Research on HIV epidemiology and control. Covers prevention policy, HIV-substance use links, TB co-treatment, and clearing infection in newborns.
A computer model developed by Johns Hopkins predicts that strengthening HIV care, including retention in care and increased testing, can avert 752,000 new infections and 276,000 AIDS deaths over 20 years. Enhanced interventions could reduce incidence by 54% and mortality by 64% at a cost-effectiveness ratio of $45,300 per QALY.
The University of Pittsburgh Graduate School of Public Health is launching a study to promote health among aging gay and bisexual men living with HIV. The research team will identify protective factors, or resiliencies, that help some men stay healthy and could be extended to others.
A new study by Dr. Susitha Wanigaratne found that pregnant refugee women in Ontario had a higher prevalence of HIV than immigrants and Canadian-born women, with rates eight times higher for refugees than immigrants and 17 times higher than Canadian-born women. The study suggests that recent changes to Canadian immigration policy may ha...
A new experimental treatment regimen combining a drug delivery system and URMC-099 has been shown to effectively combat HIV, reducing the need for daily medication. The nanoformulated protease inhibitor and URMC-099 prolonged therapeutic effects by increasing drug concentration in immune cells.
A new method allows patients to get effective treatment quickly with improved sensitivity and speed. The system operates directly on the virus' RNA rather than requiring extra steps, enabling faster detection of drug-resistant strains.
Researchers found that low-income Virginians with HIV who enrolled in Affordable Care Act healthcare plans had better virologic suppression rates (85.5%) compared to those receiving care under the state's AIDS Drug Assistance Program (ADAP) (78.7%). Patients enrolling earlier in ACA insurance also tended to have better health outcomes.
Researchers have discovered three immune system biomarkers - PD-1, Tim-3 and Lag-3 - that can predict when the HIV virus will rebound after treatment interruption. These biomarkers are associated with 'exhausted' T-cells prior to patients commencing ART.
A study by the University of Virginia found that low-income HIV patients enrolled in Affordable Care Act (ACA) health plans achieved higher viral suppression rates compared to those receiving only medications through direct AIDS Drug Assistance Program (ADAP). This approach allows the state to cover more patients in a cost-effective wa...
Research reveals that certain vaginal bacteria species can trap HIV particles, while others allow them to diffuse freely. The study suggests that altering a woman's vaginal microbiota could improve protection against STIs by increasing the barrier properties of cervicovaginal mucus.
The American College of Physicians recommends against routine pelvic exams for asymptomatic adult women due to low diagnostic accuracy. In contrast, the American College of Obstetrics and Gynecology maintains that annual exams are necessary for recognizing issues like incontinence and sexual dysfunction.
A UC Riverside-led study found a high prevalence of HPV infection among Peruvian men who have sex with men (MSM), highlighting the need for targeted HPV vaccine delivery. The study suggests that HPV vaccine can be a useful tool in preventing chronic infection and related cancers among sexually experienced individuals.
A primary care-based program has been shown to lower patients' substance dependence and encourage treatment engagement. The program's success was attributed to medication-assisted treatment, such as buprenorphine, and addressing underlying depression.
A new bi-specific antibody, DART, has been developed to bind HIV-infected cells to the immune system's killer T cells, potentially clearing HIV infection. The molecule was engineered using HIV-targeting antibodies and showed early promise in pre-clinical models.
University of Missouri researchers have discovered that Interferon Induced Transmembranes (IFITM) proteins can inhibit the transmission of HIV-1, the most common HIV strain. The study found that IFITM proteins specifically interact with the HIV-1 envelope glycoprotein and block its maturation, reducing viral infectivity and transmission.
Researchers argue that single therapies are unlikely to achieve long-term HIV remission, and propose a data-driven approach to combination therapy trials. The proposed method involves parallel animal and human studies, with combinations selected based on in vitro and existing data, accelerating the research process.
A study published in mBio found that children with cerebral malaria have an accumulation of white blood cells and platelets in the brain, which is more severe in HIV-positive children. This discovery may lead to better treatment algorithms for CM.
A clinical trial of romidepsin, an HDAC inhibitor, found that it can reverse HIV latency in individuals on long-term antiretroviral therapy. The treatment did not negatively affect T-cell function, and increased plasma HIV-1 RNA was detectable in five of six participants.
Researchers at Yale University have created a new process for synthesizing an organic compound that inhibits HIV. The approach uses aromatic nitrogen heterocycles to streamline the synthesis, reducing time and increasing efficiency.
A team of researchers has identified ERManI as a key protein that prevents HIV-1 replication, providing a potential natural defense against the disease. The discovery could lead to the development of new antiretroviral treatments and promote HIV resistance by increasing ERManI levels.
The Healthy Young Men's Study aims to improve HIV care and prevention among Black, Latino, and multiracial gay and bisexual young men. The 5-year study will investigate the use of new technologies and biomedical interventions to prevent new HIV infections in highly impacted communities.
Researchers Ivona Pandrea and Cristian Apetrei are investigating the relation between accelerated aging characteristics linked to HIV infection and non-AIDS comorbidities. They aim to develop treatments tackling these processes, aiming to improve quality of life for people on HIV medications.
Researchers find PCMH costs per physician FTE were $7,691 in Utah and $9,658 in Colorado. Family physicians with high HIV experience are more likely to adhere to antiretroviral therapy protocols. Adequate compensation is critical for practices to sustain medical home services.
Researchers at Caltech have identified a broadly neutralizing antibody that can recognize HIV's envelope spike in different conformations, making it easier to detect and neutralize the virus. This discovery could lead to the development of combination therapies to fight HIV, which is currently evolving rapidly.
Researchers have found a new strategy to eliminate HIV by reactivating latent infected cells using a class of drugs called Smac mimetics. The approach, which has shown promising results in clinical trials for cancer, may lead to a safe and effective treatment to cure the virus.
A community-based prospective study in Blantyre, Malawi found that HIV self-testing (HIVST) was widely accepted and accurate, with 94.6% of participants reporting high satisfaction. The study also showed that HIVST led to a low incidence of partner violence and suicides, and agreed with repeat HTC results in 99.4% of cases.
A simplified 'Test and Treat' intervention was associated with increased engagement in HIV/AIDS care and a 62% reduction in mortality among participants. The program improved diagnosis, linkage to care, and treatment outcomes, with a significant increase in pre-ART CD4 testing and ART initiation.
A study published in AIDS and Behavior found that the D.C. needle exchange program prevented 70% of newly diagnosed HIV cases and saved an estimated $44 million over two years by reducing the need for costly treatment. The program also provided access to health services, including HIV testing and addiction treatment.
A study found that RWHAP-funded facilities provided more comprehensive services, including case management and mental health support, compared to non-funded facilities. Despite this, nearly 75% of patients at RWHAP-funded facilities achieved viral suppression, while some subgroups benefited from these services.
The Third Coast Center for AIDS Research aims to slow and stop HIV in young gay men, a demographic group experiencing rising infections at 5% annually. The center will unite HIV researchers from different disciplines and provide services through five cores.
Researchers found that HIV's cell-to-cell transmission is the primary mechanism for massive CD4 T cell death, leading to the progression from HIV to AIDS. Disrupting this transmission effectively stopped cell death.
Research reveals HIV testing trends among adults aged 50-64 are not sustaining gains after CDC's 2006 recommendation. Testing rates remain low at around 3.7% despite risk behaviors remaining constant, underscoring the importance of patient advocacy for older adults
Participants in an agricultural intervention showed improved HIV outcomes, including increased CD4 cell counts and viral suppression rates. The program addressed food insecurity, poverty, and empowerment, demonstrating a potential solution to combat the intertwined issues of HIV/AIDS and food insecurity.
A new study suggests Ontario is close to meeting United Nations targets to end the AIDS epidemic by 2020. The study found that 87.3% of people in Ontario with HIV were receiving care, and 76% had a suppressed viral load. However, there are still gaps in healthcare access for younger adults, especially gay men and those with substance u...
Researchers constructed an atomic model of an immature retrovirus, revealing key structural features and a six-helix bundle domain that may be a target for blocking the virus. This breakthrough could lead to the development of new anti-retroviral drugs.
A recent study found that HIV virus can persist and continue to grow in patients receiving uninterrupted treatment for up to 14 years. This persistence occurs due to the virus's ability to hide inside blood cells responsible for immune response, copy itself, and automatically incorporate its genetic information into DNA.
UC Davis researchers have identified a compound, PEP005, that activates latent HIV and increases activation by up to 15-fold when combined with JQ1. This breakthrough offers promising hope for an HIV cure. The study's findings suggest that PEP005 is already approved by the FDA and has great potential to advance into clinical studies.
The amfAR report identifies key indicators and recommendations for policymakers and community stakeholders to improve HIV prevention and care outcomes in states. The report urges states to target resources to key populations, remove barriers to access, and modernize laws related to HIV exposure.
Researchers have found two combination treatments that effectively reactivated latent HIV in cells, providing novel opportunities for advancing HIV eradication strategies. Ingenol-3-angelate and PEP005, combined with JQ1, showed a 7.5-fold increase in viral reactivation compared to PEP005 alone.
The improved survival rate of HIV patients in sub-Saharan Africa facilitates the study of cardiovascular disease in these patients. Studies have shown that highly active antiretroviral treatment is associated with a 50% reduction in HIV-related cardiomyopathy, and researchers now have access to a population with both HIV and cardiovasc...
A UTHealth researcher has been awarded a grant to analyze the genetic and social network aspects of HIV transmission clusters. The study, led by Dr. Kayo Fujimoto, will compare social clustering by venue to common viral strains of HIV infection.
Canada has eliminated mother-to-child HIV transmission by ensuring all pregnant women are screened for HIV and receive treatment. Regular combination antiretroviral therapy (cART) is nearly 100% effective in preventing transmission when given during pregnancy.
A clinical study found that young, single black women in South Africa and men who have sex with men (MSM) and transgender women (TGW) in the US and Thailand adhered to a daily pill regimen for HIV prevention. The study suggests that daily PrEP dosing is an effective strategy for this population.
Dr. Fauci emphasizes the need for targeted deployment of proven prevention methods to high-transmission areas, while also reviewing effective interventions such as ART, PrEP, and treatments that prevent mother-to-child HIV transmission.
Researchers at University of California, San Diego School of Medicine have developed a novel treatment regimen that effectively treats hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus type 1 (HIV), with a 97% success rate
A Phase III trial found that conditional cash transfers for school attendance had no effect on reducing HIV incidence among high-school aged women in South Africa. However, these women reported fewer risk behaviors, such as fewer sex partners and less unprotected sex.
New research finds that HIV treatment for illicit drug users promotes improved health, socio-economic stability, and quality of life. Consistent ART treatment reduces homelessness and involvement in activities like sex work or street-based income generation.
Researchers discovered HIV exploits regulatory process between BST2 and ILT7 to limit antiviral response, allowing virus to spread and persist in long-lasting reservoirs. Blocking Vpu's action could prevent early viral expansion and dissemination, enabling pDCs to trigger effective antiviral responses.
A sociologist has revealed significant traces of HIV in Montreal's urban landscape, including public spaces like Park of Hope and the Chapel of Hope. These urban vestiges reflect the history and presence of the gay community and the fight against AIDS.
Researchers at the University of Missouri captured detailed images of the capsid protein in its natural state, revealing ordered water molecules that help stabilize the complex scaffold. This discovery aims to inform the development of new and more effective antiviral drugs.
The ASPIRE Phase III trial tested the safety and effectiveness of a vaginal ring containing dapivirine for preventing HIV in women. The study found that women who used the ring experienced reduced risk of HIV infection, paving the way for potential long-acting protection against the disease.
A study in Botswana found that each additional year of secondary school lowers the risk of HIV infection by 8 percentage points, particularly for women. The research suggests that secondary schooling could be a cost-effective way to reduce HIV transmission and has large benefits beyond HIV prevention.
In a commentary published in The New England Journal of Medicine, two experts argue that lifting federal funding bans for needle exchange programs is crucial to protect the health of injection drug users. Needle exchanges can significantly reduce HIV transmission by providing clean needles and promoting opioid replacement therapies.
The report highlights the urgent need to scale up AIDS efforts, get serious about HIV prevention, and continue expanding access to treatment in countries most affected by HIV. The Commission recommends increasing resources for HIV prevention, treatment, and research, as well as robust governance and accountability.
Researchers found that elite HIV controllers' dendritic cells are better able to detect and respond to HIV, producing higher levels of immune-boosting proteins. This unique ability allows them to generate powerful T-cell responses against the virus, which may help others control or even cure HIV without treatment.
A study found that dendritic cells in elite HIV controllers can detect early signs of HIV infection and trigger a powerful immune response. This ability helps to control the virus, suggesting new avenues for preventative or therapeutic interventions.
Research suggests that gay and bisexual men in homophobic countries are less likely to know about HIV, use condoms, but face a higher potential risk of infection as technology increases access to sexual contact
Researchers at Duke University Medical Center identified an antibody response that confers protection against HIV transmission from infected mothers. The study found a strong antibody response to the HIV envelope third variable loop, which was previously considered inadequate for protection.
A new study published in AIDS found that homophobia reduces the use of HIV prevention services and compromises health service quality among gay and bisexual men. Men living in homophobic countries are also at a heightened risk of disease, despite limited access to prevention services.
Virologists discovered that a small section of the envelope protein, located on its 'tail', is required for it to be sorted into viral particles. This finding could help researchers design more effective vaccines and target HIV with antiviral drugs.
A new study at the University of Maryland found that online hookup sites like Craigslist increase HIV infection rates in Florida, with African Americans accounting for 63% of new cases. The study also found that wealthier individuals and women were more susceptible to HIV transmission through online platforms.