Articles tagged with Viral Infections
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Researchers at EMBL and CNRS identified the key protein domain responsible for binding to host RNA molecules, allowing the virus to multiply. The PB2 cap-binding site is a promising target for designing mimics of the cap that would inhibit viral replication.
Research found that thalassemic patients had a higher prevalence of anti-HAV IgG antibodies than healthy controls. This is unexpected, as previous studies showed lower rates in thalassemics. The study recommends active immunization for transfused thalassemia patients to reduce liver infections.
Researchers found a significant association between anti-HBe antibodies and increased ALT levels among HBV-infected patients. Genotype D was the only type detected in different clinical forms of acute and chronic infections, with a higher prevalence of HBeAg-negative status among chronic hepatitis patients.
A new gastric juice PCR test has been evaluated as a highly specific and rapid method for detecting H. pylori infection in patients taking acid-reducing drugs. The study found that the test was more accurate than other methods for diagnosing the infection, which is associated with various gastrointestinal diseases.
Researchers at Ohio State University have discovered that specific structural parts of a viroid are responsible for its multiplication and spread in plants. The study's findings could lead to the development of genetic alterations to prevent viroid infection, with potential applications in human virus research.
Researchers have identified a common molecular disease pathway explaining how diverse non-infectious and infectious agents like anthrax, lung plague, SARS, and H5N1 avian influenza can cause severe lung failure with similar pathologies. Oxidative stress triggers the innate immune system, leading to severe lung damage.
Researchers have identified a tropical source for the influenza A virus, which infects North Americans each winter and causes an average of 36,000 deaths. The study found that two strains of the virus, H3N2 and H1N1, follow a distinct pattern in their seasonal emergence and evolution.
Researchers have developed a library of over 300 antibodies effective against H5N1 avian flu, offering potential treatment for infected individuals and a step towards a universal flu vaccine. The antibodies may also enable the design of vaccines with cross-subtype neutralizing activity.
A recent study published in PLOS Pathogens found that T cell proliferation is delayed by up to three days after infection, which may provide an evolutionary safeguard against autoimmune responses. This delay allows the immune system's front-line innate response to quickly control the infection before memory cell division takes place in...
The Nipah virus is a deadly brain and lung disease that spreads through contact with infected animals or contaminated food, particularly date palm sap and fruit bitten by bats. Researchers are working to identify transmission pathways and prevent further outbreaks.
Phytoplankton in major oceans produce half the world's oxygen through photosynthesis, while cyanobacteria are infected by viruses that provide genetic material for photosynthesis machinery. This symbiotic relationship highlights the essential role of viruses in planetary processes and global cooling.
Researchers develop materials impregnated with bacteria-killing viruses to prevent MRSA infection spread in hospitals. The technique allows the viruses to stay active for over 3 weeks, killing bacteria on surfaces and in wounds.
A new microarray chip can detect up to 300 different viruses infecting farm animals, birds, and insects. The chip has already been successfully used to identify a coronavirus and foot-and-mouth disease virus.
A team of researchers from the University of Leeds has identified a critical weakness in Human Papillomavirus (HPV) that may lead to new treatments for cervical cancer. The E7 protein helps HPV evade the immune system, but it also makes infected cells vulnerable to attack by Natural Killer cells.
A study on Salmonella Enteritidis infection reveals its complex life cycle in the internal organs of mice, with high concentrations found in liver and spleen. The bacteria can persist for up to 12 days in the gallbladder, a previously unknown site of carriage.
Researchers found evidence of canine influenza virus circulation in the greyhound population dating back to 1999. The discovery sheds light on a potential earlier introduction of the virus, which may have caused respiratory outbreaks at racing tracks.
A study found that about 60% of people with severe West Nile infection continue to experience symptoms years after infection. Most recovery takes place within two years following infection.
Researchers found that antibiotics offer little benefit for patients with acute rhinosinusitis-like complaints. The study suggests that doctors should not prescribe antibiotics to adults with rhinosinusitis symptoms lasting longer than 7-10 days, as there is no clear subgroup of patients who would benefit from treatment.
Research using ERIC-PCR method found that aerobe and facultative aerobes, such as Escherichia coli and Salmonella, become prominent in ducklings' intestines after S. enteritidis infection. The study aims to understand the pathogenesis of S. enteritidis infection.
Researchers have achieved images of a virus in detail two times greater than previously achieved using single-particle electron cryomicroscopy. This breakthrough provides valuable information for developing disease treatments and allows for the study of tiny biological machines found throughout our bodies.
Researchers from UT Knoxville have made a groundbreaking discovery about memory B cells, which are crucial for fighting off influenza infections. By analyzing where these cells reside after an infection, scientists can develop more effective vaccines that target specific strains and subtypes of the flu virus.
Researchers developed artificial cell-like particles made of biodegradable material that can target specific diseases or infections. The new method enhances T cell activation by up to 45 times, addressing limitations of previous immunotherapy procedures.
A combination vaccine using virus-like particles (VLPs) provides complete protection against Ebola and Marburg viruses in monkeys. This innovative approach has the potential to offer broad-based immunity and is considered a leading candidate for use as a filovirus vaccine in humans.
New analysis suggests SARS originated in bats, not palm civet cats as previously thought. The study reveals humans were the source of the virus found in those animals, contrary to earlier findings.
The researchers have developed the first animal model of the chikungunya virus infection, which allows them to study the pathophysiology of the disease. The mouse model reveals that young age and inefficient type-I interferon signaling are risk factors for severe disease.
Researchers discovered two mutations in the H1N1 avian flu virus's hemagglutinin molecule enable it to bind tightly to human upper respiratory tract receptors. This binding affinity is crucial for viral transmission and explains why certain strains are more infectious than others.
A new study finds that women with higher levels of perceived stress are more likely to have an impaired immune response to HPV16, increasing their risk of developing cervical cancer. Most HPV infections in healthy women will disappear spontaneously over time.
The Uukuniemi virus structure reveals how bunyaviruses infect host cells by changing shape in acidic environments, a mechanism shared with influenza and dengue viruses. The discovery may aid in developing drugs for treating hemorrhagic fever and encephalitis.
The study provides a global analysis of human proteins interacting with viral and bacterial proteins, revealing possible intervention points for future therapeutics. Pathogens preferentially target high-impact human proteins called hubs and bottlenecks, which are involved in cancer pathways.
Researchers at UNC School of Public Health found that noroviruses mutate genetically, similar to the flu virus. This discovery suggests a vaccine may be possible to prevent norovirus infections.
Researchers at Virginia Tech are developing a treatment for prostate cancer using the Newcastle Disease virus. The virus targets specific proteases secreted by cancer cells, generating apoptosis and killing diseased cells. This is a promising new approach to fighting cancer.
A collaborative study found that fake anti-malarial drugs, containing potentially toxic ingredients, were manufactured in China. The counterfeiters included dangerously small amounts of artesunate to fool screening tests, but these doses are too low to treat malaria effectively, encouraging the spread of resistant parasites.
A new arenavirus has been discovered in three transplant recipients who died in Victoria, Australia in April 2007. The virus was identified through rapid sequencing technology and subsequent characterization, revealing a strain sufficiently different from existing screening methods.
Researchers found that lower transmission rates increase dengue deaths by reducing the development of immunity to new strains during a critical cross-immunity period. This allows the virus to gain entry into cells and cause more severe infections.
Researchers identified children under 2 years old with very low lymphocyte levels as at high risk for severe RSV infection. The study found that 28% of infected children developed lower respiratory tract infections, with a mortality rate of 8.6%.
Researchers found that the M2 protein's motion and structure change when treated with amantadine, blocking the flu virus from infecting healthy cells. The study provides insight into developing alternative antiviral drugs for resistant flu strains.
Researchers at Queen's University have found a way to manipulate the immune system by introducing virus components that activate killer T cells. This discovery may lead to more effective vaccines against diseases like influenza or HIV, as well as enhanced immunology treatments.
Research at Umea University in Sweden has shown that hantavirus exists in human saliva, sparking concerns about its potential spread among humans. The study found virus RNA in saliva samples from 10 out of 14 patients with nephropathia epidemica during last year's epidemic.
Researchers at the University of Pittsburgh Cancer Institute have identified a novel virus strongly associated with Merkel cell carcinoma, a rare but deadly skin cancer. The Merkel cell polyomavirus (MCV) was discovered using a novel sequencing technique and has similarities to human papillomavirus (HPV).
A study compared ligase detection reaction (LDR) and real-time PCR methods for detecting low abundant YMDD mutations in hepatitis B patients. LDR was found to be more sensitive than real-time PCR, but the latter was faster and less expensive.
A study found that Salmonella enteritidis primarily penetrates the jejunum and ileum of the gastrointestinal tract after oral challenge. The bacteria can persist in these regions for up to 18 weeks, raising questions about its potential as an opportunistic pathogen in humans.
A study of 136 Bulgarian patients with HCV found that 76.5% had extra-hepatic manifestations, with common symptoms including fatigue, renal impairment, and paresthesia. The risk of developing B-cell lymphoma was higher in cryoglobulin-positive patients.
New research published in Proceedings of the National Academy of Sciences finds that community ecology principles affect parasite species interacting within a single host, impacting treatment effectiveness. The study suggests using ecological thinking to understand and control multiple infections like malaria.
Researchers at the University of Rochester Medical Center have found a way to selectively block the ability of white blood cells to migrate toward sites of injury and infection, which drives disease. This discovery suggests a new approach for treating autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis.
Nucleonics has initiated a Phase 1 human safety study of its experimental treatment NUC B1000, an expressed interfering RNA-based product designed to target and destroy HBV within infected cells. The therapy aims to reduce viral antigen load and potentially resolve viral infection in patients with mild to moderate disease.
Dengue fever, a mosquito-borne illness, is becoming increasingly prevalent along the U.S.-Mexico border and in Puerto Rico. The NIAID experts warn that widespread dengue cases in the continental US are a real possibility due to the lack of effective treatments or vaccines.
Scientists have found that avian flu viruses must bind to umbrella-shaped alpha 2-6 glycan receptors to infect humans. This new interpretation explains inconsistencies in previous models and could aid in the development of vaccines against a deadly flu pandemic.
Researchers have identified a key factor that determines influenza virus ability to infect human upper respiratory tract cells. The H5N1 avian flu virus must adapt to bind to specific sugar molecules coating the cells of our noses and throats.
A new report emphasizes the importance of good hand hygiene in preventing the spread of infections, including colds, flu, and stomach bugs. By washing hands regularly and using alcohol-based hand sanitizers, individuals can reduce the risk of transmission and protect themselves and others from harm.
Researchers at Washington University School of Medicine have identified a blood-borne immune system compound that suppresses antibody-dependent enhancement (ADE) of infection, a phenomenon linked to some viral disease outbreaks. C1q, a key immune compound, blocks ADE by blocking the virus' ability to hijack antibodies.
Researchers found that avian polyomaviruses spread through an 'upwards vertical' route, from offspring to parents via nestling faeces, highlighting a previously unnoticed cost of parental care. This study may open new research agendas on the evolution of virulence and coevolution of vectors, viruses, and hosts in the wild.
Researchers at Scripps Research Institute have developed two new tests that can identify lethal prion strains quickly and accurately. The tests, the Standard Scrapie Cell Assay and the Cell Panel Assay, significantly accelerate prion research by producing results in under two weeks.
Researchers found that treating patients with psychiatric disorders for hepatitis C yields a sustained viral response without increased risk of side effects. The study suggests using a multidisciplinary team and anti-depressant agents can lessen depressive reactions during treatment.
A new aerosol launches an immune response in the lungs to wipe out lethal infections, including bacterial and fungal infections. The treatment showed an 83% survival rate against pneumococcal pneumonia in mice treated with the aerosol before exposure.
A Chikungunya virus outbreak in Italy emphasizes the need for preparedness and response to emerging infectious threats as globalisation increases. The disease was fairly mild in nearly all cases, with only one reported death.
Researchers found that eltrombopag boosted platelet counts in a majority of patients with low platelet counts and cirrhosis due to HCV infection, allowing most to continue or start conventional antiviral treatment. The study's results are an important development for people infected with the hepatitis C virus worldwide.
New study reveals that alcohol and tobacco use do not increase the risk of head and neck cancers in people infected with HPV16, a common strain of the sexually-transmitted virus. The findings suggest two distinct causes for these major cancers, requiring different prevention and treatment strategies.
Scientists at Columbia University's Mailman School of Public Health used MassTag PCR to detect a new human rhinovirus as the cause of severe pediatric respiratory tract infections in Europe. Human rhinoviruses are frequent causes of respiratory illness worldwide, and this discovery confirms earlier findings in New York.
A recent study published by the University of Texas Medical Branch at Galveston found that bites from uninfected mosquitoes can make West Nile virus worse in lab mice. The research showed a significant increase in mortality rates when mice were exposed to multiple mosquito feedings before being infected with West Nile virus.
Researchers from Baylor College of Medicine found that viral infections like poliovirus target a protein called G3BP, which helps cells respond to stress. This disruption prevents the virus from being translated into proteins and killing the cells.