Articles tagged with Human Immunodeficiency Virus
Timothy Ray Brown, the first person cured of HIV, continues to advocate for research funding and education on the impact of an HIV cure. Despite disappointment over decreased public desire for a cure, he remains optimistic that a functional cure can be achieved with proper funding.
A new study published in PLOS Medicine provides a more accurate representation of site- and regional-level mortality among people on HIV therapy in Zambia. The research found that mortality is substantially underreported in routine provincial program data, leading to a change in the ranking of provinces by mortality rates.
Conflict-induced displacement of people in eastern Ukraine has been shown to drive the spread of HIV within the country. The largest exporters of viral lineages were regions of Donetsk and Lugansk, which then spread to central and southern regions, as well as cities like Kyiv and Odessa.
A study published in PNAS found that conflict in Ukraine has increased the risk of HIV outbreaks due to displaced people moving from war-affected regions to areas with higher risk of transmission. The research suggests that harm reduction services should be scaled up and international support provided to prevent further transmission.
A new study provides a model for accurately measuring HIV mortality rates in Zambia, which is crucial for improving treatment outcomes. The study found that mortality is substantially underreported in routine data, with some provinces showing mortality rates up to 23-fold higher than reported.
A study by Dr. Jonathon Rendina and Dr. Jeffrey Parsons found that 70% of HIV-positive and 36% of HIV-negative men perceive the 'Undetectable = Untransmittable' message as accurate, with rates increasing since earlier studies. Regular testing and PrEP use are associated with higher accuracy perceptions.
Researchers found that short-term treatment interruptions do not lead to permanent expansion of the HIV reservoir or irreversible immune damage. Upon resuming ART, participants' immune systems returned to normal levels.
A recent study published in Nature Communications presents a proof-of-concept for an oral, once-weekly drug delivery platform for HIV antiretroviral therapy. The platform demonstrates sustained oral delivery of potent anti-HIV therapies, offering a potential solution to non-adherence issues.
Researchers developed a long-acting compound that targets HIV's replication, suppressing the virus and protecting immune cells. The compound works synergistically with current treatments, enhancing their potency and potentially improving treatment for 37 million people worldwide affected by HIV.
A randomized controlled trial found nearly doubling of STI testing in a group using internet-accessed testing compared to face-to-face appointments. E-STI testing should be considered as a complement to existing services, increasing uptake and treatment rates.
Researchers found that team-based care with medication titration by a nonphysician clinician and physician leads to significant reductions in systolic blood pressure. Multilevel strategies without team-based care also show promise, reducing systolic blood pressure by 5 mm Hg.
Researchers found that FDA-approved anti-inflammatory medications tofacitinib and ruxolitinib can block HIV production from infected cells, prevent transmission to bystander cells, and decay the viral reservoir. The study suggests using Jak inhibitors as a potential treatment for HIV-infected individuals to control the virus.
A study suggests that age 25 would be the most beneficial age for a one-time screening HIV test of the general population, improving rates of HIV diagnosis and overall health outcomes. However, youth at high risk should be tested more frequently.
A Drexel University study suggests that if a quarter of high-risk men use daily PrEP, 3 out of every 10 HIV infections could be prevented. The study also found that when all preventive strategies were combined, they resulted in the prevention of 72.2% of infections.
A Michigan State University study suggests that THC in marijuana can reduce inflammatory white blood cells and decrease proteins released by the body, potentially slowing down mental decline in HIV patients. The researchers found that patients who used marijuana had lower levels of inflammatory cells compared to those who didn't use it.
Researchers analyzed monkey brains infected with SIV on antiretroviral therapy and found persistent lymphocyte-dominant inflammation, suggesting underlying cognitive problems. The study suggests that adjunctive immunomodulatory therapies may be useful in patients with HIV-associated neurocognitive disorders.
A randomized clinical trial found no benefit for a therapeutic HIV vaccine in suppressing viral infection, but provided valuable insights for future cure efforts. Four people in the placebo group exhibited spontaneous HIV suppression, exceeding expected rates among the general population.
A research team from St. Michael's Hospital is conducting a nationwide survey to identify the sources of HIV discrimination in Canada, with the goal of reducing and eliminating it. The study aims to promote changes in policy, healthcare, and individual awareness to improve the lives of people living with HIV.
Researchers at Boston Children's Hospital are developing new models to test HIV vaccines, enabling the rapid evolution of human antibodies in mice. This approach could lead to a protective version of broadly-neutralizing antibodies in uninfected individuals through preventative immunization.
A new dual-purpose drug delivery device, SCHIELD, aims to provide long-acting contraception and HIV prevention for women in low- and middle-income countries. The device, set to be launched in Kenya and South Africa, has the potential to improve health outcomes and empower women.
Researchers at Stellenbosch University found that HIV affects the brain in early stages of infection, leading to decreased blood flow and brain functional impairment. The study used fMRI scans to compare brain activity of people with and without HIV, revealing a link between frontal lobe atrophy and cognitive symptoms.
Recent studies present promising methods for early HIV identification and treatment, including self-testing and expanding antiretroviral therapy eligibility. Researchers also explore curing HIV using stem cell transplantation and discuss the ongoing growth of the Russian HIV epidemic.
Researchers have found a mechanism that prevents the formation of HIV's protein shell, which is essential for infection. The discovery could lead to the development of new anti-HIV drugs by targeting specific molecular processes.
A new study reveals that HIV drug resistance is on the rise, particularly among individuals in low- to middle-income countries, where 11.1% of those starting therapy have resistant virus strains. The research highlights the importance of improving monitoring and response strategies to combat this growing threat.
A recent study has found that a cancer drug called nivolumab can drastically decrease the reservoirs of HIV-infected cells in the body, a key step towards potentially eradicating the virus. This breakthrough has been observed in a single patient with lung cancer, who showed a sustained reduction in HIV reservoirs after treatment.
A combination of proven HIV prevention measures significantly reduced new HIV infections in a Ugandan district. The strategy includes voluntary medical male circumcision and HIV-suppressing antiretroviral therapy.
A US-funded global effort to curb HIV infection in high-risk populations appears to be working, with a 42% decline in new HIV infections. Male circumcision was shown to have a direct risk-lowering effect, while antiretroviral therapy increased the likelihood of viral suppression.
A new report by ECDC and WHO reveals that over half of HIV diagnoses in Europe occur at a late stage, leading to poorer health outcomes and increased transmission risks. Early diagnosis is crucial to prevent these outcomes, with improved testing practices and community-based services vital to addressing the issue.
A study published in PLOS Medicine found that starting antiretroviral therapy (ART) immediately following an HIV diagnosis dramatically improves retention in clinical HIV care. Patients who were eligible for ART at diagnosis were 25 percentage points more likely to start therapy and 18 percentage points more likely to remain in care at...
A large cohort study found that patients with low-level viremia are at increased risk of treatment failure and developing virological failure. Clinical interventions should take place at lower viral loads than current WHO guidelines to prevent poor outcomes.
The new guidelines, published in CMAJ, endorse pre-exposure prophylaxis (PrEP) and non-occupational post-exposure prophylaxis (nPEP) as highly effective strategies to prevent HIV infection. These biomedical interventions should be used alongside behavioral interventions like condoms and risk reduction counseling.
Low rates of routine HIV testing were reported in emergency departments and acute medical units in the UK and US, with operational and patient-specific factors hindering uptake. The study identifies providers' fears about offering HIV testing as a major barrier, stemming from perceived lack of knowledge about HIV.
A new study reveals barriers to routine HIV testing in emergency departments and acute medical units in the UK and US. The analysis found that operational and patient-specific factors hindered HIV testing coverage, while commitment from medical staff and local specialist providers facilitated its offer.
A new study suggests that a second HIV test can substantially reduce incorrect diagnoses in infants, saving costs on unnecessary treatment. The study found that confirmatory testing reduces the number of infants incorrectly diagnosed with HIV by 99.6%, leading to cost savings over a lifetime.
HIV-infected patients have a lower rate of cholesterol-lowering statin drugs and aspirin therapy, while antihypertensive medication therapy shows less significant differences. The study calls for improving the quality of cardiovascular care for people with HIV.
Adults with treated HIV experience cognitive decline and smaller brain volumes, but effective therapy may halt progression. Brain changes were observed even after two years of treatment, highlighting the importance of monitoring viral suppression in HIV patients.
Researchers have decoded the molecular process of HIV's cell spreading mechanism, a crucial step in understanding how the virus replicates itself. The findings offer new avenues for developing drugs to combat the virus.
A recent study published in PLOS Medicine reveals that HIV patients are at a higher risk of both chronic kidney disease and cardiovascular disease. The research found that nearly 11% of patients experienced both conditions within one year of each other.
A new category of immunotherapies called checkpoint inhibitors shows promise in treating cancers in HIV patients, who were previously excluded from clinical trials. The ongoing study suggests that these drugs can be safely used to manage cancer in people with HIV, providing a new hope for this population.
A new study from the University at Buffalo found that transgender women, African-Americans, and Hispanics are more likely to receive HIV testing than trans men, whites, or those with stable housing. The research aimed to identify barriers to HIV testing in urban transgender individuals.
The Transwomen Connected app aims to cater to the physical, mental and emotional needs of transgender women. The project will build a mobile app with HIV prevention tools and resources tailored specifically with their needs in mind.
A University of Maryland-led study developed a vaccine candidate that stimulates an immune response against the protective sugars of multiple HIV strains. The molecule mimics a protein-sugar part of the shield and spurs rabbits to produce antibodies, but does not prevent live HIV from infecting cells.
A comprehensive review by Australian researchers found that 15.6 million people have recently injected drugs, with 18% living with HIV infection and 52% testing positive for hepatitis C antibody. The authors highlight the need to scale up interventions for people who inject drugs to prevent the spread of blood-borne viruses.
Researchers identified specific immune memory T-cells as the site where HIV hides to evade detection, revealing a key target for future therapies. This discovery provides new insights into the chronic illness and offers potential avenues for developing a cure.
A systematic review and meta-analysis found that injured patients in LMICs are disproportionately HIV-seropositive compared to matched national estimates. These patients also face a significantly increased risk of death, especially when HIV-seronegative.
Scientists have developed a new strategy to reengineer patient immune system cells to fight HIV. The approach shows benefit in human cell cultures and mice, with T cells expressing the enhanced CAR protein being over 50 times more effective than those with the original CAR.
Researchers aim to reduce comorbid illness in people living with HIV by developing personalized prebiotic and probiotic therapies, targeting gut bacteria balance. The study seeks to attenuate metabolic health issues associated with harmful alcohol use and heart disease.
A GW School of Medicine researcher is leading a five-year study on how cocaine affects HIV replication and transcription. The goal is to identify biomarkers for cocaine use and develop therapeutics for cocaine-using HIV-infected individuals.
Researchers have developed a synthetic molecule, SUW133, that awakens dormant HIV cells and then knocks them out. The technique, called 'kick and kill,' could lower the viral reservoir enough for people with HIV to discontinue their anti-viral therapy.
A study examining HIV virulence and its effect on the human immune system found that both CD4+ T cell decline and per-pathogen pathogenicity are heritable from donor to recipient. Heritability rates revealed a significant 17% impact, indicating that viral genotype plays a crucial role in infection severity.
Researchers from Kumamoto University developed a compound that suppresses viral budding, confining the virus within host cells and leading to cell death through apoptosis. This approach aims to eradicate latent HIV reservoirs, which are key to complete recovery from AIDS.
Researchers are developing a medication adherence intervention to improve antiretroviral therapy coverage among released Indonesian prisoners. The intervention, adapted from an existing program, aims to increase treatment uptake and reduce HIV-related mortality in the country's prison population. With Indonesia's high HIV infection rat...
A new study from the University of Pennsylvania School of Nursing explores the contextual social and structural factors that drive disparate HIV/AIDS rates. The study found nuanced differences by gender and race/ethnicity in modes of transmission profiles across different geographic locations.
A recent ECDC study found that the rate of newly reported HIV cases increased by 2% each year among older adults between 2004 and 2015. This translates to around 17% of new diagnoses being among people aged over 50, accounting for 5076 reported cases.
Researchers will systematically identify resources that successful patients use to overcome HIV challenges, developing a novel public health measure called resilience. The goal is to design interventions to increase suppressed HIV viral load among patients.
A European study found that nearly one in six new HIV diagnoses in Europe are among people aged 50 or older. Older adults were more likely to be diagnosed with advanced HIV disease and acquire the virus through heterosexual contact. The study calls for increased awareness, targeted testing, and prevention programs for this age group.
Scientists at NIH and Sanofi created a trispecific antibody that protects monkeys from two strains of SHIV, a monkey form of HIV. The antibody stops more strains from infecting cells than individual natural antibodies, showing promise for long-acting prevention and treatment.
Researchers found that a combination of two broadly-neutralizing HIV-1 antibodies protected primates against infection with a mixed population of HIV viruses. The findings suggest that combination therapies might be essential to prevent HIV in people, highlighting the need for regimens that protect against several targets.
Lesotho achieves high viral load suppression rates, while Uganda's previously expanding epidemic stabilizes due to circumcision and treatment expansions. New US strategy aims to accelerate progress in high-burden countries by 2020
Researchers at the University of Montreal Hospital Research Centre have discovered a molecule that stimulates HIV replication in CD4 T cells located in the gut. By targeting this molecule, medications can significantly reduce HIV replication in undetectable patients, potentially leading to a functional cure.