Articles tagged with Human Immunodeficiency Virus
The Third Coast Center for AIDS Research aims to slow and stop HIV in young gay men, a demographic group experiencing rising infections at 5% annually. The center will unite HIV researchers from different disciplines and provide services through five cores.
Researchers found that HIV's cell-to-cell transmission is the primary mechanism for massive CD4 T cell death, leading to the progression from HIV to AIDS. Disrupting this transmission effectively stopped cell death.
Research reveals HIV testing trends among adults aged 50-64 are not sustaining gains after CDC's 2006 recommendation. Testing rates remain low at around 3.7% despite risk behaviors remaining constant, underscoring the importance of patient advocacy for older adults
Participants in an agricultural intervention showed improved HIV outcomes, including increased CD4 cell counts and viral suppression rates. The program addressed food insecurity, poverty, and empowerment, demonstrating a potential solution to combat the intertwined issues of HIV/AIDS and food insecurity.
A new study suggests Ontario is close to meeting United Nations targets to end the AIDS epidemic by 2020. The study found that 87.3% of people in Ontario with HIV were receiving care, and 76% had a suppressed viral load. However, there are still gaps in healthcare access for younger adults, especially gay men and those with substance u...
Researchers constructed an atomic model of an immature retrovirus, revealing key structural features and a six-helix bundle domain that may be a target for blocking the virus. This breakthrough could lead to the development of new anti-retroviral drugs.
A recent study found that HIV virus can persist and continue to grow in patients receiving uninterrupted treatment for up to 14 years. This persistence occurs due to the virus's ability to hide inside blood cells responsible for immune response, copy itself, and automatically incorporate its genetic information into DNA.
UC Davis researchers have identified a compound, PEP005, that activates latent HIV and increases activation by up to 15-fold when combined with JQ1. This breakthrough offers promising hope for an HIV cure. The study's findings suggest that PEP005 is already approved by the FDA and has great potential to advance into clinical studies.
The amfAR report identifies key indicators and recommendations for policymakers and community stakeholders to improve HIV prevention and care outcomes in states. The report urges states to target resources to key populations, remove barriers to access, and modernize laws related to HIV exposure.
Researchers have found two combination treatments that effectively reactivated latent HIV in cells, providing novel opportunities for advancing HIV eradication strategies. Ingenol-3-angelate and PEP005, combined with JQ1, showed a 7.5-fold increase in viral reactivation compared to PEP005 alone.
The improved survival rate of HIV patients in sub-Saharan Africa facilitates the study of cardiovascular disease in these patients. Studies have shown that highly active antiretroviral treatment is associated with a 50% reduction in HIV-related cardiomyopathy, and researchers now have access to a population with both HIV and cardiovasc...
A UTHealth researcher has been awarded a grant to analyze the genetic and social network aspects of HIV transmission clusters. The study, led by Dr. Kayo Fujimoto, will compare social clustering by venue to common viral strains of HIV infection.
Canada has eliminated mother-to-child HIV transmission by ensuring all pregnant women are screened for HIV and receive treatment. Regular combination antiretroviral therapy (cART) is nearly 100% effective in preventing transmission when given during pregnancy.
Researchers at University of California, San Diego School of Medicine have developed a novel treatment regimen that effectively treats hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus type 1 (HIV), with a 97% success rate
A Phase III trial found that conditional cash transfers for school attendance had no effect on reducing HIV incidence among high-school aged women in South Africa. However, these women reported fewer risk behaviors, such as fewer sex partners and less unprotected sex.
New research finds that HIV treatment for illicit drug users promotes improved health, socio-economic stability, and quality of life. Consistent ART treatment reduces homelessness and involvement in activities like sex work or street-based income generation.
A clinical study found that young, single black women in South Africa and men who have sex with men (MSM) and transgender women (TGW) in the US and Thailand adhered to a daily pill regimen for HIV prevention. The study suggests that daily PrEP dosing is an effective strategy for this population.
Dr. Fauci emphasizes the need for targeted deployment of proven prevention methods to high-transmission areas, while also reviewing effective interventions such as ART, PrEP, and treatments that prevent mother-to-child HIV transmission.
Researchers discovered HIV exploits regulatory process between BST2 and ILT7 to limit antiviral response, allowing virus to spread and persist in long-lasting reservoirs. Blocking Vpu's action could prevent early viral expansion and dissemination, enabling pDCs to trigger effective antiviral responses.
A sociologist has revealed significant traces of HIV in Montreal's urban landscape, including public spaces like Park of Hope and the Chapel of Hope. These urban vestiges reflect the history and presence of the gay community and the fight against AIDS.
Researchers at the University of Missouri captured detailed images of the capsid protein in its natural state, revealing ordered water molecules that help stabilize the complex scaffold. This discovery aims to inform the development of new and more effective antiviral drugs.
The ASPIRE Phase III trial tested the safety and effectiveness of a vaginal ring containing dapivirine for preventing HIV in women. The study found that women who used the ring experienced reduced risk of HIV infection, paving the way for potential long-acting protection against the disease.
A study in Botswana found that each additional year of secondary school lowers the risk of HIV infection by 8 percentage points, particularly for women. The research suggests that secondary schooling could be a cost-effective way to reduce HIV transmission and has large benefits beyond HIV prevention.
In a commentary published in The New England Journal of Medicine, two experts argue that lifting federal funding bans for needle exchange programs is crucial to protect the health of injection drug users. Needle exchanges can significantly reduce HIV transmission by providing clean needles and promoting opioid replacement therapies.
The report highlights the urgent need to scale up AIDS efforts, get serious about HIV prevention, and continue expanding access to treatment in countries most affected by HIV. The Commission recommends increasing resources for HIV prevention, treatment, and research, as well as robust governance and accountability.
Researchers found that elite HIV controllers' dendritic cells are better able to detect and respond to HIV, producing higher levels of immune-boosting proteins. This unique ability allows them to generate powerful T-cell responses against the virus, which may help others control or even cure HIV without treatment.
A study found that dendritic cells in elite HIV controllers can detect early signs of HIV infection and trigger a powerful immune response. This ability helps to control the virus, suggesting new avenues for preventative or therapeutic interventions.
Research suggests that gay and bisexual men in homophobic countries are less likely to know about HIV, use condoms, but face a higher potential risk of infection as technology increases access to sexual contact
Researchers at Duke University Medical Center identified an antibody response that confers protection against HIV transmission from infected mothers. The study found a strong antibody response to the HIV envelope third variable loop, which was previously considered inadequate for protection.
A new study published in AIDS found that homophobia reduces the use of HIV prevention services and compromises health service quality among gay and bisexual men. Men living in homophobic countries are also at a heightened risk of disease, despite limited access to prevention services.
Virologists discovered that a small section of the envelope protein, located on its 'tail', is required for it to be sorted into viral particles. This finding could help researchers design more effective vaccines and target HIV with antiviral drugs.
A new study at the University of Maryland found that online hookup sites like Craigslist increase HIV infection rates in Florida, with African Americans accounting for 63% of new cases. The study also found that wealthier individuals and women were more susceptible to HIV transmission through online platforms.
Scientists discovered the switch that turns on the immune cell's abundant sugar and nutrient pipeline, then blocked it with an experimental compound, starving HIV to death. The approach also slows the proliferation of abnormal immune cells, reducing inflammation and potentially reducing organ damage.
Research finds that socioeconomic status and race/ethnicity are key drivers of HIV seroconversion among young men who have sex with men. Younger age at sexual debut is also associated with a greater likelihood of HIV seroconversion.
Researchers at Vanderbilt University have redesigned an antibody using a computer program, increasing its potency and ability to neutralize multiple strains of HIV. The study suggests that computer-redesigned antibodies may speed the search for an effective therapy or vaccine against HIV.
HIV reservoirs are persistent cells that harbor the virus, making it difficult to achieve a cure; current therapeutic strategies focus on eliminating or controlling the virus without daily ART.
A microclinic intervention significantly reduced disengagement from care by half and decreased stigma by 25% among rural Kenyan HIV patients. By mobilizing social networks, these clinics provided crucial support to patients, ultimately improving retention in care.
A study found that microclinics significantly reduced the rate of HIV patient disengagement from care by half and decreased perceived stigma within communities. Microclinics mobilized rural Kenyan patients' informal social networks to support their staying in care.
A study published in the American Journal of Transplantation found that there are nearly 400 HIV-positive potential organ donors in the US who could provide life-saving organs for HIV-positive patients. The study estimates that these donors could reduce the waiting time for transplants, but the quality of their organs is a concern.
A new study suggests a diabetes drug may prevent cardiovascular problems in HIV-positive adults by reducing inflammation linked to heart disease and stroke. The drug, sitagliptin, improved metabolism and reduced inflammation in HIV patients taking antiretroviral therapy.
A study explores the quality of organs from HIV-positive donors for potential transplant use in the US, finding that donor kidneys may be of reduced quality. The study suggests nearly 400 potential organ donors might be available annually, but long-term viability and hepatitis C virus infection could impact organ health.
Research from the University of Southampton reveals that male HIV patients in rural South Africa reach low immunity levels required for antiretroviral treatment in less than a year, while women take up to three years. The study suggests that nutritional status and use of supplements may contribute to faster disease progression.
Scholars at Columbia University's Mailman School of Public Health explore the implications of fear-based campaigns in public health, highlighting successes and failures. While fear-based campaigns have been effective in reducing smoking rates, they may be counterproductive for HIV prevention, stigmatizing affected populations.
Research from the University of Southampton found that South African women under 26 years old with more equitable gender views were more likely to have used a condom. This suggests that communication between partners and addressing gender norms are crucial for safer sex, particularly among HIV-positive young women.
A new study has identified a temporary, but potentially troublesome unintended consequence of male circumcision: an increased risk of infecting female sexual partners while the wound heals. The study found that nearly 30% of HIV-positive men were shedding the virus two weeks after surgery, compared to less than 10% before circumcision.
A study found that wound healing and lower plasma viral loads are associated with less HIV shedding from male circumcision wounds. The likelihood of viral shedding increases initially but decreases as wounds heal.
A vaccine targeting the viral protein Tat shows promise in boosting an HIV-infected patient's immune system, increasing CD4+ T cell count and reducing latent virus DNA load. The results suggest a new treatment scenario to investigate intensified antiretroviral therapy with a vaccine.
Researchers from Oak Crest Institute of Science have developed a matchstick-sized subdermal implant that delivers potent antiretroviral drugs for up to 40 days, showing promise in stopping the spread of HIV. The implant eliminates adherence issues, a critical factor in HIV prevention.
Researchers found that people tend to seek information on HIV-related topics at the beginning of the week and engage in risky behaviors on weekends. Implementing interventions based on these patterns could lead to better outcomes, including improved ART adherence and increased testing.
The District of Columbia Center for AIDS Research (DC CFAR) will provide significant pilot award funding opportunities and mentorship through its Developmental Core, promoting scientific research in DC on HIV cure and prevention. With this grant, the DC CFAR joins ranks of leading research institutions as a full CFAR.
The District of Columbia Center for AIDS Research brings together six institutions to combat the HIV epidemic in Washington D.C. Georgetown University Medical Center plays a key role, with its Women's Interagency HIV Study and clinical and population sciences core providing critical services.
The daclatasvir-sofosbuvir combination was highly effective and well-tolerated in treating hepatitis C virus (HCV) patients with HIV co-infection. Across genotypes 1-4, the treatment resulted in a sustained virologic response rate of 97% at 12 weeks post-treatment.
A new study at The International Liver Congress 2015 reveals that sofosbuvir-based regimens are effective and well-tolerated in hepatitis C and HIV co-infected, cirrhotic patients. Sustained virologic response was observed in 98% of patients at 4 weeks and 95% at 12 weeks.
Researchers at Yale University found that men with HIV infection are more sensitive to the effects of alcohol than uninfected men. On average, HIV-infected individuals get a buzz from imbibing just a quarter less of a drink than others.
Researchers have been focusing on long-term solutions, but Levy argues that new approaches are needed to prevent infection and disease. He highlights six questions that deserve more attention, including the role of innate immune response, CD8+ T cells, and strategies for an HIV vaccine and cure.
Researchers found that the human immune system can control re-awakened HIV with a vaccine-based approach, reducing virus levels to 50 copies per ml within six weeks. This study demonstrates the potential of a 'kick and kill' strategy, which could lead to an effective cure for HIV.
Researchers found a potent antibody, 3BNC117, can dramatically reduce viral loads in HIV-infected individuals by catching the virus off guard. The treatment was well-tolerated and effective, with some individuals experiencing sustained reductions in viral loads.
A single infusion of the experimental 3BNC117 antibody significantly reduced HIV levels in infected individuals, with some remaining sensitive to the antibody for up to 28 days. The study's findings suggest that 3BNC117 is safe and potentially effective in controlling HIV levels.
A new study simulates Cabo Verde's public health using a computer model to predict the spread of disease and the efficacy of interventions. The results suggest that accelerating four efforts already underway across the country could reduce annual new HIV cases below 10 per 10,000 residents.
Researchers found a small group of mutations account for most cases of transmission-related resistance to HIV drugs. The study suggests levels of transmission of drug-resistant strains have not increased globally as much as feared, but adherence challenges persist in lower-income countries.