Research on pregnancy and the health of mothers and babies. Covers prenatal exposures, medication safety, anaemia, fetal development, and maternal care.
A malaria drug combination could counteract the negative effects of malnutrition on the female digestive tract, leading to improved birth outcomes. The research used a human organ chip model to demonstrate the potential benefits of this treatment.
A new study published in PLOS Medicine found no association between assisted reproductive technologies and body mass index in children, except when using frozen embryos. The study analyzed data from Denmark and other countries, providing insights into the health outcomes of children born through assisted reproductive technologies.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
Researchers at Texas A&M University found that it takes over a month for negative alcohol effects to wear off, and fathers' sperm are still negatively impacted by drinking even during the withdrawal process. The study suggests that men should abstain from alcohol at least three months prior to conceiving.
Researchers will compare two healthcare delivery models focusing on early detection and control of postpartum hypertension and social/mental health factors. The study aims to improve birth outcomes for women and children in underserved communities through a patient-centered approach.
Participating in baby massage has been linked to lower rates of postnatal depression and improved parent-child interactions. A systematic review found that mother-led infant massage can have a positive impact on maternal mental health and relationships.
A recent study published in JAMA Network Open analyzed data from 10,000 US adolescents and found a significant increase in e-cigarette use during late pregnancy. However, the study revealed no statistically significant association between e-cigarette use and an increased risk of small-for-gestational-age birth among adolescents.
A Cambridge-led study discovered the cause of pregnancy sickness, attributing it to a hormone produced by the fetus called GDF15. The severity of nausea and vomiting depends on the amount of GDF15 produced and the mother's sensitivity to it. Building up tolerance to GDF15 before pregnancy may prevent sickness.
A new study finds that a hormone produced by the fetus and a mother's sensitivity to it are the causes behind nausea and vomiting during pregnancy. Lowering GDF15 levels or pre-exposing women to the hormone may mitigate symptoms, providing potential ways to prevent extreme forms of pregnancy sickness.
A multicenter observational cohort study found that cannabis exposure was associated with a higher risk of small-for-gestational-age birth, medically indicated preterm birth, stillbirth, and hypertensive disorders of pregnancy. The risk was particularly pronounced among those who continued to use cannabis beyond the first trimester.
Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not show a reduction in composite neonatal adverse outcomes. The study suggests that the effect of reducing large-for-gestational-age infant risk after adding metformin to insulin warrants further investigation.
A new study found no increased risk of major congenital malformations in infants exposed to second-line non-insulin antidiabetic medications during pregnancy compared to those treated with insulin. The study examined over 3.5 million pregnancies and provided reassurance on the safety of these medications for fetuses.
Embryos with morphologically non-good-quality blastocytes and those from women aged ≥ 35 years showed lower rates of implantation, clinical pregnancy, ongoing pregnancy, and live births after blastocyst shrinkage. Post-warming blastocyst shrinkage adversely affects ART outcomes.
New research reveals that early life gene epimutations in the BRCA1 gene may increase the risk of triple-negative breast cancer (TNBC). The study found that these epimutations occurred twice as often in girls than boys and were associated with a higher risk of TNBC, particularly in women who experienced pregnancy-related changes.
Women who have had a C-section may face difficulties conceiving due to reduced fertility and increased risk of labor complications. The study found that women with fertility problems also had more C-sections.
A study found that patients with hormone receptor-positive breast cancer who paused endocrine therapy to conceive did not experience worse short-term recurrence rates. Cryopreserved embryo transfer was associated with higher pregnancy rates, and younger age and menstrual cycles returning after pausing therapy were linked to improved ou...
A retrospective cohort study of 4,732 BRCA carriers found that pregnancy following breast cancer was not associated with decreased disease-free survival. 1 in 5 patients conceived within 10 years after diagnosis.
A NIH-funded study found associations between maternal prenatal inflammation and children's attention, anxiety, depression, and aggression. The research used the Child Behavior Checklist to measure aggressive behavior, anxiety/depression, and attention problems in 4,595 participants aged 6-18 years.
A pregnant patient with severe vasospastic angina successfully carried a healthy baby to full term after starting treatment with calcium channel blockers. The case highlights the importance of careful diagnosis and treatment, which can alleviate symptoms and prevent complications.
A new study found that the Protecting Life in Global Health Assistance policy reduced provision and use of contraceptives, as well as community health volunteer services, in African countries. This policy, formerly known as the Mexico City Policy, had detrimental effects on family planning service delivery and utilization.
A study published in PLOS Medicine found that 90% of pregnant women in high-income countries lack key vitamins necessary for healthy pregnancies and fetal development. The situation is expected to worsen as more people adopt plant-based diets, leading to increased risk of nutrient deficiencies.
A new study from the University of Wisconsin-Madison found that individuals born in dry counties due to Prohibition-era laws lived longer, with an average additional lifespan of approximately 1.7 years. This increase in longevity is equivalent to nearly 15% of the overall life expectancy improvements for those born between 1900-1930.
Women who underwent bariatric surgery had lower pregnancy weight gain compared to controls with similar early pregnancy characteristics. The study found no difference in weight gain based on surgical procedure or surgery-to-conception interval, but suggested a potential benefit for women with shorter intervals.
A recent study found that nearly all pregnant women have low levels of essential vitamins and minerals, with some developing deficiencies in late pregnancy. Supplementing with over-the-counter multivitamins significantly reduced nutrient deficiencies before and during pregnancy.
Researchers discovered how biological information travels between mothers and babies during pregnancy. Microscopic extracellular vesicles, produced by placental cells, act as a protective mechanism transporting important biological information to emerging neurons.
Researchers now have access to a large amount of diet information collected from over 33,000 pregnancies and 31,000 children. This de-identified data, available through the National Institute of Child Health and Human Development's DASH Hub, will help answer important questions about nutrition and child health.
Research highlights association between maternal depressive symptoms and reduced fetal growth during critical rapid growth stage before delivery. Early screening for depressive disorders in pregnant women may be crucial for promoting healthy fetal development.
In a significant breakthrough, research revealed that macrophages 'eat' pancreatic beta cells to regulate insulin levels after pregnancy. This process helps maintain normal blood glucose levels.
Researchers found that prenatal vitamins provided short-term benefits, while postnatal vitamins offered sustained impacts on breast milk B-12 adequacy. Both types of supplements supported healthy growth and development in infants.
A study published in Science Advances found that abnormal cell stress in the placenta's syncytiotrophoblast layer may lead to preeclampsia. Researchers also developed a mouse model to demonstrate the effects of this stress, showing similar signs of high blood pressure and kidney damage.
Researchers at Gladstone Institutes have identified cells and molecules that go awry in the developing hearts of fetuses in women with diabetes, leading to higher levels of retinoic acid activity. The study could eventually lead to interventions to lower heart malformations risk in babies born to women with diabetes.
Researchers discovered that women carrying Group B Streptococcus bacteria are up to three times more likely to have newborns admitted to neonatal units. The team developed an ultrasensitive PCR test to detect the bacteria, suggesting a 'cytokine storm' may be behind increased risk of disease.
Regular aerobic exercise can help prevent and treat postpartum depression. Moderate-intensity exercises performed three to four times a week are particularly effective in reducing symptoms of the condition.
A study found that nearly one-third of US family medicine residents are training in states with abortion restrictions, highlighting the impact on reproductive health care. The analysis suggests that increased support for comprehensive reproductive health education is needed to mitigate this effect.
A new Stanford University study found that COVID-19 vaccination during pregnancy lowered the risk of preterm birth. The research analyzed natality data from California and found a significant reduction in preterm births among vaccinated mothers compared to unvaccinated ones.
A large Kaiser Permanente study found a connection between prenatal cannabis use and increased risk of low birthweight and neonatal intensive care unit (NICU) admission. The study analyzed over 360,000 mothers and infants and found a dose-response relationship between cannabis use and infant health risks.
A new study found that COVID-19 caused a significant spike in premature births, but vaccines played a crucial role in reducing the risk of preterm birth to pre-pandemic levels. The research analyzed California birth records and found that maternal COVID infection increased the risk of preterm births by 1.2 percentage points.
The Global Centre for Asian Women’s Health found that a Mediterranean diet rich in fruits, nuts, whole grains, and healthy fats can reduce the risk of gestational hypertension and preterm birth. The study also linked narrowing of retinal arterioles before conception to reduced fetal growth during pregnancy.
During pregnancy, distinct pools of stem cells in the adult brain are activated, giving rise to specific types of olfactory bulb neurons that enable mothers to recognize their own pups. These new neurons are temporarily formed and disappear after birth, highlighting the brain's ability to adapt to specific needs.
A Canadian study found that infants exposed to biologic agents during pregnancy have normal immune development and can safely receive the rotavirus vaccine. The study, involving 191 infants across six sites in Canada, aimed to change vaccination guidelines to protect more babies from severe illness.
A study of 768 married Japanese women found that postponing pregnancy during the COVID-19 pandemic was associated with increased loneliness and psychological distress. The associations were strongest in 2021, highlighting the need for improved mental healthcare systems.
A study of 452 Black pregnant patients found that 62% reported depression in combination with anxiety or stress. Prenatal screening for mental health concerns is necessary to address these co-occurring issues.
A new NIH study reveals a substantial increase in overdose mortality among pregnant and postpartum women, with the largest spike observed among those aged 35 to 44. The study highlights significant barriers, including stigma and limited socioeconomic resources, that hinder access to care.
A study from the University of Illinois found a correlation between high obesity levels at hospitals and increased C-section rates in Mexico. The researchers analyzed patient data from 226 public hospitals across Mexico, finding that hospitals with higher obesity rates were more likely to perform C-sections.
Research found that women experiencing high levels of anxiety, depression, or stress during pregnancy had children with increased symptoms of attention deficit hyperactivity disorder (ADHD) and aggressive behavior. The study suggests providing mental health care and support during pregnancy can help prevent childhood behavior problems.
A meta-analysis of 57 studies found that prenatal cannabis exposure is associated with an increased risk of preterm delivery, low birth weight, and neonatal intensive care unit (NICU) admission. However, it does not appear to increase the risk of birth defects or death within one year.
Two systematic reviews and meta-analyses found that delaying umbilical cord clamping by at least two minutes can reduce the risk of death in premature babies. The studies included over 10,000 babies from 60 studies and showed a significant reduction in mortality rates for deferred clamping compared to immediate clamping.
Two COVID-19 studies on Singapore mothers and children found vaccination during pregnancy reduces newborn infection risk by up to 44.4%. Vaccination also showed potential protection against Long COVID in children under 18, with males more likely to experience symptoms.
A study found that pregnant women with high blood pressure who received tight blood pressure control immediately after pregnancy had lower blood pressure levels and improved cardiac function compared to those with usual care. This could lead to a reduced risk of cardiovascular disease, including heart attacks and strokes.
A randomized clinical trial found that self-monitoring and physician-guided titration of antihypertensive medications reduced postpartum blood pressure compared to usual care. The study involved 220 participants in the UK and showed promising results for long-term blood pressure control.
Experts call for urgent measures to address discrimination against patients fleeing war or conflict zones, those with serious mental illnesses, and frail elderly patients. Guidelines for treating advanced breast cancer should prioritize patient preferences and involve multidisciplinary care teams.
A recent study led by Duke-NUS Medical School found that prior maternal dengue immunity substantially increases the risk of severe birth defects induced by Zika virus infection during pregnancy. Pregnant mothers with pre-existing dengue antibodies are more likely to experience microcephaly and brain damage in their foetuses after Zika ...
An mRNA SARS-CoV-2 vaccination before vs. during pregnancy and omicron infection among infants study found that maternal vaccination during the antenatal period was associated with a lower risk of Omicron SARS-CoV-2 infection in infants up to six months of age.
Researchers redesigned IVF needles to reduce fluid flow damage to eggs, improving oocyte collection and IVF success rates. The study uses computer models and mathematical simulations to optimize the design, which has been successfully tested in cattle, with plans for human trials.
A new study has found that tumor necrosis factor inhibitors, commonly used for inflammatory arthritis, are not associated with poor pregnancy outcomes. Women who continued treatment had lower risks of severe infections postpartum compared to those who stopped. The results provide reassuring data on the use of TNF blockers during pregna...
Research found that pregnant women living in neighborhoods with high levels of known stressors have significantly higher levels of testosterone, which can disrupt hormone regulation and lead to complications during and after childbirth. The study suggests that interventions to reduce neighborhood stress may improve pregnancy outcomes.
A large-scale international study found that maternal depressive symptoms can appear from early pregnancy and last up to two years after childbirth. The study emphasizes the importance of early interventions during pregnancy to mitigate symptoms and improve outcomes for both mother and child.
A new study found that oral contraceptive pill users have a lower prevalence of major depression (4.6%) compared to former users (11.4%). The researchers suggest two possible explanations for the findings: removing concerns about unwanted pregnancy and survivor bias.
A University of Missouri study found that opioid-dependent mothers experience stigma, leading to withdrawal from healthcare and negative outcomes for their infants. The research highlights the need for compassionate support and education to promote better health outcomes.
A study of 2,433 women who received in vitro fertilization treatment found that delaying frozen embryo transfer for at least six months after a preceding clinical pregnancy loss was associated with beneficial pregnancy outcomes. This delay resulted in improved rates of live births and healthy pregnancies.