Articles tagged with Cancer Patients
Mayo Clinic researchers identified critical genomic changes associated with abiraterone acetate/prednisone resistance in advanced prostate cancer. An 11-gene drug panel predicted a worse prognosis for a subset of patients, and whole-exome sequencing data revealed mechanisms of acquired resistance.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Researchers found that using the Bazett formula to assess heartbeat rhythms can lead to inaccurate chemotherapy modifications, potentially affecting patient care. Standardizing formulas with electrocardiograms can reduce this risk and improve treatment outcomes.
A recent study led by Drexel University's College of Nursing and Health Professions highlights the importance of nutrition and physical activity for both cancer patients and their caregivers. The research found similarities in beliefs about physical activity and barriers faced by both groups, including fatigue and time constraints.
Researchers at UMC Utrecht will investigate how intestinal microbiota impacts cancer immunotherapy and therapy side effects. The project aims to develop microbiota-targeted therapies to improve ICI treatment effectiveness and reduce severe inflammation.
The new SIO-ASCO guideline recommends the use of acupuncture, massage therapy, and other integrative therapies for managing breast cancer-related joint pain, general cancer pain, and chemotherapy-induced peripheral neuropathy. The guidelines also acknowledge areas that need further research to support their recommendations.
Researchers found associations between financial hardship, food insecurity, housing instability, and transportation difficulties with increased mortality risk among adults with new cancer diagnosis. The study highlights the importance of addressing social determinants of health for improving patient outcomes.
Researchers found that 12% of cancer survivors lived in poverty, experiencing negative effects on physical and mental health. Financial burden of cancer care persists years after diagnosis, leading to poor health outcomes and increased mortality.
A UC San Diego study found that cancer patients experiencing housing instability had a significantly increased risk of mortality. The research suggests that integrating health and social care can improve patient outcomes by identifying and addressing underlying social risk factors.
A new study urges regulators to take a closer look at the health and safety risks of the growing medicinal and recreational cannabis market. The research team found that many pesticides in cannabis cultivation were highly unlikely to be used, but still detected, highlighting the need for stricter regulations.
A new study provides valuable insights into the roles of B cells and plasma cells in early-stage lung cancer biology, highlighting their influence on tumor development and treatment outcomes. The research also reveals environmental factors and molecular features that contribute to the landscape of infiltrating immune cells.
In a Phase I/II trial, selpercatinib demonstrated a 44% objective response rate across multiple tumor types, including pancreatic and colorectal cancers. The study found responses regardless of cancer type or prior treatment history, confirming RET fusions as a tissue-agnostic target.
A new combination immunotherapy regimen shows remarkable activity in metastatic colorectal cancer patients without liver metastases, achieving a response rate of 40% and median overall survival exceeding 20 months. The study's findings confirm the importance of the tumor microenvironment in shaping the response to immunotherapy.
Bladder cancer researchers discovered a subset of CD8 T cells that adapts to tumor evasion strategies, offering a strategy to reduce tumor cells' ability to fight them off. The study also identified potential ways to make immunotherapy more effective against this deadly cancer by targeting the HLA-E/NKG2A axis.
A new study suggests that neoadjuvant novel hormonal therapy followed by prostatectomy can reduce the risk of recurrent and progressive cancer in high-risk prostate cancer patients. After treatment with NHAs, patients were more likely to have negative margins after surgery and fewer cases of biochemical recurrence.
A new blood test has shown promising results for detecting multiple types of cancer from tumor DNA in the blood, enabling early detection and potentially changing cancer screening practices. The test's accuracy and effectiveness have been demonstrated in a recent study, with high sensitivity and specificity rates.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
A phase 3 study shows that tumour-infiltrating lymphocytes (TIL) therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma. The treatment reduces disease progression or death by 50% in patients treated with TILs.
Researchers have developed a new safety system for CAR-T cells, called VIPER CAR-T cells, that can be turned on or off. This allows doctors to target cancer more aggressively while minimizing side effects. The new system uses an FDA-approved antiviral drug to control the cell's activity.
Late-breaking results at ESMO Congress 2022 reveal a strong association between air pollution and non-small cell lung cancer, with exposure to particulate matter linked to increased risk. The research underscores the need for environmental sustainability in oncology, particularly in cancer prevention and early detection.
A randomized phase III trial found that combination hormonal therapy, delivered for a finite treatment interval of 12 months, more durably suppresses PSA levels compared to hormone injections alone. The treatment approach improved disease progression in patients with high-risk biochemically relapsed prostate cancer.
Researchers at Mayo Clinic Comprehensive Cancer Center found that metabolic imaging, combined with traditional treatment response assessment methods, can provide critical information to guide therapy for pancreatic cancer patients. The use of positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) tracer adds significant pr...
The PROSPER RCC trial showed no difference in recurrence-free survival between arms, with higher adverse events reported in the nivolumab arm. The trial's results inform future research on neoadjuvant trials in high-risk renal cell carcinoma.
A study from the University of Gothenburg found that the number of surgeries performed by a urology surgeon has no effect on men's risk of developing postoperative urinary incontinence after prostate cancer surgery. The researchers analyzed data from over 4,600 men who underwent robot-assisted radical prostatectomy between 2017 and 2019.
Researchers conducted a study on administering immunotherapy drug pembrolizumab before surgery for oral cavity cancer and found no increased rates of complications during and after surgery. The findings are encouraging for patients who have not previously received treatment for their oral cavity cancer, suggesting that complication rat...
Breast cancer recurrence and metastatic spread remain a significant challenge, with researchers identifying a metabolic signature that can predict patient outcomes. The signature could be used to develop new therapies targeting cancer metabolism.
A large study found that obstructive sleep apnea is independently associated with an increased risk of cancer. Patients with more severe OSA were also at a greater risk of developing blood clots. Additionally, a second study linked OSA to a decline in mental processing powers, particularly in the elderly.
A newly identified link between chronic pain and lung cancer in mice suggests that old drugs such as clonidine, capsaicin, and fluphenazine may offer new treatments for chronic pain. The study found that blocking the BH4 pathway reduced pain sensitivity and decreased tumor growth in mouse models of KRAS-driven lung cancer.
A combination of immunotherapy and virotherapy using myxoma virus provides new hope for patients with treatment resistant cancers. The approach boosts the immune capacity to effectively target and destroy cancer cells, inducing a form of cell death called autosis.
Researchers identified five new hepatoblastoma tumor signatures that could help predict responses to chemotherapy treatments. The study used single-cell transcriptomic techniques to analyze tumors from infants and children, providing a window into normal development and cancer.
A study from Lund University found that Caveolin-1 protein levels in surrounding tumour tissue affect breast cancer prognosis. The study suggests that this protein could be used as a marker for precise prognosis and treatment choice.
Researchers at UVA have discovered the mechanism behind gene regulation during organ development, shedding light on how genetic material interacts with transcription factors to create different cell types. The study's findings could offer insights into the initiation of certain cancers and inspire new therapeutic development.
A University of Houston engineer has developed technology to determine which patients are likely to respond to CAR T-cell therapy for lymphoma, saving time and increasing success rates. The TIMING method analyzes interactions between T cells and tumor cells, identifying a key ligand molecule that predicts patient response.
Researchers have successfully prevented neuropathic pain associated with chemotherapy in mice treated with oxaliplatin. A Sigma-1 receptor antagonist prevents the development of neuropathy by modulating the TRPA1 ion channel, offering hope for a new therapy to treat debilitating side effects.
Researchers have discovered that reduced TGFBR2 abundance is significantly associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. An AI-based process accurately identified HCC tissue, confirming the biomarker's potential for early detection.
Cancer patients in rural areas experience higher mortality rates and are more likely to miss radiation appointments, leading to poorer overall survival. The study suggests that targeted support programs like patient navigation can help reduce disparities in cancer care.
A new study by Dana-Farber Cancer Institute found that dispensaries often prioritize sales skills over cannabis therapeutics training, leading to a lack of reliable guidance for patients. The study's findings highlight the need for standardized training and education in cannabis therapy to ensure patients receive accurate information.
Research suggests that cancer-related fatigue (CRF) contributes to balance problems in breast cancer survivors, even after chemotherapy. CRF predicts greater postural sway and changes in 'sit-to-stand' function, highlighting the need for rehabilitation professionals to consider CRF in exercise prescriptions.
A study published in Patterns shows that five digital medicine companies share browsing data related to health topics with Facebook for lead generation and advertising purposes. The researchers found that two companies targeted ads consistent with their own privacy policies, while the other three did not comply with their policies.
The study found an overall response rate of 57% and disease control rate of 83% in 23 patients with diverse cancer types. These results validate RET as a tissue-agnostic target with sensitivity to RET inhibition.
A comprehensive analysis of interstitial lung disease diagnosis and treatment in patients who received an antibody drug conjugate known as T-DXd found that close monitoring and proactive management can reduce the risk of ILD. The study results suggest that patient awareness and ongoing education can aid in early detection.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
A new scale called the Geriatric Oncology-Potentially Inappropriate Medications (GO-PIMs) Scale was found to be more effective at predicting frailty than conventional methods. The scale identifies high-risk medications linked to falls and fatigue, allowing oncology teams to deprescribe them and improve patients' overall health.
A recent study published in PLOS ONE found that opioid prescriptions declined for US patients with both cancer and non-cancer pain between 2012 and 2019. The proportion of people receiving any opioid prescription dropped from 49.7% to 30.5% for non-cancer pain and from 86.0% to 78.7% for cancer pain.
A recent study found that women with lung cancer experience significant changes in their sexual desire and vaginal pain/discomfort after diagnosis. The research highlights the need for addressing sexual health in thoracic oncology care to improve patients' quality of life and overall well-being.
A recent study published by Wiley suggests that biological sex differences are the primary reason for higher cancer rates in men compared to women. The study analyzed data from 171,274 males and 122,826 females aged 50-71 years and found that incidence was lower in men only for thyroid and gallbladder cancers.
Researchers have developed a proof-of-concept model that uses artificial intelligence to combine multiple types of data from different sources to predict patient outcomes. The models demonstrate the ability to make prognostic determinations while uncovering the predictive bases of features used to predict patient risk.
Researchers developed a small molecule that effectively controls tumor growth by inhibiting PD-1/PD-L1 binding, overcoming accessibility and cost issues of existing antibody treatments. The new molecule has advantages in terms of affordability and oral administration, making immunotherapy more accessible to all cancer patients.
Researchers at Dartmouth Cancer Center developed a new approach for detecting and quantifying tumor heterogeneity in breast cancer. High levels of heterogeneity are linked to poor patient outcomes, while specific proteins regulate its extent. The study aims to utilize this approach in therapeutic decision-making.
The NCI-backed Molecular Targets Platform streamlines and catalyzes drug development by integrating pediatric cancer targets and pathways. This platform empowers researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.
Researchers at Cedars-Sinai Cancer identified genetic signatures linked to patient response to immunotherapy in bladder and other cancers. High DDR1 expression is associated with 'cold' tumors, while high DDR2 is linked to 'hot' tumors.
A study found that cold temperatures activate brown adipose tissue that competes with tumors for glucose, inhibiting tumor growth and prolonging survival. Researchers suggest that cold therapy could be a promising approach to cancer therapy.
Researchers investigated the effects of neoadjuvant chemoradiotherapy on CD8+ tumor-infiltrating lymphocytes, PD-L1, and mucin expression in rectal cancer patients. The study found that nCRT exposure was associated with higher mucin expression and a non-significant difference in PD-L1 expression, suggesting an immunosuppressive phenotype.
A new study by CU Anschutz researchers found that over 70% of breast cancer patients experience changes in their sexual health during and after treatment. Patients desire early education and counseling from medical teams to address these issues, which are often overlooked.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
A study investigated total and out-of-pocket costs of genetic counseling among commercially insured adults with cancer, finding that these costs can significantly impact patient care. Factors contributing to higher costs were identified, highlighting the need for more affordable genetic testing options.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
A new study published in JAMA Oncology has found a significant association between daily insulin dose and increased cancer risk in patients with type 1 diabetes. The research, led by Yuanjie Mao, investigated the relationships between various risk factors and cancer incidence in this population.
Researchers discover gene AVIL responsible for deadly brain tumor also causes two forms of childhood cancer, rhabdomyosarcoma. Blocking AVIL activity prevents formation of the disease in lab samples and mouse models.
Researchers used Guardant NGS to analyze nearly 17,000 lung cancer samples and found MET amplification in 1.2% of cases, with 20.8% having overlapping oncogenic drivers. The study suggests that high gene copy numbers and smaller amplified regions can be used to enrich for the true MET-sensitive population.