Research on viral diseases and the response to them. Covers Ebola and mpox, diagnostics, post-viral fatigue, and outbreak control strategies.
A study of residents found that 60% worked while sick at least once during the academic year, with 31% doing so more than once. Presenteeism can lead to exposure of patients and colleagues to communicable disease.
Researchers at Cardiff University cloned a human virus, Human Cytomegalovirus (HCMV), which is a major cause of congenital malformations and life-threatening disease in transplant patients. The cloning of HCMV has enabled the development of new treatments and vaccines against this virus.
The Centre for Geogenetics is a globally unique facility that bridges the natural sciences and humanities, offering new insights into human migration, climate change, and disease treatment. With its advanced techniques, it aims to calculate the future more accurately by understanding the past.
A study analyzed data from influenza cases in Wisconsin and found that children with 2009 H1N1 infections were not at higher risk for hospital admission or pneumonia compared to seasonal H1N1 or H3N2 infections. Adults also showed similar risks of serious outcomes, indicating lower severity of symptoms.
A blood test analyzing individual immune responses to infection shows promise for quickly diagnosing respiratory viral illnesses, including flu. The test boasts over 95% accuracy in pinpointing the cause of disease.
Research using satellite telemetry found that migrating birds have a short 'window' of 5-15 days when they can disperse the H5N1 virus over 500km. Asymptomatic infection is crucial, and individual birds must fly quickly and take shortest routes to spread the disease.
Scientists have trained mice to identify infected duck feces, which could lead to development of disease-detecting dogs and lab instruments. This breakthrough may enable early warning systems for influenza and other diseases.
A study published in Eurosurveillance found that nearly 60% of Norway's population had measurable immunity to the pandemic H1N1 virus by January 2010. Vaccination and infection contributed to this increased immunity, with herd immunity also playing a role.
A new study has found that the antiviral gene TRIM5 plays a crucial role in suppressing the transmission of primate immunodeficiency viruses, including HIV-1 and HIV-2. The researchers used rhesus macaques with different versions of the TRIM5 gene to demonstrate its ability to block cross-species transmission of SIVs.
Researchers developed novel antisense therapies that protected monkeys infected with deadly Ebola or Marburg viruses, with survival rates over 90%. The treatments were administered up to one hour after exposure and showed promise for treating accidental infections in laboratory or hospital settings.
Researchers are testing a new drug therapy, MGAWN1, to treat individuals with West Nile fever or suspected central nervous system infection. The treatment has the potential to neutralize the virus and reduce complications associated with the disease.
Researchers found that only a subset of pre-transplant HCV viruses can infect the new liver, with these viruses having mutations in their surface protein that evade the immune response. This discovery may lead to new ways to prevent reinfection after liver transplant.
Benjamin tenOever, a leading expert in microbiology and infectious diseases, has been awarded the 2010 ICAAC Young Investigator Award. His research focuses on understanding the cell's response to infection and developing novel strategies for vaccine and antiviral drug design.
A new tetravalent vaccine developed by NIAID is being tested in a Phase I human clinical trial to prevent dengue fever. The vaccine, which protects against all four dengue viruses, aims to provide efficient and cost-effective prevention against the mosquito-borne disease.
A new antiviral drug has shown significant promise in treating hepatitis C, particularly in patients with genotype 1, the most difficult to treat. Adding the drug nearly doubled the treatment's effectiveness when given for 48 weeks.
A recent study led by Daniel Streicker analyzed hundreds of rabies viruses from 23 North American bat species, providing estimates of cross-species transmission (CST) frequency. CST occurs only once for every 72.8 transmissions within the same species, with factors like geographic range and genetics influencing its likelihood.
A study published in Science reveals that molecular sequence data can be used to quantify cross-species transmission rates, with bats being the most common source of human infections. The analysis found that rabies viruses are more likely to jump between closely related bat species than distant ones.
A UT professor has made a groundbreaking discovery on how viruses jump from host to host. The study found that cross-species transmission may be driven more by host similarity than virus mutation and contact rates.
Researchers developed an alphavirus vector to overcome neutralizing antibodies and induce immune responses in humans with advanced cancer. Genetic mutations determined breast cancer subtype by influencing Rb gene expression.
Researchers found that blocking PD-1 improves survival in a model of severe infection by restoring the host's immune function. The study suggests new drugs to reduce severity of blood infections leading to sepsis.
Researchers found that viral infection of the heart is a predictor of heart transplant failure in young children and adolescents. The study suggests that rigorously screening transplant patients for viral DNA and RNA, and using intravenous immunoglobulin therapy, may improve organ survival.
A new study published in Gastroenterology highlights the risk of hepatitis B and C virus transmission through contaminated anesthesia. Reuse of syringes and medication vials without proper sterilization can lead to viral transmission, emphasizing the need for strict adherence to sterile techniques in healthcare settings.
Researchers found that depressive symptoms are commonly overlooked in routine clinical interviews for HCV patients, leading to compromised treatment outcomes. Studies also revealed higher healthcare benefit costs and lower productivity among HCV-infected workers.
The Journal of NeuroVirology will cover new areas in neurovirology, including non-viral infections affecting the central nervous system. Springer's acquisition will support the International Society for NeuroVirology and advance knowledge in the field.
A study estimated that nearly 5 percent of the Key West population was exposed to dengue virus in 2009. This finding raises concerns about the potential for a large-scale outbreak in the region.
A study by Emory University found that sewage overflows in urban creeks and streams increase the risk of West Nile virus transmission, particularly in lower-income neighborhoods. The analysis showed a seven times higher risk for residents near affected areas compared to other parts of the city.
A new virus has been identified as a potential cause of Heart and Skeletal Muscle Inflammation (HSMI) in farmed Atlantic salmon, threatening both farmed and wild populations. The study found the virus, related to reoviruses, in 24.2% of wild salmon samples and 96.5% of infected farmed fish.
Scientists at TWINCORE have developed a mouse-adapted version of the hepatitis C virus, allowing researchers to study its interaction with the immune system. This breakthrough enables the development of new vaccines and treatments for this chronic infection.
A new virus related to hepatitis C has been discovered in Asian bats, which may provide insights into the origins of the virus and its transmission to humans. The virus, identified as GBV-D, is found in the saliva of infected bats, suggesting a potential mechanism for transmission to other hosts.
A new study suggests that adding nutrients to the sea could lower viral infection rates among phytoplankton, enhancing the biological carbon pump. This process involves transferring carbon from the atmosphere to the deep ocean, potentially helping mitigate global warming.
Researchers found that preen oil gland secretions support a natural mechanism for AIV concentration, facilitating virus diffusion in nature. This discovery has important implications for avian influenza virus surveillance and prevention strategies.
Researchers found that a specific virus interacts with a mutation in the host's genes to trigger disease. In mice, exposure to a damaging chemical and infection with a viral strain caused symptoms similar to human Crohn's disease, suggesting viruses may be key to understanding complex diseases.
A randomized clinical study published in World Journal of Gastroenterology found that Viusid reduces lipid peroxidation products and has immunomodulatory effects on cytokine secretion. The study suggests Viusid as a potential strategy for treating patients with chronic hepatitis C who have failed previous antiviral treatment.
In a study of rhesus macaques, the experimental Marburg vaccine showed 100% protection when administered 24 hours after lethal exposure, and 66.7% survival rate when treated 48 hours post-infection. The vaccine works by activating the immune system to fight off the target virus.
A small genetic change in the IL28B gene can predict how well individuals with hepatitis C will respond to treatment. Those carrying this protective allele are more likely to clear the virus and respond to therapy.
Research reveals a mechanism for autoimmune disease that depends on killer T cells expressing dual receptors for normal proteins and pathogens. The study found that viruses lacking the specific protein can still trigger the disease, suggesting a complex interplay between viral infections and genetic predisposition.
Scientists have successfully prevented monkeys exposed to the deadly Ebola virus from dying of hemorrhagic fever using a genetic material-based treatment. The study suggests that such protection could also be possible in humans, offering new hope for combating the highly contagious and lethal disease.
A groundbreaking study has shown that a novel treatment using small interfering RNAs can protect monkeys from lethal Ebola virus infection after exposure. The treatment was found to be well-tolerated and offered complete protection in some cases, paving the way for further research and potential human trials.
Researchers have found a statistically significant association between enteroviral infection and diagnosis of type-1 diabetes in children, with 83% of patients testing positive for enteroviral DNA. The study suggests that different enterovirus types may represent a significant biomarker for early-stage juvenile diabetes.
Scientists have developed an immune-deficient mouse model to study CCHF virus behavior in humans, a significant step towards vaccine and antiviral development. The model can help evaluate the safety and effectiveness of potential treatments, addressing the lack of suitable animal models for testing.
Patients with chronic hepatitis C virus infection have a higher risk of developing hepatocellular carcinoma (HCC) if they experience increased insulin resistance, regardless of their presence of type 2 diabetes mellitus. Insulin resistance is associated with fibrosis progression and poor antiviral therapy responses in these patients.
Scientists at the Trudeau Institute have identified two crucial signals that enable virus-fighting T cells to migrate to the lungs, where they can fight future infections. This breakthrough could lead to the development of vaccines designed to promote respiratory immunity.
A new study reveals that the human immune system's defences against dengue fever can actually help the virus infect more cells. This finding could lead to the development of an effective vaccine by avoiding certain antibodies produced in response to the virus.
Anna Whitfield, a Kansas State University plant pathologist, will receive a $1 million CAREER Award to study how viruses affect insect vectors. Her research may shed light on viruses that infect vertebrate animals as well as plants.
Scientists from Freiburg and Berlin have unraveled the secret of the Mx protein, which plays a crucial role in inhibiting influenza virus replication. The Mx protein forms a ring-structured macromolecular network that restrains and deactivates viral components, providing a defense mechanism against new flu viruses.
Researchers found that vaccinated birds can shed vaccine virus to infect other birds, and live vaccines do not always protect against infection from other viral strains. The use of modified live virus vaccines may be increasing the diversity of Newcastle Disease viruses circulating in wild birds.
A new study found a link between chronic HBV and progression to cancers other than hepatocellular carcinoma, specifically Non-Hodgkin Lymphoma (NHL) and Cholangiocarcinoma. Higher levels of viral replication were associated with increased risk, indicating a potential causal effect.
A new study by the University of Edinburgh found that respiratory syncytial virus (RSV) claims the lives of up to 200,000 children globally each year. The research also showed that about 3.4 million children require hospital treatment for severe lung infection caused by RSV.
Researchers have isolated a portion of the adenovirus responsible for causing pink eye, finding that its protein coating is the key to inflammation in the eyes. This discovery offers new hope for developing a treatment for this highly contagious and common condition.
Up to 200,000 children under-5 each year could be dying due to RSV-accelerated acute lower-respiratory tract infections. The Lancet study finds that RSV is the most important viral pathogen causing these infections in young children.
A study analyzing blood samples from Singapore found significant variation in H1N1 infection risks among different age groups and military personnel. Younger individuals and those with household members who seroconverted had higher infection rates, emphasizing the need for tailored interventions.
A study found that the traditional 'heel stick' test is not an effective screening tool for cytomegalovirus (CMV) infection in newborns. The test, which involves pricking a baby's heel and analyzing dried blood samples, was unable to detect CMV DNA in up to 40% of infected babies.
A study found that DNA analysis of dried blood samples from newborns did not effectively identify an infection causing congenital CMV, leading to sensorineural hearing loss. Current methods for screening newborns for this infection have low sensitivity and specificity.
An experimental immune-boosting drug that increases type I interferon production hastens tuberculosis (TB) in mice. The treatment also draws more macrophages to the lungs, where TB bacteria thrive, leading to severe lung tissue damage and worsened disease outcomes.
Researchers at the University of North Carolina found that a common cancer drug can activate an Epstein-Barr virus infection, making cancer cells more susceptible to antiviral medications. This discovery may lead to new treatment strategies for EBV-related cancers.
Researchers at Whitehead Institute have created novel mouse models that accurately reflect the immune system's response to pathogens. The models use somatic cell nuclear transfer (SCNT) to create mice from single T cells primed for toxoplasmosis, allowing for a more precise study of the immune system.
Researchers at Henry Ford Hospital found that patients with hepatitis C infection were nearly twice as likely to develop kidney cancer as those without the disease. The study, published in Cancer Epidemiology, Biomarkers & Prevention, suggests a higher risk for younger HCV-positive patients.
A recent study reveals Toxoplasma gondii is prevalent among Iberian Lynx, with 81 of 129 sampled felids testing positive for antibodies. The parasite was also found in captive breeding centers, highlighting the need for prevention measures.
Researchers at the US Department of Agriculture's Animal Diseases Research Unit have discovered the viral life cycle of malignant catarrhal fever (MCF), a leading cause of disease in American bison. The virus undergoes several changes inside the animal's body, targeting specific cell types at different stages of its own life cycle.
Researchers at Michigan State University found a bacterium, Wolbachia, that can stop the dengue virus from replicating in mosquitoes, blocking disease transmission. The study provides new hope for controlling dengue fever, which affects 2.5 billion people worldwide.