion proteins may be more effective therapeutic targets than their abnormal forms, offering new hope for treating deadly neurodegenerative diseases.
A study found a strong correlation between the presence of Streptococcus pneumoniae and increased risk for severe H1N1 pandemic influenza virus infections. The bacteria were present in most severe cases, with a 125-fold increased risk of severe disease among individuals aged 6-55.
A new study published in the New England Journal of Medicine found that young people under 18 are more susceptible to catching swine flu from an infected person in their household. However, the risk of transmission does not vary by age, with household contacts over 50 being the least likely to get infected.
A new study from the University of Pittsburgh suggests that short-term school closures can increase infection rates and prolong an epidemic. The research found that sustaining closures for at least eight weeks is crucial in decreasing the spread of infection.
Brazilian researchers have identified three distinct lung damage patterns and found that underlying medical conditions significantly contribute to fatal outcomes. The study highlights the importance of monitoring patients with pre-existing conditions, as they are at a higher risk of developing severe H1N1 infections.
A new compound, T-705, has been found to be effective and safe against H5N1 virus, a highly pathogenic bird flu virus, even three days after infection. The compound works by targeting the viral polymerase enzyme, making it a promising front-line drug for treating influenza.
Investigators at Burnham Institute for Medical Research identified 295 human cell factors that influenza A strains must harness to infect a cell. The team also found small molecule compounds that act on several of these factors and inhibit viral replication, pointing to new ways to treat flu.
Researchers discovered that a naturally occurring lung lipid, POPG, can prevent RSV infection and inhibit its spread. In cell-culture studies, POPG was shown to block RSV infection, while in mice, it reduced the infection rate by 1700 times.
A team of researchers has identified a human protein called IFITM3 that blocks the replication of H1N1 influenza virus and other viruses. The discovery could lead to the development of more effective antiviral drugs, including prophylactic drugs to slow influenza transmission.
Researchers have developed a comprehensive understanding of the interaction between H1N1 strains and human cells, revealing new targets for therapy and potential tools to speed vaccine production. The studies also identified key proteins involved in viral replication and host response.
Researchers at Berkeley Lab have identified a new genetic mutation in the H1N1 flu virus that enables it to replicate in humans. The SR polymorphism mutation enhances polymerase activity and potentially pathogenesis of the virus in humans.
Scripps Research scientists have determined the structure of the Ebola virus's critical protein VP35, which blocks the human immune system. The discovery may lead to new drug therapies and vaccines for Ebola infection.
Researchers at UC Davis have developed a fast and accurate urine test for pneumonia using nuclear magnetic resonance spectroscopy. The test identifies a unique chemical 'fingerprint' in the urine of patients infected with Streptococcus pneumoniae, distinguishing it from other types of pneumonia and noninfectious lung diseases.
A new study finds that West Nile virus can remain in the kidneys of infected individuals for years, potentially causing chronic symptoms and kidney failure. Researchers collected urine samples from patients with severe initial infections and detected viral RNA for at least six years following infection.
Researchers discovered that proteins locate genetic information in DNA by sliding down the double helix, like traveling along a screw. This finding validates a recent theory and could lead to new ways to alter DNA-binding protein behavior.
New research suggests that biodiversity loss and habitat destruction can increase the incidence and distribution of infectious diseases in humans. Studies show that extinction of plant and animal species can lead to a rise in new diseases, such as West Nile Virus, and even re-emergence of diseases thought to be in decline, like malaria.
A panel of MS experts provides comprehensive recommendations for selecting and managing patients with MS receiving TYSABRI. The guidelines emphasize the need to weigh treatment benefits against potential risks, including PML and serious adverse events.
Research in Taiwan found working after meals and H. pylori infection increase GCA risk, while healthy diet may reduce it. Healthy dietary habits and eradication of H. pylori are crucial for prevention.
Research suggests that only half of Americans with hepatitis C virus infection are aware of their diagnosis, leading to a decline in antiviral therapy treatment rates. By 2030, less than 15% of liver-related deaths from HCV will be prevented by antiviral therapy if the trend continues.
A study by Boston Children's Hospital reveals that respiratory syncytial virus (RSV) causes significantly more acute respiratory illnesses, ED visits, and hospitalizations among young children compared to seasonal flu. RSV-related illnesses lead to increased missed workdays for parents.
Yale researchers have discovered that a protein found in tick saliva helps protect mice from developing Lyme disease. The findings may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.