Articles tagged with Yellow Fever
The yellow fever virus, transmitted by Aedes aegypti mosquitoes, is a significant public health threat to the Americas. The recent resurgence of YFV in Africa and Asia, combined with vaccine shortages, highlights the need for urgent measures to prevent infection and control its spread.
Scientists at Saint Louis University are studying an investigational vaccine for yellow fever, a potentially deadly disease spread by the same mosquito that transmits Zika virus. The vaccine aims to provide protection to vulnerable groups who are at increased risk of complications if they receive the current vaccine.
A global health emergency is looming due to the rapid spread and potential future outbreaks of yellow fever, say Georgetown University professors. The ongoing epidemic, particularly in Angola, has led to a significant shortage of vaccines and calls for an urgent international response.
Researchers have developed a new trap to monitor and control Aedes aegypti mosquitoes, the primary transmitters of Zika, dengue, chikungunya, and yellow fever. The plastic ovitrap infused with pyriproxyfen has been shown to be 100% effective in preventing larvae from developing into adults.
Researchers have determined that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. This knowledge could help identify an earlier clinical outcome measure of disease severity, enabling doctors to provide more aggressive supportive care for patients.
Researchers have discovered that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. A new clinical parameter has been identified, which could help manage cases of yellow fever, allowing for earlier diagnosis and treatment.
Researchers found that a genetic tweak in yellow fever mosquitoes makes them more sensitive to human odor, particularly sulcatone, allowing them to target humans. This discovery provides insight into the evolution of mosquito behavior and could help develop new ways to prevent their bites.
A team of scientists has developed a chromosome map for about half of the genome of Aedes agypti mosquito, which transmits dengue fever and yellow fever. The study reveals striking contrasts between this mosquito and Anopheles gambiae, the malaria vector, that may help prevent diseases by manipulating sex ratios.
Researchers estimate that mass vaccination campaigns have reduced yellow fever cases and deaths across Africa by 27%. The campaigns have led to a substantial decrease in the disease's burden, with higher reductions in some countries targeted by vaccination efforts.
Scientists at Emory Vaccine Center identified a key immune cell response to yellow fever vaccine that involves the gene GCN2, which regulates autophagy in cells. This finding could lead to more effective vaccines against challenging viruses like HIV or dengue.
A systematic review assesses the reliability of global mapping of infectious diseases, finding that only a small percentage have been mapped reliably. The study suggests using novel solutions like crowdsourcing to gather data, such as analyzing Twitter messages about disease.
Yellow fever swept through Savannah, Georgia in 1854, killing almost half of the 650 people who died, with 293 being Irish immigrants. The disease primarily affected adults and those without prior exposure, highlighting a green bias in mortality rates.
Researchers found that mosquitoes are attracted first to carbon dioxide, then to skin odors, which could lead to more effective mosquito traps. The study's findings provide crucial insights into how female mosquitoes locate human hosts for diseases like malaria and yellow fever.
Researchers at UCR identified three classes of volatile odor molecules that can impair or completely disrupt mosquitoes' carbon dioxide detection machinery. The findings offer powerful advantages as potential tools for reducing mosquito-human contact and could lead to the development of new generations of insect repellents and lures.
Scientists at Emory Vaccine Center developed nanoparticles that mimic viruses to induce lifelong immunity in mice. The particles, made of biodegradable polymers, activate two different parts of the innate immune system and can be used with material from various bacteria or viruses.
A case report published in Canadian Medical Association Journal details the probable transmission of a vaccine strain of yellow fever virus from an infected mother to her infant through breastfeeding. This supports current recommendations for lactating mothers to avoid vaccination with yellow fever vaccine.
A study by Argentine scientists reveals that yellow fever outbreaks in howler monkey populations in northeastern Argentina have tragic conservation implications for the endangered brown howler monkey. The research emphasizes the importance of wildlife monitoring as an early detection method for pathogens affecting both animals and humans.
A multidisciplinary approach predicts the immunity of a vaccine based on gene expression patterns and T cell responses. The study successfully predicted immunity in up to 90% accuracy using the yellow fever vaccine as a model.
Researchers found that female mosquitoes are attracted to water containers with specific fatty acids and methyl esters from bacteria, which stimulate them to lay eggs. The study aims to use this knowledge to devise lures and traps to control yellow fever mosquito populations, preventing global diseases like dengue fever.
Researchers at the University of Arizona have discovered a complex metabolic pathway in mosquito species, which they aim to disrupt with a harmless molecule. This could lead to an insecticide that kills both mosquitoes and their eggs, slowing the spread of diseases like malaria and yellow fever.
The Rockefeller Foundation has denied rumours of abandoning its public health commitments, with President Judith Rodin assuring the global health community of continued support. The foundation's long-standing funding has contributed significantly to the development of vaccines and public health education initiatives.
Researchers have identified a specific region on the yellow fever virus protein that elicits an immune response, which could help improve existing vaccines and reduce severe side effects. The study found that antibodies produced by the immune system interact with this part of the protein to fight off infection.
Researchers have developed a chemical that discourages the landing and feeding of Aedes aegypti mosquitoes, which transmit yellow fever. The discovery provides new hope for combating the deadly disease.
A new study published in the Journal of Agricultural and Food Chemistry found that cinnamon oil is effective in killing mosquito larvae, with four compounds exhibiting strong activity against the yellow fever mosquito. The study suggests that cinnamon oil could be a good mosquito repellant, although further testing is needed.
Researchers warn that live flavivirus vaccines can recombine, resulting in new microbes with undesirable properties. The use of these vaccines requires international approval due to safety concerns, including increased virulence, disease development in compromised individuals, and birth defects.
Researchers are cloning mosquito genes to understand the hormone-controlled mechanism of diuresis, a fast process by which mosquitoes excrete waste. This study aims to develop new, selective insecticides targeting the hormone receptor, potentially controlling vector-borne diseases like dengue fever.
Researchers discover transgenic mosquitoes are severely impaired in development and reproduction, laying fewer eggs and having lower egg-adult survivorship. This finding has major implications for the competitiveness of transgenic mosquitoes against non-engineered wild-types.
A recent yellow fever outbreak in Guinea highlights insufficient international stocks of the 17D yellow fever vaccine, which can protect for at least 10 years. WHO recommends an emergency stockpile of 1 million doses to provide a rapid response to large outbreaks.
Two fatal cases of haemorrhagic fever associated with yellow fever 17DD substrain vaccine were reported in Brazil, highlighting the need to review the vaccine's safety. The cases led Philippe Marianneau and colleagues from Institut Pasteur to emphasize the importance of investigating mechanisms of attenuation of yellow-fever virus.